1pz5 - Revision history

OCA at 09:53, 16 August 2023

OCA — Wed, 16 Aug 2023 09:53:05 GMT

←Older revision		Revision as of 09:53, 16 August 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1pz5]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PZ5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1pz5]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PZ5 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[1m71\|1m71]]~~, [[~~1m7d~~\|~~1m7d~~]]~~, [[1m7i\|1m7i]]</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pz5 OCA], [https://pdbe.org/1pz5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pz5 RCSB], [https://www.ebi.ac.uk/pdbsum/1pz5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pz5 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pz5 OCA], [https://pdbe.org/1pz5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pz5 RCSB], [https://www.ebi.ac.uk/pdbsum/1pz5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pz5 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A2NHM3_MOUSE A2NHM3_MOUSE]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Bundle~~, D R~~]]	+	[[Category: Bundle DR]]
-	[[Category: Chervenak~~, M C~~]]	+	[[Category: Chervenak MC]]
-	[[Category: Pinto~~, B M~~]]	+	[[Category: Pinto BM]]
-	[[Category: Quiocho~~, F A~~]]	+	[[Category: Quiocho FA]]
-	[[Category: Vyas~~, M N~~]]	+	[[Category: Vyas MN]]
-	[[Category: Vyas~~, N K]]~~	+	[[Category: Vyas NK]]
-	~~[[Category: Antibody-antigen structure]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Peptide-carbohydrate mimicry]]~~	+
-	~~[[Category: Vaccine design~~]]	+

OCA at 09:36, 8 September 2021

OCA — Wed, 08 Sep 2021 09:36:33 GMT

←Older revision		Revision as of 09:36, 8 September 2021
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	<StructureSection load='1pz5' size='340' side='right'caption='[[1pz5]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1pz5' size='340' side='right'caption='[[1pz5]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1pz5]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZ5 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1PZ5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1pz5]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PZ5 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m71\|1m71]], [[1m7d\|1m7d]], [[1m7i\|1m7i]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1m71\|1m71]], [[1m7d\|1m7d]], [[1m7i\|1m7i]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1pz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pz5 OCA], [~~http~~://pdbe.org/1pz5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1pz5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1pz5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1pz5 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pz5 OCA], [https://pdbe.org/1pz5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pz5 RCSB], [https://www.ebi.ac.uk/pdbsum/1pz5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pz5 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	==See Also==		==See Also==
	*[[Antibody 3D structures\|Antibody 3D structures]]		*[[Antibody 3D structures\|Antibody 3D structures]]
		+	*[[3D structures of non-human antibody\|3D structures of non-human antibody]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:19, 27 November 2019

OCA — Wed, 27 Nov 2019 10:19:47 GMT

←Older revision		Revision as of 10:19, 27 November 2019
Line 1:		Line 1:

	==Structural basis of peptide-carbohydrate mimicry in an antibody combining site==		==Structural basis of peptide-carbohydrate mimicry in an antibody combining site==
-	<StructureSection load='1pz5' size='340' side='right' caption='[[1pz5]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='1pz5' size='340' side='right'caption='[[1pz5]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1pz5]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZ5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PZ5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1pz5]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZ5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PZ5 FirstGlance]. <br>
Line 26:		Line 26:
	</div>		</div>
	<div class="pdbe-citations 1pz5" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1pz5" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Bundle, D R]]		[[Category: Bundle, D R]]

OCA at 08:19, 24 February 2018

OCA — Sat, 24 Feb 2018 08:19:55 GMT

←Older revision		Revision as of 08:19, 24 February 2018
Line 1:		Line 1:
		+
	==Structural basis of peptide-carbohydrate mimicry in an antibody combining site==		==Structural basis of peptide-carbohydrate mimicry in an antibody combining site==
	<StructureSection load='1pz5' size='340' side='right' caption='[[1pz5]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1pz5' size='340' side='right' caption='[[1pz5]], [[Resolution\|resolution]] 1.80Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1pz5]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZ5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PZ5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1pz5]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZ5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PZ5 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m71\|1m71]], [[1m7d\|1m7d]], [[1m7i\|1m7i]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m71\|1m71]], [[1m7d\|1m7d]], [[1m7i\|1m7i]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pz5 OCA], [http://pdbe.org/1pz5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1pz5 RCSB], [http://www.ebi.ac.uk/pdbsum/1pz5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pz5 OCA], [http://pdbe.org/1pz5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1pz5 RCSB], [http://www.ebi.ac.uk/pdbsum/1pz5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1pz5 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 10:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pz/1pz5_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pz/1pz5_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pz5 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 25:		Line 26:
	</div>		</div>
	<div class="pdbe-citations 1pz5" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1pz5" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Antibody\|Antibody]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 00:05, 12 September 2015

OCA — Sat, 12 Sep 2015 00:05:43 GMT

←Older revision		Revision as of 00:05, 12 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[1pz5]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZ5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PZ5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1pz5]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZ5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PZ5 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m71\|1m71]], [[1m7d\|1m7d]], [[1m7i\|1m7i]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m71\|1m71]], [[1m7d\|1m7d]], [[1m7i\|1m7i]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pz5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1pz5 RCSB], [http://www.ebi.ac.uk/pdbsum/1pz5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pz5 OCA], [http://pdbe.org/1pz5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1pz5 RCSB], [http://www.ebi.ac.uk/pdbsum/1pz5 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 24:		Line 24:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1pz5" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 07:17, 6 January 2015

