1pib - Revision history

OCA at 18:55, 29 November 2023

OCA — Wed, 29 Nov 2023 18:55:51 GMT

←Older revision		Revision as of 18:55, 29 November 2023
Line 1:		Line 1:

	==Solution structure of DNA containing CPD opposited by GA==		==Solution structure of DNA containing CPD opposited by GA==
-	<StructureSection load='1pib' size='340' side='right'caption='[[1pib~~]], [[NMR_Ensembles_of_Models \| 16 NMR models~~]]' scene=''>	+	<StructureSection load='1pib' size='340' side='right'caption='[[1pib]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1pib]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PIB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PIB FirstGlance]. <br>		<table><tr><td colspan='2'>[[1pib]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PIB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PIB FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'>[[1snh\|1snh]]</div~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pib FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pib OCA], [https://pdbe.org/1pib PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pib RCSB], [https://www.ebi.ac.uk/pdbsum/1pib PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pib ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pib FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pib OCA], [https://pdbe.org/1pib PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pib RCSB], [https://www.ebi.ac.uk/pdbsum/1pib PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pib ProSAT]</span></td></tr>
	</table>		</table>
Line 21:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Choi~~, B S~~]]	+	[[Category: Choi BS]]
-	[[Category: Lee~~, J H~~]]	+	[[Category: Lee JH]]
-	[[Category: Park~~, C J~~]]	+	[[Category: Park CJ]]
-	[[Category: Shin~~, J S]]~~	+	[[Category: Shin JS]]
-	~~[[Category: Cis-syn cyclobutane pyrimidine dimer]]~~	+
-	~~[[Category: Cpd containing dna]]~~	+
-	~~[[Category: Dna]]~~	+
-	~~[[Category: Helical distortion]]~~	+
-	~~[[Category: Thyminedimer~~]]	+

OCA at 09:30, 8 September 2021

OCA — Wed, 08 Sep 2021 09:30:12 GMT

←Older revision		Revision as of 09:30, 8 September 2021
Line 3:		Line 3:
	<StructureSection load='1pib' size='340' side='right'caption='[[1pib]], [[NMR_Ensembles_of_Models \| 16 NMR models]]' scene=''>		<StructureSection load='1pib' size='340' side='right'caption='[[1pib]], [[NMR_Ensembles_of_Models \| 16 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1pib]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PIB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1PIB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1pib]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PIB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PIB FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1snh\|1snh]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1snh\|1snh]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1pib FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pib OCA], [~~http~~://pdbe.org/1pib PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1pib RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1pib PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1pib ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pib FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pib OCA], [https://pdbe.org/1pib PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pib RCSB], [https://www.ebi.ac.uk/pdbsum/1pib PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pib ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 09:50, 27 November 2019

OCA — Wed, 27 Nov 2019 09:50:16 GMT

←Older revision		Revision as of 09:50, 27 November 2019
Line 1:		Line 1:

	==Solution structure of DNA containing CPD opposited by GA==		==Solution structure of DNA containing CPD opposited by GA==
-	<StructureSection load='1pib' size='340' side='right' caption='[[1pib]], [[NMR_Ensembles_of_Models \| 16 NMR models]]' scene=''>	+	<StructureSection load='1pib' size='340' side='right'caption='[[1pib]], [[NMR_Ensembles_of_Models \| 16 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1pib]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PIB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PIB FirstGlance]. <br>		<table><tr><td colspan='2'>[[1pib]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PIB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PIB FirstGlance]. <br>
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Choi, B S]]		[[Category: Choi, B S]]
	[[Category: Lee, J H]]		[[Category: Lee, J H]]

OCA at 07:28, 15 February 2018

OCA — Thu, 15 Feb 2018 07:28:08 GMT

←Older revision		Revision as of 07:28, 15 February 2018
Line 1:		Line 1:
		+
	==Solution structure of DNA containing CPD opposited by GA==		==Solution structure of DNA containing CPD opposited by GA==
	<StructureSection load='1pib' size='340' side='right' caption='[[1pib]], [[NMR_Ensembles_of_Models \| 16 NMR models]]' scene=''>		<StructureSection load='1pib' size='340' side='right' caption='[[1pib]], [[NMR_Ensembles_of_Models \| 16 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1pib]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PIB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PIB FirstGlance]. <br>		<table><tr><td colspan='2'>[[1pib]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PIB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PIB FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1snh\|1snh]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1snh\|1snh]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pib FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pib OCA], [http://pdbe.org/1pib PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1pib RCSB], [http://www.ebi.ac.uk/pdbsum/1pib PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pib FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pib OCA], [http://pdbe.org/1pib PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1pib RCSB], [http://www.ebi.ac.uk/pdbsum/1pib PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1pib ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 01:20, 12 September 2015

