1pit - Revision history

OCA at 05:56, 17 April 2024

OCA — Wed, 17 Apr 2024 05:56:07 GMT

←Older revision		Revision as of 05:56, 17 April 2024
Line 1:		Line 1:

	==DETERMINATION OF A HIGH-QUALITY NUCLEAR MAGNETIC RESONANCE SOLUTION STRUCTURE OF THE BOVINE PANCREATIC TRYPSIN INHIBITOR AND COMPARISON WITH THREE CRYSTAL STRUCTURES==		==DETERMINATION OF A HIGH-QUALITY NUCLEAR MAGNETIC RESONANCE SOLUTION STRUCTURE OF THE BOVINE PANCREATIC TRYPSIN INHIBITOR AND COMPARISON WITH THREE CRYSTAL STRUCTURES==
-	<StructureSection load='1pit' size='340' side='right'caption='[[1pit~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='1pit' size='340' side='right'caption='[[1pit]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1pit]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Bovin Bovin~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PIT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PIT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1pit]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PIT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PIT FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pit OCA], [https://pdbe.org/1pit PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pit RCSB], [https://www.ebi.ac.uk/pdbsum/1pit PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pit ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pit OCA], [https://pdbe.org/1pit PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pit RCSB], [https://www.ebi.ac.uk/pdbsum/1pit PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pit ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/BPT1_BOVIN BPT1_BOVIN]] Inhibits trypsin, kallikrein, chymotrypsin, and plasmin.	+	[https://www.uniprot.org/uniprot/BPT1_BOVIN BPT1_BOVIN] Inhibits trypsin, kallikrein, chymotrypsin, and plasmin.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 18:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pit ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pit ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	A high-quality three-dimensional structure of the bovine pancreatic trypsin inhibitor (BPTI) in aqueous solution was determined by 1H nuclear magnetic resonance (n.m.r.) spectroscopy and compared to the three available high-resolution X-ray crystal structures. A newly collected input of 642 distance constraints derived from nuclear Overhauser effects and 115 dihedral angle constraints was used for the structure calculations with the program DIANA, followed by restrained energy minimization with the program AMBER. The BPTI solution structure is represented by a group of 20 conformers with an average root-mean-square deviation (RMSD) relative to the mean solution structure of 0.43 A for backbone atoms and 0.92 A for all heavy atoms of residues 2 to 56. The pairwise RMSD values of the three crystal structures relative to the mean solution structure are 0.76 to 0.85 A for the backbone atoms and 1.24 to 1.33 A for all heavy atoms of residues 2 to 56. Small local differences in backbone atom positions between the solution structure and the X-ray structures near residues 9, 25 to 27, 46 to 48 and 52 to 58, and conformational differences for individual amino acid side-chains were analyzed for possible correlations with intermolecular protein-protein contacts in the crystal lattices, using the pairwise RMSD values among the three crystal structures as a reference.
-
-	Determination of a high-quality nuclear magnetic resonance solution structure of the bovine pancreatic trypsin inhibitor and comparison with three crystal structures.,Berndt KD, Guntert P, Orbons LP, Wuthrich K J Mol Biol. 1992 Oct 5;227(3):757-75. PMID:1383552<ref>PMID:1383552</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1pit" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[BPTI 3D structures\|BPTI 3D structures]]		*[[BPTI 3D structures\|BPTI 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bovin~~]]	+	[[Category: Bos taurus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Berndt~~, K D~~]]	+	[[Category: Berndt KD]]
-	[[Category: Guntert, P]]	+	[[Category: Guntert P]]
-	[[Category: Orbons~~, L P.M~~]]	+	[[Category: Orbons LPM]]
-	[[Category: Wuthrich, K]]	+	[[Category: Wuthrich K]]

OCA at 09:30, 8 September 2021

OCA — Wed, 08 Sep 2021 09:30:29 GMT

←Older revision		Revision as of 09:30, 8 September 2021
Line 3:		Line 3:
	<StructureSection load='1pit' size='340' side='right'caption='[[1pit]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1pit' size='340' side='right'caption='[[1pit]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1pit]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bovin Bovin]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PIT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1PIT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1pit]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bovin Bovin]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PIT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PIT FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1pit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pit OCA], [~~http~~://pdbe.org/1pit PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1pit RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1pit PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1pit ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pit OCA], [https://pdbe.org/1pit PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pit RCSB], [https://www.ebi.ac.uk/pdbsum/1pit PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pit ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/BPT1_BOVIN BPT1_BOVIN]] Inhibits trypsin, kallikrein, chymotrypsin, and plasmin.	+	[[https://www.uniprot.org/uniprot/BPT1_BOVIN BPT1_BOVIN]] Inhibits trypsin, kallikrein, chymotrypsin, and plasmin.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 09:46, 27 November 2019

