1p7c - Revision history

OCA at 09:38, 16 August 2023

OCA — Wed, 16 Aug 2023 09:38:39 GMT

←Older revision		Revision as of 09:38, 16 August 2023
Line 3:		Line 3:
	<StructureSection load='1p7c' size='340' side='right'caption='[[1p7c]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1p7c' size='340' side='right'caption='[[1p7c]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1p7c]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Hhv-1 Hhv-~~1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P7C OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1P7C FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1p7c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_1_strain_17 Human alphaherpesvirus 1 strain 17]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P7C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P7C FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=T5A:P1~~-~~(5-ADENOSYL)P5-(5-THYMIDYL)PENTAPHOSPHATE'>T5A</scene>~~, ~~<scene name='pdbligand=THM:THYMIDINE'>THM</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1p75\|1p75]], [[1p72\|1p72]], [[1p6x\|1p6x]], [[1p73\|1p73]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=T5A:P1-(5-ADENOSYL)P5-(5-THYMIDYL)PENTAPHOSPHATE'>T5A</scene>, <scene name='pdbligand=THM:THYMIDINE'>THM</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b></td><td class="sblockDat">TK OR UL23~~ (~~[http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=~~5~~&id=10299 HHV~~-1])~~</td~~></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p7c OCA], [https://pdbe.org/1p7c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p7c RCSB], [https://www.ebi.ac.uk/pdbsum/1p7c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p7c ProSAT]</span></td></tr>
-	<~~tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[http://en.wikipedia.org/wiki/Thymidine_kinase Thymidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.21 2.7.1.21]~~ </~~span~~></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1p7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p7c OCA], [~~http~~://pdbe.org/1p7c PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1p7c RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1p7c PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1p7c ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/KITH_HHV11 KITH_HHV11]] In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome (By similarity).	+	[https://www.uniprot.org/uniprot/KITH_HHV11 KITH_HHV11] In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 31:

	==See Also==		==See Also==
-	*[[Thymidine kinase\|Thymidine kinase]]	+	*[[Thymidine kinase 3D structures\|Thymidine kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Hhv-~~1]]	+	[[Category: Human alphaherpesvirus 1 strain 17]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Thymidine kinase]]~~	+	[[Category: Gardberg A]]
-	[[Category: Gardberg, A]]	+	[[Category: Konrad M]]
-	[[Category: Konrad, M]]	+	[[Category: Lavie A]]
-	[[Category: Lavie, A]]	+	[[Category: Monnerjahn C]]
-	[[Category: Monnerjahn, C]]	+	[[Category: Shuvalova L]]
-	[[Category: Shuvalova, L]]	+
-	~~[[Category: Bisubstrate inhibitor]]~~	+
-	~~[[Category: Lid]]~~	+
-	~~[[Category: P-loop]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 07:24, 9 December 2020

OCA — Wed, 09 Dec 2020 07:24:45 GMT

←Older revision		Revision as of 07:24, 9 December 2020
Line 1:		Line 1:

	==Crystal Structure of HSV1-TK complexed with TP5A==		==Crystal Structure of HSV1-TK complexed with TP5A==
-	<StructureSection load='1p7c' size='340' side='right' caption='[[1p7c]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='1p7c' size='340' side='right'caption='[[1p7c]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1p7c]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hhv-1 Hhv-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P7C OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1P7C FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1p7c]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hhv-1 Hhv-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P7C OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1P7C FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=T5A:P1-(5-ADENOSYL)P5-(5-THYMIDYL)PENTAPHOSPHATE'>T5A</scene>, <scene name='pdbligand=THM:THYMIDINE'>THM</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=T5A:P1-(5-ADENOSYL)P5-(5-THYMIDYL)PENTAPHOSPHATE'>T5A</scene>, <scene name='pdbligand=THM:THYMIDINE'>THM</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p75\|1p75]], [[1p72\|1p72]], [[1p6x\|1p6x]], [[1p73\|1p73]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1p75\|1p75]], [[1p72\|1p72]], [[1p6x\|1p6x]], [[1p73\|1p73]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TK OR UL23 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10299 HHV-1])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TK OR UL23 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10299 HHV-1])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidine_kinase Thymidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.21 2.7.1.21] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidine_kinase Thymidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.21 2.7.1.21] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1p7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p7c OCA], [http://pdbe.org/1p7c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1p7c RCSB], [http://www.ebi.ac.uk/pdbsum/1p7c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1p7c ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1p7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p7c OCA], [http://pdbe.org/1p7c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1p7c RCSB], [http://www.ebi.ac.uk/pdbsum/1p7c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1p7c ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 31:		Line 31:
	</div>		</div>
	<div class="pdbe-citations 1p7c" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1p7c" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Thymidine kinase\|Thymidine kinase]]
	== References ==		== References ==
	<references/>		<references/>
Line 36:		Line 39:
	</StructureSection>		</StructureSection>
	[[Category: Hhv-1]]		[[Category: Hhv-1]]
		+	[[Category: Large Structures]]
	[[Category: Thymidine kinase]]		[[Category: Thymidine kinase]]
	[[Category: Gardberg, A]]		[[Category: Gardberg, A]]

