1q1q - Revision history

OCA at 09:55, 16 August 2023

OCA — Wed, 16 Aug 2023 09:55:03 GMT

←Older revision		Revision as of 09:55, 16 August 2023
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	<StructureSection load='1q1q' size='340' side='right'caption='[[1q1q]], [[Resolution\|resolution]] 2.91Å' scene=''>		<StructureSection load='1q1q' size='340' side='right'caption='[[1q1q]], [[Resolution\|resolution]] 2.91Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1q1q]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q1Q OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1Q1Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1q1q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q1Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q1Q FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=A3P:ADENOSINE~~-~~3-5-DIPHOSPHATE'>A3P</scene>~~, ~~<scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NHE:2-~~[~~N-CYCLOHEXYLAMINO~~]~~ETHANE+SULFONIC+ACID'>NHE</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.91Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[1q1z\|1q1z]], [[1q20\|1q20]], [[1q22\|1q22]]~~</~~div~~><~~/td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NHE:2-[N-CYCLOHEXYLAMINO]ETHANE+SULFONIC+ACID'>NHE</scene></td></tr>
-	<~~tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>~~[~~[Gene\|Gene:~~]~~]</b~~></td>~~<td class="sblockDat">SULT2B1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q1q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q1q OCA], [https://pdbe.org/1q1q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q1q RCSB], [https://www.ebi.ac.uk/pdbsum/1q1q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q1q ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1q1q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q1q OCA], [~~http~~://pdbe.org/1q1q PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1q1q RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1q1q PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1q1q ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/ST2B1_HUMAN ST2B1_HUMAN]] Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol, and isoform 2 avidly sulfonates pregnenolone but not cholesterol.<ref>PMID:9799594</ref> <ref>PMID:12145317</ref>	+	[https://www.uniprot.org/uniprot/ST2B1_HUMAN ST2B1_HUMAN] Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol, and isoform 2 avidly sulfonates pregnenolone but not cholesterol.<ref>PMID:9799594</ref> <ref>PMID:12145317</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
-	*[[Sulfotransferase\|Sulfotransferase]]	+	*[[Sulfotransferase 3D structures\|Sulfotransferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Fuda, H]]	+	[[Category: Fuda H]]
-	[[Category: Lee~~, K A~~]]	+	[[Category: Lee KA]]
-	[[Category: Lee~~, Y C~~]]	+	[[Category: Lee YC]]
-	[[Category: Negishi, M]]	+	[[Category: Negishi M]]
-	[[Category: Pedersen~~, L C~~]]	+	[[Category: Pedersen LC]]
-	[[Category: Strott~~, C A]]~~	+	[[Category: Strott CA]]
-	~~[[Category: Pap]]~~	+
-	~~[[Category: Pregnenolone]]~~	+
-	~~[[Category: Sulfotransferase]]~~	+
-	~~[[Category: Sult2b1]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 07:41, 9 December 2020

OCA — Wed, 09 Dec 2020 07:41:14 GMT

←Older revision		Revision as of 07:41, 9 December 2020
Line 1:		Line 1:

	==Crystal structure of human pregnenolone sulfotransferase (SULT2B1a) in the presence of PAP==		==Crystal structure of human pregnenolone sulfotransferase (SULT2B1a) in the presence of PAP==
-	<StructureSection load='1q1q' size='340' side='right' caption='[[1q1q]], [[Resolution\|resolution]] 2.91Å' scene=''>	+	<StructureSection load='1q1q' size='340' side='right'caption='[[1q1q]], [[Resolution\|resolution]] 2.91Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1q1q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q1Q OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1Q1Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1q1q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q1Q OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1Q1Q FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NHE:2-[N-CYCLOHEXYLAMINO]ETHANE+SULFONIC+ACID'>NHE</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NHE:2-[N-CYCLOHEXYLAMINO]ETHANE+SULFONIC+ACID'>NHE</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1q1z\|1q1z]], [[1q20\|1q20]], [[1q22\|1q22]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1q1z\|1q1z]], [[1q20\|1q20]], [[1q22\|1q22]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SULT2B1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SULT2B1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1q1q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q1q OCA], [http://pdbe.org/1q1q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1q1q RCSB], [http://www.ebi.ac.uk/pdbsum/1q1q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1q1q ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1q1q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q1q OCA], [http://pdbe.org/1q1q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1q1q RCSB], [http://www.ebi.ac.uk/pdbsum/1q1q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1q1q ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 15:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q1/1q1q_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q1/1q1q_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 30:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 1q1q" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1q1q" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Sulfotransferase\|Sulfotransferase]]
	== References ==		== References ==
	<references/>		<references/>
Line 35:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Fuda, H]]		[[Category: Fuda, H]]
	[[Category: Lee, K A]]		[[Category: Lee, K A]]

