1p9b - Revision history

OCA at 07:22, 25 October 2023

OCA — Wed, 25 Oct 2023 07:22:15 GMT

←Older revision		Revision as of 07:22, 25 October 2023
Line 3:		Line 3:
	<StructureSection load='1p9b' size='340' side='right'caption='[[1p9b]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1p9b' size='340' side='right'caption='[[1p9b]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1p9b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Plafa Plafa~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P9B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P9B FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1p9b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P9B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P9B FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=HDA:HADACIDIN'>HDA</scene>, <scene name='pdbligand=IMO:6-O-PHOSPHORYL+INOSINE+MONOPHOSPHATE'>IMO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Adenylosuccinate_synthase Adenylosuccinate synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.4 6.3.4.4] </span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=HDA:HADACIDIN'>HDA</scene>, <scene name='pdbligand=IMO:6-O-PHOSPHORYL+INOSINE+MONOPHOSPHATE'>IMO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p9b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p9b OCA], [https://pdbe.org/1p9b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p9b RCSB], [https://www.ebi.ac.uk/pdbsum/1p9b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p9b ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p9b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p9b OCA], [https://pdbe.org/1p9b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p9b RCSB], [https://www.ebi.ac.uk/pdbsum/1p9b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p9b ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PURA_PLAFA PURA_PLAFA]] Plays an important role in the salvage pathway for purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity).<ref>PMID:12071700</ref> <ref>PMID:15500910</ref> <ref>PMID:20654742</ref>	+	[https://www.uniprot.org/uniprot/PURA_PLAFA PURA_PLAFA] Plays an important role in the salvage pathway for purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity).<ref>PMID:12071700</ref> <ref>PMID:15500910</ref> <ref>PMID:20654742</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Adenylosuccinate synthase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Plafa~~]]	+	[[Category: Plasmodium falciparum]]
-	[[Category: Anand~~, R P~~]]	+	[[Category: Anand RP]]
-	[[Category: Balaram, H]]	+	[[Category: Balaram H]]
-	[[Category: Eaazhisai, K]]	+	[[Category: Eaazhisai K]]
-	[[Category: Gayathri, P]]	+	[[Category: Gayathri P]]
-	[[Category: Jayalakshmi, R]]	+	[[Category: Jayalakshmi R]]
-	[[Category: Murthy~~, M R~~]]	+	[[Category: Murthy MR]]
-	[[Category: Sumathy, K]]	+	[[Category: Sumathy K]]
-	~~[[Category: Ligase~~]]	+

OCA at 09:26, 8 September 2021

OCA — Wed, 08 Sep 2021 09:26:37 GMT

←Older revision		Revision as of 09:26, 8 September 2021
Line 3:		Line 3:
	<StructureSection load='1p9b' size='340' side='right'caption='[[1p9b]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1p9b' size='340' side='right'caption='[[1p9b]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1p9b]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P9B OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1P9B FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1p9b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P9B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P9B FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=HDA:HADACIDIN'>HDA</scene>, <scene name='pdbligand=IMO:6-O-PHOSPHORYL+INOSINE+MONOPHOSPHATE'>IMO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=HDA:HADACIDIN'>HDA</scene>, <scene name='pdbligand=IMO:6-O-PHOSPHORYL+INOSINE+MONOPHOSPHATE'>IMO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Adenylosuccinate_synthase Adenylosuccinate synthase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.4 6.3.4.4] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Adenylosuccinate_synthase Adenylosuccinate synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.4 6.3.4.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1p9b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p9b OCA], [~~http~~://pdbe.org/1p9b PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1p9b RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1p9b PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1p9b ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p9b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p9b OCA], [https://pdbe.org/1p9b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p9b RCSB], [https://www.ebi.ac.uk/pdbsum/1p9b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p9b ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PURA_PLAFA PURA_PLAFA]] Plays an important role in the salvage pathway for purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity).<ref>PMID:12071700</ref> <ref>PMID:15500910</ref> <ref>PMID:20654742</ref>	+	[[https://www.uniprot.org/uniprot/PURA_PLAFA PURA_PLAFA]] Plays an important role in the salvage pathway for purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity).<ref>PMID:12071700</ref> <ref>PMID:15500910</ref> <ref>PMID:20654742</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 10:37, 27 November 2019

OCA — Wed, 27 Nov 2019 10:37:56 GMT

←Older revision		Revision as of 10:37, 27 November 2019
Line 1:		Line 1:

	==Structure of fully ligated Adenylosuccinate synthetase from Plasmodium falciparum==		==Structure of fully ligated Adenylosuccinate synthetase from Plasmodium falciparum==
-	<StructureSection load='1p9b' size='340' side='right' caption='[[1p9b]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='1p9b' size='340' side='right'caption='[[1p9b]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1p9b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P9B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P9B FirstGlance]. <br>		<table><tr><td colspan='2'>[[1p9b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P9B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P9B FirstGlance]. <br>
Line 29:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 1p9b" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1p9b" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Adenylosuccinate synthetase 3D structures\|Adenylosuccinate synthetase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 34:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Adenylosuccinate synthase]]		[[Category: Adenylosuccinate synthase]]
		+	[[Category: Large Structures]]
	[[Category: Plafa]]		[[Category: Plafa]]
	[[Category: Anand, R P]]		[[Category: Anand, R P]]

