1p7p - Revision history

OCA at 09:39, 16 August 2023

OCA — Wed, 16 Aug 2023 09:39:13 GMT

←Older revision		Revision as of 09:39, 16 August 2023
Line 3:		Line 3:
	<StructureSection load='1p7p' size='340' side='right'caption='[[1p7p]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1p7p' size='340' side='right'caption='[[1p7p]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1p7p]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P7P OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1P7P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1p7p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P7P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P7P FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=MPH:(1~~-~~AMINO-3-METHYLSULFANYL-PROPYL)-PHOSPHONIC+ACID'>MPH</scene>~~, ~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto~~; ~~max-height: 3em;'>[[1pfu\|1pfu]], [[1pfv\|1pfv]], [[1pfw\|1pfw]], [[1pfy\|1pfy]], [[1pg0\|1pg0]], [[1pg2\|1pg2]]</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MPH:(1-AMINO-3-METHYLSULFANYL-PROPYL)-PHOSPHONIC+ACID'>MPH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>METG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~562~~ "~~Bacillus coli~~" ~~Migula 1895])</td~~><~~/tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p7p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p7p OCA], [https://pdbe.org/1p7p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p7p RCSB], [https://www.ebi.ac.uk/pdbsum/1p7p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p7p ProSAT]</span></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[http://en.wikipedia.org/wiki/Methionine--tRNA_ligase Methionine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.10 6.1.1.10]~~ </~~span~~></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1p7p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p7p OCA], [~~http~~://pdbe.org/1p7p PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1p7p RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1p7p PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1p7p ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/SYM_ECOLI SYM_ECOLI]] Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.[HAMAP-Rule:MF_00098]	+	[https://www.uniprot.org/uniprot/SYM_ECOLI SYM_ECOLI] Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.[HAMAP-Rule:MF_00098]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ coli ~~migula 1895~~]]	+	[[Category: Escherichia coli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Methionine--tRNA ligase]]~~	+	[[Category: Blanquet S]]
-	[[Category: Blanquet, S]]	+	[[Category: Crepin T]]
-	[[Category: Crepin, T]]	+	[[Category: Honek JF]]
-	[[Category: Honek~~, J F~~]]	+	[[Category: Mechulam Y]]
-	[[Category: Mechulam, Y]]	+	[[Category: Sampson PB]]
-	[[Category: Sampson~~, P B~~]]	+	[[Category: Schmitt E]]
-	[[Category: Schmitt, E]]	+	[[Category: Vaughan MD]]
-	[[Category: Vaughan~~, M D]]~~	+
-	~~[[Category: Ligase]]~~	+
-	~~[[Category: Rossmann fold~~]]	+

OCA at 07:25, 9 December 2020

OCA — Wed, 09 Dec 2020 07:25:04 GMT

←Older revision		Revision as of 07:25, 9 December 2020
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	==Methionyl-tRNA synthetase from Escherichia coli complexed with methionine phosphonate==		==Methionyl-tRNA synthetase from Escherichia coli complexed with methionine phosphonate==
-	<StructureSection load='1p7p' size='340' side='right' caption='[[1p7p]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='1p7p' size='340' side='right'caption='[[1p7p]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1p7p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P7P OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1P7P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1p7p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P7P OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1P7P FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPH:(1-AMINO-3-METHYLSULFANYL-PROPYL)-PHOSPHONIC+ACID'>MPH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MPH:(1-AMINO-3-METHYLSULFANYL-PROPYL)-PHOSPHONIC+ACID'>MPH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1pfu\|1pfu]], [[1pfv\|1pfv]], [[1pfw\|1pfw]], [[1pfy\|1pfy]], [[1pg0\|1pg0]], [[1pg2\|1pg2]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1pfu\|1pfu]], [[1pfv\|1pfv]], [[1pfw\|1pfw]], [[1pfy\|1pfy]], [[1pg0\|1pg0]], [[1pg2\|1pg2]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">METG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">METG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methionine--tRNA_ligase Methionine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.10 6.1.1.10] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methionine--tRNA_ligase Methionine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.10 6.1.1.10] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1p7p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p7p OCA], [http://pdbe.org/1p7p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1p7p RCSB], [http://www.ebi.ac.uk/pdbsum/1p7p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1p7p ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1p7p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p7p OCA], [http://pdbe.org/1p7p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1p7p RCSB], [http://www.ebi.ac.uk/pdbsum/1p7p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1p7p ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 1p7p" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1p7p" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Aminoacyl tRNA synthetase 3D structures\|Aminoacyl tRNA synthetase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 36:		Line 39:
	</StructureSection>		</StructureSection>
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
		+	[[Category: Large Structures]]
	[[Category: Methionine--tRNA ligase]]		[[Category: Methionine--tRNA ligase]]
	[[Category: Blanquet, S]]		[[Category: Blanquet, S]]

