1pzm - Revision history

OCA at 09:53, 16 August 2023

OCA — Wed, 16 Aug 2023 09:53:28 GMT

←Older revision		Revision as of 09:53, 16 August 2023
Line 3:		Line 3:
	<StructureSection load='1pzm' size='340' side='right'caption='[[1pzm]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1pzm' size='340' side='right'caption='[[1pzm]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1pzm]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Leita Leita~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZM OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1PZM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1pzm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_tarentolae Leishmania tarentolae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PZM FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=5GP:GUANOSINE~~-~~5-MONOPHOSPHATE'>5GP</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>hgprt ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~5689 LEITA])</td~~><~~/tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5GP:GUANOSINE-5-MONOPHOSPHATE'>5GP</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[http://en.wikipedia.org/wiki/Hypoxanthine_phosphoribosyltransferase Hypoxanthine phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.8 2.4.2.8]~~ </~~span~~></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pzm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pzm OCA], [https://pdbe.org/1pzm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pzm RCSB], [https://www.ebi.ac.uk/pdbsum/1pzm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pzm ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1pzm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pzm OCA], [~~http~~://pdbe.org/1pzm PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1pzm RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1pzm PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1pzm ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q9NJI5_LEITA Q9NJI5_LEITA]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Hypoxanthine phosphoribosyltransferase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Leita~~]]	+	[[Category: Leishmania tarentolae]]
-	[[Category: Monzani~~, P S~~]]	+	[[Category: Monzani PS]]
-	[[Category: Oliva, G]]	+	[[Category: Oliva G]]
-	[[Category: Thiemann~~, O H~~]]	+	[[Category: Thiemann OH]]
-	[[Category: Trapani, S]]	+	[[Category: Trapani S]]
-	~~[[Category: Transferase~~]]	+

OCA at 07:39, 9 December 2020

OCA — Wed, 09 Dec 2020 07:39:31 GMT

←Older revision		Revision as of 07:39, 9 December 2020
Line 1:		Line 1:

	==Crystal structure of HGPRT-ase from Leishmania tarentolae in complex with GMP==		==Crystal structure of HGPRT-ase from Leishmania tarentolae in complex with GMP==
-	<StructureSection load='1pzm' size='340' side='right' caption='[[1pzm]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='1pzm' size='340' side='right'caption='[[1pzm]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1pzm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Leita Leita]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZM OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1PZM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1pzm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Leita Leita]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZM OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1PZM FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5GP:GUANOSINE-5-MONOPHOSPHATE'>5GP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5GP:GUANOSINE-5-MONOPHOSPHATE'>5GP</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hgprt ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5689 LEITA])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hgprt ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5689 LEITA])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hypoxanthine_phosphoribosyltransferase Hypoxanthine phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.8 2.4.2.8] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hypoxanthine_phosphoribosyltransferase Hypoxanthine phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.8 2.4.2.8] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1pzm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pzm OCA], [http://pdbe.org/1pzm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1pzm RCSB], [http://www.ebi.ac.uk/pdbsum/1pzm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1pzm ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1pzm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pzm OCA], [http://pdbe.org/1pzm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1pzm RCSB], [http://www.ebi.ac.uk/pdbsum/1pzm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1pzm ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 28:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 1pzm" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1pzm" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Phosphoribosyltransferase 3D structures\|Phosphoribosyltransferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 33:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Hypoxanthine phosphoribosyltransferase]]		[[Category: Hypoxanthine phosphoribosyltransferase]]
		+	[[Category: Large Structures]]
	[[Category: Leita]]		[[Category: Leita]]
	[[Category: Monzani, P S]]		[[Category: Monzani, P S]]

