1p3g - Revision history

OCA at 09:36, 16 August 2023

OCA — Wed, 16 Aug 2023 09:36:38 GMT

←Older revision		Revision as of 09:36, 16 August 2023
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	<StructureSection load='1p3g' size='340' side='right'caption='[[1p3g]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='1p3g' size='340' side='right'caption='[[1p3g]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1p3g]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/ ] and [https://en.wikipedia.org/wiki/~~African_clawed_frog African clawed frog~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P3G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P3G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1p3g]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P3G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P3G FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[1aoi\|1aoi]]~~, [[~~1f66~~\|~~1f66~~]], [[1id3\|1id3]], [[1kx3\|1kx3]], [[1kx4\|1kx4]], [[1kx5\|1kx5]], [[1p34\|1p34]], [[1p3a\|1p3a]], [[1p3b\|1p3b]], [[1p3f\|1p3f]], [[1p3i\|1p3i]], [[1p3k\|1p3k]], [[1p3l\|1p3l]], [[1p3m\|1p3m]], [[1p3o\|1p3o]], [[1p3p\|1p3p]]</div></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p3g OCA], [https://pdbe.org/1p3g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p3g RCSB], [https://www.ebi.ac.uk/pdbsum/1p3g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p3g ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p3g OCA], [https://pdbe.org/1p3g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p3g RCSB], [https://www.ebi.ac.uk/pdbsum/1p3g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p3g ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/H4_XENLA H4_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [[https://www.uniprot.org/uniprot/H2B11_XENLA H2B11_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	+	[https://www.uniprot.org/uniprot/H32_XENLA H32_XENLA] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~African clawed frog~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bao, Y]]	+	[[Category: Xenopus laevis]]
-	[[Category: Dyer~~, P N~~]]	+	[[Category: Bao Y]]
-	[[Category: Edayathumangalam~~, R S~~]]	+	[[Category: Dyer PN]]
-	[[Category: Forsberg~~, L J~~]]	+	[[Category: Edayathumangalam RS]]
-	[[Category: Luger, K]]	+	[[Category: Forsberg LJ]]
-	[[Category: Muthurajan~~, U M~~]]	+	[[Category: Luger K]]
-	[[Category: White~~, C L]]~~	+	[[Category: Muthurajan UM]]
-	~~[[Category: Chromatin]]~~	+	[[Category: White CL]]
-	~~[[Category: Nucleosome core particle]]~~	+
-	~~[[Category: Protein/dna interaction]]~~	+
-	~~[[Category: Sin mutant]]~~	+
-	~~[[Category: Structural protein-dna complex~~]]	+

OCA at 09:24, 8 September 2021

OCA — Wed, 08 Sep 2021 09:24:47 GMT

←Older revision		Revision as of 09:24, 8 September 2021
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	<StructureSection load='1p3g' size='340' side='right'caption='[[1p3g]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='1p3g' size='340' side='right'caption='[[1p3g]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1p3g]] is a 10 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/ ] and [~~http~~://en.wikipedia.org/wiki/African_clawed_frog African clawed frog]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P3G OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1P3G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1p3g]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/ ] and [https://en.wikipedia.org/wiki/African_clawed_frog African clawed frog]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P3G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P3G FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aoi\|1aoi]], [[1f66\|1f66]], [[1id3\|1id3]], [[1kx3\|1kx3]], [[1kx4\|1kx4]], [[1kx5\|1kx5]], [[1p34\|1p34]], [[1p3a\|1p3a]], [[1p3b\|1p3b]], [[1p3f\|1p3f]], [[1p3i\|1p3i]], [[1p3k\|1p3k]], [[1p3l\|1p3l]], [[1p3m\|1p3m]], [[1p3o\|1p3o]], [[1p3p\|1p3p]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1aoi\|1aoi]], [[1f66\|1f66]], [[1id3\|1id3]], [[1kx3\|1kx3]], [[1kx4\|1kx4]], [[1kx5\|1kx5]], [[1p34\|1p34]], [[1p3a\|1p3a]], [[1p3b\|1p3b]], [[1p3f\|1p3f]], [[1p3i\|1p3i]], [[1p3k\|1p3k]], [[1p3l\|1p3l]], [[1p3m\|1p3m]], [[1p3o\|1p3o]], [[1p3p\|1p3p]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1p3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p3g OCA], [~~http~~://pdbe.org/1p3g PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1p3g RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1p3g PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1p3g ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p3g OCA], [https://pdbe.org/1p3g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p3g RCSB], [https://www.ebi.ac.uk/pdbsum/1p3g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p3g ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/H4_XENLA H4_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [[~~http~~://www.uniprot.org/uniprot/H2B11_XENLA H2B11_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	+	[[https://www.uniprot.org/uniprot/H4_XENLA H4_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [[https://www.uniprot.org/uniprot/H2B11_XENLA H2B11_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 09:56, 27 November 2019

