1pzi - Revision history

OCA at 09:53, 16 August 2023

OCA — Wed, 16 Aug 2023 09:53:26 GMT

←Older revision		Revision as of 09:53, 16 August 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1pzi]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PZI FirstGlance]. <br>		<table><tr><td colspan='2'>[[1pzi]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PZI FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1DM:N-(2-MORPHOLIN-4-YL-1-MORPHOLIN-4-YLMETHYL-ETHYL)-3-NITRO-5-(3,4,5-TRIHYDROXY-6-HYDROXYMETHYL-TETRAHYDRO-PYRAN-2-YLOXY)-BENZAMIDE'>1DM</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.99Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1DM:N-(2-MORPHOLIN-4-YL-1-MORPHOLIN-4-YLMETHYL-ETHYL)-3-NITRO-5-(3,4,5-TRIHYDROXY-6-HYDROXYMETHYL-TETRAHYDRO-PYRAN-2-YLOXY)-BENZAMIDE'>1DM</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pzi OCA], [https://pdbe.org/1pzi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pzi RCSB], [https://www.ebi.ac.uk/pdbsum/1pzi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pzi ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pzi OCA], [https://pdbe.org/1pzi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pzi RCSB], [https://www.ebi.ac.uk/pdbsum/1pzi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pzi ProSAT]</span></td></tr>
	</table>		</table>

OCA at 12:25, 1 February 2023

OCA — Wed, 01 Feb 2023 12:25:12 GMT

←Older revision		Revision as of 12:25, 1 February 2023
Line 3:		Line 3:
	<StructureSection load='1pzi' size='340' side='right'caption='[[1pzi]], [[Resolution\|resolution]] 1.99Å' scene=''>		<StructureSection load='1pzi' size='340' side='right'caption='[[1pzi]], [[Resolution\|resolution]] 1.99Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1pzi]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PZI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1pzi]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PZI FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1DM:N-(2-MORPHOLIN-4-YL-1-MORPHOLIN-4-YLMETHYL-ETHYL)-3-NITRO-5-(3,4,5-TRIHYDROXY-6-HYDROXYMETHYL-TETRAHYDRO-PYRAN-2-YLOXY)-BENZAMIDE'>1DM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1DM:N-(2-MORPHOLIN-4-YL-1-MORPHOLIN-4-YLMETHYL-ETHYL)-3-NITRO-5-(3,4,5-TRIHYDROXY-6-HYDROXYMETHYL-TETRAHYDRO-PYRAN-2-YLOXY)-BENZAMIDE'>1DM</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1pzj\|1pzj]], [[1pzk\|1pzk]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ELTB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pzi OCA], [https://pdbe.org/1pzi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pzi RCSB], [https://www.ebi.ac.uk/pdbsum/1pzi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pzi ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pzi OCA], [https://pdbe.org/1pzi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pzi RCSB], [https://www.ebi.ac.uk/pdbsum/1pzi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pzi ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ELBP_ECOLX ELBP_ECOLX]] The biological activity of the toxin is produced by the A chain, which activates intracellular adenyl cyclase.	+	[https://www.uniprot.org/uniprot/ELBP_ECOLX ELBP_ECOLX] The biological activity of the toxin is produced by the A chain, which activates intracellular adenyl cyclase.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 28:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ coli ~~migula 1895~~]]	+	[[Category: Escherichia coli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Fan, E]]	+	[[Category: Fan E]]
-	[[Category: Hol~~, W G.J~~]]	+	[[Category: Hol WGJ]]
-	[[Category: Korotkov, K]]	+	[[Category: Korotkov K]]
-	[[Category: Mitchell~~, D D~~]]	+	[[Category: Mitchell DD]]
-	[[Category: Pickens~~, J C]]~~	+	[[Category: Pickens JC]]
-	~~[[Category: Inhibitor]]~~	+
-	~~[[Category: Monovalent]]~~	+
-	~~[[Category: Pentamer]]~~	+
-	~~[[Category: Toxin]]~~	+
-	~~[[Category: Toxin inhibitor~~]]	+