OCA at 07:28, 15 February 2018

OCA — Thu, 15 Feb 2018 07:28:38 GMT

←Older revision		Revision as of 07:28, 15 February 2018
Line 1:		Line 1:
		+
	==Crystal Structure of HSV1-TK complexed with TP5A==		==Crystal Structure of HSV1-TK complexed with TP5A==
	<StructureSection load='1p7c' size='340' side='right' caption='[[1p7c]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1p7c' size='340' side='right' caption='[[1p7c]], [[Resolution\|resolution]] 2.10Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TK OR UL23 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10299 HHV-1])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TK OR UL23 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10299 HHV-1])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidine_kinase Thymidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.21 2.7.1.21] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidine_kinase Thymidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.21 2.7.1.21] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p7c OCA], [http://pdbe.org/1p7c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1p7c RCSB], [http://www.ebi.ac.uk/pdbsum/1p7c PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p7c OCA], [http://pdbe.org/1p7c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1p7c RCSB], [http://www.ebi.ac.uk/pdbsum/1p7c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1p7c ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 15:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p7/1p7c_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p7/1p7c_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 30:		Line 31:
	</div>		</div>
	<div class="pdbe-citations 1p7c" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1p7c" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Thymidine kinase\|Thymidine kinase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:23, 9 February 2016

OCA — Tue, 09 Feb 2016 07:23:41 GMT

←Older revision		Revision as of 07:23, 9 February 2016
Line 19:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1p7c ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 19:56, 10 September 2015

OCA — Thu, 10 Sep 2015 19:56:19 GMT

←Older revision		Revision as of 19:56, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1p7c' size='340' side='right' caption='[[1p7c]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1p7c' size='340' side='right' caption='[[1p7c]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1p7c]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Herpes_simplex_virus_(type_1_/_strain_17) Herpes simplex virus (type~~ 1 ~~/ strain 17)~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P7C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P7C FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1p7c]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hhv-1 Hhv-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P7C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P7C FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=T5A:P1-(5-ADENOSYL)P5-(5-THYMIDYL)PENTAPHOSPHATE'>T5A</scene>, <scene name='pdbligand=THM:THYMIDINE'>THM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=T5A:P1-(5-ADENOSYL)P5-(5-THYMIDYL)PENTAPHOSPHATE'>T5A</scene>, <scene name='pdbligand=THM:THYMIDINE'>THM</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p75\|1p75]], [[1p72\|1p72]], [[1p6x\|1p6x]], [[1p73\|1p73]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p75\|1p75]], [[1p72\|1p72]], [[1p6x\|1p6x]], [[1p73\|1p73]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TK OR UL23 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10299 ~~Herpes simplex virus (type~~ 1 ~~/ strain 17)~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TK OR UL23 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10299 HHV-1])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidine_kinase Thymidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.21 2.7.1.21] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidine_kinase Thymidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.21 2.7.1.21] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p7c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1p7c RCSB], [http://www.ebi.ac.uk/pdbsum/1p7c PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p7c OCA], [http://pdbe.org/1p7c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1p7c RCSB], [http://www.ebi.ac.uk/pdbsum/1p7c PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 29:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1p7c" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 36:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Hhv-1]]
	[[Category: Thymidine kinase]]		[[Category: Thymidine kinase]]
	[[Category: Gardberg, A]]		[[Category: Gardberg, A]]

