1p2q - Revision history

OCA at 09:35, 16 August 2023

OCA — Wed, 16 Aug 2023 09:35:50 GMT

←Older revision		Revision as of 09:35, 16 August 2023
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	<StructureSection load='1p2q' size='340' side='right'caption='[[1p2q]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1p2q' size='340' side='right'caption='[[1p2q]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1p2q]] is a 4 chain structure with sequence from ~~[https://en.wikipedia.org/wiki/Bovin Bovin] and~~ [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P2Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P2Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1p2q]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P2Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P2Q FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~, ~~<scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-~~1~~,3-DIOL'>TRS</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1p2i\|1p2i]], [[1p2j\|1p2j]], [[1p2k\|1p2k]], [[1p2m\|1p2m]], [[1p2n\|1p2n]], [[1p2o\|1p2o]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Chymotrypsin Chymotrypsin], with EC number [https://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=3.4.21.~~1 3~~.4.21.1]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p2q OCA], [https://pdbe.org/1p2q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p2q RCSB], [https://www.ebi.ac.uk/pdbsum/1p2q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p2q ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p2q OCA], [https://pdbe.org/1p2q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p2q RCSB], [https://www.ebi.ac.uk/pdbsum/1p2q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p2q ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~BPT1_BOVIN BPT1_BOVIN~~]~~] Inhibits trypsin, kallikrein, chymotrypsin, and plasmin.~~	+	[https://www.uniprot.org/uniprot/CTRA_BOVIN CTRA_BOVIN]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
-	[[Category: Bovin]]
-	[[Category: Chymotrypsin]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Czapinska, H]]	+	[[Category: Czapinska H]]
-	[[Category: Helland, R]]	+	[[Category: Helland R]]
-	[[Category: Leiros, I]]	+	[[Category: Leiros I]]
-	[[Category: Olufsen, M]]	+	[[Category: Olufsen M]]
-	[[Category: Otlewski, J]]	+	[[Category: Otlewski J]]
-	[[Category: Smalaas~~, A O]]~~	+	[[Category: Smalaas AO]]
-	~~[[Category: Bovine pancreatic trypsin inhibitor]]~~	+
-	~~[[Category: Crystal structure]]~~	+
-	~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~	+
-	~~[[Category: Non-cognate binding]]~~	+
-	~~[[Category: Primary specificity]]~~	+
-	~~[[Category: Protein-protein interaction]]~~	+
-	~~[[Category: S1 pocket]]~~	+
-	~~[[Category: Serine proteinase]]~~	+
-	~~[[Category: Trypsin~~]]	+

OCA at 09:24, 8 September 2021

OCA — Wed, 08 Sep 2021 09:24:21 GMT

←Older revision		Revision as of 09:24, 8 September 2021
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	<StructureSection load='1p2q' size='340' side='right'caption='[[1p2q]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1p2q' size='340' side='right'caption='[[1p2q]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1p2q]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bovin Bovin] and [~~http~~://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P2Q OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1P2Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1p2q]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bovin Bovin] and [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P2Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P2Q FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p2i\|1p2i]], [[1p2j\|1p2j]], [[1p2k\|1p2k]], [[1p2m\|1p2m]], [[1p2n\|1p2n]], [[1p2o\|1p2o]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1p2i\|1p2i]], [[1p2j\|1p2j]], [[1p2k\|1p2k]], [[1p2m\|1p2m]], [[1p2n\|1p2n]], [[1p2o\|1p2o]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Chymotrypsin Chymotrypsin], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.1 3.4.21.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Chymotrypsin Chymotrypsin], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.1 3.4.21.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1p2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p2q OCA], [~~http~~://pdbe.org/1p2q PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1p2q RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1p2q PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1p2q ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p2q OCA], [https://pdbe.org/1p2q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p2q RCSB], [https://www.ebi.ac.uk/pdbsum/1p2q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p2q ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/BPT1_BOVIN BPT1_BOVIN]] Inhibits trypsin, kallikrein, chymotrypsin, and plasmin.	+	[[https://www.uniprot.org/uniprot/BPT1_BOVIN BPT1_BOVIN]] Inhibits trypsin, kallikrein, chymotrypsin, and plasmin.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 10:04, 27 November 2019

OCA — Wed, 27 Nov 2019 10:04:45 GMT

←Older revision		Revision as of 10:04, 27 November 2019
Line 1:		Line 1:

	==Structural consequences of accommodation of four non-cognate amino-acid residues in the S1 pocket of bovine trypsin and chymotrypsin==		==Structural consequences of accommodation of four non-cognate amino-acid residues in the S1 pocket of bovine trypsin and chymotrypsin==
-	<StructureSection load='1p2q' size='340' side='right' caption='[[1p2q]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='1p2q' size='340' side='right'caption='[[1p2q]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1p2q]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin] and [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P2Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P2Q FirstGlance]. <br>		<table><tr><td colspan='2'>[[1p2q]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin] and [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P2Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P2Q FirstGlance]. <br>
Line 30:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 1p2q" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1p2q" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[BPTI 3D structures\|BPTI 3D structures]]
		+	*[[Chymotrypsin 3D structures\|Chymotrypsin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 37:		Line 41:
	[[Category: Bovin]]		[[Category: Bovin]]
	[[Category: Chymotrypsin]]		[[Category: Chymotrypsin]]
		+	[[Category: Large Structures]]
	[[Category: Czapinska, H]]		[[Category: Czapinska, H]]
	[[Category: Helland, R]]		[[Category: Helland, R]]

