1pkv - Revision history

OCA at 09:44, 16 August 2023

OCA — Wed, 16 Aug 2023 09:44:46 GMT

←Older revision		Revision as of 09:44, 16 August 2023
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	<StructureSection load='1pkv' size='340' side='right'caption='[[1pkv]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='1pkv' size='340' side='right'caption='[[1pkv]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1pkv]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PKV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1PKV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1pkv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PKV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PKV FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=RBF:RIBOFLAVIN'>RBF</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max~~-~~height: 3em;'>[[1hze\|1hze]]~~, [[~~1i8d~~\|~~1i8d]], [[1kzl\|1kzl~~]]~~</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RBF:RIBOFLAVIN'>RBF</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>RIBE OR RIBC OR B1662 OR SF1690 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~562~~ "~~Bacillus coli~~" ~~Migula 1895])</td~~><~~/tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pkv OCA], [https://pdbe.org/1pkv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pkv RCSB], [https://www.ebi.ac.uk/pdbsum/1pkv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pkv ProSAT]</span></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[http://en.wikipedia.org/wiki/Riboflavin_synthase Riboflavin synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.9 2.5.1.9]~~ </~~span~~></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1pkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pkv OCA], [~~http~~://pdbe.org/1pkv PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1pkv RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1pkv PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1pkv ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/RISA_ECOLI RISA_ECOLI]] Catalyzes the dismutation of two molecules of 6,7-dimethyl-8-ribityllumazine, resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil.	+	[https://www.uniprot.org/uniprot/RISA_ECOLI RISA_ECOLI] Catalyzes the dismutation of two molecules of 6,7-dimethyl-8-ribityllumazine, resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ coli ~~migula 1895~~]]	+	[[Category: Escherichia coli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Riboflavin synthase]]~~	+	[[Category: Bacher A]]
-	[[Category: Bacher, A]]	+	[[Category: Eberhardt S]]
-	[[Category: Eberhardt, S]]	+	[[Category: Ladenstein R]]
-	[[Category: Ladenstein, R]]	+	[[Category: Meining W]]
-	[[Category: Meining, W]]	+
-	~~[[Category: Beta-barrel]]~~	+
-	~~[[Category: Dimer]]~~	+
-	~~[[Category: Greek key motif]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 07:31, 9 December 2020

OCA — Wed, 09 Dec 2020 07:31:55 GMT

←Older revision		Revision as of 07:31, 9 December 2020
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	==The N-terminal domain of riboflavin synthase in complex with riboflavin==		==The N-terminal domain of riboflavin synthase in complex with riboflavin==
-	<StructureSection load='1pkv' size='340' side='right' caption='[[1pkv]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='1pkv' size='340' side='right'caption='[[1pkv]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1pkv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PKV OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1PKV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1pkv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PKV OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1PKV FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RBF:RIBOFLAVIN'>RBF</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RBF:RIBOFLAVIN'>RBF</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hze\|1hze]], [[1i8d\|1i8d]], [[1kzl\|1kzl]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1hze\|1hze]], [[1i8d\|1i8d]], [[1kzl\|1kzl]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RIBE OR RIBC OR B1662 OR SF1690 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RIBE OR RIBC OR B1662 OR SF1690 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Riboflavin_synthase Riboflavin synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.9 2.5.1.9] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Riboflavin_synthase Riboflavin synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.9 2.5.1.9] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1pkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pkv OCA], [http://pdbe.org/1pkv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1pkv RCSB], [http://www.ebi.ac.uk/pdbsum/1pkv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1pkv ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1pkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pkv OCA], [http://pdbe.org/1pkv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1pkv RCSB], [http://www.ebi.ac.uk/pdbsum/1pkv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1pkv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</StructureSection>		</StructureSection>
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
		+	[[Category: Large Structures]]
	[[Category: Riboflavin synthase]]		[[Category: Riboflavin synthase]]
	[[Category: Bacher, A]]		[[Category: Bacher, A]]

OCA at 07:57, 24 February 2018

OCA — Sat, 24 Feb 2018 07:57:25 GMT

←Older revision		Revision as of 07:57, 24 February 2018
Line 1:		Line 1:
		+
	==The N-terminal domain of riboflavin synthase in complex with riboflavin==		==The N-terminal domain of riboflavin synthase in complex with riboflavin==
	<StructureSection load='1pkv' size='340' side='right' caption='[[1pkv]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='1pkv' size='340' side='right' caption='[[1pkv]], [[Resolution\|resolution]] 2.60Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RIBE OR RIBC OR B1662 OR SF1690 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RIBE OR RIBC OR B1662 OR SF1690 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Riboflavin_synthase Riboflavin synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.9 2.5.1.9] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Riboflavin_synthase Riboflavin synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.9 2.5.1.9] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pkv OCA], [http://pdbe.org/1pkv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1pkv RCSB], [http://www.ebi.ac.uk/pdbsum/1pkv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pkv OCA], [http://pdbe.org/1pkv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1pkv RCSB], [http://www.ebi.ac.uk/pdbsum/1pkv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1pkv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 15:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pk/1pkv_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pk/1pkv_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pkv ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 01:21, 12 September 2015

