1psm - Revision history

OCA at 09:18, 6 December 2023

OCA — Wed, 06 Dec 2023 09:18:04 GMT

←Older revision		Revision as of 09:18, 6 December 2023
Line 1:		Line 1:

	==SOLUTION STRUCTURE OF A POLYPEPTIDE CONTAINING FOUR HEPTAD REPEATS FROM A MEROZOITE SURFACE ANTIGEN OF PLASMODIUM FALCIPARUM==		==SOLUTION STRUCTURE OF A POLYPEPTIDE CONTAINING FOUR HEPTAD REPEATS FROM A MEROZOITE SURFACE ANTIGEN OF PLASMODIUM FALCIPARUM==
-	<StructureSection load='1psm' size='340' side='right'caption='[[1psm~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='1psm' size='340' side='right'caption='[[1psm]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1psm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Plafa Plafa~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PSM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PSM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1psm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PSM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PSM FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1psm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1psm OCA], [https://pdbe.org/1psm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1psm RCSB], [https://www.ebi.ac.uk/pdbsum/1psm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1psm ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1psm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1psm OCA], [https://pdbe.org/1psm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1psm RCSB], [https://www.ebi.ac.uk/pdbsum/1psm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1psm ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q9NIG6_PLAFA Q9NIG6_PLAFA]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Plafa~~]]	+	[[Category: Plasmodium falciparum]]
-	[[Category: Mulhern~~, T D~~]]	+	[[Category: Mulhern TD]]
-	[[Category: Norton~~, R S]]~~	+	[[Category: Norton RS]]
-	~~[[Category: Polymorphic antigen~~]]	+

OCA at 09:34, 8 September 2021

OCA — Wed, 08 Sep 2021 09:34:16 GMT

←Older revision		Revision as of 09:34, 8 September 2021
Line 3:		Line 3:
	<StructureSection load='1psm' size='340' side='right'caption='[[1psm]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1psm' size='340' side='right'caption='[[1psm]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1psm]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Plafa Plafa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PSM OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1PSM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1psm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plafa Plafa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PSM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PSM FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1psm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1psm OCA], [~~http~~://pdbe.org/1psm PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1psm RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1psm PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1psm ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1psm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1psm OCA], [https://pdbe.org/1psm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1psm RCSB], [https://www.ebi.ac.uk/pdbsum/1psm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1psm ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 09:55, 27 November 2019

OCA — Wed, 27 Nov 2019 09:55:05 GMT

←Older revision		Revision as of 09:55, 27 November 2019
Line 1:		Line 1:

	==SOLUTION STRUCTURE OF A POLYPEPTIDE CONTAINING FOUR HEPTAD REPEATS FROM A MEROZOITE SURFACE ANTIGEN OF PLASMODIUM FALCIPARUM==		==SOLUTION STRUCTURE OF A POLYPEPTIDE CONTAINING FOUR HEPTAD REPEATS FROM A MEROZOITE SURFACE ANTIGEN OF PLASMODIUM FALCIPARUM==
-	<StructureSection load='1psm' size='340' side='right' caption='[[1psm]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='1psm' size='340' side='right'caption='[[1psm]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1psm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafa Plafa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PSM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PSM FirstGlance]. <br>		<table><tr><td colspan='2'>[[1psm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafa Plafa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PSM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PSM FirstGlance]. <br>
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Plafa]]		[[Category: Plafa]]
	[[Category: Mulhern, T D]]		[[Category: Mulhern, T D]]
	[[Category: Norton, R S]]		[[Category: Norton, R S]]
	[[Category: Polymorphic antigen]]		[[Category: Polymorphic antigen]]

OCA at 07:58, 24 February 2018

OCA — Sat, 24 Feb 2018 07:58:10 GMT

←Older revision		Revision as of 07:58, 24 February 2018
Line 1:		Line 1:
		+
	==SOLUTION STRUCTURE OF A POLYPEPTIDE CONTAINING FOUR HEPTAD REPEATS FROM A MEROZOITE SURFACE ANTIGEN OF PLASMODIUM FALCIPARUM==		==SOLUTION STRUCTURE OF A POLYPEPTIDE CONTAINING FOUR HEPTAD REPEATS FROM A MEROZOITE SURFACE ANTIGEN OF PLASMODIUM FALCIPARUM==
	<StructureSection load='1psm' size='340' side='right' caption='[[1psm]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1psm' size='340' side='right' caption='[[1psm]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1psm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafa Plafa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PSM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PSM FirstGlance]. <br>		<table><tr><td colspan='2'>[[1psm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafa Plafa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PSM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PSM FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1psm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1psm OCA], [http://pdbe.org/1psm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1psm RCSB], [http://www.ebi.ac.uk/pdbsum/1psm PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1psm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1psm OCA], [http://pdbe.org/1psm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1psm RCSB], [http://www.ebi.ac.uk/pdbsum/1psm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1psm ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 22:41, 9 September 2015