OCA at 07:37, 15 February 2018

OCA — Thu, 15 Feb 2018 07:37:17 GMT

←Older revision		Revision as of 07:37, 15 February 2018
Line 1:		Line 1:
		+
	==Structural consequences of accommodation of four non-cognate amino-acid residues in the S1 pocket of bovine trypsin and chymotrypsin==		==Structural consequences of accommodation of four non-cognate amino-acid residues in the S1 pocket of bovine trypsin and chymotrypsin==
	<StructureSection load='1p2q' size='340' side='right' caption='[[1p2q]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1p2q' size='340' side='right' caption='[[1p2q]], [[Resolution\|resolution]] 1.80Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p2i\|1p2i]], [[1p2j\|1p2j]], [[1p2k\|1p2k]], [[1p2m\|1p2m]], [[1p2n\|1p2n]], [[1p2o\|1p2o]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p2i\|1p2i]], [[1p2j\|1p2j]], [[1p2k\|1p2k]], [[1p2m\|1p2m]], [[1p2n\|1p2n]], [[1p2o\|1p2o]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chymotrypsin Chymotrypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.1 3.4.21.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chymotrypsin Chymotrypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.1 3.4.21.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p2q OCA], [http://pdbe.org/1p2q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1p2q RCSB], [http://www.ebi.ac.uk/pdbsum/1p2q PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p2q OCA], [http://pdbe.org/1p2q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1p2q RCSB], [http://www.ebi.ac.uk/pdbsum/1p2q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1p2q ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p2/1p2q_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p2/1p2q_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 29:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 1p2q" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1p2q" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Basic Pancreatic Trypsin Inhibitor\|Basic Pancreatic Trypsin Inhibitor]]
-	*[[Chymotrypsin\|Chymotrypsin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:43, 7 February 2016

OCA — Sun, 07 Feb 2016 16:43:54 GMT

←Older revision		Revision as of 16:43, 7 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1p2q ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 03:20, 10 September 2015

OCA — Thu, 10 Sep 2015 03:20:58 GMT

←Older revision		Revision as of 03:20, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1p2q' size='340' side='right' caption='[[1p2q]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1p2q' size='340' side='right' caption='[[1p2q]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1p2q]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P2Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P2Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1p2q]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin] and [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P2Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P2Q FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p2i\|1p2i]], [[1p2j\|1p2j]], [[1p2k\|1p2k]], [[1p2m\|1p2m]], [[1p2n\|1p2n]], [[1p2o\|1p2o]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p2i\|1p2i]], [[1p2j\|1p2j]], [[1p2k\|1p2k]], [[1p2m\|1p2m]], [[1p2n\|1p2n]], [[1p2o\|1p2o]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chymotrypsin Chymotrypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.1 3.4.21.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chymotrypsin Chymotrypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.1 3.4.21.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p2q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1p2q RCSB], [http://www.ebi.ac.uk/pdbsum/1p2q PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p2q OCA], [http://pdbe.org/1p2q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1p2q RCSB], [http://www.ebi.ac.uk/pdbsum/1p2q PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1p2q" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 37:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
		+	[[Category: Bovin]]
	[[Category: Chymotrypsin]]		[[Category: Chymotrypsin]]
	[[Category: Czapinska, H]]		[[Category: Czapinska, H]]

OCA at 16:47, 24 December 2014

OCA — Wed, 24 Dec 2014 16:47:16 GMT

←Older revision		Revision as of 16:47, 24 December 2014
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1p2q]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P2Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P2Q FirstGlance]. <br>		<table><tr><td colspan='2'>[[1p2q]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P2Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P2Q FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p2i\|1p2i]], [[1p2j\|1p2j]], [[1p2k\|1p2k]], [[1p2m\|1p2m]], [[1p2n\|1p2n]], [[1p2o\|1p2o]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p2i\|1p2i]], [[1p2j\|1p2j]], [[1p2k\|1p2k]], [[1p2m\|1p2m]], [[1p2n\|1p2n]], [[1p2o\|1p2o]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chymotrypsin Chymotrypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.1 3.4.21.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chymotrypsin Chymotrypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.1 3.4.21.1] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p2q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1p2q RCSB], [http://www.ebi.ac.uk/pdbsum/1p2q PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p2q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1p2q RCSB], [http://www.ebi.ac.uk/pdbsum/1p2q PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BPT1_BOVIN BPT1_BOVIN]] Inhibits trypsin, kallikrein, chymotrypsin, and plasmin.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Chymotrypsin]]		[[Category: Chymotrypsin]]
-	[[Category: Czapinska, H.]]	+	[[Category: Czapinska, H]]
-	[[Category: Helland, R.]]	+	[[Category: Helland, R]]
-	[[Category: Leiros, I.]]	+	[[Category: Leiros, I]]
-	[[Category: Olufsen, M.]]	+	[[Category: Olufsen, M]]
-	[[Category: Otlewski, J.]]	+	[[Category: Otlewski, J]]
-	[[Category: Smalaas, A O.]]	+	[[Category: Smalaas, A O]]
	[[Category: Bovine pancreatic trypsin inhibitor]]		[[Category: Bovine pancreatic trypsin inhibitor]]
-	[[Category: Chymotrypsin]]
	[[Category: Crystal structure]]		[[Category: Crystal structure]]
	[[Category: Hydrolase-hydrolase inhibitor complex]]		[[Category: Hydrolase-hydrolase inhibitor complex]]

