1pxq - Revision history

OCA at 11:49, 14 June 2023

OCA — Wed, 14 Jun 2023 11:49:12 GMT

←Older revision		Revision as of 11:49, 14 June 2023
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	==Structure of Subtilisin A==		==Structure of Subtilisin A==
-	<StructureSection load='1pxq' size='340' side='right'caption='[[1pxq~~]], [[NMR_Ensembles_of_Models \| 8 NMR models~~]]' scene=''>	+	<StructureSection load='1pxq' size='340' side='right'caption='[[1pxq]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1pxq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PXQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PXQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1pxq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PXQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PXQ FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=2TL:D-ALLOTHREONINE'>2TL</scene>, <scene name='pdbligand=DPN:D-PHENYLALANINE'>DPN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2TL:D-ALLOTHREONINE'>2TL</scene>, <scene name='pdbligand=DPN:D-PHENYLALANINE'>DPN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pxq OCA], [https://pdbe.org/1pxq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pxq RCSB], [https://www.ebi.ac.uk/pdbsum/1pxq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pxq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pxq OCA], [https://pdbe.org/1pxq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pxq RCSB], [https://www.ebi.ac.uk/pdbsum/1pxq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pxq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/SBOA_BACSU SBOA_BACSU]] Has bacteriocidal activity against some Gram-positive bacteria such as Listeria, some species of Bacillus and E.faecium.<ref>PMID:10572140</ref>	+	[https://www.uniprot.org/uniprot/SBOA_BACSU SBOA_BACSU] Has bacteriocidal activity against some Gram-positive bacteria such as Listeria, some species of Bacillus and E.faecium.<ref>PMID:10572140</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 27:
	[[Category: Bacillus subtilis]]		[[Category: Bacillus subtilis]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Diaper~~, C M~~]]	+	[[Category: Diaper CM]]
-	[[Category: Kawulka~~, K E~~]]	+	[[Category: Kawulka KE]]
-	[[Category: McKay~~, R T~~]]	+	[[Category: McKay RT]]
-	[[Category: Mercier, P]]	+	[[Category: Mercier P]]
-	[[Category: Sprules, T]]	+	[[Category: Sprules T]]
-	[[Category: Vederas~~, J C~~]]	+	[[Category: Vederas JC]]
-	[[Category: Zuber, P]]	+	[[Category: Zuber P]]
-	~~[[Category: Antimicrobial protein]]~~	+
-	~~[[Category: Bacteriocin]]~~	+
-	~~[[Category: Cyclic peptide]]~~	+
-	~~[[Category: Thioether bridge~~]]	+

OCA at 09:36, 8 September 2021

OCA — Wed, 08 Sep 2021 09:36:02 GMT

←Older revision		Revision as of 09:36, 8 September 2021
Line 3:		Line 3:
	<StructureSection load='1pxq' size='340' side='right'caption='[[1pxq]], [[NMR_Ensembles_of_Models \| 8 NMR models]]' scene=''>		<StructureSection load='1pxq' size='340' side='right'caption='[[1pxq]], [[NMR_Ensembles_of_Models \| 8 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1pxq]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PXQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1PXQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1pxq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PXQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PXQ FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=2TL:D-ALLOTHREONINE'>2TL</scene>, <scene name='pdbligand=DPN:D-PHENYLALANINE'>DPN</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=2TL:D-ALLOTHREONINE'>2TL</scene>, <scene name='pdbligand=DPN:D-PHENYLALANINE'>DPN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1pxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pxq OCA], [~~http~~://pdbe.org/1pxq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1pxq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1pxq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1pxq ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pxq OCA], [https://pdbe.org/1pxq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pxq RCSB], [https://www.ebi.ac.uk/pdbsum/1pxq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pxq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/SBOA_BACSU SBOA_BACSU]] Has bacteriocidal activity against some Gram-positive bacteria such as Listeria, some species of Bacillus and E.faecium.<ref>PMID:10572140</ref>	+	[[https://www.uniprot.org/uniprot/SBOA_BACSU SBOA_BACSU]] Has bacteriocidal activity against some Gram-positive bacteria such as Listeria, some species of Bacillus and E.faecium.<ref>PMID:10572140</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 20:

	==See Also==		==See Also==
-	*[[Subtilisin\|Subtilisin]]	+	*[[Subtilisin 3D structures\|Subtilisin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:56, 27 November 2019

OCA — Wed, 27 Nov 2019 09:56:33 GMT

←Older revision		Revision as of 09:56, 27 November 2019
Line 1:		Line 1:

	==Structure of Subtilisin A==		==Structure of Subtilisin A==
-	<StructureSection load='1pxq' size='340' side='right' caption='[[1pxq]], [[NMR_Ensembles_of_Models \| 8 NMR models]]' scene=''>	+	<StructureSection load='1pxq' size='340' side='right'caption='[[1pxq]], [[NMR_Ensembles_of_Models \| 8 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1pxq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PXQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PXQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1pxq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PXQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PXQ FirstGlance]. <br>
Line 18:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 1pxq" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1pxq" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Subtilisin\|Subtilisin]]
	== References ==		== References ==
	<references/>		<references/>
Line 23:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Bacillus subtilis]]		[[Category: Bacillus subtilis]]
		+	[[Category: Large Structures]]
	[[Category: Diaper, C M]]		[[Category: Diaper, C M]]
	[[Category: Kawulka, K E]]		[[Category: Kawulka, K E]]