OCA — Sat, 12 Sep 2015 01:21:10 GMT

←Older revision		Revision as of 01:21, 12 September 2015
Line 2:		Line 2:
	<StructureSection load='1pkv' size='340' side='right' caption='[[1pkv]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='1pkv' size='340' side='right' caption='[[1pkv]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1pkv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia~~ coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PKV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PKV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1pkv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PKV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PKV FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RBF:RIBOFLAVIN'>RBF</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RBF:RIBOFLAVIN'>RBF</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hze\|1hze]], [[1i8d\|1i8d]], [[1kzl\|1kzl]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hze\|1hze]], [[1i8d\|1i8d]], [[1kzl\|1kzl]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RIBE OR RIBC OR B1662 OR SF1690 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 ~~Escherichia~~ coli])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RIBE OR RIBC OR B1662 OR SF1690 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Riboflavin_synthase Riboflavin synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.9 2.5.1.9] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Riboflavin_synthase Riboflavin synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.9 2.5.1.9] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pkv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1pkv RCSB], [http://www.ebi.ac.uk/pdbsum/1pkv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pkv OCA], [http://pdbe.org/1pkv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1pkv RCSB], [http://www.ebi.ac.uk/pdbsum/1pkv PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 29:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1pkv" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Escherichia~~ coli]]	+	[[Category: Bacillus coli migula 1895]]
	[[Category: Riboflavin synthase]]		[[Category: Riboflavin synthase]]
	[[Category: Bacher, A]]		[[Category: Bacher, A]]

OCA at 21:56, 25 December 2014

OCA — Thu, 25 Dec 2014 21:56:12 GMT

←Older revision		Revision as of 21:56, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1pkv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PKV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PKV FirstGlance]. <br>		<table><tr><td colspan='2'>[[1pkv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PKV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PKV FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RBF:RIBOFLAVIN'>RBF</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RBF:RIBOFLAVIN'>RBF</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hze\|1hze]], [[1i8d\|1i8d]], [[1kzl\|1kzl]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hze\|1hze]], [[1i8d\|1i8d]], [[1kzl\|1kzl]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RIBE OR RIBC OR B1662 OR SF1690 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RIBE OR RIBC OR B1662 OR SF1690 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Riboflavin_synthase Riboflavin synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.9 2.5.1.9] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Riboflavin_synthase Riboflavin synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.9 2.5.1.9] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pkv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1pkv RCSB], [http://www.ebi.ac.uk/pdbsum/1pkv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pkv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1pkv RCSB], [http://www.ebi.ac.uk/pdbsum/1pkv PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RISA_ECOLI RISA_ECOLI]] Catalyzes the dismutation of two molecules of 6,7-dimethyl-8-ribityllumazine, resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Riboflavin synthase]]		[[Category: Riboflavin synthase]]
-	[[Category: Bacher, A.]]	+	[[Category: Bacher, A]]
-	[[Category: Eberhardt, S.]]	+	[[Category: Eberhardt, S]]
-	[[Category: Ladenstein, R.]]	+	[[Category: Ladenstein, R]]
-	[[Category: Meining, W.]]	+	[[Category: Meining, W]]
	[[Category: Beta-barrel]]		[[Category: Beta-barrel]]
	[[Category: Dimer]]		[[Category: Dimer]]
	[[Category: Greek key motif]]		[[Category: Greek key motif]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 23:14, 28 September 2014

OCA — Sun, 28 Sep 2014 23:14:55 GMT

←Older revision		Revision as of 23:14, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1pkv.~~png~~\|~~left~~\|200px]]	+	==The N-terminal domain of riboflavin synthase in complex with riboflavin==
		+	<StructureSection load='1pkv' size='340' side='right' caption='[[1pkv]], [[Resolution\|resolution]] 2.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1pkv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PKV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PKV FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RBF:RIBOFLAVIN'>RBF</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hze\|1hze]], [[1i8d\|1i8d]], [[1kzl\|1kzl]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RIBE OR RIBC OR B1662 OR SF1690 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Riboflavin_synthase Riboflavin synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.9 2.5.1.9] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pkv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1pkv RCSB], [http://www.ebi.ac.uk/pdbsum/1pkv PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pk/1pkv_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Riboflavin synthase of Escherichia coli is a homotrimer with a molecular mass of 70 kDa. The enzyme catalyzes the dismutation of 6,7-dimethyl-8-(1'-D-ribityl)-lumazine, affording riboflavin and 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione. The N-terminal segment (residues 1-87) and the C-terminal segment (residues 98-187) form beta-barrels with similar fold and a high degree of sequence similarity. A recombinant peptide comprising amino acid residues 1-97 forms a dimer, which binds riboflavin with high affinity. Here, we report the structure of this construct in complex with riboflavin at 2.6A resolution. It is demonstrated that the complex can serve as a model for ligand-binding in the native enzyme. The structure and riboflavin-binding mode is in excellent agreement with structural information obtained from the native enzyme from Escherichia coli and riboflavin synthase from Schizosaccharomyces pombe. The implications for the binding specificity and the regiospecificity of the catalyzed reaction are discussed.

