1p92 - Revision history

OCA at 09:40, 16 August 2023

OCA — Wed, 16 Aug 2023 09:40:46 GMT

←Older revision		Revision as of 09:40, 16 August 2023
Line 3:		Line 3:
	<StructureSection load='1p92' size='340' side='right'caption='[[1p92]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1p92' size='340' side='right'caption='[[1p92]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1p92]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_diphtheriae"_kruse_in_flugge_1886 "bacillus~~ diphtheriae~~" kruse in flugge 1886~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P92 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P92 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1p92]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Corynebacterium_diphtheriae Corynebacterium diphtheriae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P92 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P92 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=BME:BETA~~-~~MERCAPTOETHANOL'>BME</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[2tdx\|2tdx]], [[1ddn\|1ddn]], [[1dpr\|1dpr]]~~</~~div~~>~~</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DTXR ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1717 "Bacillus diphtheriae" Kruse in Flugge 1886])</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p92 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p92 OCA], [https://pdbe.org/1p92 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p92 RCSB], [https://www.ebi.ac.uk/pdbsum/1p92 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p92 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p92 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p92 OCA], [https://pdbe.org/1p92 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p92 RCSB], [https://www.ebi.ac.uk/pdbsum/1p92 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p92 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/DTXR_CORDI DTXR_CORDI]] Iron-binding repressor of the dipheteria toxin gene expression. May serve as a global regulator of gene expression. Represses ripA under iron excess.	+	[https://www.uniprot.org/uniprot/DTXR_CORDI DTXR_CORDI] Iron-binding repressor of the dipheteria toxin gene expression. May serve as a global regulator of gene expression. Represses ripA under iron excess.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ diphtheriae ~~kruse in flugge 1886~~]]	+	[[Category: Corynebacterium diphtheriae]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Aquino~~, J A.D~~]]	+	[[Category: D'Aquino JA]]
-	[[Category: Ringe, D]]	+	[[Category: Ringe D]]
-	~~[[Category: Diphtheria toxin repressor]]~~	+
-	~~[[Category: Dna binding protein]]~~	+
-	~~[[Category: Dna-binding protein]]~~	+
-	~~[[Category: Dtxr]]~~	+
-	~~[[Category: Helix-turn-helix]]~~	+
-	~~[[Category: Metal ion binding site]]~~	+
-	~~[[Category: Sh3-like~~]]	+

OCA at 15:13, 27 October 2021

OCA — Wed, 27 Oct 2021 15:13:35 GMT

←Older revision		Revision as of 15:13, 27 October 2021
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	<StructureSection load='1p92' size='340' side='right'caption='[[1p92]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1p92' size='340' side='right'caption='[[1p92]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1p92]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_diphtheriae"_kruse_in_flugge_1886 "bacillus diphtheriae" kruse in flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P92 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1P92 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1p92]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_diphtheriae"_kruse_in_flugge_1886 "bacillus diphtheriae" kruse in flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P92 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P92 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2tdx\|2tdx]], [[1ddn\|1ddn]], [[1dpr\|1dpr]]</div></td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2tdx\|2tdx]], [[1ddn\|1ddn]], [[1dpr\|1dpr]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DTXR ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1717 "Bacillus diphtheriae" Kruse in Flugge 1886])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DTXR ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1717 "Bacillus diphtheriae" Kruse in Flugge 1886])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1p92 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p92 OCA], [~~http~~://pdbe.org/1p92 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1p92 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1p92 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1p92 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p92 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p92 OCA], [https://pdbe.org/1p92 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p92 RCSB], [https://www.ebi.ac.uk/pdbsum/1p92 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p92 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/DTXR_CORDI DTXR_CORDI]] Iron-binding repressor of the dipheteria toxin gene expression. May serve as a global regulator of gene expression. Represses ripA under iron excess.	+	[[https://www.uniprot.org/uniprot/DTXR_CORDI DTXR_CORDI]] Iron-binding repressor of the dipheteria toxin gene expression. May serve as a global regulator of gene expression. Represses ripA under iron excess.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 07:26, 9 December 2020