OCA at 06:02, 28 April 2021

OCA — Wed, 28 Apr 2021 06:02:12 GMT

←Older revision		Revision as of 06:02, 28 April 2021
Line 3:		Line 3:
	<StructureSection load='1pzi' size='340' side='right'caption='[[1pzi]], [[Resolution\|resolution]] 1.99Å' scene=''>		<StructureSection load='1pzi' size='340' side='right'caption='[[1pzi]], [[Resolution\|resolution]] 1.99Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1pzi]] is a 5 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1PZI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1pzi]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PZI FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1DM:N-(2-MORPHOLIN-4-YL-1-MORPHOLIN-4-YLMETHYL-ETHYL)-3-NITRO-5-(3,4,5-TRIHYDROXY-6-HYDROXYMETHYL-TETRAHYDRO-PYRAN-2-YLOXY)-BENZAMIDE'>1DM</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1DM:N-(2-MORPHOLIN-4-YL-1-MORPHOLIN-4-YLMETHYL-ETHYL)-3-NITRO-5-(3,4,5-TRIHYDROXY-6-HYDROXYMETHYL-TETRAHYDRO-PYRAN-2-YLOXY)-BENZAMIDE'>1DM</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1pzj\|1pzj]], [[1pzk\|1pzk]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1pzj\|1pzj]], [[1pzk\|1pzk]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ELTB ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ELTB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1pzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pzi OCA], [~~http~~://pdbe.org/1pzi PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1pzi RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1pzi PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1pzi ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pzi OCA], [https://pdbe.org/1pzi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pzi RCSB], [https://www.ebi.ac.uk/pdbsum/1pzi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pzi ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ELBP_ECOLX ELBP_ECOLX]] The biological activity of the toxin is produced by the A chain, which activates intracellular adenyl cyclase.	+	[[https://www.uniprot.org/uniprot/ELBP_ECOLX ELBP_ECOLX]] The biological activity of the toxin is produced by the A chain, which activates intracellular adenyl cyclase.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 06:57, 24 July 2019

OCA — Wed, 24 Jul 2019 06:57:32 GMT

←Older revision		Revision as of 06:57, 24 July 2019
Line 1:		Line 1:

	==Heat-Labile Enterotoxin B-Pentamer Complexed With Nitrophenyl Galactoside 2a==		==Heat-Labile Enterotoxin B-Pentamer Complexed With Nitrophenyl Galactoside 2a==
-	<StructureSection load='1pzi' size='340' side='right' caption='[[1pzi]], [[Resolution\|resolution]] 1.99Å' scene=''>	+	<StructureSection load='1pzi' size='340' side='right'caption='[[1pzi]], [[Resolution\|resolution]] 1.99Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1pzi]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PZI FirstGlance]. <br>		<table><tr><td colspan='2'>[[1pzi]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PZI FirstGlance]. <br>
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 1pzi" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1pzi" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Cholera toxin 3D structures\|Cholera toxin 3D structures]]
		+	*[[User:David Solfiell/sandbox 1\|User:David Solfiell/sandbox 1]]
	== References ==		== References ==
	<references/>		<references/>
Line 25:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
		+	[[Category: Large Structures]]
	[[Category: Fan, E]]		[[Category: Fan, E]]
	[[Category: Hol, W G.J]]		[[Category: Hol, W G.J]]

OCA at 07:52, 24 February 2018

OCA — Sat, 24 Feb 2018 07:52:23 GMT

←Older revision		Revision as of 07:52, 24 February 2018
Line 1:		Line 1:
		+
	==Heat-Labile Enterotoxin B-Pentamer Complexed With Nitrophenyl Galactoside 2a==		==Heat-Labile Enterotoxin B-Pentamer Complexed With Nitrophenyl Galactoside 2a==
	<StructureSection load='1pzi' size='340' side='right' caption='[[1pzi]], [[Resolution\|resolution]] 1.99Å' scene=''>		<StructureSection load='1pzi' size='340' side='right' caption='[[1pzi]], [[Resolution\|resolution]] 1.99Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1pzj\|1pzj]], [[1pzk\|1pzk]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1pzj\|1pzj]], [[1pzk\|1pzk]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ELTB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ELTB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pzi OCA], [http://pdbe.org/1pzi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1pzi RCSB], [http://www.ebi.ac.uk/pdbsum/1pzi PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pzi OCA], [http://pdbe.org/1pzi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1pzi RCSB], [http://www.ebi.ac.uk/pdbsum/1pzi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1pzi ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 1pzi" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1pzi" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Cholera toxin\|Cholera toxin]]
-	*[[User:David Solfiell/sandbox 1\|User:David Solfiell/sandbox 1]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 17:34, 10 September 2015