-	~~{{STRUCTURE_1pkv\| PDB=1pkv \| SCENE= }}~~	+	The structure of the N-terminal domain of riboflavin synthase in complex with riboflavin at 2.6A resolution.,Meining W, Eberhardt S, Bacher A, Ladenstein R J Mol Biol. 2003 Aug 29;331(5):1053-63. PMID:12927541<ref>PMID:12927541</ref>

-	~~===The N-terminal domain~~ of ~~riboflavin synthase in complex with riboflavin===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_12927541}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1pkv]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli Escherichia coli]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1PKV OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:012927541<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Riboflavin synthase]]		[[Category: Riboflavin synthase]]

OCA: Protected "1pkv" [edit=sysop:move=sysop]

OCA — Wed, 19 Dec 2012 11:54:47 GMT

Protected "1pkv" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:54, 19 December 2012

OCA at 11:54, 19 December 2012

OCA — Wed, 19 Dec 2012 11:54:44 GMT

←Older revision		Revision as of 11:54, 19 December 2012
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-	{{Seed}}
	[[Image:1pkv.png\|left\|200px]]		[[Image:1pkv.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1pkv", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1pkv\| PDB=1pkv \| SCENE= }}		{{STRUCTURE_1pkv\| PDB=1pkv \| SCENE= }}

	===The N-terminal domain of riboflavin synthase in complex with riboflavin===		===The N-terminal domain of riboflavin synthase in complex with riboflavin===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_12927541}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 12927541 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_12927541}}		{{ABSTRACT_PUBMED_12927541}}

	==About this Structure==		==About this Structure==
-	~~1PKV~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PKV OCA].	+	[[1pkv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PKV OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~12927541~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:012927541</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Riboflavin synthase]]		[[Category: Riboflavin synthase]]
Line 33:		Line 21:
	[[Category: Dimer]]		[[Category: Dimer]]
	[[Category: Greek key motif]]		[[Category: Greek key motif]]
-		+	[[Category: Transferase]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Wed Feb 18 09:05:04 2009''~~	+

OCA at 07:05, 18 February 2009

OCA — Wed, 18 Feb 2009 07:05:06 GMT

←Older revision		Revision as of 07:05, 18 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	1PKV is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PKV OCA].	+	1PKV is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PKV OCA].

	==Reference==		==Reference==
-	~~The structure of the N-terminal domain of riboflavin synthase in complex with riboflavin at 2.6A resolution., Meining W, Eberhardt S, Bacher A, Ladenstein R, J Mol Biol. 2003 Aug 29;331(5):1053-63.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/12927541 12927541]~~	+	<ref group="xtra">PMID:12927541</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Riboflavin synthase]]		[[Category: Riboflavin synthase]]
-	[[Category: Single protein]]
	[[Category: Bacher, A.]]		[[Category: Bacher, A.]]
	[[Category: Eberhardt, S.]]		[[Category: Eberhardt, S.]]
Line 35:		Line 34:
	[[Category: Greek key motif]]		[[Category: Greek key motif]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 29 15:~~18:~~36 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:05:04 2009''

OCA at 12:18, 29 July 2008

OCA — Tue, 29 Jul 2008 12:18:44 GMT

←Older revision		Revision as of 12:18, 29 July 2008
Line 1:		Line 1:
-	[[Image:1pkv.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:1pkv.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_1pkv\| PDB=1pkv \| SCENE= }}		{{STRUCTURE_1pkv\| PDB=1pkv \| SCENE= }}

-	~~'''~~The N-terminal domain of riboflavin synthase in complex with riboflavin~~'''~~	+	===The N-terminal domain of riboflavin synthase in complex with riboflavin===


-	~~==Overview==~~	+	<!--
-	~~Riboflavin synthase of Escherichia coli is a homotrimer with a molecular mass of 70 kDa.~~ The ~~enzyme catalyzes the dismutation of 6~~,~~7-dimethyl-8-(1'-D-ribityl)-lumazine~~, ~~affording riboflavin and 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione. The N-terminal segment (residues 1-87) and~~ the ~~C-terminal segment~~ (~~residues 98-187) form beta-barrels with similar fold and a high degree of sequence similarity~~. ~~A recombinant peptide comprising amino acid residues 1-97 forms a dimer, which binds riboflavin with high affinity~~. ~~Here~~, ~~we report the structure of this construct in complex with riboflavin at 2.6A resolution. It~~ is ~~demonstrated that~~ the ~~complex can serve as a model for ligand-binding in the native enzyme~~. ~~The structure and riboflavin~~-binding mode is in excellent agreement with structural information obtained from the native enzyme from Escherichia coli and riboflavin synthase from Schizosaccharomyces pombe. The implications for the binding specificity and the regiospecificity of the catalyzed reaction are discussed.	+	The line below this paragraph, {{ABSTRACT_PUBMED_12927541}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 12927541 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_12927541}}

	==About this Structure==		==About this Structure==
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	[[Category: Dimer]]		[[Category: Dimer]]
	[[Category: Greek key motif]]		[[Category: Greek key motif]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 05~~:12:03 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:18:36 2008''