1p6f - Revision history

OCA at 05:53, 17 April 2024

OCA — Wed, 17 Apr 2024 05:53:04 GMT

←Older revision		Revision as of 05:53, 17 April 2024
Line 3:		Line 3:
	<StructureSection load='1p6f' size='340' side='right'caption='[[1p6f]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1p6f' size='340' side='right'caption='[[1p6f]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1p6f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P6F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P6F FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1p6f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P6F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P6F FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p6f OCA], [https://pdbe.org/1p6f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p6f RCSB], [https://www.ebi.ac.uk/pdbsum/1p6f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p6f ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p6f OCA], [https://pdbe.org/1p6f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p6f RCSB], [https://www.ebi.ac.uk/pdbsum/1p6f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p6f ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/NCTR1_HUMAN NCTR1_HUMAN]] Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.<ref>PMID:9730896</ref>	+	[https://www.uniprot.org/uniprot/NCTR1_HUMAN NCTR1_HUMAN] Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.<ref>PMID:9730896</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 18:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1p6f ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1p6f ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Natural cytotoxicity receptors (NCR) mediate lysis of a variety of tumor and virus-infected cells by natural killer (NK) cells. Upon engagement, NCR trigger the cytolytic activity and cytokine release of NK cells through association with ITAM-containing signaling molecules. To further understand the function of these receptors in activation of natural cytotoxicity, we determined the crystal structure of the extracellular ligand binding domain of human NKp46, one of three known NCR, at 2.2-A resolution. The overall fold and disposition of the two C2-set immunoglobulin domains are similar to the D1D2 domains of inhibitory killer cell Ig-like receptor (KIR) and Ig-like transcript (ILT) receptors. As the cellular ligands of NKp46 have not yet been defined, the known ligand binding sites of KIR and ILT were compared with the corresponding structural regions of NKp46 in an effort to identify potential areas suitable for molecular recognition. A potential binding site for influenza hemagglutinin is located near the interdomain hinge, a region that mediates ligand binding in KIR. The structural similarity of NKp46 to inhibitory KIR receptors may have implications for how NK cells balance activating and inhibitory signals.
-
-	Crystal structure of the human natural killer (NK) cell activating receptor NKp46 reveals structural relationship to other leukocyte receptor complex immunoreceptors.,Foster CE, Colonna M, Sun PD J Biol Chem. 2003 Nov 14;278(46):46081-6. Epub 2003 Sep 4. PMID:12960161<ref>PMID:12960161</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1p6f" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Colonna, M]]	+	[[Category: Colonna M]]
-	[[Category: Foster~~, C E~~]]	+	[[Category: Foster CE]]
-	[[Category: Sun~~, P D]]~~	+	[[Category: Sun PD]]
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Immunoglobulin fold]]~~	+
-	~~[[Category: Natural cytotoxicity receptor]]~~	+
-	~~[[Category: Nk cell receptor]]~~	+
-	~~[[Category: Nkp46~~]]	+

OCA at 09:25, 8 September 2021

OCA — Wed, 08 Sep 2021 09:25:46 GMT

←Older revision		Revision as of 09:25, 8 September 2021
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	<StructureSection load='1p6f' size='340' side='right'caption='[[1p6f]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1p6f' size='340' side='right'caption='[[1p6f]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1p6f]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P6F OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1P6F FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1p6f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P6F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P6F FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1p6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p6f OCA], [~~http~~://pdbe.org/1p6f PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1p6f RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1p6f PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1p6f ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p6f OCA], [https://pdbe.org/1p6f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p6f RCSB], [https://www.ebi.ac.uk/pdbsum/1p6f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p6f ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/NCTR1_HUMAN NCTR1_HUMAN]] Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.<ref>PMID:9730896</ref>	+	[[https://www.uniprot.org/uniprot/NCTR1_HUMAN NCTR1_HUMAN]] Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.<ref>PMID:9730896</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 10:26, 27 November 2019

OCA — Wed, 27 Nov 2019 10:26:52 GMT

←Older revision		Revision as of 10:26, 27 November 2019
Line 1:		Line 1:

	==Structure of the human natural cytotoxicity receptor NKp46==		==Structure of the human natural cytotoxicity receptor NKp46==
-	<StructureSection load='1p6f' size='340' side='right' caption='[[1p6f]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='1p6f' size='340' side='right'caption='[[1p6f]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1p6f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P6F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P6F FirstGlance]. <br>		<table><tr><td colspan='2'>[[1p6f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P6F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P6F FirstGlance]. <br>
Line 27:		Line 27:
	</div>		</div>
	<div class="pdbe-citations 1p6f" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1p6f" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[NK cell receptor\|NK cell receptor]]
	== References ==		== References ==
	<references/>		<references/>
Line 32:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Colonna, M]]		[[Category: Colonna, M]]
	[[Category: Foster, C E]]		[[Category: Foster, C E]]

OCA at 07:55, 15 February 2018

OCA — Thu, 15 Feb 2018 07:55:04 GMT

←Older revision		Revision as of 07:55, 15 February 2018
Line 1:		Line 1:
		+
	==Structure of the human natural cytotoxicity receptor NKp46==		==Structure of the human natural cytotoxicity receptor NKp46==
	<StructureSection load='1p6f' size='340' side='right' caption='[[1p6f]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1p6f' size='340' side='right' caption='[[1p6f]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1p6f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P6F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P6F FirstGlance]. <br>		<table><tr><td colspan='2'>[[1p6f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P6F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P6F FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p6f OCA], [http://pdbe.org/1p6f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1p6f RCSB], [http://www.ebi.ac.uk/pdbsum/1p6f PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p6f OCA], [http://pdbe.org/1p6f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1p6f RCSB], [http://www.ebi.ac.uk/pdbsum/1p6f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1p6f ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p6/1p6f_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p6/1p6f_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1p6f ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 27:
	</div>		</div>
	<div class="pdbe-citations 1p6f" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1p6f" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[NK cell receptor\|NK cell receptor]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:19, 11 September 2015

OCA — Fri, 11 Sep 2015 13:19:07 GMT

←Older revision		Revision as of 13:19, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1p6f' size='340' side='right' caption='[[1p6f]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1p6f' size='340' side='right' caption='[[1p6f]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1p6f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P6F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P6F FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1p6f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P6F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P6F FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p6f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1p6f RCSB], [http://www.ebi.ac.uk/pdbsum/1p6f PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p6f OCA], [http://pdbe.org/1p6f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1p6f RCSB], [http://www.ebi.ac.uk/pdbsum/1p6f PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1p6f" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 32:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Colonna, M]]		[[Category: Colonna, M]]
	[[Category: Foster, C E]]		[[Category: Foster, C E]]

OCA at 16:58, 25 December 2014

OCA — Thu, 25 Dec 2014 16:58:23 GMT

←Older revision		Revision as of 16:58, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1p6f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P6F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P6F FirstGlance]. <br>		<table><tr><td colspan='2'>[[1p6f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P6F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P6F FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p6f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1p6f RCSB], [http://www.ebi.ac.uk/pdbsum/1p6f PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p6f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1p6f RCSB], [http://www.ebi.ac.uk/pdbsum/1p6f PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NCTR1_HUMAN NCTR1_HUMAN]] Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.<ref>PMID:9730896</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Colonna, M.]]	+	[[Category: Colonna, M]]
-	[[Category: Foster, C E.]]	+	[[Category: Foster, C E]]
-	[[Category: Sun, P D.]]	+	[[Category: Sun, P D]]
	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: Immunoglobulin fold]]		[[Category: Immunoglobulin fold]]