OCA at 08:02, 24 February 2018

OCA — Sat, 24 Feb 2018 08:02:52 GMT

←Older revision		Revision as of 08:02, 24 February 2018
Line 1:		Line 1:
		+
	==Crystal structure of HGPRT-ase from Leishmania tarentolae in complex with GMP==		==Crystal structure of HGPRT-ase from Leishmania tarentolae in complex with GMP==
	<StructureSection load='1pzm' size='340' side='right' caption='[[1pzm]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1pzm' size='340' side='right' caption='[[1pzm]], [[Resolution\|resolution]] 2.10Å' scene=''>
Line 6:		Line 7:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hgprt ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5689 LEITA])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hgprt ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5689 LEITA])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hypoxanthine_phosphoribosyltransferase Hypoxanthine phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.8 2.4.2.8] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hypoxanthine_phosphoribosyltransferase Hypoxanthine phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.8 2.4.2.8] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pzm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pzm OCA], [http://pdbe.org/1pzm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1pzm RCSB], [http://www.ebi.ac.uk/pdbsum/1pzm PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pzm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pzm OCA], [http://pdbe.org/1pzm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1pzm RCSB], [http://www.ebi.ac.uk/pdbsum/1pzm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1pzm ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pz/1pzm_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pz/1pzm_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 27:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 1pzm" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1pzm" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Phosphoribosyltransferase\|Phosphoribosyltransferase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 02:19, 7 February 2016

OCA — Sun, 07 Feb 2016 02:19:32 GMT

←Older revision		Revision as of 02:19, 7 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pzm ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 20:44, 9 September 2015

OCA — Wed, 09 Sep 2015 20:44:42 GMT

←Older revision		Revision as of 20:44, 9 September 2015
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	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hgprt ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5689 LEITA])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hgprt ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5689 LEITA])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hypoxanthine_phosphoribosyltransferase Hypoxanthine phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.8 2.4.2.8] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hypoxanthine_phosphoribosyltransferase Hypoxanthine phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.8 2.4.2.8] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pzm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pzm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1pzm RCSB], [http://www.ebi.ac.uk/pdbsum/1pzm PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pzm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pzm OCA], [http://pdbe.org/1pzm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1pzm RCSB], [http://www.ebi.ac.uk/pdbsum/1pzm PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1pzm" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 06:54, 6 January 2015

OCA — Tue, 06 Jan 2015 06:54:44 GMT

←Older revision		Revision as of 06:54, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1pzm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Leita Leita]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PZM FirstGlance]. <br>		<table><tr><td colspan='2'>[[1pzm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Leita Leita]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PZM FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5GP:GUANOSINE-5-MONOPHOSPHATE'>5GP</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5GP:GUANOSINE-5-MONOPHOSPHATE'>5GP</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hgprt ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5689 LEITA])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hgprt ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5689 LEITA])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hypoxanthine_phosphoribosyltransferase Hypoxanthine phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.8 2.4.2.8] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hypoxanthine_phosphoribosyltransferase Hypoxanthine phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.8 2.4.2.8] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pzm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pzm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1pzm RCSB], [http://www.ebi.ac.uk/pdbsum/1pzm PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pzm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pzm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1pzm RCSB], [http://www.ebi.ac.uk/pdbsum/1pzm PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	[[Category: Hypoxanthine phosphoribosyltransferase]]		[[Category: Hypoxanthine phosphoribosyltransferase]]
	[[Category: Leita]]		[[Category: Leita]]
-	[[Category: Monzani, P S.]]	+	[[Category: Monzani, P S]]
-	[[Category: Oliva, G.]]	+	[[Category: Oliva, G]]
-	[[Category: Thiemann, O H.]]	+	[[Category: Thiemann, O H]]
-	[[Category: Trapani, S.]]	+	[[Category: Trapani, S]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 08:26, 3 October 2014

