1pwo - Revision history

OCA at 06:11, 3 April 2024

OCA — Wed, 03 Apr 2024 06:11:07 GMT

←Older revision		Revision as of 06:11, 3 April 2024
Line 3:		Line 3:
	<StructureSection load='1pwo' size='340' side='right'caption='[[1pwo]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='1pwo' size='340' side='right'caption='[[1pwo]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1pwo]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Micropechis_ikaheka~~ Micropechis ~~ikaheka~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PWO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PWO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1pwo]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Micropechis_ikaheca Micropechis ikaheca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PWO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PWO FirstGlance]. <br>
-	</td></tr><tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"~~><span class~~=~~'plainlinks'~~>[~~https://en.wikipedia.org/wiki/Phospholipase_A(~~2~~) Phospholipase A(2)], with EC number [https://www~~.~~brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pwo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pwo OCA], [https://pdbe.org/1pwo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pwo RCSB], [https://www.ebi.ac.uk/pdbsum/1pwo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pwo ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pwo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pwo OCA], [https://pdbe.org/1pwo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pwo RCSB], [https://www.ebi.ac.uk/pdbsum/1pwo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pwo ProSAT]</span></td></tr>
	</table>		</table>
Line 17:		Line 17:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pwo ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pwo ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Comparison of the crystal structures of three Micropechis ikaheka phospholipase A2 isoenzymes (MiPLA2, MiPLA3 and MiPLA4, which exhibit different levels of pharmacological effects) shows that their C-terminus (residues 110-124) is the most variable. M-Type receptor binding affinity of the isoenzymes has also been investigated and MiPLA4 binds to the rabbit M-type receptor with high affinity. Examination of surface charges of the isoenzymes reveals a trend of increase in positive charges with potency. The isoenzymes are shown to oligomerize in a concentration-dependent manner in a semi-denaturing gel. The C-termini of the medium (MiPLA4) and highly potent (MiPLA2) isoenzyme molecules cluster together, forming a highly exposed area. A BLAST search using the sequence of the most potent MiPLA2 results in high similarity to Staphylococcus aureus clotting factor A and cadherin 11. This might explain the myotoxicity, anticoagulant and hemoglobinuria effects of MiPLA2s.
-
-	Structure and function comparison of Micropechis ikaheka snake venom phospholipase A2 isoenzymes.,Lok SM, Gao R, Rouault M, Lambeau G, Gopalakrishnakone P, Swaminathan K FEBS J. 2005 Mar;272(5):1211-20. PMID:15720395<ref>PMID:15720395</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1pwo" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Phospholipase A2 3D structures\|Phospholipase A2 3D structures]]		*[[Phospholipase A2 3D structures\|Phospholipase A2 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Micropechis ~~ikaheka~~]]	+	[[Category: Micropechis ikaheca]]
-	[[Category: Lok~~, S M~~]]	+	[[Category: Lok SM]]
-	[[Category: Swaminathan, K]]	+	[[Category: Swaminathan K]]
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Pancreatic loop]]~~	+
-	~~[[Category: Phospholipase a2~~]]	+

OCA at 09:35, 8 September 2021

OCA — Wed, 08 Sep 2021 09:35:44 GMT

←Older revision		Revision as of 09:35, 8 September 2021
Line 3:		Line 3:
	<StructureSection load='1pwo' size='340' side='right'caption='[[1pwo]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='1pwo' size='340' side='right'caption='[[1pwo]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1pwo]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Micropechis_ikaheka Micropechis ikaheka]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PWO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1PWO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1pwo]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Micropechis_ikaheka Micropechis ikaheka]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PWO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PWO FirstGlance]. <br>
-	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>	+	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1pwo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pwo OCA], [~~http~~://pdbe.org/1pwo PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1pwo RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1pwo PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1pwo ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pwo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pwo OCA], [https://pdbe.org/1pwo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pwo RCSB], [https://www.ebi.ac.uk/pdbsum/1pwo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pwo ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 10:03, 27 November 2019

OCA — Wed, 27 Nov 2019 10:03:40 GMT

←Older revision		Revision as of 10:03, 27 November 2019
Line 1:		Line 1:

	==Crystal Structure of Phospholipase A2 (MIPLA2) from Micropechis Ikaheka==		==Crystal Structure of Phospholipase A2 (MIPLA2) from Micropechis Ikaheka==
-	<StructureSection load='1pwo' size='340' side='right' caption='[[1pwo]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='1pwo' size='340' side='right'caption='[[1pwo]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1pwo]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Micropechis_ikaheka Micropechis ikaheka]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PWO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PWO FirstGlance]. <br>		<table><tr><td colspan='2'>[[1pwo]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Micropechis_ikaheka Micropechis ikaheka]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PWO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PWO FirstGlance]. <br>
Line 26:		Line 26:
	</div>		</div>
	<div class="pdbe-citations 1pwo" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1pwo" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Phospholipase A2 3D structures\|Phospholipase A2 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Micropechis ikaheka]]		[[Category: Micropechis ikaheka]]
	[[Category: Lok, S M]]		[[Category: Lok, S M]]

OCA at 08:04, 24 February 2018

OCA — Sat, 24 Feb 2018 08:04:52 GMT

←Older revision		Revision as of 08:04, 24 February 2018
Line 1:		Line 1:
		+
	==Crystal Structure of Phospholipase A2 (MIPLA2) from Micropechis Ikaheka==		==Crystal Structure of Phospholipase A2 (MIPLA2) from Micropechis Ikaheka==
	<StructureSection load='1pwo' size='340' side='right' caption='[[1pwo]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='1pwo' size='340' side='right' caption='[[1pwo]], [[Resolution\|resolution]] 2.60Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1pwo]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Micropechis_ikaheka Micropechis ikaheka]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PWO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PWO FirstGlance]. <br>		<table><tr><td colspan='2'>[[1pwo]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Micropechis_ikaheka Micropechis ikaheka]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PWO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PWO FirstGlance]. <br>
	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>		</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pwo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pwo OCA], [http://pdbe.org/1pwo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1pwo RCSB], [http://www.ebi.ac.uk/pdbsum/1pwo PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pwo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pwo OCA], [http://pdbe.org/1pwo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1pwo RCSB], [http://www.ebi.ac.uk/pdbsum/1pwo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1pwo ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 10:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pw/1pwo_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pw/1pwo_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pwo ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 25:		Line 26:
	</div>		</div>
	<div class="pdbe-citations 1pwo" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1pwo" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Phospholipase A2\|Phospholipase A2]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 14:29, 11 September 2015

OCA — Fri, 11 Sep 2015 14:29:17 GMT

←Older revision		Revision as of 14:29, 11 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[1pwo]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Micropechis_ikaheka Micropechis ikaheka]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PWO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PWO FirstGlance]. <br>		<table><tr><td colspan='2'>[[1pwo]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Micropechis_ikaheka Micropechis ikaheka]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PWO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PWO FirstGlance]. <br>
	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>		</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pwo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pwo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1pwo RCSB], [http://www.ebi.ac.uk/pdbsum/1pwo PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pwo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pwo OCA], [http://pdbe.org/1pwo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1pwo RCSB], [http://www.ebi.ac.uk/pdbsum/1pwo PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 24:		Line 24:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1pwo" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 07:57, 6 January 2015

OCA — Tue, 06 Jan 2015 07:57:08 GMT

←Older revision		Revision as of 07:57, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1pwo]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Micropechis_ikaheka Micropechis ikaheka]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PWO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PWO FirstGlance]. <br>		<table><tr><td colspan='2'>[[1pwo]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Micropechis_ikaheka Micropechis ikaheka]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PWO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PWO FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>	+	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pwo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pwo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1pwo RCSB], [http://www.ebi.ac.uk/pdbsum/1pwo PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pwo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pwo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1pwo RCSB], [http://www.ebi.ac.uk/pdbsum/1pwo PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Micropechis ikaheka]]		[[Category: Micropechis ikaheka]]
-	[[Category: Lok, S M.]]	+	[[Category: Lok, S M]]
-	[[Category: Swaminathan, K.]]	+	[[Category: Swaminathan, K]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
-	[[Category: Micropechis ikaheka]]
	[[Category: Pancreatic loop]]		[[Category: Pancreatic loop]]
	[[Category: Phospholipase a2]]		[[Category: Phospholipase a2]]