OCA — Wed, 09 Sep 2015 22:41:34 GMT

←Older revision		Revision as of 22:41, 9 September 2015
Line 2:		Line 2:
	<StructureSection load='1psm' size='340' side='right' caption='[[1psm]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1psm' size='340' side='right' caption='[[1psm]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1psm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Plasmodium_falciparum Plasmodium falciparum~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PSM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PSM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1psm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafa Plafa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PSM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PSM FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1psm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1psm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1psm RCSB], [http://www.ebi.ac.uk/pdbsum/1psm PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1psm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1psm OCA], [http://pdbe.org/1psm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1psm RCSB], [http://www.ebi.ac.uk/pdbsum/1psm PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 13:		Line 13:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1psm" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Plasmodium falciparum~~]]	+	[[Category: Plafa]]
	[[Category: Mulhern, T D]]		[[Category: Mulhern, T D]]
	[[Category: Norton, R S]]		[[Category: Norton, R S]]
	[[Category: Polymorphic antigen]]		[[Category: Polymorphic antigen]]

OCA at 06:47, 6 January 2015

OCA — Tue, 06 Jan 2015 06:47:59 GMT

←Older revision		Revision as of 06:47, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1psm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PSM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PSM FirstGlance]. <br>		<table><tr><td colspan='2'>[[1psm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PSM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PSM FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1psm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1psm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1psm RCSB], [http://www.ebi.ac.uk/pdbsum/1psm PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1psm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1psm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1psm RCSB], [http://www.ebi.ac.uk/pdbsum/1psm PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]
-	[[Category: Mulhern, T D.]]	+	[[Category: Mulhern, T D]]
-	[[Category: Norton, R S.]]	+	[[Category: Norton, R S]]
	[[Category: Polymorphic antigen]]		[[Category: Polymorphic antigen]]

OCA at 20:52, 28 September 2014

OCA — Sun, 28 Sep 2014 20:52:23 GMT

←Older revision		Revision as of 20:52, 28 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1psm.~~png\|left\|200px~~]]	+	==SOLUTION STRUCTURE OF A POLYPEPTIDE CONTAINING FOUR HEPTAD REPEATS FROM A MEROZOITE SURFACE ANTIGEN OF PLASMODIUM FALCIPARUM==
		+	<StructureSection load='1psm' size='340' side='right' caption='[[1psm]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1psm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PSM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PSM FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1psm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1psm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1psm RCSB], [http://www.ebi.ac.uk/pdbsum/1psm PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Plasmodium falciparum antigen SPAM (secreted polymorphic antigen associated with merozoites) contains an unusual set of heptad repeat units with alanine at the a and d positions. Twelve heptads with the consensus sequence AXXAXXX occur in three blocks of four, linked by short nonrepetitive sequences. A 38-residue polypeptide comprising the first block of four heptad units and five flanking residues at either end, SPAM-H1, has been synthesized and its structure in aqueous solution determined from 1H NMR data. Sedimentation equilibrium showed the peptide to be monomeric in aqueous solution. Its structure was determined from 1H NMR-derived distance and dihedral angle constraints by using distance geometry calculations, restrained simulated annealing, and conjugate gradient energy minimization in the CHARMm force field. The polypeptide contains an alpha-helix extending from Ser10 (position e of the first heptad) to at least Lys32 (position f of the fourth heptad) and possibly as far as Val35. The helix is bent, partly as result of a kink around residues 19-20. The conformations of the nine N-terminal residues and the six C-terminal residues are not well defined by the NMR data. The rms deviation from the average of the 20 best structures over the well-defined region (residues 11-31, which have backbone angular order parameters > 0.8) was 1.56 A for backbone heavy atoms (N, C alpha, and C) and 2.12 A for all heavy atoms. 2H2O exchange experiments identified slowly exchanging amide protons near the C-terminus and the last two turns of the helix. The unusual stability of the C-terminus reflects the presence of a new C-capping motif, which may involve the side chain of an asparagine in a position external to the C-cap residue. Possible interactions of the H1 sequence with the other two heptad repeat units in the intact merozoite antigen are discussed.

-	~~{{STRUCTURE_1psm\| PDB=1psm \| SCENE= }}~~	+	Solution structure of a polypeptide containing four heptad repeat units from a merozoite surface antigen of Plasmodium falciparum.,Mulhern TD, Howlett GJ, Reid GE, Simpson RJ, McColl DJ, Anders RF, Norton RS Biochemistry. 1995 Mar 21;34(11):3479-91. PMID:7893643<ref>PMID:7893643</ref>

-	~~===SOLUTION STRUCTURE OF A POLYPEPTIDE CONTAINING FOUR HEPTAD REPEATS FROM A MEROZOITE SURFACE ANTIGEN OF PLASMODIUM FALCIPARUM===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_7893643}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[1psm]] is a 1 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PSM OCA].~~	+	</StructureSection>
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]
	[[Category: Mulhern, T D.]]		[[Category: Mulhern, T D.]]
	[[Category: Norton, R S.]]		[[Category: Norton, R S.]]
	[[Category: Polymorphic antigen]]		[[Category: Polymorphic antigen]]

OCA: Protected "1psm" [edit=sysop:move=sysop]