OCA at 07:40, 15 February 2018

OCA — Thu, 15 Feb 2018 07:40:22 GMT

←Older revision		Revision as of 07:40, 15 February 2018
Line 1:		Line 1:
		+
	==Methionyl-tRNA synthetase from Escherichia coli complexed with methionine phosphonate==		==Methionyl-tRNA synthetase from Escherichia coli complexed with methionine phosphonate==
	<StructureSection load='1p7p' size='340' side='right' caption='[[1p7p]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1p7p' size='340' side='right' caption='[[1p7p]], [[Resolution\|resolution]] 1.80Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">METG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">METG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methionine--tRNA_ligase Methionine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.10 6.1.1.10] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methionine--tRNA_ligase Methionine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.10 6.1.1.10] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p7p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p7p OCA], [http://pdbe.org/1p7p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1p7p RCSB], [http://www.ebi.ac.uk/pdbsum/1p7p PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p7p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p7p OCA], [http://pdbe.org/1p7p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1p7p RCSB], [http://www.ebi.ac.uk/pdbsum/1p7p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1p7p ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 15:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p7/1p7p_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p7/1p7p_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1p7p ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</div>		</div>
	<div class="pdbe-citations 1p7p" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1p7p" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Aminoacyl tRNA Synthetase\|Aminoacyl tRNA Synthetase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 14:33, 11 September 2015

OCA — Fri, 11 Sep 2015 14:33:28 GMT

←Older revision		Revision as of 14:33, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1p7p' size='340' side='right' caption='[[1p7p]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1p7p' size='340' side='right' caption='[[1p7p]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1p7p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia~~ coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P7P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P7P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1p7p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P7P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P7P FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPH:(1-AMINO-3-METHYLSULFANYL-PROPYL)-PHOSPHONIC+ACID'>MPH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPH:(1-AMINO-3-METHYLSULFANYL-PROPYL)-PHOSPHONIC+ACID'>MPH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1pfu\|1pfu]], [[1pfv\|1pfv]], [[1pfw\|1pfw]], [[1pfy\|1pfy]], [[1pg0\|1pg0]], [[1pg2\|1pg2]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1pfu\|1pfu]], [[1pfv\|1pfv]], [[1pfw\|1pfw]], [[1pfy\|1pfy]], [[1pg0\|1pg0]], [[1pg2\|1pg2]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">METG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 ~~Escherichia~~ coli])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">METG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methionine--tRNA_ligase Methionine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.10 6.1.1.10] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methionine--tRNA_ligase Methionine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.10 6.1.1.10] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p7p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p7p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1p7p RCSB], [http://www.ebi.ac.uk/pdbsum/1p7p PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p7p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p7p OCA], [http://pdbe.org/1p7p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1p7p RCSB], [http://www.ebi.ac.uk/pdbsum/1p7p PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 29:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1p7p" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 36:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Escherichia~~ coli]]	+	[[Category: Bacillus coli migula 1895]]
	[[Category: Methionine--tRNA ligase]]		[[Category: Methionine--tRNA ligase]]
	[[Category: Blanquet, S]]		[[Category: Blanquet, S]]

