1p8t - Revision history

OCA at 05:53, 17 April 2024

OCA — Wed, 17 Apr 2024 05:53:36 GMT

←Older revision		Revision as of 05:53, 17 April 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1p8t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P8T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P8T FirstGlance]. <br>		<table><tr><td colspan='2'>[[1p8t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P8T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P8T FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.2Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p8t OCA], [https://pdbe.org/1p8t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p8t RCSB], [https://www.ebi.ac.uk/pdbsum/1p8t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p8t ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p8t OCA], [https://pdbe.org/1p8t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p8t RCSB], [https://www.ebi.ac.uk/pdbsum/1p8t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p8t ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/RTN4R_HUMAN RTN4R_HUMAN]] Receptor for RTN4, OMG and MAG. Mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. Acts in conjunction with RTN4 and LIGO1 in regulating neuronal precursor cell motility during cortical development (By similarity).<ref>PMID:12037567</ref> <ref>PMID:14966521</ref>	+	[https://www.uniprot.org/uniprot/RTN4R_HUMAN RTN4R_HUMAN] Receptor for RTN4, OMG and MAG. Mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. Acts in conjunction with RTN4 and LIGO1 in regulating neuronal precursor cell motility during cortical development (By similarity).<ref>PMID:12037567</ref> <ref>PMID:14966521</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 19:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1p8t ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1p8t ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The myelin-derived proteins Nogo, MAG and OMgp limit axonal regeneration after injury of the spinal cord and brain. These cell-surface proteins signal through multi-subunit neuronal receptors that contain a common ligand-binding glycosylphosphatidylinositol-anchored subunit termed the Nogo-66 receptor (NgR). By deletion analysis, we show that the binding of soluble fragments of Nogo, MAG and NgR to cell-surface NgR requires the entire leucine-rich repeat (LRR) region of NgR, but not other portions of the protein. Despite sharing extensive sequence similarity with NgR, two related proteins, NgR2 and NgR3, which we have identified, do not bind Nogo, MAG, OMgp or NgR. To investigate NgR specificity and multi-ligand binding, we determined the crystal structure of the biologically active ligand-binding soluble ectodomain of NgR. The molecule is banana shaped with elongation and curvature arising from eight LRRs flanked by an N-terminal cap and a small C-terminal subdomain. The NgR structure analysis, as well as a comparison of NgR surface residues not conserved in NgR2 and NgR3, identifies potential protein interaction sites important in the assembly of a functional signaling complex.
-
-	Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins.,Barton WA, Liu BP, Tzvetkova D, Jeffrey PD, Fournier AE, Sah D, Cate R, Strittmatter SM, Nikolov DB EMBO J. 2003 Jul 1;22(13):3291-302. PMID:12839991<ref>PMID:12839991</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1p8t" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
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	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Barton~~, W A~~]]	+	[[Category: Barton WA]]
-	[[Category: Cate, R]]	+	[[Category: Cate R]]
-	[[Category: Fournier~~, A E~~]]	+	[[Category: Fournier AE]]
-	[[Category: Jeffrey~~, P D~~]]	+	[[Category: Jeffrey PD]]
-	[[Category: Liu~~, B P~~]]	+	[[Category: Liu BP]]
-	[[Category: Nikolov~~, D B~~]]	+	[[Category: Nikolov DB]]
-	[[Category: Sah, D]]	+	[[Category: Sah D]]
-	[[Category: Strittmatter~~, S M~~]]	+	[[Category: Strittmatter SM]]
-	[[Category: Tzvetkova, D]]	+	[[Category: Tzvetkova D]]
-	~~[[Category: Ngr]]~~	+
-	~~[[Category: Nogo-66]]~~	+
-	~~[[Category: Signaling protein~~]]	+