OCA — Wed, 27 Nov 2019 09:46:28 GMT

←Older revision		Revision as of 09:46, 27 November 2019
Line 1:		Line 1:

	==DETERMINATION OF A HIGH-QUALITY NUCLEAR MAGNETIC RESONANCE SOLUTION STRUCTURE OF THE BOVINE PANCREATIC TRYPSIN INHIBITOR AND COMPARISON WITH THREE CRYSTAL STRUCTURES==		==DETERMINATION OF A HIGH-QUALITY NUCLEAR MAGNETIC RESONANCE SOLUTION STRUCTURE OF THE BOVINE PANCREATIC TRYPSIN INHIBITOR AND COMPARISON WITH THREE CRYSTAL STRUCTURES==
-	<StructureSection load='1pit' size='340' side='right' caption='[[1pit]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='1pit' size='340' side='right'caption='[[1pit]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1pit]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PIT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PIT FirstGlance]. <br>		<table><tr><td colspan='2'>[[1pit]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PIT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PIT FirstGlance]. <br>
Line 27:		Line 27:
	</div>		</div>
	<div class="pdbe-citations 1pit" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1pit" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[BPTI 3D structures\|BPTI 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 32:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Bovin]]		[[Category: Bovin]]
		+	[[Category: Large Structures]]
	[[Category: Berndt, K D]]		[[Category: Berndt, K D]]
	[[Category: Guntert, P]]		[[Category: Guntert, P]]
	[[Category: Orbons, L P.M]]		[[Category: Orbons, L P.M]]
	[[Category: Wuthrich, K]]		[[Category: Wuthrich, K]]

OCA at 07:25, 15 February 2018

OCA — Thu, 15 Feb 2018 07:25:17 GMT

←Older revision		Revision as of 07:25, 15 February 2018
Line 1:		Line 1:
		+
	==DETERMINATION OF A HIGH-QUALITY NUCLEAR MAGNETIC RESONANCE SOLUTION STRUCTURE OF THE BOVINE PANCREATIC TRYPSIN INHIBITOR AND COMPARISON WITH THREE CRYSTAL STRUCTURES==		==DETERMINATION OF A HIGH-QUALITY NUCLEAR MAGNETIC RESONANCE SOLUTION STRUCTURE OF THE BOVINE PANCREATIC TRYPSIN INHIBITOR AND COMPARISON WITH THREE CRYSTAL STRUCTURES==
	<StructureSection load='1pit' size='340' side='right' caption='[[1pit]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1pit' size='340' side='right' caption='[[1pit]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1pit]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PIT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PIT FirstGlance]. <br>		<table><tr><td colspan='2'>[[1pit]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PIT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PIT FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pit OCA], [http://pdbe.org/1pit PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1pit RCSB], [http://www.ebi.ac.uk/pdbsum/1pit PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pit OCA], [http://pdbe.org/1pit PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1pit RCSB], [http://www.ebi.ac.uk/pdbsum/1pit PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1pit ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pi/1pit_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pi/1pit_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 26:		Line 27:
	</div>		</div>
	<div class="pdbe-citations 1pit" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1pit" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Basic Pancreatic Trypsin Inhibitor\|Basic Pancreatic Trypsin Inhibitor]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:56, 9 February 2016

OCA — Tue, 09 Feb 2016 08:56:50 GMT

←Older revision		Revision as of 08:56, 9 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pit ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 20:39, 10 September 2015

OCA — Thu, 10 Sep 2015 20:39:28 GMT

←Older revision		Revision as of 20:39, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1pit' size='340' side='right' caption='[[1pit]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1pit' size='340' side='right' caption='[[1pit]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1pit]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bos_taurus Bos taurus~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PIT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PIT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1pit]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PIT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PIT FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pit OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1pit RCSB], [http://www.ebi.ac.uk/pdbsum/1pit PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pit OCA], [http://pdbe.org/1pit PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1pit RCSB], [http://www.ebi.ac.uk/pdbsum/1pit PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1pit" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 32:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bos taurus~~]]	+	[[Category: Bovin]]
	[[Category: Berndt, K D]]		[[Category: Berndt, K D]]
	[[Category: Guntert, P]]		[[Category: Guntert, P]]
	[[Category: Orbons, L P.M]]		[[Category: Orbons, L P.M]]
	[[Category: Wuthrich, K]]		[[Category: Wuthrich, K]]

