1peb - Revision history

OCA at 09:41, 16 August 2023

OCA — Wed, 16 Aug 2023 09:41:56 GMT

←Older revision		Revision as of 09:41, 16 August 2023
Line 3:		Line 3:
	<StructureSection load='1peb' size='340' side='right'caption='[[1peb]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='1peb' size='340' side='right'caption='[[1peb]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1peb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PEB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PEB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1peb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PEB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PEB FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[1n3w\|1n3w]], [[1n3x\|1n3x]], [[1nl5\|1nl5]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">MALE OR B4034 OR Z5632 OR ECS5017 ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=562 "Bacillus coli" Migula 1895])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1peb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1peb OCA], [https://pdbe.org/1peb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1peb RCSB], [https://www.ebi.ac.uk/pdbsum/1peb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1peb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1peb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1peb OCA], [https://pdbe.org/1peb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1peb RCSB], [https://www.ebi.ac.uk/pdbsum/1peb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1peb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.	+	[https://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ coli ~~migula 1895~~]]	+	[[Category: Escherichia coli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Shilton~~, B H~~]]	+	[[Category: Shilton BH]]
-	[[Category: Telmer~~, P G]]~~	+	[[Category: Telmer PG]]
-	~~[[Category: Engineered]]~~	+
-	~~[[Category: High-affinity mutant]]~~	+
-	~~[[Category: Maltose-binding protein]]~~	+
-	~~[[Category: Mbp]]~~	+
-	~~[[Category: Sugar binding protein~~]]	+

OCA at 15:14, 27 October 2021

OCA — Wed, 27 Oct 2021 15:14:06 GMT

←Older revision		Revision as of 15:14, 27 October 2021
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	<StructureSection load='1peb' size='340' side='right'caption='[[1peb]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='1peb' size='340' side='right'caption='[[1peb]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1peb]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PEB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1PEB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1peb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PEB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PEB FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1n3w\|1n3w]], [[1n3x\|1n3x]], [[1nl5\|1nl5]]</div></td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1n3w\|1n3w]], [[1n3x\|1n3x]], [[1nl5\|1nl5]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MALE OR B4034 OR Z5632 OR ECS5017 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MALE OR B4034 OR Z5632 OR ECS5017 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1peb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1peb OCA], [~~http~~://pdbe.org/1peb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1peb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1peb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1peb ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1peb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1peb OCA], [https://pdbe.org/1peb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1peb RCSB], [https://www.ebi.ac.uk/pdbsum/1peb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1peb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.	+	[[https://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 07:28, 9 December 2020

OCA — Wed, 09 Dec 2020 07:28:18 GMT

←Older revision		Revision as of 07:28, 9 December 2020
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	==LIGAND-FREE HIGH-AFFINITY MALTOSE-BINDING PROTEIN==		==LIGAND-FREE HIGH-AFFINITY MALTOSE-BINDING PROTEIN==
-	<StructureSection load='1peb' size='340' side='right' caption='[[1peb]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='1peb' size='340' side='right'caption='[[1peb]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1peb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PEB OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1PEB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1peb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PEB OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1PEB FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1n3w\|1n3w]], [[1n3x\|1n3x]], [[1nl5\|1nl5]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1n3w\|1n3w]], [[1n3x\|1n3x]], [[1nl5\|1nl5]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MALE OR B4034 OR Z5632 OR ECS5017 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MALE OR B4034 OR Z5632 OR ECS5017 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1peb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1peb OCA], [http://pdbe.org/1peb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1peb RCSB], [http://www.ebi.ac.uk/pdbsum/1peb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1peb ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1peb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1peb OCA], [http://pdbe.org/1peb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1peb RCSB], [http://www.ebi.ac.uk/pdbsum/1peb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1peb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pe/1peb_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pe/1peb_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 29:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 1peb" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1peb" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Maltose-binding protein 3D structures\|Maltose-binding protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 34:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
		+	[[Category: Large Structures]]
	[[Category: Shilton, B H]]		[[Category: Shilton, B H]]
	[[Category: Telmer, P G]]		[[Category: Telmer, P G]]

OCA at 13:51, 12 October 2017

OCA — Thu, 12 Oct 2017 13:51:28 GMT

←Older revision		Revision as of 13:51, 12 October 2017
Line 1:		Line 1:
		+
	==LIGAND-FREE HIGH-AFFINITY MALTOSE-BINDING PROTEIN==		==LIGAND-FREE HIGH-AFFINITY MALTOSE-BINDING PROTEIN==
	<StructureSection load='1peb' size='340' side='right' caption='[[1peb]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='1peb' size='340' side='right' caption='[[1peb]], [[Resolution\|resolution]] 2.60Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1n3w\|1n3w]], [[1n3x\|1n3x]], [[1nl5\|1nl5]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1n3w\|1n3w]], [[1n3x\|1n3x]], [[1nl5\|1nl5]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MALE OR B4034 OR Z5632 OR ECS5017 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MALE OR B4034 OR Z5632 OR ECS5017 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1peb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1peb OCA], [http://pdbe.org/1peb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1peb RCSB], [http://www.ebi.ac.uk/pdbsum/1peb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1peb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1peb OCA], [http://pdbe.org/1peb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1peb RCSB], [http://www.ebi.ac.uk/pdbsum/1peb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1peb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 1peb" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1peb" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Maltose-binding protein\|Maltose-binding protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 20:25, 8 February 2016

OCA — Mon, 08 Feb 2016 20:25:19 GMT

←Older revision		Revision as of 20:25, 8 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1peb ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 15:05, 10 September 2015