OCA — Thu, 10 Sep 2015 17:34:08 GMT

←Older revision		Revision as of 17:34, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1pzi' size='340' side='right' caption='[[1pzi]], [[Resolution\|resolution]] 1.99Å' scene=''>		<StructureSection load='1pzi' size='340' side='right' caption='[[1pzi]], [[Resolution\|resolution]] 1.99Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1pzi]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia~~ coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PZI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1pzi]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PZI FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1DM:N-(2-MORPHOLIN-4-YL-1-MORPHOLIN-4-YLMETHYL-ETHYL)-3-NITRO-5-(3,4,5-TRIHYDROXY-6-HYDROXYMETHYL-TETRAHYDRO-PYRAN-2-YLOXY)-BENZAMIDE'>1DM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1DM:N-(2-MORPHOLIN-4-YL-1-MORPHOLIN-4-YLMETHYL-ETHYL)-3-NITRO-5-(3,4,5-TRIHYDROXY-6-HYDROXYMETHYL-TETRAHYDRO-PYRAN-2-YLOXY)-BENZAMIDE'>1DM</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1pzj\|1pzj]], [[1pzk\|1pzk]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1pzj\|1pzj]], [[1pzk\|1pzk]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ELTB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 ~~Escherichia~~ coli])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ELTB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pzi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1pzi RCSB], [http://www.ebi.ac.uk/pdbsum/1pzi PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pzi OCA], [http://pdbe.org/1pzi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1pzi RCSB], [http://www.ebi.ac.uk/pdbsum/1pzi PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~ELBP_ECOLI ELBP_ECOLI~~]] The biological activity of the toxin is produced by the A chain, which activates intracellular adenyl cyclase.	+	[[http://www.uniprot.org/uniprot/ELBP_ECOLX ELBP_ECOLX]] The biological activity of the toxin is produced by the A chain, which activates intracellular adenyl cyclase.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1pzi" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 26:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Escherichia~~ coli]]	+	[[Category: Bacillus coli migula 1895]]
	[[Category: Fan, E]]		[[Category: Fan, E]]
	[[Category: Hol, W G.J]]		[[Category: Hol, W G.J]]

OCA at 03:40, 25 December 2014

OCA — Thu, 25 Dec 2014 03:40:57 GMT

←Older revision		Revision as of 03:40, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1pzi]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PZI FirstGlance]. <br>		<table><tr><td colspan='2'>[[1pzi]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PZI FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1DM:N-(2-MORPHOLIN-4-YL-1-MORPHOLIN-4-YLMETHYL-ETHYL)-3-NITRO-5-(3,4,5-TRIHYDROXY-6-HYDROXYMETHYL-TETRAHYDRO-PYRAN-2-YLOXY)-BENZAMIDE'>1DM</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1DM:N-(2-MORPHOLIN-4-YL-1-MORPHOLIN-4-YLMETHYL-ETHYL)-3-NITRO-5-(3,4,5-TRIHYDROXY-6-HYDROXYMETHYL-TETRAHYDRO-PYRAN-2-YLOXY)-BENZAMIDE'>1DM</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1pzj\|1pzj]], [[1pzk\|1pzk]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1pzj\|1pzj]], [[1pzk\|1pzk]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ELTB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ELTB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pzi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1pzi RCSB], [http://www.ebi.ac.uk/pdbsum/1pzi PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pzi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1pzi RCSB], [http://www.ebi.ac.uk/pdbsum/1pzi PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ELBP_ECOLI ELBP_ECOLI]] The biological activity of the toxin is produced by the A chain, which activates intracellular adenyl cyclase.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: Fan, E.]]	+	[[Category: Fan, E]]
-	[[Category: Hol, W G.J.]]	+	[[Category: Hol, W G.J]]
-	[[Category: Korotkov, K.]]	+	[[Category: Korotkov, K]]
-	[[Category: Mitchell, D D.]]	+	[[Category: Mitchell, D D]]
-	[[Category: Pickens, J C.]]	+	[[Category: Pickens, J C]]
	[[Category: Inhibitor]]		[[Category: Inhibitor]]
	[[Category: Monovalent]]		[[Category: Monovalent]]