OCA at 22:03, 28 September 2014

OCA — Sun, 28 Sep 2014 22:03:50 GMT

←Older revision		Revision as of 22:03, 28 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1p6f.~~png\|left~~\|200px]]	+	==Structure of the human natural cytotoxicity receptor NKp46==
		+	<StructureSection load='1p6f' size='340' side='right' caption='[[1p6f]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1p6f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P6F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P6F FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p6f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1p6f RCSB], [http://www.ebi.ac.uk/pdbsum/1p6f PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p6/1p6f_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Natural cytotoxicity receptors (NCR) mediate lysis of a variety of tumor and virus-infected cells by natural killer (NK) cells. Upon engagement, NCR trigger the cytolytic activity and cytokine release of NK cells through association with ITAM-containing signaling molecules. To further understand the function of these receptors in activation of natural cytotoxicity, we determined the crystal structure of the extracellular ligand binding domain of human NKp46, one of three known NCR, at 2.2-A resolution. The overall fold and disposition of the two C2-set immunoglobulin domains are similar to the D1D2 domains of inhibitory killer cell Ig-like receptor (KIR) and Ig-like transcript (ILT) receptors. As the cellular ligands of NKp46 have not yet been defined, the known ligand binding sites of KIR and ILT were compared with the corresponding structural regions of NKp46 in an effort to identify potential areas suitable for molecular recognition. A potential binding site for influenza hemagglutinin is located near the interdomain hinge, a region that mediates ligand binding in KIR. The structural similarity of NKp46 to inhibitory KIR receptors may have implications for how NK cells balance activating and inhibitory signals.

-	~~{{STRUCTURE_1p6f\| PDB=1p6f \| SCENE= }}~~	+	Crystal structure of the human natural killer (NK) cell activating receptor NKp46 reveals structural relationship to other leukocyte receptor complex immunoreceptors.,Foster CE, Colonna M, Sun PD J Biol Chem. 2003 Nov 14;278(46):46081-6. Epub 2003 Sep 4. PMID:12960161<ref>PMID:12960161</ref>

-	~~===Structure~~ of the ~~human natural cytotoxicity receptor NKp46===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_12960161}}~~	+	==See Also==
-		+	*[[NK cell receptor\|NK cell receptor]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~1p6f~~]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P6F OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:012960161<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Colonna, M.]]		[[Category: Colonna, M.]]

OCA: Protected "1p6f" [edit=sysop:move=sysop]

OCA — Wed, 19 Dec 2012 12:03:11 GMT

Protected "1p6f" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:03, 19 December 2012

OCA at 12:03, 19 December 2012

OCA — Wed, 19 Dec 2012 12:03:09 GMT

←Older revision		Revision as of 12:03, 19 December 2012
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-	{{Seed}}
	[[Image:1p6f.png\|left\|200px]]		[[Image:1p6f.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1p6f", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
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	{{STRUCTURE_1p6f\| PDB=1p6f \| SCENE= }}		{{STRUCTURE_1p6f\| PDB=1p6f \| SCENE= }}

	===Structure of the human natural cytotoxicity receptor NKp46===		===Structure of the human natural cytotoxicity receptor NKp46===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_12960161}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 12960161 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_12960161}}		{{ABSTRACT_PUBMED_12960161}}

	==About this Structure==		==About this Structure==
-	~~1P6F~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P6F OCA].	+	[[1p6f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P6F OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~12960161~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:012960161</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Colonna, M.]]		[[Category: Colonna, M.]]
	[[Category: Foster, C E.]]		[[Category: Foster, C E.]]
	[[Category: Sun, P D.]]		[[Category: Sun, P D.]]
		+	[[Category: Immune system]]
	[[Category: Immunoglobulin fold]]		[[Category: Immunoglobulin fold]]
	[[Category: Natural cytotoxicity receptor]]		[[Category: Natural cytotoxicity receptor]]
	[[Category: Nk cell receptor]]		[[Category: Nk cell receptor]]
	[[Category: Nkp46]]		[[Category: Nkp46]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 22:32:49 2009''

OCA at 20:32, 17 February 2009

OCA — Tue, 17 Feb 2009 20:32:51 GMT

←Older revision		Revision as of 20:32, 17 February 2009
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	==About this Structure==		==About this Structure==
-	1P6F is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P6F OCA].	+	1P6F is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P6F OCA].

	==Reference==		==Reference==
-	Crystal structure of the human natural killer (NK) cell activating receptor NKp46 reveals structural relationship to other leukocyte receptor complex immunoreceptors., Foster CE, Colonna M, Sun PD, J Biol Chem. 2003 Nov 14;278(46):46081-6. Epub 2003 Sep 4. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/12960161 12960161]~~	+	<ref group="xtra">PMID:12960161</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Single protein]]
	[[Category: Colonna, M.]]		[[Category: Colonna, M.]]
	[[Category: Foster, C E.]]		[[Category: Foster, C E.]]
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	[[Category: Nkp46]]		[[Category: Nkp46]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue ~~Jul 29 06~~:43:~~15 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 22:32:49 2009''