OCA — Wed, 09 Dec 2020 07:26:09 GMT

←Older revision		Revision as of 07:26, 9 December 2020
Line 1:		Line 1:

	==Crystal Structure of (H79A)DtxR==		==Crystal Structure of (H79A)DtxR==
-	<StructureSection load='1p92' size='340' side='right' caption='[[1p92]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='1p92' size='340' side='right'caption='[[1p92]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1p92]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_diphtheriae"_kruse_in_flugge_1886 "bacillus diphtheriae" kruse in flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P92 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1P92 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1p92]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_diphtheriae"_kruse_in_flugge_1886 "bacillus diphtheriae" kruse in flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P92 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1P92 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2tdx\|2tdx]], [[1ddn\|1ddn]], [[1dpr\|1dpr]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2tdx\|2tdx]], [[1ddn\|1ddn]], [[1dpr\|1dpr]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DTXR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1717 "Bacillus diphtheriae" Kruse in Flugge 1886])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DTXR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1717 "Bacillus diphtheriae" Kruse in Flugge 1886])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1p92 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p92 OCA], [http://pdbe.org/1p92 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1p92 RCSB], [http://www.ebi.ac.uk/pdbsum/1p92 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1p92 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1p92 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p92 OCA], [http://pdbe.org/1p92 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1p92 RCSB], [http://www.ebi.ac.uk/pdbsum/1p92 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1p92 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 1p92" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1p92" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Diphtheria toxin repressor\|Diphtheria toxin repressor]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Bacillus diphtheriae kruse in flugge 1886]]		[[Category: Bacillus diphtheriae kruse in flugge 1886]]
		+	[[Category: Large Structures]]
	[[Category: Aquino, J A.D]]		[[Category: Aquino, J A.D]]
	[[Category: Ringe, D]]		[[Category: Ringe, D]]

OCA at 07:54, 15 February 2018

OCA — Thu, 15 Feb 2018 07:54:20 GMT

←Older revision		Revision as of 07:54, 15 February 2018
Line 1:		Line 1:
		+
	==Crystal Structure of (H79A)DtxR==		==Crystal Structure of (H79A)DtxR==
	<StructureSection load='1p92' size='340' side='right' caption='[[1p92]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1p92' size='340' side='right' caption='[[1p92]], [[Resolution\|resolution]] 2.10Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2tdx\|2tdx]], [[1ddn\|1ddn]], [[1dpr\|1dpr]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2tdx\|2tdx]], [[1ddn\|1ddn]], [[1dpr\|1dpr]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DTXR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1717 "Bacillus diphtheriae" Kruse in Flugge 1886])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DTXR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1717 "Bacillus diphtheriae" Kruse in Flugge 1886])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p92 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p92 OCA], [http://pdbe.org/1p92 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1p92 RCSB], [http://www.ebi.ac.uk/pdbsum/1p92 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p92 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p92 OCA], [http://pdbe.org/1p92 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1p92 RCSB], [http://www.ebi.ac.uk/pdbsum/1p92 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1p92 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p9/1p92_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p9/1p92_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 29:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 1p92" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1p92" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Diphtheria toxin repressor\|Diphtheria toxin repressor]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 15:30, 8 February 2016

OCA — Mon, 08 Feb 2016 15:30:57 GMT

←Older revision		Revision as of 15:30, 8 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1p92 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 12:58, 10 September 2015