OCA at 07:58, 24 February 2018

OCA — Sat, 24 Feb 2018 07:58:58 GMT

←Older revision		Revision as of 07:58, 24 February 2018
Line 1:		Line 1:
		+
	==Structure of Subtilisin A==		==Structure of Subtilisin A==
	<StructureSection load='1pxq' size='340' side='right' caption='[[1pxq]], [[NMR_Ensembles_of_Models \| 8 NMR models]]' scene=''>		<StructureSection load='1pxq' size='340' side='right' caption='[[1pxq]], [[NMR_Ensembles_of_Models \| 8 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1pxq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PXQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PXQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1pxq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PXQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PXQ FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=2TL:D-ALLOTHREONINE'>2TL</scene>, <scene name='pdbligand=DPN:D-PHENYLALANINE'>DPN</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=2TL:D-ALLOTHREONINE'>2TL</scene>, <scene name='pdbligand=DPN:D-PHENYLALANINE'>DPN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pxq OCA], [http://pdbe.org/1pxq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1pxq RCSB], [http://www.ebi.ac.uk/pdbsum/1pxq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pxq OCA], [http://pdbe.org/1pxq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1pxq RCSB], [http://www.ebi.ac.uk/pdbsum/1pxq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1pxq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 1pxq" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1pxq" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Subtilisin\|Subtilisin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:55, 10 September 2015

OCA — Thu, 10 Sep 2015 06:55:59 GMT

←Older revision		Revision as of 06:55, 10 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[1pxq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PXQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PXQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1pxq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PXQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PXQ FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=2TL:D-ALLOTHREONINE'>2TL</scene>, <scene name='pdbligand=DPN:D-PHENYLALANINE'>DPN</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=2TL:D-ALLOTHREONINE'>2TL</scene>, <scene name='pdbligand=DPN:D-PHENYLALANINE'>DPN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pxq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1pxq RCSB], [http://www.ebi.ac.uk/pdbsum/1pxq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pxq OCA], [http://pdbe.org/1pxq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1pxq RCSB], [http://www.ebi.ac.uk/pdbsum/1pxq PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1pxq" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 19:50, 24 December 2014

OCA — Wed, 24 Dec 2014 19:50:26 GMT

←Older revision		Revision as of 19:50, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1pxq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PXQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PXQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1pxq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PXQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PXQ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=2TL:D-ALLOTHREONINE'>2TL</scene>, <scene name='pdbligand=DPN:D-PHENYLALANINE'>DPN</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=2TL:D-ALLOTHREONINE'>2TL</scene>, <scene name='pdbligand=DPN:D-PHENYLALANINE'>DPN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pxq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1pxq RCSB], [http://www.ebi.ac.uk/pdbsum/1pxq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pxq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1pxq RCSB], [http://www.ebi.ac.uk/pdbsum/1pxq PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SBOA_BACSU SBOA_BACSU]] Has bacteriocidal activity against some Gram-positive bacteria such as Listeria, some species of Bacillus and E.faecium.<ref>PMID:10572140</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Bacillus subtilis]]		[[Category: Bacillus subtilis]]
-	[[Category: Diaper, C M.]]	+	[[Category: Diaper, C M]]
-	[[Category: Kawulka, K E.]]	+	[[Category: Kawulka, K E]]
-	[[Category: McKay, R T.]]	+	[[Category: McKay, R T]]
-	[[Category: Mercier, P.]]	+	[[Category: Mercier, P]]
-	[[Category: Sprules, T.]]	+	[[Category: Sprules, T]]
-	[[Category: Vederas, J C.]]	+	[[Category: Vederas, J C]]
-	[[Category: Zuber, P.]]	+	[[Category: Zuber, P]]
	[[Category: Antimicrobial protein]]		[[Category: Antimicrobial protein]]
	[[Category: Bacteriocin]]		[[Category: Bacteriocin]]
	[[Category: Cyclic peptide]]		[[Category: Cyclic peptide]]
	[[Category: Thioether bridge]]		[[Category: Thioether bridge]]