OCA — Sat, 12 Sep 2015 01:20:14 GMT

←Older revision		Revision as of 01:20, 12 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[1pib]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PIB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PIB FirstGlance]. <br>		<table><tr><td colspan='2'>[[1pib]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PIB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PIB FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1snh\|1snh]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1snh\|1snh]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pib FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pib OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1pib RCSB], [http://www.ebi.ac.uk/pdbsum/1pib PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pib FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pib OCA], [http://pdbe.org/1pib PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1pib RCSB], [http://www.ebi.ac.uk/pdbsum/1pib PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 14:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1pib" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:44, 6 January 2015

OCA — Tue, 06 Jan 2015 06:44:40 GMT

←Older revision		Revision as of 06:44, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1pib]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PIB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PIB FirstGlance]. <br>		<table><tr><td colspan='2'>[[1pib]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PIB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PIB FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1snh\|1snh]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1snh\|1snh]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pib FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pib OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1pib RCSB], [http://www.ebi.ac.uk/pdbsum/1pib PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pib FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pib OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1pib RCSB], [http://www.ebi.ac.uk/pdbsum/1pib PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Choi, B S.]]	+	[[Category: Choi, B S]]
-	[[Category: Lee, J H.]]	+	[[Category: Lee, J H]]
-	[[Category: Park, C J.]]	+	[[Category: Park, C J]]
-	[[Category: Shin, J S.]]	+	[[Category: Shin, J S]]
	[[Category: Cis-syn cyclobutane pyrimidine dimer]]		[[Category: Cis-syn cyclobutane pyrimidine dimer]]
	[[Category: Cpd containing dna]]		[[Category: Cpd containing dna]]

OCA at 23:13, 28 September 2014

OCA — Sun, 28 Sep 2014 23:13:50 GMT

←Older revision		Revision as of 23:13, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1pib.~~png~~\|~~left~~\|~~200px~~]]	+	==Solution structure of DNA containing CPD opposited by GA==
		+	<StructureSection load='1pib' size='340' side='right' caption='[[1pib]], [[NMR_Ensembles_of_Models \| 16 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1pib]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PIB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PIB FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1snh\|1snh]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pib FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pib OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1pib RCSB], [http://www.ebi.ac.uk/pdbsum/1pib PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The cis-syn cyclobutane pyrimidine dimer (CPD) is a cytotoxic, mutagenic and carcinogenic DNA photoproduct and is repaired by the nucleotide excision repair (NER) pathway in mammalian cells. The XPC-hHR23B complex as the initiator of global genomic NER binds to sites of certain kinds of DNA damage. Although CPDs are rarely recognized by the XPC-hHR23B complex, the presence of mismatched bases opposite a CPD significantly increased the binding affinity of the XPC-hHR23B complex to the CPD. In order to decipher the properties of the DNA structures that determine the binding affinity for XPC-hHR23B to DNA, we carried out structural analyses of the various types of CPDs by NMR spectroscopy. The DNA duplex which contains a single 3' TG wobble pair in a CPD (CPD/GA duplex) induces little conformational distortion. However, severe distortion of the helical conformation occurs when a CPD contains double TG wobble pairs (CPD/GG duplex) even though the T residues of the CPD form stable hydrogen bonds with the opposite G residues. The helical bending angle of the CPD/GG duplex was larger than those of the CPD/GA duplex and properly matched CPD/AA duplex. The fluctuation of the backbone conformation and significant changes in the widths of the major and minor grooves at the double T*G wobble paired site were also observed in the CPD/GG duplex. These structural features were also found in a duplex that contains the (6-4) adduct, which is efficiently recognized by the XPC-hHR23B complex. Thus, we suggest that the unique structural features of the DNA double helix (that is, helical bending, flexible backbone conformation, and significant changes of the major and/or minor grooves) might be important factors in determining the binding affinity of the XPC-hHR23B complex to DNA.

-	~~{{STRUCTURE_1pib\| PDB=1pib \| SCENE= }}~~	+	NMR structure of the DNA decamer duplex containing double T*G mismatches of cis-syn cyclobutane pyrimidine dimer: implications for DNA damage recognition by the XPC-hHR23B complex.,Lee JH, Park CJ, Shin JS, Ikegami T, Akutsu H, Choi BS Nucleic Acids Res. 2004 Apr 30;32(8):2474-81. Print 2004. PMID:15121904<ref>PMID:15121904</ref>

-	~~===Solution structure~~ of ~~DNA containing CPD opposited by GA===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15121904}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[1pib]] is a 2 chain structure. Full experimental information is available from [http:~~//~~oca.weizmann.ac.il/oca-bin/ocashort?id=1PIB OCA].~~	+	</StructureSection>
	[[Category: Choi, B S.]]		[[Category: Choi, B S.]]
	[[Category: Lee, J H.]]		[[Category: Lee, J H.]]