OCA — Thu, 10 Sep 2015 12:58:32 GMT

←Older revision		Revision as of 12:58, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1p92' size='340' side='right' caption='[[1p92]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1p92' size='340' side='right' caption='[[1p92]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1p92]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Corynebacterium_diphtheriae Corynebacterium~~ diphtheriae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P92 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P92 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1p92]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_diphtheriae"_kruse_in_flugge_1886 "bacillus diphtheriae" kruse in flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P92 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P92 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2tdx\|2tdx]], [[1ddn\|1ddn]], [[1dpr\|1dpr]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2tdx\|2tdx]], [[1ddn\|1ddn]], [[1dpr\|1dpr]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DTXR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1717 ~~Corynebacterium~~ diphtheriae])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DTXR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1717 "Bacillus diphtheriae" Kruse in Flugge 1886])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p92 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p92 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1p92 RCSB], [http://www.ebi.ac.uk/pdbsum/1p92 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p92 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p92 OCA], [http://pdbe.org/1p92 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1p92 RCSB], [http://www.ebi.ac.uk/pdbsum/1p92 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1p92" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Corynebacterium~~ diphtheriae]]	+	[[Category: Bacillus diphtheriae kruse in flugge 1886]]
	[[Category: Aquino, J A.D]]		[[Category: Aquino, J A.D]]
	[[Category: Ringe, D]]		[[Category: Ringe, D]]

OCA at 00:21, 25 December 2014

OCA — Thu, 25 Dec 2014 00:21:11 GMT

←Older revision		Revision as of 00:21, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1p92]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Corynebacterium_diphtheriae Corynebacterium diphtheriae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P92 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P92 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1p92]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Corynebacterium_diphtheriae Corynebacterium diphtheriae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P92 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P92 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2tdx\|2tdx]], [[1ddn\|1ddn]], [[1dpr\|1dpr]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2tdx\|2tdx]], [[1ddn\|1ddn]], [[1dpr\|1dpr]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DTXR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1717 Corynebacterium diphtheriae])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DTXR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1717 Corynebacterium diphtheriae])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p92 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p92 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1p92 RCSB], [http://www.ebi.ac.uk/pdbsum/1p92 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p92 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p92 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1p92 RCSB], [http://www.ebi.ac.uk/pdbsum/1p92 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DTXR_CORDI DTXR_CORDI]] Iron-binding repressor of the dipheteria toxin gene expression. May serve as a global regulator of gene expression. Represses ripA under iron excess.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Corynebacterium diphtheriae]]		[[Category: Corynebacterium diphtheriae]]
-	[[Category: Aquino, J A.D.]]	+	[[Category: Aquino, J A.D]]
-	[[Category: Ringe, D.]]	+	[[Category: Ringe, D]]
	[[Category: Diphtheria toxin repressor]]		[[Category: Diphtheria toxin repressor]]
	[[Category: Dna binding protein]]		[[Category: Dna binding protein]]

OCA at 10:05, 3 October 2014

OCA — Fri, 03 Oct 2014 10:05:03 GMT

←Older revision		Revision as of 10:05, 3 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1p92~~\| ~~PDB~~=1p92 \| ~~SCENE~~= }}	+	==Crystal Structure of (H79A)DtxR==
-	===~~Crystal Structure of~~ (~~H79A~~)~~DtxR~~===	+	<StructureSection load='1p92' size='340' side='right' caption='[[1p92]], [[Resolution\|resolution]] 2.10Å' scene=''>
-	~~{{ABSTRACT_PUBMED_12837782}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1p92]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Corynebacterium_diphtheriae Corynebacterium diphtheriae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P92 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P92 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2tdx\|2tdx]], [[1ddn\|1ddn]], [[1dpr\|1dpr]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DTXR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1717 Corynebacterium diphtheriae])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p92 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p92 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1p92 RCSB], [http://www.ebi.ac.uk/pdbsum/1p92 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p9/1p92_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In eukaryotes, the Src homology domain 3 (SH3) is a very important motif in signal transduction. SH3 domains recognize poly-proline-rich peptides and are involved in protein-protein interactions. Until now, the existence of SH3 domains has not been demonstrated in prokaryotes. However, the structure of the C-terminal domain of DtxR clearly shows that the fold of this domain is very similar to that of the SH3 domain. In addition, there is evidence that the C-terminal domain of DtxR binds to poly-proline-rich regions. Other bacterial proteins have domains that are structurally similar to the SH3 domain but whose functions are unknown or differ from that of the SH3 domain. The observed similarities between the structures of the C-terminal domain of DtxR and the SH3 domain constitute a perfect system to gain insight into their function and information about their evolution. Our results show that the C-terminal domain of DtxR shares a number of conserved key hydrophobic positions not recognizable from sequence comparison that might be responsible for the integrity of the SH3-like fold. Structural alignment of an ensemble of such domains from unrelated proteins shows a common structural core that seems to be conserved despite the lack of sequence similarity. This core constitutes the minimal requirements of protein architecture for the SH3-like fold.