OCA at 07:49, 12 October 2017

OCA — Thu, 12 Oct 2017 07:49:00 GMT

←Older revision		Revision as of 07:49, 12 October 2017
Line 1:		Line 1:
		+
	==Crystal structure of human pregnenolone sulfotransferase (SULT2B1a) in the presence of PAP==		==Crystal structure of human pregnenolone sulfotransferase (SULT2B1a) in the presence of PAP==
	<StructureSection load='1q1q' size='340' side='right' caption='[[1q1q]], [[Resolution\|resolution]] 2.91Å' scene=''>		<StructureSection load='1q1q' size='340' side='right' caption='[[1q1q]], [[Resolution\|resolution]] 2.91Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1q1z\|1q1z]], [[1q20\|1q20]], [[1q22\|1q22]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1q1z\|1q1z]], [[1q20\|1q20]], [[1q22\|1q22]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SULT2B1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SULT2B1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q1q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q1q OCA], [http://pdbe.org/1q1q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1q1q RCSB], [http://www.ebi.ac.uk/pdbsum/1q1q PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q1q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q1q OCA], [http://pdbe.org/1q1q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1q1q RCSB], [http://www.ebi.ac.uk/pdbsum/1q1q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1q1q ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 1q1q" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1q1q" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Sulfotransferase\|Sulfotransferase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 18:01, 7 February 2016

OCA — Sun, 07 Feb 2016 18:01:25 GMT

←Older revision		Revision as of 18:01, 7 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1q1q ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 03:51, 10 September 2015

OCA — Thu, 10 Sep 2015 03:51:29 GMT

←Older revision		Revision as of 03:51, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1q1q' size='340' side='right' caption='[[1q1q]], [[Resolution\|resolution]] 2.91Å' scene=''>		<StructureSection load='1q1q' size='340' side='right' caption='[[1q1q]], [[Resolution\|resolution]] 2.91Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1q1q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q1Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Q1Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1q1q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q1Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Q1Q FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NHE:2-[N-CYCLOHEXYLAMINO]ETHANE+SULFONIC+ACID'>NHE</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NHE:2-[N-CYCLOHEXYLAMINO]ETHANE+SULFONIC+ACID'>NHE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1q1z\|1q1z]], [[1q20\|1q20]], [[1q22\|1q22]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1q1z\|1q1z]], [[1q20\|1q20]], [[1q22\|1q22]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SULT2B1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SULT2B1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q1q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q1q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1q1q RCSB], [http://www.ebi.ac.uk/pdbsum/1q1q PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q1q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q1q OCA], [http://pdbe.org/1q1q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1q1q RCSB], [http://www.ebi.ac.uk/pdbsum/1q1q PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1q1q" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Fuda, H]]		[[Category: Fuda, H]]
	[[Category: Lee, K A]]		[[Category: Lee, K A]]

OCA at 17:16, 24 December 2014

OCA — Wed, 24 Dec 2014 17:16:35 GMT

←Older revision		Revision as of 17:16, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1q1q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q1Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Q1Q FirstGlance]. <br>		<table><tr><td colspan='2'>[[1q1q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q1Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Q1Q FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NHE:2-[N-CYCLOHEXYLAMINO]ETHANE+SULFONIC+ACID'>NHE</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NHE:2-[N-CYCLOHEXYLAMINO]ETHANE+SULFONIC+ACID'>NHE</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1q1z\|1q1z]], [[1q20\|1q20]], [[1q22\|1q22]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1q1z\|1q1z]], [[1q20\|1q20]], [[1q22\|1q22]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SULT2B1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SULT2B1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q1q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q1q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1q1q RCSB], [http://www.ebi.ac.uk/pdbsum/1q1q PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q1q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q1q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1q1q RCSB], [http://www.ebi.ac.uk/pdbsum/1q1q PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ST2B1_HUMAN ST2B1_HUMAN]] Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol, and isoform 2 avidly sulfonates pregnenolone but not cholesterol.<ref>PMID:9799594</ref> <ref>PMID:12145317</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Fuda, H.]]	+	[[Category: Fuda, H]]
-	[[Category: Lee, K A.]]	+	[[Category: Lee, K A]]
-	[[Category: Lee, Y C.]]	+	[[Category: Lee, Y C]]
-	[[Category: Negishi, M.]]	+	[[Category: Negishi, M]]
-	[[Category: Pedersen, L C.]]	+	[[Category: Pedersen, L C]]
-	[[Category: Strott, C A.]]	+	[[Category: Strott, C A]]
	[[Category: Pap]]		[[Category: Pap]]
	[[Category: Pregnenolone]]		[[Category: Pregnenolone]]