OCA at 05:51, 25 December 2014

OCA — Thu, 25 Dec 2014 05:51:47 GMT

←Older revision		Revision as of 05:51, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1pit]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PIT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PIT FirstGlance]. <br>		<table><tr><td colspan='2'>[[1pit]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PIT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PIT FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pit OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1pit RCSB], [http://www.ebi.ac.uk/pdbsum/1pit PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pit OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1pit RCSB], [http://www.ebi.ac.uk/pdbsum/1pit PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BPT1_BOVIN BPT1_BOVIN]] Inhibits trypsin, kallikrein, chymotrypsin, and plasmin.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
-	[[Category: Berndt, K D.]]	+	[[Category: Berndt, K D]]
-	[[Category: Guntert, P.]]	+	[[Category: Guntert, P]]
-	[[Category: Orbons, L P.M.]]	+	[[Category: Orbons, L P.M]]
-	[[Category: Wuthrich, K.]]	+	[[Category: Wuthrich, K]]

OCA at 23:11, 28 September 2014

OCA — Sun, 28 Sep 2014 23:11:21 GMT

←Older revision		Revision as of 23:11, 28 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1pit.~~png\|left~~\|200px]]	+	==DETERMINATION OF A HIGH-QUALITY NUCLEAR MAGNETIC RESONANCE SOLUTION STRUCTURE OF THE BOVINE PANCREATIC TRYPSIN INHIBITOR AND COMPARISON WITH THREE CRYSTAL STRUCTURES==
		+	<StructureSection load='1pit' size='340' side='right' caption='[[1pit]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1pit]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PIT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PIT FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pit OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1pit RCSB], [http://www.ebi.ac.uk/pdbsum/1pit PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pi/1pit_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A high-quality three-dimensional structure of the bovine pancreatic trypsin inhibitor (BPTI) in aqueous solution was determined by 1H nuclear magnetic resonance (n.m.r.) spectroscopy and compared to the three available high-resolution X-ray crystal structures. A newly collected input of 642 distance constraints derived from nuclear Overhauser effects and 115 dihedral angle constraints was used for the structure calculations with the program DIANA, followed by restrained energy minimization with the program AMBER. The BPTI solution structure is represented by a group of 20 conformers with an average root-mean-square deviation (RMSD) relative to the mean solution structure of 0.43 A for backbone atoms and 0.92 A for all heavy atoms of residues 2 to 56. The pairwise RMSD values of the three crystal structures relative to the mean solution structure are 0.76 to 0.85 A for the backbone atoms and 1.24 to 1.33 A for all heavy atoms of residues 2 to 56. Small local differences in backbone atom positions between the solution structure and the X-ray structures near residues 9, 25 to 27, 46 to 48 and 52 to 58, and conformational differences for individual amino acid side-chains were analyzed for possible correlations with intermolecular protein-protein contacts in the crystal lattices, using the pairwise RMSD values among the three crystal structures as a reference.

-	~~{{STRUCTURE_1pit\| PDB=1pit \| SCENE= }}~~	+	Determination of a high-quality nuclear magnetic resonance solution structure of the bovine pancreatic trypsin inhibitor and comparison with three crystal structures.,Berndt KD, Guntert P, Orbons LP, Wuthrich K J Mol Biol. 1992 Oct 5;227(3):757-75. PMID:1383552<ref>PMID:1383552</ref>

-	~~===DETERMINATION OF A HIGH-QUALITY NUCLEAR MAGNETIC RESONANCE SOLUTION STRUCTURE OF THE BOVINE PANCREATIC TRYPSIN INHIBITOR AND COMPARISON WITH THREE CRYSTAL STRUCTURES===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_1383552}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1pit]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bos_taurus Bos taurus]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1PIT OCA].~~	+

	==See Also==		==See Also==
	*[[Basic Pancreatic Trypsin Inhibitor\|Basic Pancreatic Trypsin Inhibitor]]		*[[Basic Pancreatic Trypsin Inhibitor\|Basic Pancreatic Trypsin Inhibitor]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:001383552<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Berndt, K D.]]		[[Category: Berndt, K D.]]

OCA at 13:20, 20 October 2012

OCA — Sat, 20 Oct 2012 13:20:36 GMT

←Older revision		Revision as of 13:20, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1pit]] is a 1 chain structure ~~of [[Basic Pancreatic Trypsin Inhibitor]]~~ with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PIT OCA].	+	[[1pit]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PIT OCA].

	==See Also==		==See Also==

OCA: Protected "1pit" [edit=sysop:move=sysop]

OCA — Thu, 26 Jul 2012 11:39:30 GMT

Protected "1pit" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:39, 26 July 2012