1pzw - Revision history

OCA at 08:11, 14 February 2024

OCA — Wed, 14 Feb 2024 08:11:42 GMT

←Older revision		Revision as of 08:11, 14 February 2024
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	<StructureSection load='1pzw' size='340' side='right'caption='[[1pzw]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1pzw' size='340' side='right'caption='[[1pzw]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1pzw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Drome Drome~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PZW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1pzw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PZW FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~grauzone ([https~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pzw OCA], [https://pdbe.org/1pzw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pzw RCSB], [https://www.ebi.ac.uk/pdbsum/1pzw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pzw ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pzw OCA], [https://pdbe.org/1pzw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pzw RCSB], [https://www.ebi.ac.uk/pdbsum/1pzw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pzw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/GRAU_DROME GRAU_DROME]] Transcription factor essential for the completion of meiosis in oocytes. Grauzone binds to the promoter region of cort via the zf-AD domain and activates cort expression in ovaries.<ref>PMID:10683177</ref> <ref>PMID:10924478</ref>	+	[https://www.uniprot.org/uniprot/GRAU_DROME GRAU_DROME] Transcription factor essential for the completion of meiosis in oocytes. Grauzone binds to the promoter region of cort via the zf-AD domain and activates cort expression in ovaries.<ref>PMID:10683177</ref> <ref>PMID:10924478</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pzw ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pzw ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	About one-third of the more than 300 C2H2 zinc finger proteins of Drosophila contain a conserved sequence motif, the zinc finger-associated domain (ZAD). Genes that encode ZAD proteins are specific for and expanded in the genomes of insects. Only three ZAD-encoding gene functions are established, and the role of ZAD is unknown. Here we present the crystal structure of the ZAD of Grauzone (ZAD(Grau)), a Drosophila transcription factor that specifically controls the maternal Cdc20-like APC subunit Cortex. ZAD forms an atypical treble-clef-like zinc-coordinating fold. Head-to-tail arrangement of two ZAD(Grau) molecules in the crystals suggests dimer formation, an observation supported by crosslinking and dynamic light scattering. The results indicate that ZAD provides a novel protein-protein interaction module that characterizes a large family of insect transcription factors.
-
-	The zinc finger-associated domain of the Drosophila transcription factor grauzone is a novel zinc-coordinating protein-protein interaction module.,Jauch R, Bourenkov GP, Chung HR, Urlaub H, Reidt U, Jackle H, Wahl MC Structure. 2003 Nov;11(11):1393-402. PMID:14604529<ref>PMID:14604529</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1pzw" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Drome~~]]	+	[[Category: Drosophila melanogaster]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bourenkov~~, G P~~]]	+	[[Category: Bourenkov GP]]
-	[[Category: Chung, H R]]	+	[[Category: Chung H-R]]
-	[[Category: Jaeckle, H]]	+	[[Category: Jaeckle H]]
-	[[Category: Jauch, R]]	+	[[Category: Jauch R]]
-	[[Category: Reidt, U]]	+	[[Category: Reidt U]]
-	[[Category: Urlaub, H]]	+	[[Category: Urlaub H]]
-	[[Category: Wahl~~, M C]]~~	+	[[Category: Wahl MC]]
-	~~[[Category: Dimerization]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Transcription regulation]]~~	+
-	~~[[Category: Treble-clef zinc finger]]~~	+
-	~~[[Category: Zad~~]]	+

OCA at 06:02, 28 April 2021

OCA — Wed, 28 Apr 2021 06:02:16 GMT

←Older revision		Revision as of 06:02, 28 April 2021
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	<StructureSection load='1pzw' size='340' side='right'caption='[[1pzw]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1pzw' size='340' side='right'caption='[[1pzw]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1pzw]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1PZW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1pzw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PZW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">grauzone ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">grauzone ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1pzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pzw OCA], [~~http~~://pdbe.org/1pzw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1pzw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1pzw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1pzw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pzw OCA], [https://pdbe.org/1pzw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pzw RCSB], [https://www.ebi.ac.uk/pdbsum/1pzw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pzw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/GRAU_DROME GRAU_DROME]] Transcription factor essential for the completion of meiosis in oocytes. Grauzone binds to the promoter region of cort via the zf-AD domain and activates cort expression in ovaries.<ref>PMID:10683177</ref> <ref>PMID:10924478</ref>	+	[[https://www.uniprot.org/uniprot/GRAU_DROME GRAU_DROME]] Transcription factor essential for the completion of meiosis in oocytes. Grauzone binds to the promoter region of cort via the zf-AD domain and activates cort expression in ovaries.<ref>PMID:10683177</ref> <ref>PMID:10924478</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 06:57, 24 July 2019