OCA at 09:26, 8 September 2021

OCA — Wed, 08 Sep 2021 09:26:29 GMT

←Older revision		Revision as of 09:26, 8 September 2021
Line 3:		Line 3:
	<StructureSection load='1p8t' size='340' side='right'caption='[[1p8t]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='1p8t' size='340' side='right'caption='[[1p8t]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1p8t]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P8T OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1P8T FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1p8t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P8T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P8T FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1p8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p8t OCA], [~~http~~://pdbe.org/1p8t PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1p8t RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1p8t PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1p8t ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p8t OCA], [https://pdbe.org/1p8t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p8t RCSB], [https://www.ebi.ac.uk/pdbsum/1p8t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p8t ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/RTN4R_HUMAN RTN4R_HUMAN]] Receptor for RTN4, OMG and MAG. Mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. Acts in conjunction with RTN4 and LIGO1 in regulating neuronal precursor cell motility during cortical development (By similarity).<ref>PMID:12037567</ref> <ref>PMID:14966521</ref>	+	[[https://www.uniprot.org/uniprot/RTN4R_HUMAN RTN4R_HUMAN]] Receptor for RTN4, OMG and MAG. Mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. Acts in conjunction with RTN4 and LIGO1 in regulating neuronal precursor cell motility during cortical development (By similarity).<ref>PMID:12037567</ref> <ref>PMID:14966521</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 10:25, 27 November 2019

OCA — Wed, 27 Nov 2019 10:25:29 GMT

←Older revision		Revision as of 10:25, 27 November 2019
Line 1:		Line 1:

	==Crystal structure of Nogo-66 Receptor==		==Crystal structure of Nogo-66 Receptor==
-	<StructureSection load='1p8t' size='340' side='right' caption='[[1p8t]], [[Resolution\|resolution]] 3.20Å' scene=''>	+	<StructureSection load='1p8t' size='340' side='right'caption='[[1p8t]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1p8t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P8T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P8T FirstGlance]. <br>		<table><tr><td colspan='2'>[[1p8t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P8T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P8T FirstGlance]. <br>
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
	[[Category: Barton, W A]]		[[Category: Barton, W A]]
	[[Category: Cate, R]]		[[Category: Cate, R]]

OCA at 07:53, 15 February 2018

OCA — Thu, 15 Feb 2018 07:53:56 GMT

←Older revision		Revision as of 07:53, 15 February 2018
Line 1:		Line 1:
		+
	==Crystal structure of Nogo-66 Receptor==		==Crystal structure of Nogo-66 Receptor==
	<StructureSection load='1p8t' size='340' side='right' caption='[[1p8t]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='1p8t' size='340' side='right' caption='[[1p8t]], [[Resolution\|resolution]] 3.20Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1p8t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P8T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P8T FirstGlance]. <br>		<table><tr><td colspan='2'>[[1p8t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P8T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P8T FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p8t OCA], [http://pdbe.org/1p8t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1p8t RCSB], [http://www.ebi.ac.uk/pdbsum/1p8t PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p8t OCA], [http://pdbe.org/1p8t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1p8t RCSB], [http://www.ebi.ac.uk/pdbsum/1p8t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1p8t ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p8/1p8t_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p8/1p8t_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 12:02, 8 February 2016

OCA — Mon, 08 Feb 2016 12:02:43 GMT

←Older revision		Revision as of 12:02, 8 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1p8t ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 11:23, 10 September 2015

OCA — Thu, 10 Sep 2015 11:23:15 GMT

←Older revision		Revision as of 11:23, 10 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[1p8t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P8T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P8T FirstGlance]. <br>		<table><tr><td colspan='2'>[[1p8t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P8T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P8T FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p8t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1p8t RCSB], [http://www.ebi.ac.uk/pdbsum/1p8t PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p8t OCA], [http://pdbe.org/1p8t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1p8t RCSB], [http://www.ebi.ac.uk/pdbsum/1p8t PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1p8t" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 23:10, 24 December 2014

OCA — Wed, 24 Dec 2014 23:10:16 GMT

←Older revision		Revision as of 23:10, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1p8t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P8T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P8T FirstGlance]. <br>		<table><tr><td colspan='2'>[[1p8t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P8T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P8T FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p8t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1p8t RCSB], [http://www.ebi.ac.uk/pdbsum/1p8t PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p8t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1p8t RCSB], [http://www.ebi.ac.uk/pdbsum/1p8t PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RTN4R_HUMAN RTN4R_HUMAN]] Receptor for RTN4, OMG and MAG. Mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. Acts in conjunction with RTN4 and LIGO1 in regulating neuronal precursor cell motility during cortical development (By similarity).<ref>PMID:12037567</ref> <ref>PMID:14966521</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Barton, W A.]]	+	[[Category: Barton, W A]]
-	[[Category: Cate, R.]]	+	[[Category: Cate, R]]
-	[[Category: Fournier, A E.]]	+	[[Category: Fournier, A E]]
-	[[Category: Jeffrey, P D.]]	+	[[Category: Jeffrey, P D]]
-	[[Category: Liu, B P.]]	+	[[Category: Liu, B P]]
-	[[Category: Nikolov, D B.]]	+	[[Category: Nikolov, D B]]
-	[[Category: Sah, D.]]	+	[[Category: Sah, D]]
-	[[Category: Strittmatter, S M.]]	+	[[Category: Strittmatter, S M]]
-	[[Category: Tzvetkova, D.]]	+	[[Category: Tzvetkova, D]]
	[[Category: Ngr]]		[[Category: Ngr]]
	[[Category: Nogo-66]]		[[Category: Nogo-66]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]