OCA at 17:47, 25 December 2014

OCA — Thu, 25 Dec 2014 17:47:16 GMT

←Older revision		Revision as of 17:47, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1p7p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P7P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P7P FirstGlance]. <br>		<table><tr><td colspan='2'>[[1p7p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P7P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P7P FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPH:(1-AMINO-3-METHYLSULFANYL-PROPYL)-PHOSPHONIC+ACID'>MPH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPH:(1-AMINO-3-METHYLSULFANYL-PROPYL)-PHOSPHONIC+ACID'>MPH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1pfu\|1pfu]], [[1pfv\|1pfv]], [[1pfw\|1pfw]], [[1pfy\|1pfy]], [[1pg0\|1pg0]], [[1pg2\|1pg2]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1pfu\|1pfu]], [[1pfv\|1pfv]], [[1pfw\|1pfw]], [[1pfy\|1pfy]], [[1pg0\|1pg0]], [[1pg2\|1pg2]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">METG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">METG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methionine--tRNA_ligase Methionine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.10 6.1.1.10] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methionine--tRNA_ligase Methionine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.10 6.1.1.10] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p7p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p7p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1p7p RCSB], [http://www.ebi.ac.uk/pdbsum/1p7p PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p7p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p7p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1p7p RCSB], [http://www.ebi.ac.uk/pdbsum/1p7p PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SYM_ECOLI SYM_ECOLI]] Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.[HAMAP-Rule:MF_00098]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 38:
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Methionine--tRNA ligase]]		[[Category: Methionine--tRNA ligase]]
-	[[Category: Blanquet, S.]]	+	[[Category: Blanquet, S]]
-	[[Category: Crepin, T.]]	+	[[Category: Crepin, T]]
-	[[Category: Honek, J F.]]	+	[[Category: Honek, J F]]
-	[[Category: Mechulam, Y.]]	+	[[Category: Mechulam, Y]]
-	[[Category: Sampson, P B.]]	+	[[Category: Sampson, P B]]
-	[[Category: Schmitt, E.]]	+	[[Category: Schmitt, E]]
-	[[Category: Vaughan, M D.]]	+	[[Category: Vaughan, M D]]
	[[Category: Ligase]]		[[Category: Ligase]]
	[[Category: Rossmann fold]]		[[Category: Rossmann fold]]

OCA at 22:51, 28 September 2014

OCA — Sun, 28 Sep 2014 22:51:47 GMT

←Older revision		Revision as of 22:51, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1p7p.~~png~~\|~~left~~\|200px]]	+	==Methionyl-tRNA synthetase from Escherichia coli complexed with methionine phosphonate==
		+	<StructureSection load='1p7p' size='340' side='right' caption='[[1p7p]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1p7p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P7P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P7P FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPH:(1-AMINO-3-METHYLSULFANYL-PROPYL)-PHOSPHONIC+ACID'>MPH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1pfu\|1pfu]], [[1pfv\|1pfv]], [[1pfw\|1pfw]], [[1pfy\|1pfy]], [[1pg0\|1pg0]], [[1pg2\|1pg2]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">METG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methionine--tRNA_ligase Methionine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.10 6.1.1.10] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p7p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p7p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1p7p RCSB], [http://www.ebi.ac.uk/pdbsum/1p7p PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p7/1p7p_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Binding of methionine to methionyl-tRNA synthetase (MetRS) is known to promote conformational changes within the active site. However, the contribution of these rearrangements to enzyme catalysis is not fully understood. In this study, several methionine and methionyl adenylate analogues were diffused into crystals of the monomeric form of Escherichia coli methionyl-tRNA synthetase. The structures of the corresponding complexes were solved at resolutions below 1.9A and compared to those of the enzyme free or complexed with methionine. Residues Y15 and W253 play key roles in the strength of the binding of the amino acid and of its analogues. Indeed, full motions of these residues are required to recover the maximum in free energy of binding. Residue Y15 also controls the size of the hydrophobic pocket where the amino acid side-chain interacts. H301 appears to participate to the specific recognition of the sulphur atom of methionine. Complexes with methionyl adenylate analogues illustrate the shielding by MetRS of the region joining the methionine and adenosine moieties. Finally, the structure of MetRS complexed to a methionine analogue mimicking the tetrahedral carbon of the transition state in the aminoacylation reaction was solved. On the basis of this model, we propose that, in response to the binding of the 3'-end of tRNA, Y15 moves again in order to deshield the anhydride bond in the natural adenylate.