OCA at 22:16, 28 September 2014

OCA — Sun, 28 Sep 2014 22:16:35 GMT

←Older revision		Revision as of 22:16, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1pxq.~~png~~\|~~left\|200px~~]]	+	==Structure of Subtilisin A==
		+	<StructureSection load='1pxq' size='340' side='right' caption='[[1pxq]], [[NMR_Ensembles_of_Models \| 8 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1pxq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PXQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PXQ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=2TL:D-ALLOTHREONINE'>2TL</scene>, <scene name='pdbligand=DPN:D-PHENYLALANINE'>DPN</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pxq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1pxq RCSB], [http://www.ebi.ac.uk/pdbsum/1pxq PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The complete primary and three-dimensional solution structures of subtilosin A (1), a bacteriocin from Bacillus subtilis, were determined by multidimensional NMR studies on peptide produced using isotopically labeled [(13)C,(15)N]medium derived from Anabaena sp. grown on sodium [(13)C]bicarbonate and [(15)N]nitrate. Additional samples of 1 were also generated by separate incorporations of [U-(13)C,(15)N]-L-phenylalanine and [U-(13)C,(15)N]-L-threonine using otherwise unlabeled media. The results demonstrate that in addition to having a cyclized peptide backbone (amide between N and C termini), three cross-links are formed between the sulfurs of Cys13, Cys7, and Cys4 and the alpha-positions of Phe22, Thr28, and Phe31, respectively. The stereochemistry of all residues in 1 except for the three modified ones was confirmed to be L by complete desulfurization with nickel boride, acid hydrolysis to the constituent amino acids, and conversion of these to the corresponding pentafluoropropanamide isopropyl esters for chiral GC MS analysis. The stereochemistry at the modified residues was determined by subjecting each of the eight possible stereoisomers of 1 to eight rounds of ARIA structure calculations, starting with the same NMR peak files and assignments. The stereoisomer with the l stereochemistry at Phe22 (alpha-R) and d stereochemistry at Thr28 (alpha-S) and Phe31 (alpha-S) (LDD isomer) fit the NMR data, giving the lowest energy family of structures with the best rmsd. Thus, biochemical formation of the unusual thio links proceeds with net retention of configuration at Phe22, and inversion at Thr28 and Phe31. Model amino acid derivatives bearing a sulfide moiety at the alpha-carbon were synthesized by reaction of the corresponding alpha-alkoxy compounds with benzyl thiol and SnCl(4). Separation of their pure stereoisomers and desulfurization with nickel boride demonstrated that the reduction of such compounds proceeds with epimerization, in contrast to the previously reported retention of stereochemistry for analogous reaction of steroidal sulfides. However, desulfurization of subtilosin A to cyclic peptide 14, which is inactive as an antimicrobial agent, occurs with inversion of stereochemistry at the alpha-carbons of Phe22 and Thr28 and with 4:1 retention at Phe31. This indicates that the desulfurization reaction proceeds via an N-acyl imine and that the structure of the surrounding peptide controls the geometry of reduction. Posttranslational linkage of a thiol to the alpha-carbon of an amino acid residue is unprecedented in ribosomally synthesized peptides or proteins, and very rare in secondary metabolites. Subtilosin A (1) represents a new class of bacteriocins.

-	~~{{STRUCTURE_1pxq\| PDB=1pxq \| SCENE= }}~~	+	Structure of subtilosin A, a cyclic antimicrobial peptide from Bacillus subtilis with unusual sulfur to alpha-carbon cross-links: formation and reduction of alpha-thio-alpha-amino acid derivatives.,Kawulka KE, Sprules T, Diaper CM, Whittal RM, McKay RT, Mercier P, Zuber P, Vederas JC Biochemistry. 2004 Mar 30;43(12):3385-95. PMID:15035610<ref>PMID:15035610</ref>

-	~~===Structure~~ of ~~Subtilisin A===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15035610}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1pxq]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bacillus_subtilis Bacillus subtilis]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1PXQ OCA].~~	+

	==See Also==		==See Also==
	*[[Subtilisin\|Subtilisin]]		*[[Subtilisin\|Subtilisin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:015035610<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Bacillus subtilis]]		[[Category: Bacillus subtilis]]
	[[Category: Diaper, C M.]]		[[Category: Diaper, C M.]]

OCA at 08:34, 20 October 2012

OCA — Sat, 20 Oct 2012 08:34:09 GMT

←Older revision		Revision as of 08:34, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1pxq]] is a 1 chain structure ~~of [[Subtilisin]]~~ with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PXQ OCA].	+	[[1pxq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PXQ OCA].

	==See Also==		==See Also==

OCA at 19:56, 25 July 2012

OCA — Wed, 25 Jul 2012 19:56:48 GMT

←Older revision		Revision as of 19:56, 25 July 2012
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	[[Image:1pxq.png\|left\|200px]]		[[Image:1pxq.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_1pxq\| PDB=1pxq \| SCENE= }}		{{STRUCTURE_1pxq\| PDB=1pxq \| SCENE= }}

	===Structure of Subtilisin A===		===Structure of Subtilisin A===

-
-	<!--
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-	(as it appears on PubMed at http://www.pubmed.gov), where 15035610 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_15035610}}		{{ABSTRACT_PUBMED_15035610}}

	==About this Structure==		==About this Structure==
-	[[1pxq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PXQ OCA].	+	[[1pxq]] is a 1 chain structure of [[Subtilisin]] with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PXQ OCA].
		+
		+	==See Also==
		+	*[[Subtilisin\|Subtilisin]]

	==Reference==		==Reference==

OCA: Protected "1pxq" [edit=sysop:move=sysop]

OCA — Wed, 05 Oct 2011 05:54:11 GMT

Protected "1pxq" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:54, 5 October 2011