OCA — Wed, 27 Nov 2019 09:56:47 GMT

←Older revision		Revision as of 09:56, 27 November 2019
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	==Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants==		==Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants==
-	<StructureSection load='1p3g' size='340' side='right' caption='[[1p3g]], [[Resolution\|resolution]] 2.70Å' scene=''>	+	<StructureSection load='1p3g' size='340' side='right'caption='[[1p3g]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1p3g]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/African_clawed_frog African clawed frog]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P3G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P3G FirstGlance]. <br>		<table><tr><td colspan='2'>[[1p3g]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/African_clawed_frog African clawed frog]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P3G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P3G FirstGlance]. <br>
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	</div>		</div>
	<div class="pdbe-citations 1p3g" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1p3g" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Histone 3D structures\|Histone 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: African clawed frog]]		[[Category: African clawed frog]]
		+	[[Category: Large Structures]]
	[[Category: Bao, Y]]		[[Category: Bao, Y]]
	[[Category: Dyer, P N]]		[[Category: Dyer, P N]]

OCA at 07:32, 15 February 2018

OCA — Thu, 15 Feb 2018 07:32:07 GMT

←Older revision		Revision as of 07:32, 15 February 2018
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		+
	==Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants==		==Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants==
	<StructureSection load='1p3g' size='340' side='right' caption='[[1p3g]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='1p3g' size='340' side='right' caption='[[1p3g]], [[Resolution\|resolution]] 2.70Å' scene=''>
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	<table><tr><td colspan='2'>[[1p3g]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/African_clawed_frog African clawed frog]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P3G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P3G FirstGlance]. <br>		<table><tr><td colspan='2'>[[1p3g]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/African_clawed_frog African clawed frog]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P3G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P3G FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aoi\|1aoi]], [[1f66\|1f66]], [[1id3\|1id3]], [[1kx3\|1kx3]], [[1kx4\|1kx4]], [[1kx5\|1kx5]], [[1p34\|1p34]], [[1p3a\|1p3a]], [[1p3b\|1p3b]], [[1p3f\|1p3f]], [[1p3i\|1p3i]], [[1p3k\|1p3k]], [[1p3l\|1p3l]], [[1p3m\|1p3m]], [[1p3o\|1p3o]], [[1p3p\|1p3p]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aoi\|1aoi]], [[1f66\|1f66]], [[1id3\|1id3]], [[1kx3\|1kx3]], [[1kx4\|1kx4]], [[1kx5\|1kx5]], [[1p34\|1p34]], [[1p3a\|1p3a]], [[1p3b\|1p3b]], [[1p3f\|1p3f]], [[1p3i\|1p3i]], [[1p3k\|1p3k]], [[1p3l\|1p3l]], [[1p3m\|1p3m]], [[1p3o\|1p3o]], [[1p3p\|1p3p]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p3g OCA], [http://pdbe.org/1p3g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1p3g RCSB], [http://www.ebi.ac.uk/pdbsum/1p3g PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p3g OCA], [http://pdbe.org/1p3g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1p3g RCSB], [http://www.ebi.ac.uk/pdbsum/1p3g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1p3g ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p3/1p3g_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p3/1p3g_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	</div>		</div>
	<div class="pdbe-citations 1p3g" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1p3g" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Histone\|Histone]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 00:22, 8 February 2016