OCA — Tue, 06 Jan 2015 07:17:58 GMT

←Older revision		Revision as of 07:17, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1pz5]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZ5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PZ5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1pz5]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZ5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PZ5 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m71\|1m71]], [[1m7d\|1m7d]], [[1m7i\|1m7i]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m71\|1m71]], [[1m7d\|1m7d]], [[1m7i\|1m7i]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pz5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1pz5 RCSB], [http://www.ebi.ac.uk/pdbsum/1pz5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pz5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1pz5 RCSB], [http://www.ebi.ac.uk/pdbsum/1pz5 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Bundle, D R.]]	+	[[Category: Bundle, D R]]
-	[[Category: Chervenak, M C.]]	+	[[Category: Chervenak, M C]]
-	[[Category: Pinto, B M.]]	+	[[Category: Pinto, B M]]
-	[[Category: Quiocho, F A.]]	+	[[Category: Quiocho, F A]]
-	[[Category: Vyas, M N.]]	+	[[Category: Vyas, M N]]
-	[[Category: Vyas, N K.]]	+	[[Category: Vyas, N K]]
	[[Category: Antibody-antigen structure]]		[[Category: Antibody-antigen structure]]
	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: Peptide-carbohydrate mimicry]]		[[Category: Peptide-carbohydrate mimicry]]
	[[Category: Vaccine design]]		[[Category: Vaccine design]]

OCA at 22:29, 28 September 2014

OCA — Sun, 28 Sep 2014 22:29:57 GMT

←Older revision		Revision as of 22:29, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1pz5.~~png~~\|~~left~~\|200px]]	+	==Structural basis of peptide-carbohydrate mimicry in an antibody combining site==
		+	<StructureSection load='1pz5' size='340' side='right' caption='[[1pz5]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1pz5]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZ5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PZ5 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m71\|1m71]], [[1m7d\|1m7d]], [[1m7i\|1m7i]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pz5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1pz5 RCSB], [http://www.ebi.ac.uk/pdbsum/1pz5 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pz/1pz5_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The structure of a complex between the Fab fragment of the antibody (SYA/J6) specific for the cell surface O-antigen polysaccharide of the pathogen Shigella flexneri Y and an octapeptide (Met-Asp-Trp-Asn-Met-His-Ala-Ala), a functional mimic of the O-antigen, has been determined at 1.8-A resolution. Comparison of the structure with that of the complex with the pentasaccharide antigen [-->2)-alpha-L-Rha-(1-->2)-alpha-L-Rha-(1-->3)-alpha-L-Rha-(1-->3)-beta-D- GlcNAc-(1-->2)-alpha-L-Rha-(1-->] reveals the molecular recognition process by which a peptide mimics a carbohydrate in binding to an antibody. The binding modes of the two ligands differ considerably. Octapeptide binding complements the shape of the combining site groove much better than pentasaccharide binding. Moreover, the peptide makes a much greater number of contacts (126), which are mostly van der Waals interactions, with the Fab than the saccharide (74). An unusual feature is also the involvement of 12 water molecules in mediating hydrogen bonds between residues within the peptide or of the peptide and Fab. Despite better shape complementarity and greater number of contacts, the octapeptide binds with an affinity (KA = 2.5 x 10(5) M-1, measured by calorimetry) only approximately 2-fold tighter than the pentasaccharide. The structural results are relevant to the design of peptide mimetics with improved affinity for use as vaccines.

-	~~{{STRUCTURE_1pz5\| PDB=1pz5 \| SCENE= }}~~	+	Structural basis of peptide-carbohydrate mimicry in an antibody-combining site.,Vyas NK, Vyas MN, Chervenak MC, Bundle DR, Pinto BM, Quiocho FA Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15023-8. Epub 2003 Nov 25. PMID:14645714<ref>PMID:14645714</ref>

-	~~===Structural basis~~ of ~~peptide-carbohydrate mimicry in an antibody combining site===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_14645714}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1pz5]] is a 3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1PZ5 OCA].~~	+

	==See Also==		==See Also==
	*[[Antibody\|Antibody]]		*[[Antibody\|Antibody]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:014645714<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Bundle, D R.]]		[[Category: Bundle, D R.]]

OCA at 21:42, 20 October 2012

OCA — Sat, 20 Oct 2012 21:42:23 GMT

←Older revision		Revision as of 21:42, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1pz5]] is a 3 chain structure ~~of [[Antibody]]~~ with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZ5 OCA].	+	[[1pz5]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZ5 OCA].

	==See Also==		==See Also==

OCA at 14:02, 27 July 2012

OCA — Fri, 27 Jul 2012 14:02:20 GMT

←Older revision		Revision as of 14:02, 27 July 2012
Line 1:		Line 1:
	[[Image:1pz5.png\|left\|200px]]		[[Image:1pz5.png\|left\|200px]]

-	<!--
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-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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	{{STRUCTURE_1pz5\| PDB=1pz5 \| SCENE= }}		{{STRUCTURE_1pz5\| PDB=1pz5 \| SCENE= }}

	===Structural basis of peptide-carbohydrate mimicry in an antibody combining site===		===Structural basis of peptide-carbohydrate mimicry in an antibody combining site===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_14645714}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 14645714 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_14645714}}		{{ABSTRACT_PUBMED_14645714}}

	==About this Structure==		==About this Structure==
-	[[1pz5]] is a 3 chain structure of [[~~Monoclonal~~ Antibody]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZ5 OCA].	+	[[1pz5]] is a 3 chain structure of [[Antibody]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZ5 OCA].

	==See Also==		==See Also==
-	*[[~~Monoclonal~~ Antibody]]	+	*[[Antibody\|Antibody]]

	==Reference==		==Reference==

OCA: Protected "1pz5" [edit=sysop:move=sysop]

OCA — Wed, 16 Nov 2011 10:55:57 GMT

Protected "1pz5" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:55, 16 November 2011