OCA at 20:35, 28 September 2014

OCA — Sun, 28 Sep 2014 20:35:05 GMT

←Older revision		Revision as of 20:35, 28 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1p8t.~~png\|left~~\|200px]]	+	==Crystal structure of Nogo-66 Receptor==
		+	<StructureSection load='1p8t' size='340' side='right' caption='[[1p8t]], [[Resolution\|resolution]] 3.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1p8t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P8T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P8T FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p8t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1p8t RCSB], [http://www.ebi.ac.uk/pdbsum/1p8t PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p8/1p8t_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The myelin-derived proteins Nogo, MAG and OMgp limit axonal regeneration after injury of the spinal cord and brain. These cell-surface proteins signal through multi-subunit neuronal receptors that contain a common ligand-binding glycosylphosphatidylinositol-anchored subunit termed the Nogo-66 receptor (NgR). By deletion analysis, we show that the binding of soluble fragments of Nogo, MAG and NgR to cell-surface NgR requires the entire leucine-rich repeat (LRR) region of NgR, but not other portions of the protein. Despite sharing extensive sequence similarity with NgR, two related proteins, NgR2 and NgR3, which we have identified, do not bind Nogo, MAG, OMgp or NgR. To investigate NgR specificity and multi-ligand binding, we determined the crystal structure of the biologically active ligand-binding soluble ectodomain of NgR. The molecule is banana shaped with elongation and curvature arising from eight LRRs flanked by an N-terminal cap and a small C-terminal subdomain. The NgR structure analysis, as well as a comparison of NgR surface residues not conserved in NgR2 and NgR3, identifies potential protein interaction sites important in the assembly of a functional signaling complex.

-	~~{{STRUCTURE_1p8t\| PDB=1p8t \| SCENE= }}~~	+	Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins.,Barton WA, Liu BP, Tzvetkova D, Jeffrey PD, Fournier AE, Sah D, Cate R, Strittmatter SM, Nikolov DB EMBO J. 2003 Jul 1;22(13):3291-302. PMID:12839991<ref>PMID:12839991</ref>

-	~~===Crystal structure~~ of ~~Nogo-66 Receptor===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_12839991}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1p8t]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1P8T OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:012839991<~~/~~ref~~><~~ref group="xtra">PMID:016342940</ref><references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Barton, W A.]]		[[Category: Barton, W A.]]

OCA: Protected "1p8t" [edit=sysop:move=sysop]

OCA — Wed, 19 Dec 2012 12:01:36 GMT

Protected "1p8t" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:01, 19 December 2012

OCA at 12:01, 19 December 2012

OCA — Wed, 19 Dec 2012 12:01:33 GMT

←Older revision		Revision as of 12:01, 19 December 2012
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-	{{Seed}}
	[[Image:1p8t.png\|left\|200px]]		[[Image:1p8t.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1p8t", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
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	{{STRUCTURE_1p8t\| PDB=1p8t \| SCENE= }}		{{STRUCTURE_1p8t\| PDB=1p8t \| SCENE= }}

	===Crystal structure of Nogo-66 Receptor===		===Crystal structure of Nogo-66 Receptor===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_12839991}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 12839991 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_12839991}}		{{ABSTRACT_PUBMED_12839991}}

	==About this Structure==		==About this Structure==
-	~~1P8T~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P8T OCA].	+	[[1p8t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P8T OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~12839991~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:012839991</ref><ref group="xtra">PMID:016342940</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Barton, W A.]]		[[Category: Barton, W A.]]
Line 36:		Line 24:
	[[Category: Ngr]]		[[Category: Ngr]]
	[[Category: Nogo-66]]		[[Category: Nogo-66]]
-		+	[[Category: Signaling protein]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Mon Feb 16 21:50:50 2009''~~	+