OCA — Mon, 08 Feb 2016 00:22:43 GMT

←Older revision		Revision as of 00:22, 8 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1p3g ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:10, 10 September 2015

OCA — Thu, 10 Sep 2015 06:10:46 GMT

←Older revision		Revision as of 06:10, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1p3g' size='340' side='right' caption='[[1p3g]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='1p3g' size='340' side='right' caption='[[1p3g]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1p3g]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~] and [http://en.wikipedia.org/wiki/~~Xenopus_laevis Xenopus laevis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P3G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P3G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1p3g]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/African_clawed_frog African clawed frog]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P3G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P3G FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aoi\|1aoi]], [[1f66\|1f66]], [[1id3\|1id3]], [[1kx3\|1kx3]], [[1kx4\|1kx4]], [[1kx5\|1kx5]], [[1p34\|1p34]], [[1p3a\|1p3a]], [[1p3b\|1p3b]], [[1p3f\|1p3f]], [[1p3i\|1p3i]], [[1p3k\|1p3k]], [[1p3l\|1p3l]], [[1p3m\|1p3m]], [[1p3o\|1p3o]], [[1p3p\|1p3p]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aoi\|1aoi]], [[1f66\|1f66]], [[1id3\|1id3]], [[1kx3\|1kx3]], [[1kx4\|1kx4]], [[1kx5\|1kx5]], [[1p34\|1p34]], [[1p3a\|1p3a]], [[1p3b\|1p3b]], [[1p3f\|1p3f]], [[1p3i\|1p3i]], [[1p3k\|1p3k]], [[1p3l\|1p3l]], [[1p3m\|1p3m]], [[1p3o\|1p3o]], [[1p3p\|1p3p]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p3g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1p3g RCSB], [http://www.ebi.ac.uk/pdbsum/1p3g PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p3g OCA], [http://pdbe.org/1p3g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1p3g RCSB], [http://www.ebi.ac.uk/pdbsum/1p3g PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/H4_XENLA H4_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	+	[[http://www.uniprot.org/uniprot/H4_XENLA H4_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [[http://www.uniprot.org/uniprot/H2B11_XENLA H2B11_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1p3g" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens]]~~	+	[[Category: African clawed frog]]
-	~~[[Category: Xenopus laevis~~]]	+
	[[Category: Bao, Y]]		[[Category: Bao, Y]]
	[[Category: Dyer, P N]]		[[Category: Dyer, P N]]

OCA at 19:13, 24 December 2014

OCA — Wed, 24 Dec 2014 19:13:12 GMT

←Older revision		Revision as of 19:13, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1p3g]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P3G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P3G FirstGlance]. <br>		<table><tr><td colspan='2'>[[1p3g]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P3G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P3G FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aoi\|1aoi]], [[1f66\|1f66]], [[1id3\|1id3]], [[1kx3\|1kx3]], [[1kx4\|1kx4]], [[1kx5\|1kx5]], [[1p34\|1p34]], [[1p3a\|1p3a]], [[1p3b\|1p3b]], [[1p3f\|1p3f]], [[1p3i\|1p3i]], [[1p3k\|1p3k]], [[1p3l\|1p3l]], [[1p3m\|1p3m]], [[1p3o\|1p3o]], [[1p3p\|1p3p]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aoi\|1aoi]], [[1f66\|1f66]], [[1id3\|1id3]], [[1kx3\|1kx3]], [[1kx4\|1kx4]], [[1kx5\|1kx5]], [[1p34\|1p34]], [[1p3a\|1p3a]], [[1p3b\|1p3b]], [[1p3f\|1p3f]], [[1p3i\|1p3i]], [[1p3k\|1p3k]], [[1p3l\|1p3l]], [[1p3m\|1p3m]], [[1p3o\|1p3o]], [[1p3p\|1p3p]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p3g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1p3g RCSB], [http://www.ebi.ac.uk/pdbsum/1p3g PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p3g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1p3g RCSB], [http://www.ebi.ac.uk/pdbsum/1p3g PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/H4_XENLA H4_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Xenopus laevis]]		[[Category: Xenopus laevis]]
-	[[Category: Bao, Y.]]	+	[[Category: Bao, Y]]
-	[[Category: Dyer, P N.]]	+	[[Category: Dyer, P N]]
-	[[Category: Edayathumangalam, R S.]]	+	[[Category: Edayathumangalam, R S]]
-	[[Category: Forsberg, L J.]]	+	[[Category: Forsberg, L J]]
-	[[Category: Luger, K.]]	+	[[Category: Luger, K]]
-	[[Category: Muthurajan, U M.]]	+	[[Category: Muthurajan, U M]]
-	[[Category: White, C L.]]	+	[[Category: White, C L]]
	[[Category: Chromatin]]		[[Category: Chromatin]]
	[[Category: Nucleosome core particle]]		[[Category: Nucleosome core particle]]