OCA — Wed, 24 Jul 2019 06:57:39 GMT

←Older revision		Revision as of 06:57, 24 July 2019
Line 1:		Line 1:

	==Crystal structure of the zinc finger associated domain of the Drosophila transcription factor Grauzone==		==Crystal structure of the zinc finger associated domain of the Drosophila transcription factor Grauzone==
-	<StructureSection load='1pzw' size='340' side='right' caption='[[1pzw]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='1pzw' size='340' side='right'caption='[[1pzw]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1pzw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PZW FirstGlance]. <br>		<table><tr><td colspan='2'>[[1pzw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PZW FirstGlance]. <br>
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Drome]]		[[Category: Drome]]
		+	[[Category: Large Structures]]
	[[Category: Bourenkov, G P]]		[[Category: Bourenkov, G P]]
	[[Category: Chung, H R]]		[[Category: Chung, H R]]

OCA at 07:59, 24 February 2018

OCA — Sat, 24 Feb 2018 07:59:58 GMT

←Older revision		Revision as of 07:59, 24 February 2018
Line 1:		Line 1:
		+
	==Crystal structure of the zinc finger associated domain of the Drosophila transcription factor Grauzone==		==Crystal structure of the zinc finger associated domain of the Drosophila transcription factor Grauzone==
	<StructureSection load='1pzw' size='340' side='right' caption='[[1pzw]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1pzw' size='340' side='right' caption='[[1pzw]], [[Resolution\|resolution]] 2.00Å' scene=''>
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">grauzone ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">grauzone ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pzw OCA], [http://pdbe.org/1pzw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1pzw RCSB], [http://www.ebi.ac.uk/pdbsum/1pzw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pzw OCA], [http://pdbe.org/1pzw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1pzw RCSB], [http://www.ebi.ac.uk/pdbsum/1pzw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1pzw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pz/1pzw_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pz/1pzw_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 14:30, 8 February 2016

OCA — Mon, 08 Feb 2016 14:30:40 GMT

←Older revision		Revision as of 14:30, 8 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pzw ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 12:29, 10 September 2015

OCA — Thu, 10 Sep 2015 12:29:48 GMT

←Older revision		Revision as of 12:29, 10 September 2015
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	<StructureSection load='1pzw' size='340' side='right' caption='[[1pzw]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1pzw' size='340' side='right' caption='[[1pzw]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1pzw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Drosophila_melanogaster Drosophila melanogaster~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PZW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1pzw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PZW FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">grauzone ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 ~~Drosophila melanogaster~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">grauzone ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pzw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1pzw RCSB], [http://www.ebi.ac.uk/pdbsum/1pzw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pzw OCA], [http://pdbe.org/1pzw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1pzw RCSB], [http://www.ebi.ac.uk/pdbsum/1pzw PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1pzw" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Drosophila melanogaster~~]]	+	[[Category: Drome]]
	[[Category: Bourenkov, G P]]		[[Category: Bourenkov, G P]]
	[[Category: Chung, H R]]		[[Category: Chung, H R]]

OCA at 00:01, 25 December 2014

OCA — Thu, 25 Dec 2014 00:01:14 GMT

←Older revision		Revision as of 00:01, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1pzw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PZW FirstGlance]. <br>		<table><tr><td colspan='2'>[[1pzw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PZW FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">grauzone ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">grauzone ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pzw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1pzw RCSB], [http://www.ebi.ac.uk/pdbsum/1pzw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pzw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1pzw RCSB], [http://www.ebi.ac.uk/pdbsum/1pzw PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GRAU_DROME GRAU_DROME]] Transcription factor essential for the completion of meiosis in oocytes. Grauzone binds to the promoter region of cort via the zf-AD domain and activates cort expression in ovaries.<ref>PMID:10683177</ref> <ref>PMID:10924478</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Drosophila melanogaster]]		[[Category: Drosophila melanogaster]]
-	[[Category: Bourenkov, G P.]]	+	[[Category: Bourenkov, G P]]
-	[[Category: Chung, H R.]]	+	[[Category: Chung, H R]]
-	[[Category: Jaeckle, H.]]	+	[[Category: Jaeckle, H]]
-	[[Category: Jauch, R.]]	+	[[Category: Jauch, R]]
-	[[Category: Reidt, U.]]	+	[[Category: Reidt, U]]
-	[[Category: Urlaub, H.]]	+	[[Category: Urlaub, H]]
-	[[Category: Wahl, M C.]]	+	[[Category: Wahl, M C]]
	[[Category: Dimerization]]		[[Category: Dimerization]]
	[[Category: Transcription]]		[[Category: Transcription]]