OCA at 19:16, 28 September 2014

OCA — Sun, 28 Sep 2014 19:16:10 GMT

←Older revision		Revision as of 19:16, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1q1q.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of human pregnenolone sulfotransferase (SULT2B1a) in the presence of PAP==
		+	<StructureSection load='1q1q' size='340' side='right' caption='[[1q1q]], [[Resolution\|resolution]] 2.91Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1q1q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q1Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Q1Q FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NHE:2-[N-CYCLOHEXYLAMINO]ETHANE+SULFONIC+ACID'>NHE</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1q1z\|1q1z]], [[1q20\|1q20]], [[1q22\|1q22]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SULT2B1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q1q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q1q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1q1q RCSB], [http://www.ebi.ac.uk/pdbsum/1q1q PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q1/1q1q_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The gene for human hydroxysteroid sulfotransferase (SULT2B1) encodes two peptides, SULT2B1a and SULT2B1b, that differ only at their amino termini. SULT2B1b has a predilection for cholesterol but is also capable of sulfonating pregnenolone, whereas SULT2B1a preferentially sulfonates pregnenolone and only minimally sulfonates cholesterol. We have determined the crystal structure of SULT2B1a and SULT2B1b bound to the substrate donor product 3'-phosphoadenosine 5'-phosphate at 2.9 and 2.4 A, respectively, as well as SULT2B1b in the presence of the acceptor substrate pregnenolone at 2.3 A. These structures reveal a different catalytic binding orientation for the substrate from a previously determined structure of hydroxysteroid sulfotransferase (SULT2A1) binding dehydroepiandrosterone. In addition, the amino-terminal helix comprising residues Asp19 to Lys26, which determines the specificity difference between the SULT2B1 isoforms, becomes ordered upon pregnenolone binding, covering the substrate binding pocket.

-	~~{{STRUCTURE_1q1q\| PDB=1q1q \| SCENE= }}~~	+	Crystal structure of human cholesterol sulfotransferase (SULT2B1b) in the presence of pregnenolone and 3'-phosphoadenosine 5'-phosphate. Rationale for specificity differences between prototypical SULT2A1 and the SULT2BG1 isoforms.,Lee KA, Fuda H, Lee YC, Negishi M, Strott CA, Pedersen LC J Biol Chem. 2003 Nov 7;278(45):44593-9. Epub 2003 Aug 14. PMID:12923182<ref>PMID:12923182</ref>

-	~~===Crystal structure~~ of ~~human pregnenolone sulfotransferase (SULT2B1a) in~~ the ~~presence of PAP===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_12923182}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1q1q]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1Q1Q OCA].~~	+

	==See Also==		==See Also==
	*[[Sulfotransferase\|Sulfotransferase]]		*[[Sulfotransferase\|Sulfotransferase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:012923182<~~/~~ref~~><~~ref group="xtra">PMID:017425406</ref><references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Fuda, H.]]		[[Category: Fuda, H.]]

OCA at 07:27, 20 October 2012

OCA — Sat, 20 Oct 2012 07:27:38 GMT

←Older revision		Revision as of 07:27, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1q1q]] is a 1 chain structure ~~of [[Sulfotransferase]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q1Q OCA].	+	[[1q1q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q1Q OCA].

	==See Also==		==See Also==

OCA: Protected "1q1q" [edit=sysop:move=sysop]

OCA — Wed, 25 Jul 2012 16:23:27 GMT

Protected "1q1q" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:23, 25 July 2012

OCA at 16:23, 25 July 2012

OCA — Wed, 25 Jul 2012 16:23:26 GMT

←Older revision		Revision as of 16:23, 25 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1q1q.png\|left\|200px]]		[[Image:1q1q.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1q1q", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1q1q\| PDB=1q1q \| SCENE= }}		{{STRUCTURE_1q1q\| PDB=1q1q \| SCENE= }}

	===Crystal structure of human pregnenolone sulfotransferase (SULT2B1a) in the presence of PAP===		===Crystal structure of human pregnenolone sulfotransferase (SULT2B1a) in the presence of PAP===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_12923182}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 12923182 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_12923182}}		{{ABSTRACT_PUBMED_12923182}}

	==About this Structure==		==About this Structure==
-	~~1Q1Q~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q1Q OCA].	+	[[1q1q]] is a 1 chain structure of [[Sulfotransferase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q1Q OCA].
		+
		+	==See Also==
		+	*[[Sulfotransferase\|Sulfotransferase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~12923182~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:012923182</ref><ref group="xtra">PMID:017425406</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Fuda, H.]]		[[Category: Fuda, H.]]
Line 35:		Line 26:
	[[Category: Sulfotransferase]]		[[Category: Sulfotransferase]]
	[[Category: Sult2b1]]		[[Category: Sult2b1]]
-		+	[[Category: Transferase]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Mon Feb 16 15:36:13 2009''~~	+