OCA — Thu, 10 Sep 2015 15:05:58 GMT

←Older revision		Revision as of 15:05, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1peb' size='340' side='right' caption='[[1peb]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='1peb' size='340' side='right' caption='[[1peb]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1peb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia~~ coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PEB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PEB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1peb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PEB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PEB FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1n3w\|1n3w]], [[1n3x\|1n3x]], [[1nl5\|1nl5]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1n3w\|1n3w]], [[1n3x\|1n3x]], [[1nl5\|1nl5]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MALE OR B4034 OR Z5632 OR ECS5017 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 ~~Escherichia~~ coli])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MALE OR B4034 OR Z5632 OR ECS5017 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1peb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1peb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1peb RCSB], [http://www.ebi.ac.uk/pdbsum/1peb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1peb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1peb OCA], [http://pdbe.org/1peb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1peb RCSB], [http://www.ebi.ac.uk/pdbsum/1peb PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1peb" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Escherichia~~ coli]]	+	[[Category: Bacillus coli migula 1895]]
	[[Category: Shilton, B H]]		[[Category: Shilton, B H]]
	[[Category: Telmer, P G]]		[[Category: Telmer, P G]]

OCA at 01:55, 25 December 2014

OCA — Thu, 25 Dec 2014 01:55:33 GMT

←Older revision		Revision as of 01:55, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1peb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PEB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PEB FirstGlance]. <br>		<table><tr><td colspan='2'>[[1peb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PEB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PEB FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1n3w\|1n3w]], [[1n3x\|1n3x]], [[1nl5\|1nl5]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1n3w\|1n3w]], [[1n3x\|1n3x]], [[1nl5\|1nl5]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MALE OR B4034 OR Z5632 OR ECS5017 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MALE OR B4034 OR Z5632 OR ECS5017 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1peb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1peb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1peb RCSB], [http://www.ebi.ac.uk/pdbsum/1peb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1peb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1peb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1peb RCSB], [http://www.ebi.ac.uk/pdbsum/1peb PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: Shilton, B H.]]	+	[[Category: Shilton, B H]]
-	[[Category: Telmer, P G.]]	+	[[Category: Telmer, P G]]
	[[Category: Engineered]]		[[Category: Engineered]]
	[[Category: High-affinity mutant]]		[[Category: High-affinity mutant]]

OCA at 23:27, 28 September 2014

OCA — Sun, 28 Sep 2014 23:27:27 GMT

←Older revision		Revision as of 23:27, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1peb.~~png~~\|~~left~~\|200px]]	+	==LIGAND-FREE HIGH-AFFINITY MALTOSE-BINDING PROTEIN==
		+	<StructureSection load='1peb' size='340' side='right' caption='[[1peb]], [[Resolution\|resolution]] 2.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1peb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PEB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PEB FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1n3w\|1n3w]], [[1n3x\|1n3x]], [[1nl5\|1nl5]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MALE OR B4034 OR Z5632 OR ECS5017 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1peb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1peb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1peb RCSB], [http://www.ebi.ac.uk/pdbsum/1peb PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pe/1peb_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The affinity of maltose-binding protein (MBP) for maltose and related carbohydrates was greatly increased by removal of groups in the interface opposite the ligand binding cleft. The wild-type protein has a KD of 1200 nM for maltose; mutation of residues Met-321 and Gln-325, both to alanine, resulted in a KD for maltose of 70 nM; deletion of 4 residues, Glu-172, Asn-173, Lys-175, and Tyr-176, which are part of a poorly ordered loop, results in a KD for maltose of 110 nM. Combining the mutations yields an increased affinity for maltodextrins and a KD of 6 nM for maltotriose. Comparison of ligand binding by the mutants, using surface plasmon resonance spectroscopy, indicates that decreases in the off-rate are responsible for the increased affinity. Small-angle x-ray scattering was used to demonstrate that the mutations do not significantly affect the solution conformation of MBP in either the presence or absence of maltose. The crystal structures of selected mutants showed that the mutations do not cause significant structural changes in either the closed or open conformation of MBP. These studies show that interactions in the interface opposite the ligand binding cleft, which we term the "balancing interface," are responsible for modulating the affinity of MBP for its ligand. Our results are consistent with a model in which the ligand-bound protein alternates between the closed and open conformations, and removal of interactions in the balancing interface decreases the stability of the open conformation, without affecting the closed conformation.

-	~~{{STRUCTURE_1peb\| PDB=1peb \| SCENE= }}~~	+	Insights into the conformational equilibria of maltose-binding protein by analysis of high affinity mutants.,Telmer PG, Shilton BH J Biol Chem. 2003 Sep 5;278(36):34555-67. Epub 2003 Jun 6. PMID:12794084<ref>PMID:12794084</ref>

-	~~===LIGAND-FREE HIGH-AFFINITY MALTOSE-BINDING PROTEIN===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_12794084}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1peb]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli Escherichia coli]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1PEB OCA].~~	+

	==See Also==		==See Also==
	*[[Maltose-binding protein\|Maltose-binding protein]]		*[[Maltose-binding protein\|Maltose-binding protein]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:012794084<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Shilton, B H.]]		[[Category: Shilton, B H.]]

OCA at 11:22, 20 October 2012

OCA — Sat, 20 Oct 2012 11:22:17 GMT

←Older revision		Revision as of 11:22, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1peb]] is a 1 chain structure ~~of [[Maltose-binding protein]]~~ with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PEB OCA].	+	[[1peb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PEB OCA].

	==See Also==		==See Also==

OCA: Protected "1peb" [edit=sysop:move=sysop]

OCA — Thu, 26 Jul 2012 05:08:32 GMT

Protected "1peb" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:08, 26 July 2012