-	~~==Function==~~	+	Determinants of the SRC homology domain 3-like fold.,D'Aquino JA, Ringe D J Bacteriol. 2003 Jul;185(14):4081-6. PMID:12837782<ref>PMID:12837782</ref>
-	~~[[http://www.uniprot.org/uniprot/DTXR_CORDI DTXR_CORDI]] Iron-binding repressor~~ of the ~~dipheteria toxin gene expression~~. ~~May serve as a global regulator of gene expression~~. ~~Represses ripA under iron excess~~.	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[1p92]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Corynebacterium_diphtheriae Corynebacterium diphtheriae]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1P92 OCA].~~	+	</div>

	==See Also==		==See Also==
	*[[Diphtheria toxin repressor\|Diphtheria toxin repressor]]		*[[Diphtheria toxin repressor\|Diphtheria toxin repressor]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:012837782</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Corynebacterium diphtheriae]]		[[Category: Corynebacterium diphtheriae]]
	[[Category: Aquino, J A.D.]]		[[Category: Aquino, J A.D.]]

OCA at 10:51, 16 April 2014

OCA — Wed, 16 Apr 2014 10:51:28 GMT

←Older revision		Revision as of 10:51, 16 April 2014
Line 1:		Line 1:
-	[[Image:1p92.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_1p92", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1p92\| PDB=1p92 \| SCENE= }}		{{STRUCTURE_1p92\| PDB=1p92 \| SCENE= }}
-
	===Crystal Structure of (H79A)DtxR===		===Crystal Structure of (H79A)DtxR===
		+	{{ABSTRACT_PUBMED_12837782}}

-		+	==Function==
-	~~<!--~~	+	[[http://www.uniprot.org/uniprot/DTXR_CORDI DTXR_CORDI]] Iron-binding repressor of the dipheteria toxin gene expression. May serve as a global regulator of gene expression. Represses ripA under iron excess.
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_12837782}}, adds the Publication Abstract to the page~~	+
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov), where 12837782 is~~ the ~~PubMed ID number~~.	+
-	~~-->~~	+
-	~~{{ABSTRACT_PUBMED_12837782}}~~	+

	==About this Structure==		==About this Structure==
	[[1p92]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Corynebacterium_diphtheriae Corynebacterium diphtheriae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P92 OCA].		[[1p92]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Corynebacterium_diphtheriae Corynebacterium diphtheriae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P92 OCA].
		+
		+	==See Also==
		+	*[[Diphtheria toxin repressor\|Diphtheria toxin repressor]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:012837782</ref><references group="xtra"/>	+	<ref group="xtra">PMID:012837782</ref><references group="xtra"/><references/>
	[[Category: Corynebacterium diphtheriae]]		[[Category: Corynebacterium diphtheriae]]
	[[Category: Aquino, J A.D.]]		[[Category: Aquino, J A.D.]]

OCA: Protected "1p92" [edit=sysop:move=sysop]

OCA — Wed, 16 Nov 2011 11:11:06 GMT

Protected "1p92" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:11, 16 November 2011