OCA at 21:37, 28 September 2014

OCA — Sun, 28 Sep 2014 21:37:17 GMT

←Older revision		Revision as of 21:37, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1p3g.~~png~~\|~~left~~\|200px]]	+	==Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants==
		+	<StructureSection load='1p3g' size='340' side='right' caption='[[1p3g]], [[Resolution\|resolution]] 2.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1p3g]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P3G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P3G FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aoi\|1aoi]], [[1f66\|1f66]], [[1id3\|1id3]], [[1kx3\|1kx3]], [[1kx4\|1kx4]], [[1kx5\|1kx5]], [[1p34\|1p34]], [[1p3a\|1p3a]], [[1p3b\|1p3b]], [[1p3f\|1p3f]], [[1p3i\|1p3i]], [[1p3k\|1p3k]], [[1p3l\|1p3l]], [[1p3m\|1p3m]], [[1p3o\|1p3o]], [[1p3p\|1p3p]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p3g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1p3g RCSB], [http://www.ebi.ac.uk/pdbsum/1p3g PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p3/1p3g_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Here we describe 11 crystal structures of nucleosome core particles containing individual point mutations in the structured regions of histones H3 and H4. The mutated residues are located at the two protein-DNA interfaces flanking the nucleosomal dyad. Five of the mutations partially restore the in vivo effects of SWI/SNF inactivation in yeast. We find that even nonconservative mutations of these residues (which exhibit a distinct phenotype in vivo) have only moderate effects on global nucleosome structure. Rather, local protein-DNA interactions are disrupted and weakened in a subtle and complex manner. The number of lost protein-DNA interactions correlates directly with an increased propensity of the histone octamer to reposition with respect to the DNA, and with an overall destabilization of the nucleosome. Thus, the disruption of only two to six of the approximately 120 direct histone-DNA interactions within the nucleosome has a pronounced effect on nucleosome mobility and stability. This has implications for our understanding of how these structures are made accessible to the transcription and replication machinery in vivo.

-	~~{{STRUCTURE_1p3g\| PDB=1p3g \| SCENE= }}~~	+	Crystal structures of histone Sin mutant nucleosomes reveal altered protein-DNA interactions.,Muthurajan UM, Bao Y, Forsberg LJ, Edayathumangalam RS, Dyer PN, White CL, Luger K EMBO J. 2004 Jan 28;23(2):260-71. Epub 2004 Jan 22. PMID:14739929<ref>PMID:14739929</ref>

-	~~===Crystallographic Studies~~ of ~~Nucleosome Core Particles containing Histone 'Sin' Mutants===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_14739929}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1p3g]] is a 10 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens] and [http://en~~.~~wikipedia.org~~/~~wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P3G OCA].~~	+

	==See Also==		==See Also==
	*[[Histone\|Histone]]		*[[Histone\|Histone]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:014739929<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Xenopus laevis]]		[[Category: Xenopus laevis]]

OCA at 08:17, 20 October 2012

OCA — Sat, 20 Oct 2012 08:17:09 GMT

←Older revision		Revision as of 08:17, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1p3g]] is a 10 chain structure ~~of [[Histone]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P3G OCA].	+	[[1p3g]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P3G OCA].

	==See Also==		==See Also==

OCA: Protected "1p3g" [edit=sysop:move=sysop]

OCA — Wed, 25 Jul 2012 19:03:22 GMT

Protected "1p3g" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:03, 25 July 2012