OCA: Protected "1pib" [edit=sysop:move=sysop]

OCA — Wed, 19 Dec 2012 11:52:59 GMT

Protected "1pib" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:52, 19 December 2012

OCA at 11:52, 19 December 2012

OCA — Wed, 19 Dec 2012 11:52:56 GMT

←Older revision		Revision as of 11:52, 19 December 2012
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-	{{Seed}}
	[[Image:1pib.png\|left\|200px]]		[[Image:1pib.png\|left\|200px]]

-	<!--
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-	or leave the SCENE parameter empty for the default display.
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	{{STRUCTURE_1pib\| PDB=1pib \| SCENE= }}		{{STRUCTURE_1pib\| PDB=1pib \| SCENE= }}

	===Solution structure of DNA containing CPD opposited by GA===		===Solution structure of DNA containing CPD opposited by GA===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15121904}}, adds the Publication Abstract to the page
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	{{ABSTRACT_PUBMED_15121904}}		{{ABSTRACT_PUBMED_15121904}}

	==About this Structure==		==About this Structure==
-	Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PIB OCA].	+	[[1pib]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PIB OCA].
-		+
-	~~==Reference==~~	+
-	NMR structure of the DNA decamer duplex containing double T*G mismatches of cis-syn cyclobutane pyrimidine dimer: implications for DNA damage recognition by the XPC-hHR23B complex., Lee JH, Park CJ, Shin JS, Ikegami T, Akutsu H, Choi BS, Nucleic Acids Res. 2004 Apr 30;32(8):2474-81. Print 2004. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15121904 15121904]	+
	[[Category: Choi, B S.]]		[[Category: Choi, B S.]]
	[[Category: Lee, J H.]]		[[Category: Lee, J H.]]
Line 30:		Line 15:
	[[Category: Cis-syn cyclobutane pyrimidine dimer]]		[[Category: Cis-syn cyclobutane pyrimidine dimer]]
	[[Category: Cpd containing dna]]		[[Category: Cpd containing dna]]
		+	[[Category: Dna]]
	[[Category: Helical distortion]]		[[Category: Helical distortion]]
	[[Category: Thyminedimer]]		[[Category: Thyminedimer]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:17:17 2008''

OCA at 12:17, 29 July 2008

OCA — Tue, 29 Jul 2008 12:17:18 GMT

←Older revision		Revision as of 12:17, 29 July 2008
Line 1:		Line 1:
-	[[Image:1pib.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:1pib.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_1pib\| PDB=1pib \| SCENE= }}		{{STRUCTURE_1pib\| PDB=1pib \| SCENE= }}

-	~~'''~~Solution structure of DNA containing CPD opposited by GA~~'''~~	+	===Solution structure of DNA containing CPD opposited by GA===


-	~~==Overview==~~	+	<!--
-	The ~~cis-syn cyclobutane pyrimidine dimer (CPD) is a cytotoxic~~, mutagenic and carcinogenic DNA photoproduct and is repaired by the nucleotide excision repair (NER) pathway in mammalian cells. The XPC-hHR23B complex as the initiator of global genomic NER binds to sites of certain kinds of DNA damage. Although CPDs are rarely recognized by the XPC-hHR23B complex, the ~~presence of mismatched bases opposite a CPD significantly increased the binding affinity of the XPC-hHR23B complex~~ to the CPD. In order to decipher the properties of the DNA structures that determine the binding affinity for XPC-hHR23B to DNA, we carried out structural analyses of the various types of CPDs by NMR spectroscopy. The DNA duplex which contains a single 3' TG wobble pair in a CPD (~~CPD~~/~~GA duplex) induces little conformational distortion. However, severe distortion of the helical conformation occurs when a CPD contains double TG wobble pairs (CPD~~/~~GG duplex) even though the T residues of the CPD form stable hydrogen bonds with the opposite G residues~~. ~~The helical bending angle of the CPD/GG duplex was larger than those of the CPD/GA duplex and properly matched CPD/AA duplex~~. The fluctuation of the backbone conformation and significant changes in the widths of the major and minor grooves at the double T*G wobble paired site were also observed in the CPD/GG duplex. These structural features were also found in a duplex that contains the (6-4) ~~adduct~~, ~~which~~ is ~~efficiently recognized by~~ the ~~XPC-hHR23B complex~~. Thus, we suggest that the unique structural features of the DNA double helix (that is, helical bending, flexible backbone conformation, and significant changes of the major and/or minor grooves) might be important factors in determining the binding affinity of the XPC-~~hHR23B complex to DNA.~~	+	The line below this paragraph, {{ABSTRACT_PUBMED_15121904}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 15121904 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_15121904}}

	==About this Structure==		==About this Structure==
-	Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PIB OCA].	+	Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PIB OCA].

	==Reference==		==Reference==
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	[[Category: Helical distortion]]		[[Category: Helical distortion]]
	[[Category: Thyminedimer]]		[[Category: Thyminedimer]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 05~~:06:45 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:17:17 2008''