OCA at 23:52, 28 September 2014

OCA — Sun, 28 Sep 2014 23:52:53 GMT

←Older revision		Revision as of 23:52, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1p2q.~~png~~\|~~left~~\|200px]]	+	==Structural consequences of accommodation of four non-cognate amino-acid residues in the S1 pocket of bovine trypsin and chymotrypsin==
		+	<StructureSection load='1p2q' size='340' side='right' caption='[[1p2q]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1p2q]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P2Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P2Q FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p2i\|1p2i]], [[1p2j\|1p2j]], [[1p2k\|1p2k]], [[1p2m\|1p2m]], [[1p2n\|1p2n]], [[1p2o\|1p2o]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chymotrypsin Chymotrypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.1 3.4.21.1] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p2q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1p2q RCSB], [http://www.ebi.ac.uk/pdbsum/1p2q PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p2/1p2q_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Crystal structures of P1 Gly, Val, Leu and Phe bovine pancreatic trypsin inhibitor (BPTI) variants in complex with two serine proteinases, bovine trypsin and chymotrypsin, have been determined. The association constants for the four mutants with the two enzymes show that the enlargement of the volume of the P1 residue is accompanied by an increase of the binding energy, which is more pronounced for bovine chymotrypsin. Since the conformation of the P1 side-chains in the two S1 pockets is very similar, we suggest that the difference in DeltaG values between the enzymes must arise from the more polar environment of the S1 site of trypsin. This results mainly from the substitutions of Met192 and Ser189 observed in chymotrypsin with Gln192 and Asp189 present in trypsin. The more polar interior of the S1 site of trypsin is reflected by a much higher order of the solvent network in the empty pocket of the enzyme, as is observed in the complexes of the two enzymes with the P1 Gly BPTI variant. The more optimal binding of the large hydrophobic P1 residues by chymotrypsin is also reflected by shrinkage of the S1 pocket upon the accommodation of the cognate residues of this enzyme. Conversely, the S1 pocket of trypsin expands upon binding of such side-chains, possibly to avoid interaction with the polar residues of the walls. Further differentiation between the two enzymes is achieved by small differences in the shape of the S1 sites, resulting in an unequal steric hindrance of some of the side-chains, as observed for the gamma-branched P1 Leu variant of BPTI, which is much more favored by bovine chymotrypsin than trypsin. Analysis of the discrimination of beta-branched residues by trypsin and chymotrypsin is based on the complexes with the P1 Val BPTI variant. Steric repulsion of the P1 Val residue by the walls of the S1 pocket of both enzymes prevents the P1 Val side-chain from adopting the most optimal chi1 value.

-	~~{{STRUCTURE_1p2q\| PDB=1p2q \| SCENE= }}~~	+	Structural consequences of accommodation of four non-cognate amino acid residues in the S1 pocket of bovine trypsin and chymotrypsin.,Helland R, Czapinska H, Leiros I, Olufsen M, Otlewski J, Smalas AO J Mol Biol. 2003 Oct 31;333(4):845-61. PMID:14568540<ref>PMID:14568540</ref>

-	~~===Structural consequences~~ of ~~accommodation of four non-cognate amino-acid residues in~~ the ~~S1 pocket of bovine trypsin and chymotrypsin===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_14568540}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1p2q]] is a 4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bos_taurus Bos taurus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1P2Q OCA].~~	+

	==See Also==		==See Also==
	*[[Basic Pancreatic Trypsin Inhibitor\|Basic Pancreatic Trypsin Inhibitor]]		*[[Basic Pancreatic Trypsin Inhibitor\|Basic Pancreatic Trypsin Inhibitor]]
	*[[Chymotrypsin\|Chymotrypsin]]		*[[Chymotrypsin\|Chymotrypsin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:014568540<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Chymotrypsin]]		[[Category: Chymotrypsin]]

OCA at 07:16, 20 October 2012

OCA — Sat, 20 Oct 2012 07:16:01 GMT

←Older revision		Revision as of 07:16, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1p2q]] is a 4 chain structure ~~of [[Basic Pancreatic Trypsin Inhibitor]] and [[Chymotrypsin]]~~ with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P2Q OCA].	+	[[1p2q]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P2Q OCA].

	==See Also==		==See Also==

OCA: Protected "1p2q" [edit=sysop:move=sysop]

OCA — Wed, 25 Jul 2012 15:46:06 GMT

Protected "1p2q" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:46, 25 July 2012