1pjd - Revision history

OCA at 11:24, 2 August 2023

OCA — Wed, 02 Aug 2023 11:24:14 GMT

←Older revision		Revision as of 11:24, 2 August 2023
Line 1:		Line 1:

	==Structure and Topology of a Peptide Segment of the 6th Transmembrane Domain of the Saccharomyces cerevisiae alpha-Factor Receptor in Phospholipid Bilayers==		==Structure and Topology of a Peptide Segment of the 6th Transmembrane Domain of the Saccharomyces cerevisiae alpha-Factor Receptor in Phospholipid Bilayers==
-	<StructureSection load='1pjd' size='340' side='right'caption='[[1pjd~~]], [[NMR_Ensembles_of_Models \| 1 NMR models~~]]' scene=''>	+	<StructureSection load='1pjd' size='340' side='right'caption='[[1pjd]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1pjd]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PJD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PJD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1pjd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PJD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PJD FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pjd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pjd OCA], [https://pdbe.org/1pjd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pjd RCSB], [https://www.ebi.ac.uk/pdbsum/1pjd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pjd ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solid-state NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pjd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pjd OCA], [https://pdbe.org/1pjd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pjd RCSB], [https://www.ebi.ac.uk/pdbsum/1pjd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pjd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/STE2_YEAST STE2_YEAST]] Receptor for the peptide pheromone alpha factor, the mating factor of yeast.	+	[https://www.uniprot.org/uniprot/STE2_YEAST STE2_YEAST] Receptor for the peptide pheromone alpha factor, the mating factor of yeast.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Arshava, B]]	+	[[Category: Saccharomyces cerevisiae]]
-	[[Category: Becker~~, J M~~]]	+	[[Category: Arshava B]]
-	[[Category: Ding, F X]]	+	[[Category: Becker JM]]
-	[[Category: Liu, S F]]	+	[[Category: Ding F-X]]
-	[[Category: Marassi~~, F M~~]]	+	[[Category: Liu S-F]]
-	[[Category: Naider, F]]	+	[[Category: Marassi FM]]
-	[[Category: Nevzorov~~, A A~~]]	+	[[Category: Naider F]]
-	[[Category: Opella~~, S J~~]]	+	[[Category: Nevzorov AA]]
-	[[Category: Valentine~~, K G~~]]	+	[[Category: Opella SJ]]
-	[[Category: Veglia, G]]	+	[[Category: Valentine KG]]
-	[[Category: Wang, S H]]	+	[[Category: Veglia G]]
-	~~[[Category: Alpha helix]]~~	+	[[Category: Wang S-H]]
-	~~[[Category: Membrane protein~~]]	+

OCA at 09:30, 8 September 2021

OCA — Wed, 08 Sep 2021 09:30:38 GMT

←Older revision		Revision as of 09:30, 8 September 2021
Line 3:		Line 3:
	<StructureSection load='1pjd' size='340' side='right'caption='[[1pjd]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='1pjd' size='340' side='right'caption='[[1pjd]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1pjd]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PJD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1PJD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1pjd]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PJD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PJD FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1pjd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pjd OCA], [~~http~~://pdbe.org/1pjd PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1pjd RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1pjd PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1pjd ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pjd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pjd OCA], [https://pdbe.org/1pjd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pjd RCSB], [https://www.ebi.ac.uk/pdbsum/1pjd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pjd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/STE2_YEAST STE2_YEAST]] Receptor for the peptide pheromone alpha factor, the mating factor of yeast.	+	[[https://www.uniprot.org/uniprot/STE2_YEAST STE2_YEAST]] Receptor for the peptide pheromone alpha factor, the mating factor of yeast.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 10:25, 27 November 2019

OCA — Wed, 27 Nov 2019 10:25:45 GMT

←Older revision		Revision as of 10:25, 27 November 2019
Line 1:		Line 1:

	==Structure and Topology of a Peptide Segment of the 6th Transmembrane Domain of the Saccharomyces cerevisiae alpha-Factor Receptor in Phospholipid Bilayers==		==Structure and Topology of a Peptide Segment of the 6th Transmembrane Domain of the Saccharomyces cerevisiae alpha-Factor Receptor in Phospholipid Bilayers==
-	<StructureSection load='1pjd' size='340' side='right' caption='[[1pjd]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>	+	<StructureSection load='1pjd' size='340' side='right'caption='[[1pjd]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1pjd]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PJD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PJD FirstGlance]. <br>		<table><tr><td colspan='2'>[[1pjd]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PJD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PJD FirstGlance]. <br>
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Arshava, B]]		[[Category: Arshava, B]]
	[[Category: Becker, J M]]		[[Category: Becker, J M]]

OCA at 07:54, 15 February 2018

OCA — Thu, 15 Feb 2018 07:54:17 GMT

←Older revision		Revision as of 07:54, 15 February 2018
Line 1:		Line 1:
		+
	==Structure and Topology of a Peptide Segment of the 6th Transmembrane Domain of the Saccharomyces cerevisiae alpha-Factor Receptor in Phospholipid Bilayers==		==Structure and Topology of a Peptide Segment of the 6th Transmembrane Domain of the Saccharomyces cerevisiae alpha-Factor Receptor in Phospholipid Bilayers==
	<StructureSection load='1pjd' size='340' side='right' caption='[[1pjd]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='1pjd' size='340' side='right' caption='[[1pjd]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1pjd]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PJD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PJD FirstGlance]. <br>		<table><tr><td colspan='2'>[[1pjd]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PJD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PJD FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pjd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pjd OCA], [http://pdbe.org/1pjd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1pjd RCSB], [http://www.ebi.ac.uk/pdbsum/1pjd PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pjd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pjd OCA], [http://pdbe.org/1pjd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1pjd RCSB], [http://www.ebi.ac.uk/pdbsum/1pjd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1pjd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 17:55, 11 September 2015

OCA — Fri, 11 Sep 2015 17:55:54 GMT

←Older revision		Revision as of 17:55, 11 September 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1pjd]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PJD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PJD FirstGlance]. <br>		<table><tr><td colspan='2'>[[1pjd]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PJD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PJD FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pjd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pjd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1pjd RCSB], [http://www.ebi.ac.uk/pdbsum/1pjd PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pjd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pjd OCA], [http://pdbe.org/1pjd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1pjd RCSB], [http://www.ebi.ac.uk/pdbsum/1pjd PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 15:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1pjd" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 19:52, 25 December 2014

OCA — Thu, 25 Dec 2014 19:52:37 GMT

←Older revision		Revision as of 19:52, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1pjd]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PJD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PJD FirstGlance]. <br>		<table><tr><td colspan='2'>[[1pjd]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PJD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PJD FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pjd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pjd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1pjd RCSB], [http://www.ebi.ac.uk/pdbsum/1pjd PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pjd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pjd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1pjd RCSB], [http://www.ebi.ac.uk/pdbsum/1pjd PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/STE2_YEAST STE2_YEAST]] Receptor for the peptide pheromone alpha factor, the mating factor of yeast.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 17:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Arshava, B.]]	+	[[Category: Arshava, B]]
-	[[Category: Becker, J M.]]	+	[[Category: Becker, J M]]
-	[[Category: Ding, F X.]]	+	[[Category: Ding, F X]]
-	[[Category: Liu, S F.]]	+	[[Category: Liu, S F]]
-	[[Category: Marassi, F M.]]	+	[[Category: Marassi, F M]]
-	[[Category: Naider, F.]]	+	[[Category: Naider, F]]
-	[[Category: Nevzorov, A A.]]	+	[[Category: Nevzorov, A A]]
-	[[Category: Opella, S J.]]	+	[[Category: Opella, S J]]
-	[[Category: Valentine, K G.]]	+	[[Category: Valentine, K G]]
-	[[Category: Veglia, G.]]	+	[[Category: Veglia, G]]
-	[[Category: Wang, S H.]]	+	[[Category: Wang, S H]]
	[[Category: Alpha helix]]		[[Category: Alpha helix]]
	[[Category: Membrane protein]]		[[Category: Membrane protein]]