OCA at 05:20, 25 December 2014

OCA — Thu, 25 Dec 2014 05:20:08 GMT

←Older revision		Revision as of 05:20, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1p7c]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Herpes_simplex_virus_(type_1_/_strain_17) Herpes simplex virus (type 1 / strain 17)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P7C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P7C FirstGlance]. <br>		<table><tr><td colspan='2'>[[1p7c]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Herpes_simplex_virus_(type_1_/_strain_17) Herpes simplex virus (type 1 / strain 17)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P7C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P7C FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=T5A:P1-(5-ADENOSYL)P5-(5-THYMIDYL)PENTAPHOSPHATE'>T5A</scene>, <scene name='pdbligand=THM:THYMIDINE'>THM</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=T5A:P1-(5-ADENOSYL)P5-(5-THYMIDYL)PENTAPHOSPHATE'>T5A</scene>, <scene name='pdbligand=THM:THYMIDINE'>THM</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p75\|1p75]], [[1p72\|1p72]], [[1p6x\|1p6x]], [[1p73\|1p73]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p75\|1p75]], [[1p72\|1p72]], [[1p6x\|1p6x]], [[1p73\|1p73]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TK OR UL23 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10299 Herpes simplex virus (type 1 / strain 17)])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TK OR UL23 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10299 Herpes simplex virus (type 1 / strain 17)])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidine_kinase Thymidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.21 2.7.1.21] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidine_kinase Thymidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.21 2.7.1.21] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p7c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1p7c RCSB], [http://www.ebi.ac.uk/pdbsum/1p7c PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p7c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1p7c RCSB], [http://www.ebi.ac.uk/pdbsum/1p7c PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/KITH_HHV11 KITH_HHV11]] In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Thymidine kinase]]		[[Category: Thymidine kinase]]
-	[[Category: Gardberg, A.]]	+	[[Category: Gardberg, A]]
-	[[Category: Konrad, M.]]	+	[[Category: Konrad, M]]
-	[[Category: Lavie, A.]]	+	[[Category: Lavie, A]]
-	[[Category: Monnerjahn, C.]]	+	[[Category: Monnerjahn, C]]
-	[[Category: Shuvalova, L.]]	+	[[Category: Shuvalova, L]]
	[[Category: Bisubstrate inhibitor]]		[[Category: Bisubstrate inhibitor]]
	[[Category: Lid]]		[[Category: Lid]]
	[[Category: P-loop]]		[[Category: P-loop]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 22:43, 28 September 2014

OCA — Sun, 28 Sep 2014 22:43:30 GMT

←Older revision		Revision as of 22:43, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1p7c.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure of HSV1-TK complexed with TP5A==
		+	<StructureSection load='1p7c' size='340' side='right' caption='[[1p7c]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1p7c]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Herpes_simplex_virus_(type_1_/_strain_17) Herpes simplex virus (type 1 / strain 17)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P7C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P7C FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=T5A:P1-(5-ADENOSYL)P5-(5-THYMIDYL)PENTAPHOSPHATE'>T5A</scene>, <scene name='pdbligand=THM:THYMIDINE'>THM</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p75\|1p75]], [[1p72\|1p72]], [[1p6x\|1p6x]], [[1p73\|1p73]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TK OR UL23 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10299 Herpes simplex virus (type 1 / strain 17)])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidine_kinase Thymidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.21 2.7.1.21] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p7c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1p7c RCSB], [http://www.ebi.ac.uk/pdbsum/1p7c PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p7/1p7c_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Crystal structures of equine herpesvirus type-4 thymidine kinase (EHV4-TK) in complex with (i). thymidine and ADP, (ii). thymidine and SO(4) and the bisubstrate analogs, (iii). TP(4)A, and (iv). TP(5)A have been solved. Additionally, the structure of herpes simplex virus type-1 thymidine kinase (HSV1-TK) in complex with TP(5)A has been determined. These are the first structures of nucleoside kinases revealing conformational transitions upon binding of bisubstrate analogs. The structural basis for the dual thymidine and thymidylate kinase activity of these TKs is elucidated. While the active sites of HSV1-TK and EHV4-TK resemble one another, notable differences are observed in the Lid regions and in the way the enzymes bind the base of the phosphoryl-acceptor. The latter difference could partly explain the higher activity of EHV4-TK toward the prodrug ganciclovir.