OCA — Wed, 19 Dec 2012 11:55:56 GMT

Protected "1psm" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:55, 19 December 2012

OCA at 11:55, 19 December 2012

OCA — Wed, 19 Dec 2012 11:55:54 GMT

←Older revision		Revision as of 11:55, 19 December 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1psm.png\|left\|200px]]		[[Image:1psm.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_1psm\| PDB=1psm \| SCENE= }}		{{STRUCTURE_1psm\| PDB=1psm \| SCENE= }}

	===SOLUTION STRUCTURE OF A POLYPEPTIDE CONTAINING FOUR HEPTAD REPEATS FROM A MEROZOITE SURFACE ANTIGEN OF PLASMODIUM FALCIPARUM===		===SOLUTION STRUCTURE OF A POLYPEPTIDE CONTAINING FOUR HEPTAD REPEATS FROM A MEROZOITE SURFACE ANTIGEN OF PLASMODIUM FALCIPARUM===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_7893643}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 7893643 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_7893643}}		{{ABSTRACT_PUBMED_7893643}}

	==About this Structure==		==About this Structure==
-	~~1PSM is a~~ [[~~Single protein~~]] structure of sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PSM OCA].	+	[[1psm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PSM OCA].
-		+
-	~~==Reference==~~	+
-	Solution structure of a polypeptide containing four heptad repeat units from a merozoite surface antigen of Plasmodium falciparum., Mulhern TD, Howlett GJ, Reid GE, Simpson RJ, McColl DJ, Anders RF, Norton RS, Biochemistry. 1995 Mar 21;34(11):3479-91. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7893643 7893643]	+
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]
-	[[Category: Single protein]]
	[[Category: Mulhern, T D.]]		[[Category: Mulhern, T D.]]
	[[Category: Norton, R S.]]		[[Category: Norton, R S.]]
	[[Category: Polymorphic antigen]]		[[Category: Polymorphic antigen]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:02:55 2008''

OCA at 11:03, 27 July 2008

OCA — Sun, 27 Jul 2008 11:03:00 GMT

←Older revision		Revision as of 11:03, 27 July 2008
Line 1:		Line 1:
-	[[Image:1psm.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:1psm.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_1psm\| PDB=1psm \| SCENE= }}		{{STRUCTURE_1psm\| PDB=1psm \| SCENE= }}

-	~~'''~~SOLUTION STRUCTURE OF A POLYPEPTIDE CONTAINING FOUR HEPTAD REPEATS FROM A MEROZOITE SURFACE ANTIGEN OF PLASMODIUM FALCIPARUM~~'''~~	+	===SOLUTION STRUCTURE OF A POLYPEPTIDE CONTAINING FOUR HEPTAD REPEATS FROM A MEROZOITE SURFACE ANTIGEN OF PLASMODIUM FALCIPARUM===


-	~~==Overview==~~	+	<!--
-	The Plasmodium falciparum antigen SPAM (secreted polymorphic antigen associated with merozoites) contains an unusual set of heptad repeat units with alanine at the a and d positions. Twelve heptads with the consensus sequence AXXAXXX occur in three blocks of four, ~~linked by short nonrepetitive sequences. A 38-residue polypeptide comprising the first block of four heptad units and five flanking residues at either end~~, ~~SPAM-H1, has been synthesized and its structure in aqueous solution determined from 1H NMR data. Sedimentation equilibrium showed~~ the ~~peptide~~ to be monomeric in aqueous solution. Its structure was determined from 1H NMR-derived distance and dihedral angle constraints by using distance geometry calculations, restrained simulated annealing, and conjugate gradient energy minimization in the ~~CHARMm force field. The polypeptide contains an alpha-helix extending from Ser10~~ (~~position e of the first heptad) to~~ at ~~least Lys32 (position f of the fourth heptad) and possibly as far as Val35~~. ~~The helix is bent, partly as result of a kink around residues 19-20~~. The conformations of the nine N-terminal residues and the six C-terminal residues are not well defined by the NMR data. The rms deviation from the average of the 20 best structures over the well-defined region (residues 11-31, which have backbone angular order parameters > 0.8) ~~was 1.56 A for backbone heavy atoms (N~~, ~~C alpha, and C) and 2.12 A for all heavy atoms. 2H2O exchange experiments identified slowly exchanging amide protons near~~ the ~~C-terminus and the last two turns of the helix~~. ~~The unusual stability of the C~~-~~terminus reflects the presence of a new C~~-capping motif, which may involve the side chain of an asparagine in a position external to the C-cap residue. Possible interactions of the H1 sequence with the other two heptad repeat units in the intact merozoite antigen are discussed.	+	The line below this paragraph, {{ABSTRACT_PUBMED_7893643}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 7893643 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_7893643}}

	==About this Structure==		==About this Structure==
-	1PSM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PSM OCA].	+	1PSM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PSM OCA].

	==Reference==		==Reference==
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	[[Category: Norton, R S.]]		[[Category: Norton, R S.]]
	[[Category: Polymorphic antigen]]		[[Category: Polymorphic antigen]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 05~~:26:21 2008''	+
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