OCA at 20:35, 28 September 2014

OCA — Sun, 28 Sep 2014 20:35:17 GMT

←Older revision		Revision as of 20:35, 28 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1pjd.~~png\|left\|200px~~]]	+	==Structure and Topology of a Peptide Segment of the 6th Transmembrane Domain of the Saccharomyces cerevisiae alpha-Factor Receptor in Phospholipid Bilayers==
		+	<StructureSection load='1pjd' size='340' side='right' caption='[[1pjd]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1pjd]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PJD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PJD FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pjd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pjd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1pjd RCSB], [http://www.ebi.ac.uk/pdbsum/1pjd PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A detailed analysis of the structure of an 18-residue peptide AQSLLVPSIIFILAYSLK [M6(252-269, C252A)] in 1,2-dimyristoyl-sn-glycero-phosphocholine bilayers was carried out using solid state NMR and attenuated total reflection Fourier transform infrared spectroscopy. The peptide corresponds to a portion of the 6th transmembrane domain of the alpha-factor receptor of Saccharomyces cerevisiae. Ten homologs of M6(252-269, C252A) were synthesized in which individual residues were labeled with (15)N. One- and two-dimensional solid state NMR experiments were used to determine the chemical shifts and (1)H-(15)N dipolar coupling constants for the (15)N-labeled peptides in oriented dimyristoylphosphatidylcholine bilayers on stacked glass plates. These parameters were used to calculate the structure and orientation of M6(252-269, C252A) in the bilayers. The results indicate that the carboxyl terminal residues (9-14) are alpha-helical and oriented with an angle of about 8 degrees with respect to the bilayer normal. Independently, an attenuated total reflection Fourier transform infrared spectroscopy analysis on M6(252-269, C252A) in a 1,2-dimyristoyl-sn-glycero-phosphocholine bilayer concluded that the helix tilt angle was about 12.5 degrees. The results on the structure of M6(252-269, C252A) in bilayers are in good agreement with the structure determined in trifluoroethanol/water solutions (B. Arshava et al. Biopolymers, 1998, Vol. 46, pp. 343-357). The present study shows that solid state NMR spectroscopy can provide high resolution information on the structure of transmembrane domains of a G protein-coupled receptor.

-	~~{{STRUCTURE_1pjd\| PDB=1pjd \| SCENE= }}~~	+	Structure and topology of a peptide segment of the 6th transmembrane domain of the Saccharomyces cerevisae alpha-factor receptor in phospholipid bilayers.,Valentine KG, Liu SF, Marassi FM, Veglia G, Opella SJ, Ding FX, Wang SH, Arshava B, Becker JM, Naider F Biopolymers. 2001 Oct 5;59(4):243-56. PMID:11473349<ref>PMID:11473349</ref>

-	~~===Structure and Topology of~~ a ~~Peptide Segment~~ of the ~~6th Transmembrane Domain~~ of ~~the Saccharomyces cerevisiae alpha-Factor Receptor in Phospholipid Bilayers===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_11473349}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[1pjd]] is a 1 chain structure. Full experimental information is available from [http:~~//~~oca.weizmann.ac.il/oca-bin/ocashort?id=1PJD OCA].~~	+	</StructureSection>
	[[Category: Arshava, B.]]		[[Category: Arshava, B.]]
	[[Category: Becker, J M.]]		[[Category: Becker, J M.]]

OCA: Protected "1pjd" [edit=sysop:move=sysop]

OCA — Wed, 19 Dec 2012 12:02:08 GMT

Protected "1pjd" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:02, 19 December 2012

OCA at 12:02, 19 December 2012

OCA — Wed, 19 Dec 2012 12:02:04 GMT

←Older revision		Revision as of 12:02, 19 December 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1pjd.png\|left\|200px]]		[[Image:1pjd.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1pjd", creates the "Structure Box" on the page.
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	{{STRUCTURE_1pjd\| PDB=1pjd \| SCENE= }}		{{STRUCTURE_1pjd\| PDB=1pjd \| SCENE= }}

	===Structure and Topology of a Peptide Segment of the 6th Transmembrane Domain of the Saccharomyces cerevisiae alpha-Factor Receptor in Phospholipid Bilayers===		===Structure and Topology of a Peptide Segment of the 6th Transmembrane Domain of the Saccharomyces cerevisiae alpha-Factor Receptor in Phospholipid Bilayers===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_11473349}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 11473349 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_11473349}}		{{ABSTRACT_PUBMED_11473349}}