OCA at 08:04, 15 February 2018

OCA — Thu, 15 Feb 2018 08:04:34 GMT

←Older revision		Revision as of 08:04, 15 February 2018
Line 1:		Line 1:
		+
	==Structure of fully ligated Adenylosuccinate synthetase from Plasmodium falciparum==		==Structure of fully ligated Adenylosuccinate synthetase from Plasmodium falciparum==
	<StructureSection load='1p9b' size='340' side='right' caption='[[1p9b]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1p9b' size='340' side='right' caption='[[1p9b]], [[Resolution\|resolution]] 2.00Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=HDA:HADACIDIN'>HDA</scene>, <scene name='pdbligand=IMO:6-O-PHOSPHORYL+INOSINE+MONOPHOSPHATE'>IMO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=HDA:HADACIDIN'>HDA</scene>, <scene name='pdbligand=IMO:6-O-PHOSPHORYL+INOSINE+MONOPHOSPHATE'>IMO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylosuccinate_synthase Adenylosuccinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.4 6.3.4.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylosuccinate_synthase Adenylosuccinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.4 6.3.4.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p9b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p9b OCA], [http://pdbe.org/1p9b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1p9b RCSB], [http://www.ebi.ac.uk/pdbsum/1p9b PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p9b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p9b OCA], [http://pdbe.org/1p9b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1p9b RCSB], [http://www.ebi.ac.uk/pdbsum/1p9b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1p9b ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p9/1p9b_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p9/1p9b_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1p9b ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 1p9b" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1p9b" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Adenylosuccinate Synthetase\|Adenylosuccinate Synthetase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 22:44, 11 September 2015

OCA — Fri, 11 Sep 2015 22:44:36 GMT

←Older revision		Revision as of 22:44, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1p9b' size='340' side='right' caption='[[1p9b]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1p9b' size='340' side='right' caption='[[1p9b]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1p9b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Plasmodium_falciparum Plasmodium falciparum~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P9B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P9B FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1p9b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P9B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P9B FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=HDA:HADACIDIN'>HDA</scene>, <scene name='pdbligand=IMO:6-O-PHOSPHORYL+INOSINE+MONOPHOSPHATE'>IMO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=HDA:HADACIDIN'>HDA</scene>, <scene name='pdbligand=IMO:6-O-PHOSPHORYL+INOSINE+MONOPHOSPHATE'>IMO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylosuccinate_synthase Adenylosuccinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.4 6.3.4.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylosuccinate_synthase Adenylosuccinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.4 6.3.4.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p9b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p9b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1p9b RCSB], [http://www.ebi.ac.uk/pdbsum/1p9b PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p9b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p9b OCA], [http://pdbe.org/1p9b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1p9b RCSB], [http://www.ebi.ac.uk/pdbsum/1p9b PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1p9b" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Adenylosuccinate synthase]]		[[Category: Adenylosuccinate synthase]]
-	[[Category: ~~Plasmodium falciparum~~]]	+	[[Category: Plafa]]
	[[Category: Anand, R P]]		[[Category: Anand, R P]]
	[[Category: Balaram, H]]		[[Category: Balaram, H]]

OCA at 20:26, 25 December 2014

OCA — Thu, 25 Dec 2014 20:26:19 GMT

←Older revision		Revision as of 20:26, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1p9b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P9B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P9B FirstGlance]. <br>		<table><tr><td colspan='2'>[[1p9b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P9B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P9B FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=HDA:HADACIDIN'>HDA</scene>, <scene name='pdbligand=IMO:6-O-PHOSPHORYL+INOSINE+MONOPHOSPHATE'>IMO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=HDA:HADACIDIN'>HDA</scene>, <scene name='pdbligand=IMO:6-O-PHOSPHORYL+INOSINE+MONOPHOSPHATE'>IMO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylosuccinate_synthase Adenylosuccinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.4 6.3.4.4] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylosuccinate_synthase Adenylosuccinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.4 6.3.4.4] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p9b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p9b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1p9b RCSB], [http://www.ebi.ac.uk/pdbsum/1p9b PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p9b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p9b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1p9b RCSB], [http://www.ebi.ac.uk/pdbsum/1p9b PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PURA_PLAFA PURA_PLAFA]] Plays an important role in the salvage pathway for purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity).<ref>PMID:12071700</ref> <ref>PMID:15500910</ref> <ref>PMID:20654742</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	[[Category: Adenylosuccinate synthase]]		[[Category: Adenylosuccinate synthase]]
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]
-	[[Category: Anand, R P.]]	+	[[Category: Anand, R P]]
-	[[Category: Balaram, H.]]	+	[[Category: Balaram, H]]
-	[[Category: Eaazhisai, K.]]	+	[[Category: Eaazhisai, K]]
-	[[Category: Gayathri, P.]]	+	[[Category: Gayathri, P]]
-	[[Category: Jayalakshmi, R.]]	+	[[Category: Jayalakshmi, R]]
-	[[Category: Murthy, M R.]]	+	[[Category: Murthy, M R]]
-	[[Category: Sumathy, K.]]	+	[[Category: Sumathy, K]]
	[[Category: Ligase]]		[[Category: Ligase]]