-	~~{{STRUCTURE_1p7p\| PDB=1p7p \| SCENE= }}~~	+	Use of analogues of methionine and methionyl adenylate to sample conformational changes during catalysis in Escherichia coli methionyl-tRNA synthetase.,Crepin T, Schmitt E, Mechulam Y, Sampson PB, Vaughan MD, Honek JF, Blanquet S J Mol Biol. 2003 Sep 5;332(1):59-72. PMID:12946347<ref>PMID:12946347</ref>

-	~~===Methionyl-tRNA synthetase from Escherichia coli complexed with methionine phosphonate===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_12946347}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1p7p]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli Escherichia coli]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1P7P OCA].~~	+

	==See Also==		==See Also==
	*[[Aminoacyl tRNA Synthetase\|Aminoacyl tRNA Synthetase]]		*[[Aminoacyl tRNA Synthetase\|Aminoacyl tRNA Synthetase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:012946347<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Methionine--tRNA ligase]]		[[Category: Methionine--tRNA ligase]]

OCA at 19:37, 20 October 2012

OCA — Sat, 20 Oct 2012 19:37:17 GMT

←Older revision		Revision as of 19:37, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1p7p]] is a 1 chain structure ~~of [[Aminoacyl tRNA Synthetase]]~~ with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P7P OCA].	+	[[1p7p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P7P OCA].

	==See Also==		==See Also==

OCA: Protected "1p7p" [edit=sysop:move=sysop]

OCA — Fri, 27 Jul 2012 07:57:05 GMT

Protected "1p7p" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:57, 27 July 2012

OCA at 07:57, 27 July 2012

OCA — Fri, 27 Jul 2012 07:57:03 GMT

←Older revision		Revision as of 07:57, 27 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1p7p.png\|left\|200px]]		[[Image:1p7p.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1p7p", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1p7p\| PDB=1p7p \| SCENE= }}		{{STRUCTURE_1p7p\| PDB=1p7p \| SCENE= }}

	===Methionyl-tRNA synthetase from Escherichia coli complexed with methionine phosphonate===		===Methionyl-tRNA synthetase from Escherichia coli complexed with methionine phosphonate===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_12946347}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 12946347 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_12946347}}		{{ABSTRACT_PUBMED_12946347}}

	==About this Structure==		==About this Structure==
-	~~1P7P~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P7P OCA].	+	[[1p7p]] is a 1 chain structure of [[Aminoacyl tRNA Synthetase]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P7P OCA].
		+
		+	==See Also==
		+	*[[Aminoacyl tRNA Synthetase\|Aminoacyl tRNA Synthetase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~12946347~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:012946347</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Methionine--tRNA ligase]]		[[Category: Methionine--tRNA ligase]]
Line 35:		Line 26:
	[[Category: Ligase]]		[[Category: Ligase]]
	[[Category: Rossmann fold]]		[[Category: Rossmann fold]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 00:37:44 2009''

OCA at 22:37, 17 February 2009

OCA — Tue, 17 Feb 2009 22:37:47 GMT

←Older revision		Revision as of 22:37, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	1P7P is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P7P OCA].	+	1P7P is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P7P OCA].

	==Reference==		==Reference==
-	Use of analogues of methionine and methionyl adenylate to sample conformational changes during catalysis in Escherichia coli methionyl-tRNA synthetase., Crepin T, Schmitt E, Mechulam Y, Sampson PB, Vaughan MD, Honek JF, Blanquet S, J Mol Biol. 2003 Sep 5;332(1):59-72. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/12946347 12946347]~~	+	<ref group="xtra">PMID:12946347</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Methionine--tRNA ligase]]		[[Category: Methionine--tRNA ligase]]
-	[[Category: Single protein]]
	[[Category: Blanquet, S.]]		[[Category: Blanquet, S.]]
	[[Category: Crepin, T.]]		[[Category: Crepin, T.]]
Line 37:		Line 36:
	[[Category: Rossmann fold]]		[[Category: Rossmann fold]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 29 08~~:01:44 ~~2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 00:37:44 2009''