OCA at 15:27, 29 September 2014

OCA — Mon, 29 Sep 2014 15:27:10 GMT

←Older revision		Revision as of 15:27, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1pzw.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of the zinc finger associated domain of the Drosophila transcription factor Grauzone==
		+	<StructureSection load='1pzw' size='340' side='right' caption='[[1pzw]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1pzw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PZW FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">grauzone ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pzw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1pzw RCSB], [http://www.ebi.ac.uk/pdbsum/1pzw PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pz/1pzw_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	About one-third of the more than 300 C2H2 zinc finger proteins of Drosophila contain a conserved sequence motif, the zinc finger-associated domain (ZAD). Genes that encode ZAD proteins are specific for and expanded in the genomes of insects. Only three ZAD-encoding gene functions are established, and the role of ZAD is unknown. Here we present the crystal structure of the ZAD of Grauzone (ZAD(Grau)), a Drosophila transcription factor that specifically controls the maternal Cdc20-like APC subunit Cortex. ZAD forms an atypical treble-clef-like zinc-coordinating fold. Head-to-tail arrangement of two ZAD(Grau) molecules in the crystals suggests dimer formation, an observation supported by crosslinking and dynamic light scattering. The results indicate that ZAD provides a novel protein-protein interaction module that characterizes a large family of insect transcription factors.

-	~~{{STRUCTURE_1pzw\| PDB=1pzw \| SCENE= }}~~	+	The zinc finger-associated domain of the Drosophila transcription factor grauzone is a novel zinc-coordinating protein-protein interaction module.,Jauch R, Bourenkov GP, Chung HR, Urlaub H, Reidt U, Jackle H, Wahl MC Structure. 2003 Nov;11(11):1393-402. PMID:14604529<ref>PMID:14604529</ref>

-	~~===Crystal structure~~ of the ~~zinc finger associated domain of the Drosophila transcription factor Grauzone===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_14604529}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1pzw]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Drosophila_melanogaster Drosophila melanogaster]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1PZW OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:014604529<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Drosophila melanogaster]]		[[Category: Drosophila melanogaster]]
	[[Category: Bourenkov, G P.]]		[[Category: Bourenkov, G P.]]

OCA: Protected "1pzw" [edit=sysop:move=sysop]

OCA — Wed, 02 Jan 2013 09:57:09 GMT

Protected "1pzw" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:57, 2 January 2013

OCA at 09:57, 2 January 2013

OCA — Wed, 02 Jan 2013 09:57:06 GMT

←Older revision		Revision as of 09:57, 2 January 2013
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-	{{Seed}}
	[[Image:1pzw.png\|left\|200px]]		[[Image:1pzw.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1pzw", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1pzw\| PDB=1pzw \| SCENE= }}		{{STRUCTURE_1pzw\| PDB=1pzw \| SCENE= }}

	===Crystal structure of the zinc finger associated domain of the Drosophila transcription factor Grauzone===		===Crystal structure of the zinc finger associated domain of the Drosophila transcription factor Grauzone===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_14604529}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 14604529 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_14604529}}		{{ABSTRACT_PUBMED_14604529}}

	==About this Structure==		==About this Structure==
-	~~1PZW~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZW OCA].	+	[[1pzw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZW OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~14604529~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:014604529</ref><references group="xtra"/>
	[[Category: Drosophila melanogaster]]		[[Category: Drosophila melanogaster]]
	[[Category: Bourenkov, G P.]]		[[Category: Bourenkov, G P.]]
Line 33:		Line 21:
	[[Category: Wahl, M C.]]		[[Category: Wahl, M C.]]
	[[Category: Dimerization]]		[[Category: Dimerization]]
		+	[[Category: Transcription]]
	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]
	[[Category: Treble-clef zinc finger]]		[[Category: Treble-clef zinc finger]]
-	[[Category: X-ray crystallography]]
	[[Category: Zad]]		[[Category: Zad]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 23:39:51 2009''