-	~~{{STRUCTURE_1p7c\| PDB=1p7c \| SCENE= }}~~	+	Structural basis for the dual thymidine and thymidylate kinase activity of herpes thymidine kinases.,Gardberg A, Shuvalova L, Monnerjahn C, Konrad M, Lavie A Structure. 2003 Oct;11(10):1265-77. PMID:14527394<ref>PMID:14527394</ref>

-	~~===Crystal Structure~~ of ~~HSV1-TK complexed with TP5A===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_14527394}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1p7c]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Herpes_simplex_virus_(type_1_/_strain_17) Herpes simplex virus (type 1 / strain 17)]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1P7C OCA].~~	+

	==See Also==		==See Also==
	*[[Thymidine kinase\|Thymidine kinase]]		*[[Thymidine kinase\|Thymidine kinase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:014527394<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Thymidine kinase]]		[[Category: Thymidine kinase]]
	[[Category: Gardberg, A.]]		[[Category: Gardberg, A.]]

OCA at 13:06, 20 October 2012

OCA — Sat, 20 Oct 2012 13:06:14 GMT

←Older revision		Revision as of 13:06, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1p7c]] is a 2 chain structure ~~of [[Thymidine kinase]]~~ with sequence from [http://en.wikipedia.org/wiki/~~Viruses Viruses~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P7C OCA].	+	[[1p7c]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Herpes_simplex_virus_(type_1_/_strain_17) Herpes simplex virus (type 1 / strain 17)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P7C OCA].

	==See Also==		==See Also==
Line 16:		Line 16:
	<ref group="xtra">PMID:014527394</ref><references group="xtra"/>		<ref group="xtra">PMID:014527394</ref><references group="xtra"/>
	[[Category: Thymidine kinase]]		[[Category: Thymidine kinase]]
-	[[Category: Viruses]]
	[[Category: Gardberg, A.]]		[[Category: Gardberg, A.]]
	[[Category: Konrad, M.]]		[[Category: Konrad, M.]]

OCA: Protected "1p7c" [edit=sysop:move=sysop]

OCA — Thu, 26 Jul 2012 10:54:55 GMT

Protected "1p7c" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:54, 26 July 2012

OCA at 10:54, 26 July 2012

OCA — Thu, 26 Jul 2012 10:54:53 GMT

←Older revision		Revision as of 10:54, 26 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1p7c.png\|left\|200px]]		[[Image:1p7c.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1p7c", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1p7c\| PDB=1p7c \| SCENE= }}		{{STRUCTURE_1p7c\| PDB=1p7c \| SCENE= }}

	===Crystal Structure of HSV1-TK complexed with TP5A===		===Crystal Structure of HSV1-TK complexed with TP5A===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_14527394}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 14527394 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_14527394}}		{{ABSTRACT_PUBMED_14527394}}

	==About this Structure==		==About this Structure==
-	~~1P7C~~ is a 2 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/~~Human_herpesvirus_1 Human herpesvirus 1~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P7C OCA].	+	[[1p7c]] is a 2 chain structure of [[Thymidine kinase]] with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P7C OCA].
		+
		+	==See Also==
		+	*[[Thymidine kinase\|Thymidine kinase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~14527394~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:014527394</ref><references group="xtra"/>
-	~~[[Category: Human herpesvirus 1]]~~	+
	[[Category: Thymidine kinase]]		[[Category: Thymidine kinase]]
		+	[[Category: Viruses]]
	[[Category: Gardberg, A.]]		[[Category: Gardberg, A.]]
	[[Category: Konrad, M.]]		[[Category: Konrad, M.]]
Line 34:		Line 25:
	[[Category: Lid]]		[[Category: Lid]]
	[[Category: P-loop]]		[[Category: P-loop]]
-		+	[[Category: Transferase]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 07:56:14 2009''~~	+