OCA at 21:27, 28 September 2014

OCA — Sun, 28 Sep 2014 21:27:53 GMT

←Older revision		Revision as of 21:27, 28 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1p9b.~~png\|left~~\|200px]]	+	==Structure of fully ligated Adenylosuccinate synthetase from Plasmodium falciparum==
		+	<StructureSection load='1p9b' size='340' side='right' caption='[[1p9b]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1p9b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P9B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P9B FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=HDA:HADACIDIN'>HDA</scene>, <scene name='pdbligand=IMO:6-O-PHOSPHORYL+INOSINE+MONOPHOSPHATE'>IMO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene><br>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylosuccinate_synthase Adenylosuccinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.4 6.3.4.4] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p9b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p9b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1p9b RCSB], [http://www.ebi.ac.uk/pdbsum/1p9b PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p9/1p9b_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In the absence of the de novo purine nucleotide biosynthetic pathway in parasitic protozoa, purine salvage is of primary importance for parasite survival. Enzymes of the salvage pathway are, therefore, good targets for anti-parasitic drugs. Adenylosuccinate synthetase (AdSS), catalysing the first committed step in the synthesis of AMP from IMP, is a potential target for anti-protozoal chemotherapy. We report here the crystal structure of adenylosuccinate synthetase from the malaria parasite, Plasmodium falciparum, complexed to 6-phosphoryl IMP, GDP, Mg2+ and the aspartate analogue, hadacidin at 2 A resolution. The overall architecture of P. falciparum AdSS (PfAdSS) is similar to the known structures from Escherichia coli, mouse and plants. Differences in substrate interactions seen in this structure provide a plausible explanation for the kinetic differences between PfAdSS and the enzyme from other species. Additional hydrogen bonding interactions of the protein with GDP may account for the ordered binding of substrates to the enzyme. The dimer interface of PfAdSS is also different, with a pronounced excess of positively charged residues. Differences highlighted here provide a basis for the design of species-specific inhibitors of the enzyme.

-	~~{{STRUCTURE_1p9b\| PDB=1p9b \| SCENE= }}~~	+	Crystal structure of fully ligated adenylosuccinate synthetase from Plasmodium falciparum.,Eaazhisai K, Jayalakshmi R, Gayathri P, Anand RP, Sumathy K, Balaram H, Murthy MR J Mol Biol. 2004 Jan 30;335(5):1251-64. PMID:14729341<ref>PMID:14729341</ref>

-	~~===Structure~~ of ~~fully ligated Adenylosuccinate synthetase from Plasmodium falciparum===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_14729341}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1p9b]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Plasmodium_falciparum Plasmodium falciparum]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1P9B OCA].~~	+

	==See Also==		==See Also==
	*[[Adenylosuccinate Synthetase\|Adenylosuccinate Synthetase]]		*[[Adenylosuccinate Synthetase\|Adenylosuccinate Synthetase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:014729341<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Adenylosuccinate synthase]]		[[Category: Adenylosuccinate synthase]]
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]

OCA at 21:06, 20 October 2012

OCA — Sat, 20 Oct 2012 21:06:03 GMT

←Older revision		Revision as of 21:06, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1p9b]] is a 1 chain structure ~~of [[Adenylosuccinate Synthetase]]~~ with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P9B OCA].	+	[[1p9b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P9B OCA].

	==See Also==		==See Also==

OCA: Protected "1p9b" [edit=sysop:move=sysop]

OCA — Fri, 27 Jul 2012 12:35:27 GMT

Protected "1p9b" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:35, 27 July 2012

OCA at 12:35, 27 July 2012

OCA — Fri, 27 Jul 2012 12:35:25 GMT

←Older revision		Revision as of 12:35, 27 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1p9b.png\|left\|200px]]		[[Image:1p9b.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1p9b", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1p9b\| PDB=1p9b \| SCENE= }}		{{STRUCTURE_1p9b\| PDB=1p9b \| SCENE= }}

	===Structure of fully ligated Adenylosuccinate synthetase from Plasmodium falciparum===		===Structure of fully ligated Adenylosuccinate synthetase from Plasmodium falciparum===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_14729341}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 14729341 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_14729341}}		{{ABSTRACT_PUBMED_14729341}}

	==About this Structure==		==About this Structure==
-	~~1P9B~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P9B OCA].	+	[[1p9b]] is a 1 chain structure of [[Adenylosuccinate Synthetase]] with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P9B OCA].
		+
		+	==See Also==
		+	*[[Adenylosuccinate Synthetase\|Adenylosuccinate Synthetase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~14729341~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:014729341</ref><references group="xtra"/>
	[[Category: Adenylosuccinate synthase]]		[[Category: Adenylosuccinate synthase]]
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]
Line 34:		Line 25:
	[[Category: Sumathy, K.]]		[[Category: Sumathy, K.]]
	[[Category: Ligase]]		[[Category: Ligase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 06:12:06 2009''