	==About this Structure==		==About this Structure==
-	~~1PJD is a~~ [[~~Single protein~~]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PJD OCA].	+	[[1pjd]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PJD OCA].
-		+
-	~~==Reference==~~	+
-	Structure and topology of a peptide segment of the 6th transmembrane domain of the Saccharomyces cerevisae alpha-factor receptor in phospholipid bilayers., Valentine KG, Liu SF, Marassi FM, Veglia G, Opella SJ, Ding FX, Wang SH, Arshava B, Becker JM, Naider F, Biopolymers. 2001 Oct 5;59(4):243-56. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11473349 11473349]	+
-	~~[[Category: Single protein]]~~	+
	[[Category: Arshava, B.]]		[[Category: Arshava, B.]]
	[[Category: Becker, J M.]]		[[Category: Becker, J M.]]
Line 37:		Line 21:
	[[Category: Wang, S H.]]		[[Category: Wang, S H.]]
	[[Category: Alpha helix]]		[[Category: Alpha helix]]
-		+	[[Category: Membrane protein]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Jul 29 11:57:26 2008''~~	+

OCA at 08:57, 29 July 2008

OCA — Tue, 29 Jul 2008 08:57:32 GMT

←Older revision		Revision as of 08:57, 29 July 2008
Line 1:		Line 1:
-	[[Image:1pjd.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:1pjd.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_1pjd\| PDB=1pjd \| SCENE= }}		{{STRUCTURE_1pjd\| PDB=1pjd \| SCENE= }}

-	~~'''~~Structure and Topology of a Peptide Segment of the 6th Transmembrane Domain of the Saccharomyces cerevisiae alpha-Factor Receptor in Phospholipid Bilayers~~'''~~	+	===Structure and Topology of a Peptide Segment of the 6th Transmembrane Domain of the Saccharomyces cerevisiae alpha-Factor Receptor in Phospholipid Bilayers===


-	~~==Overview==~~	+	<!--
-	~~A detailed analysis of the structure of an 18~~-~~residue peptide AQSLLVPSIIFILAYSLK [M6(252~~-~~269~~, ~~C252A)] in 1~~,~~2-dimyristoyl-sn-glycero-phosphocholine bilayers was carried out using solid state NMR and attenuated total reflection Fourier transform infrared spectroscopy. The peptide corresponds to a portion of~~ the 6th transmembrane domain of the alpha-factor receptor of Saccharomyces cerevisiae. Ten homologs of M6(252-269, C252A) were synthesized in which individual residues were labeled with (15)N. One- and two-dimensional solid state NMR experiments were used to ~~determine~~ the ~~chemical shifts and~~ (~~1)H-(15)N dipolar coupling constants for the (15)N-labeled peptides in oriented dimyristoylphosphatidylcholine bilayers~~ on ~~stacked glass plates~~. ~~These parameters were used to calculate the structure and orientation of M6(252-269, C252A) in the bilayers~~. ~~The results indicate that the carboxyl terminal residues (9-14~~) ~~are alpha-helical and oriented with an angle of about 8 degrees with respect to the bilayer normal. Independently~~, ~~an attenuated total reflection Fourier transform infrared spectroscopy analysis on M6(252-269, C252A) in a 1,2-dimyristoyl-sn-glycero-phosphocholine bilayer concluded that~~ the ~~helix tilt angle was about 12~~.~~5 degrees. The results on the structure of M6(252~~-~~269, C252A) in bilayers are in good agreement with the structure determined in trifluoroethanol/water solutions (B. Arshava et al. Biopolymers, 1998, Vol. 46, pp. 343~~-~~357). The present study shows that solid state NMR spectroscopy can provide high resolution information on the structure of transmembrane domains of a G protein-coupled receptor.~~	+	The line below this paragraph, {{ABSTRACT_PUBMED_11473349}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 11473349 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_11473349}}

	==About this Structure==		==About this Structure==
-	1PJD is a [[Single protein]] structure. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PJD OCA].	+	1PJD is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PJD OCA].

	==Reference==		==Reference==
Line 33:		Line 37:
	[[Category: Wang, S H.]]		[[Category: Wang, S H.]]
	[[Category: Alpha helix]]		[[Category: Alpha helix]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 05:08~~:57 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:57:26 2008''