OCA — Fri, 03 Oct 2014 08:26:58 GMT

←Older revision		Revision as of 08:26, 3 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1pzm\| PDB=1pzm \| SCENE= }}~~	+	==Crystal structure of HGPRT-ase from Leishmania tarentolae in complex with GMP==
-	===Crystal structure of HGPRT-ase from Leishmania tarentolae in complex with GMP===	+	<StructureSection load='1pzm' size='340' side='right' caption='[[1pzm]], [[Resolution\|resolution]] 2.10Å' scene=''>
-	~~{{ABSTRACT_PUBMED_17894860}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1pzm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Leita Leita]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PZM FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5GP:GUANOSINE-5-MONOPHOSPHATE'>5GP</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hgprt ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5689 LEITA])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hypoxanthine_phosphoribosyltransferase Hypoxanthine phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.8 2.4.2.8] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pzm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pzm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1pzm RCSB], [http://www.ebi.ac.uk/pdbsum/1pzm PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pz/1pzm_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	BACKGROUND: Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) (EC 2.4.2.8) is a central enzyme in the purine recycling pathway. Parasitic protozoa of the order Kinetoplastida cannot synthesize purines de novo and use the salvage pathway to synthesize purine bases, making this an attractive target for antiparasitic drug design. RESULTS: The glycosomal HGPRT from Leishmania tarentolae in a catalytically active form purified and co-crystallized with a guanosine monophosphate (GMP) in the active site. The dimeric structure of HGPRT has been solved by molecular replacement and refined against data extending to 2.1 A resolution. The structure reveals the contacts of the active site residues with GMP. CONCLUSION: Comparative analysis of the active sites of Leishmania and human HGPRT revealed subtle differences in the position of the ligand and its interaction with the active site residues, which could be responsible for the different reactivities of the enzymes to allopurinol reported in the literature. The solution and analysis of the structure of Leishmania HGPRT may contribute to further investigations leading to a full understanding of this important enzyme family in protozoan parasites.

-	~~==About this Structure==~~	+	Crystal structure of Leishmania tarentolae hypoxanthine-guanine phosphoribosyltransferase.,Monzani PS, Trapani S, Thiemann OH, Oliva G BMC Struct Biol. 2007 Sep 25;7:59. PMID:17894860<ref>PMID:17894860</ref>
-	~~[[1pzm]] is a 2 chain~~ structure ~~with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Leita Leita]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=1PZM OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Phosphoribosyltransferase\|Phosphoribosyltransferase]]		*[[Phosphoribosyltransferase\|Phosphoribosyltransferase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:017894860</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Hypoxanthine phosphoribosyltransferase]]		[[Category: Hypoxanthine phosphoribosyltransferase]]
	[[Category: Leita]]		[[Category: Leita]]

OCA at 10:52, 16 April 2014

OCA — Wed, 16 Apr 2014 10:52:38 GMT

←Older revision		Revision as of 10:52, 16 April 2014
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-	[[Image:1pzm.png\|left\|200px]]
-
-	<!--
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-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
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	{{STRUCTURE_1pzm\| PDB=1pzm \| SCENE= }}		{{STRUCTURE_1pzm\| PDB=1pzm \| SCENE= }}
-
	===Crystal structure of HGPRT-ase from Leishmania tarentolae in complex with GMP===		===Crystal structure of HGPRT-ase from Leishmania tarentolae in complex with GMP===
-
-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17894860}}, adds the Publication Abstract to the page
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	{{ABSTRACT_PUBMED_17894860}}		{{ABSTRACT_PUBMED_17894860}}

	==About this Structure==		==About this Structure==
-	[[1pzm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Leishmania_tarentolae Leishmania tarentolae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZM OCA].	+	[[1pzm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Leita Leita]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZM OCA].
		+
		+	==See Also==
		+	*[[Phosphoribosyltransferase\|Phosphoribosyltransferase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:017894860</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017894860</ref><references group="xtra"/><references/>
	[[Category: Hypoxanthine phosphoribosyltransferase]]		[[Category: Hypoxanthine phosphoribosyltransferase]]
-	[[Category: ~~Leishmania tarentolae~~]]	+	[[Category: Leita]]
	[[Category: Monzani, P S.]]		[[Category: Monzani, P S.]]
	[[Category: Oliva, G.]]		[[Category: Oliva, G.]]

OCA: Protected "1pzm" [edit=sysop:move=sysop]

OCA — Sat, 02 Jun 2012 09:38:34 GMT

Protected "1pzm" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:38, 2 June 2012