OCA at 22:48, 28 September 2014

OCA — Sun, 28 Sep 2014 22:48:54 GMT

←Older revision		Revision as of 22:48, 28 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1pwo.~~png\|left~~\|200px]]	+	==Crystal Structure of Phospholipase A2 (MIPLA2) from Micropechis Ikaheka==
		+	<StructureSection load='1pwo' size='340' side='right' caption='[[1pwo]], [[Resolution\|resolution]] 2.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1pwo]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Micropechis_ikaheka Micropechis ikaheka]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PWO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PWO FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pwo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pwo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1pwo RCSB], [http://www.ebi.ac.uk/pdbsum/1pwo PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pw/1pwo_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Comparison of the crystal structures of three Micropechis ikaheka phospholipase A2 isoenzymes (MiPLA2, MiPLA3 and MiPLA4, which exhibit different levels of pharmacological effects) shows that their C-terminus (residues 110-124) is the most variable. M-Type receptor binding affinity of the isoenzymes has also been investigated and MiPLA4 binds to the rabbit M-type receptor with high affinity. Examination of surface charges of the isoenzymes reveals a trend of increase in positive charges with potency. The isoenzymes are shown to oligomerize in a concentration-dependent manner in a semi-denaturing gel. The C-termini of the medium (MiPLA4) and highly potent (MiPLA2) isoenzyme molecules cluster together, forming a highly exposed area. A BLAST search using the sequence of the most potent MiPLA2 results in high similarity to Staphylococcus aureus clotting factor A and cadherin 11. This might explain the myotoxicity, anticoagulant and hemoglobinuria effects of MiPLA2s.

-	~~{{STRUCTURE_1pwo\| PDB=1pwo \| SCENE= }}~~	+	Structure and function comparison of Micropechis ikaheka snake venom phospholipase A2 isoenzymes.,Lok SM, Gao R, Rouault M, Lambeau G, Gopalakrishnakone P, Swaminathan K FEBS J. 2005 Mar;272(5):1211-20. PMID:15720395<ref>PMID:15720395</ref>

-	~~===Crystal Structure~~ of ~~Phospholipase A2 (MIPLA2) from Micropechis Ikaheka===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15720395}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1pwo]] is a 4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Micropechis_ikaheka Micropechis ikaheka]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1PWO OCA].~~	+

	==See Also==		==See Also==
	*[[Phospholipase A2\|Phospholipase A2]]		*[[Phospholipase A2\|Phospholipase A2]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:015720395<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Micropechis ikaheka]]		[[Category: Micropechis ikaheka]]
	[[Category: Lok, S M.]]		[[Category: Lok, S M.]]

OCA at 19:35, 20 October 2012

OCA — Sat, 20 Oct 2012 19:35:33 GMT

←Older revision		Revision as of 19:35, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1pwo]] is a 4 chain structure ~~of [[Phospholipase A2]]~~ with sequence from [http://en.wikipedia.org/wiki/Micropechis_ikaheka Micropechis ikaheka]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PWO OCA].	+	[[1pwo]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Micropechis_ikaheka Micropechis ikaheka]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PWO OCA].

	==See Also==		==See Also==

OCA: Protected "1pwo" [edit=sysop:move=sysop]

OCA — Fri, 27 Jul 2012 07:51:26 GMT

Protected "1pwo" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:51, 27 July 2012

OCA at 07:51, 27 July 2012

OCA — Fri, 27 Jul 2012 07:51:25 GMT

←Older revision		Revision as of 07:51, 27 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1pwo.png\|left\|200px]]		[[Image:1pwo.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1pwo", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1pwo\| PDB=1pwo \| SCENE= }}		{{STRUCTURE_1pwo\| PDB=1pwo \| SCENE= }}

	===Crystal Structure of Phospholipase A2 (MIPLA2) from Micropechis Ikaheka===		===Crystal Structure of Phospholipase A2 (MIPLA2) from Micropechis Ikaheka===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15720395}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15720395 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15720395}}		{{ABSTRACT_PUBMED_15720395}}

	==About this Structure==		==About this Structure==
-	~~1PWO~~ is a 4 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Micropechis_ikaheka Micropechis ikaheka]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PWO OCA].	+	[[1pwo]] is a 4 chain structure of [[Phospholipase A2]] with sequence from [http://en.wikipedia.org/wiki/Micropechis_ikaheka Micropechis ikaheka]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PWO OCA].
		+
		+	==See Also==
		+	*[[Phospholipase A2\|Phospholipase A2]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15720395~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015720395</ref><references group="xtra"/>
	[[Category: Micropechis ikaheka]]		[[Category: Micropechis ikaheka]]
	[[Category: Lok, S M.]]		[[Category: Lok, S M.]]
	[[Category: Swaminathan, K.]]		[[Category: Swaminathan, K.]]
		+	[[Category: Hydrolase]]
	[[Category: Micropechis ikaheka]]		[[Category: Micropechis ikaheka]]
	[[Category: Pancreatic loop]]		[[Category: Pancreatic loop]]
	[[Category: Phospholipase a2]]		[[Category: Phospholipase a2]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 00:33:59 2009''