OCA at 20:46, 28 September 2014

OCA — Sun, 28 Sep 2014 20:46:17 GMT

←Older revision		Revision as of 20:46, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1pzi.~~png~~\|~~left~~\|~~200px~~]]	+	==Heat-Labile Enterotoxin B-Pentamer Complexed With Nitrophenyl Galactoside 2a==
		+	<StructureSection load='1pzi' size='340' side='right' caption='[[1pzi]], [[Resolution\|resolution]] 1.99Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1pzi]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PZI FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1DM:N-(2-MORPHOLIN-4-YL-1-MORPHOLIN-4-YLMETHYL-ETHYL)-3-NITRO-5-(3,4,5-TRIHYDROXY-6-HYDROXYMETHYL-TETRAHYDRO-PYRAN-2-YLOXY)-BENZAMIDE'>1DM</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1pzj\|1pzj]], [[1pzk\|1pzk]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ELTB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pzi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1pzi RCSB], [http://www.ebi.ac.uk/pdbsum/1pzi PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	With the aim of developing high-affinity mono and multivalent antagonists of cholera toxin (CT) and Escherichia coli heat-labile enterotoxin (LT) we are using the galactose portion of the natural receptor ganglioside GM1 as an anchoring fragment in structure-based inhibitor design efforts. In order to establish a better structure-activity relationship for guiding these studies, we designed and prepared a small focused library of twenty 3,5-substituted phenylgalactosides based on two previous leads. The compounds were tested for their ability to block CTB(5) binding to immobilized ganglioside receptor and compared to the two previous leads. The crystal structures of the most promising compounds bound to either CTB(5) or LTB(5) were then determined in order to understand the basis for affinity differences. The most potent new compound yielded a six-fold improvement over our benchmark lead m-nitrophenyl-alpha-d-galactopyranoside (MNPG), and a two-fold improvement in IC(50) over a newer MNPG derivative. These results support the notion that the m-nitrophenyl moiety of MNPG and its derivatives is an important element to retain in future optimization efforts. Additionally, a consensus binding-pocket for the alkylmorpholine or piperazine moiety present in all of the designed antagonists was established as an important area of the GM1 binding site to target in future work.

-	~~{{STRUCTURE_1pzi\| PDB=1pzi \| SCENE= }}~~	+	3,5-Substituted phenyl galactosides as leads in designing effective cholera toxin antagonists; synthesis and crystallographic studies.,Mitchell DD, Pickens JC, Korotkov K, Fan E, Hol WG Bioorg Med Chem. 2004 Mar 1;12(5):907-20. PMID:14980603<ref>PMID:14980603</ref>

-	~~===Heat-Labile Enterotoxin B-Pentamer Complexed With Nitrophenyl Galactoside 2a===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_14980603}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1pzi]] is~~ a ~~5 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli Escherichia coli]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1PZI OCA].~~	+

	==See Also==		==See Also==
	*[[Cholera toxin\|Cholera toxin]]		*[[Cholera toxin\|Cholera toxin]]
	*[[User:David Solfiell/sandbox 1\|User:David Solfiell/sandbox 1]]		*[[User:David Solfiell/sandbox 1\|User:David Solfiell/sandbox 1]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:014980603<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Fan, E.]]		[[Category: Fan, E.]]

OCA at 12:16, 20 October 2012

OCA — Sat, 20 Oct 2012 12:16:49 GMT

←Older revision		Revision as of 12:16, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1pzi]] is a 5 chain structure ~~of [[Cholera toxin]] and [[User:David Solfiell/sandbox 1]]~~ with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZI OCA].	+	[[1pzi]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZI OCA].

	==See Also==		==See Also==

OCA at 08:11, 26 July 2012

OCA — Thu, 26 Jul 2012 08:11:46 GMT

←Older revision		Revision as of 08:11, 26 July 2012
Line 1:		Line 1:
	[[Image:1pzi.png\|left\|200px]]		[[Image:1pzi.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1pzi", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1pzi\| PDB=1pzi \| SCENE= }}		{{STRUCTURE_1pzi\| PDB=1pzi \| SCENE= }}

	===Heat-Labile Enterotoxin B-Pentamer Complexed With Nitrophenyl Galactoside 2a===		===Heat-Labile Enterotoxin B-Pentamer Complexed With Nitrophenyl Galactoside 2a===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_14980603}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 14980603 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_14980603}}		{{ABSTRACT_PUBMED_14980603}}

	==About this Structure==		==About this Structure==
-	[[1pzi]] is a 5 chain structure of [[Cholera toxin]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZI OCA].	+	[[1pzi]] is a 5 chain structure of [[Cholera toxin]] and [[User:David Solfiell/sandbox 1]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZI OCA].

	==See Also==		==See Also==
-	*[[Cholera toxin]]	+	*[[Cholera toxin\|Cholera toxin]]
		+	*[[User:David Solfiell/sandbox 1\|User:David Solfiell/sandbox 1]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~14980603~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:014980603</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Fan, E.]]		[[Category: Fan, E.]]