1q1u - Revision history

OCA at 09:55, 16 August 2023

OCA — Wed, 16 Aug 2023 09:55:17 GMT

←Older revision		Revision as of 09:55, 16 August 2023
Line 3:		Line 3:
	<StructureSection load='1q1u' size='340' side='right'caption='[[1q1u]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='1q1u' size='340' side='right'caption='[[1q1u]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1q1u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q1U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q1U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1q1u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q1U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q1U FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q1u OCA], [https://pdbe.org/1q1u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q1u RCSB], [https://www.ebi.ac.uk/pdbsum/1q1u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q1u ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q1u OCA], [https://pdbe.org/1q1u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q1u RCSB], [https://www.ebi.ac.uk/pdbsum/1q1u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q1u ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/FGF12_HUMAN FGF12_HUMAN]] Probably involved in nervous system development and function.	+	[https://www.uniprot.org/uniprot/FGF12_HUMAN FGF12_HUMAN] Probably involved in nervous system development and function.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Eliseenkova~~, A V~~]]	+	[[Category: Eliseenkova AV]]
-	[[Category: Garbi, M]]	+	[[Category: Garbi M]]
-	[[Category: Goldfarb, M]]	+	[[Category: Goldfarb M]]
-	[[Category: Mohammadi, M]]	+	[[Category: Mohammadi M]]
-	[[Category: Olsen~~, S K~~]]	+	[[Category: Olsen SK]]
-	[[Category: Ornitz~~, D M~~]]	+	[[Category: Ornitz DM]]
-	[[Category: Zampieri, N]]	+	[[Category: Zampieri N]]
-	~~[[Category: Crystal structure]]~~	+
-	~~[[Category: Fgf-12]]~~	+
-	~~[[Category: Hormone-growth factor complex~~]]	+

OCA at 09:37, 8 September 2021

OCA — Wed, 08 Sep 2021 09:37:23 GMT

←Older revision		Revision as of 09:37, 8 September 2021
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	<StructureSection load='1q1u' size='340' side='right'caption='[[1q1u]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='1q1u' size='340' side='right'caption='[[1q1u]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1q1u]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q1U OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1Q1U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1q1u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q1U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q1U FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1q1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q1u OCA], [~~http~~://pdbe.org/1q1u PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1q1u RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1q1u PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1q1u ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q1u OCA], [https://pdbe.org/1q1u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q1u RCSB], [https://www.ebi.ac.uk/pdbsum/1q1u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q1u ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/FGF12_HUMAN FGF12_HUMAN]] Probably involved in nervous system development and function.	+	[[https://www.uniprot.org/uniprot/FGF12_HUMAN FGF12_HUMAN]] Probably involved in nervous system development and function.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 09:39, 27 November 2019

OCA — Wed, 27 Nov 2019 09:39:42 GMT

←Older revision		Revision as of 09:39, 27 November 2019
Line 1:		Line 1:

	==Crystal structure of human FHF1b (FGF12b)==		==Crystal structure of human FHF1b (FGF12b)==
-	<StructureSection load='1q1u' size='340' side='right' caption='[[1q1u]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='1q1u' size='340' side='right'caption='[[1q1u]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1q1u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q1U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Q1U FirstGlance]. <br>		<table><tr><td colspan='2'>[[1q1u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q1U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Q1U FirstGlance]. <br>
Line 28:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 1q1u" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1q1u" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Fibroblast growth factor 3D structures\|Fibroblast growth factor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 33:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Eliseenkova, A V]]		[[Category: Eliseenkova, A V]]
	[[Category: Garbi, M]]		[[Category: Garbi, M]]

OCA at 07:50, 24 February 2018

OCA — Sat, 24 Feb 2018 07:50:51 GMT

←Older revision		Revision as of 07:50, 24 February 2018
Line 1:		Line 1:
		+
	==Crystal structure of human FHF1b (FGF12b)==		==Crystal structure of human FHF1b (FGF12b)==
	<StructureSection load='1q1u' size='340' side='right' caption='[[1q1u]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='1q1u' size='340' side='right' caption='[[1q1u]], [[Resolution\|resolution]] 1.70Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1q1u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q1U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Q1U FirstGlance]. <br>		<table><tr><td colspan='2'>[[1q1u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q1U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Q1U FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q1u OCA], [http://pdbe.org/1q1u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1q1u RCSB], [http://www.ebi.ac.uk/pdbsum/1q1u PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q1u OCA], [http://pdbe.org/1q1u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1q1u RCSB], [http://www.ebi.ac.uk/pdbsum/1q1u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1q1u ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q1/1q1u_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q1/1q1u_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1q1u ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 1q1u" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1q1u" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Fibroblast growth factor\|Fibroblast growth factor]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 22:44, 11 September 2015

OCA — Fri, 11 Sep 2015 22:44:53 GMT

←Older revision		Revision as of 22:44, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1q1u' size='340' side='right' caption='[[1q1u]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='1q1u' size='340' side='right' caption='[[1q1u]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1q1u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q1U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Q1U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1q1u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q1U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Q1U FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q1u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1q1u RCSB], [http://www.ebi.ac.uk/pdbsum/1q1u PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q1u OCA], [http://pdbe.org/1q1u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1q1u RCSB], [http://www.ebi.ac.uk/pdbsum/1q1u PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1q1u" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Eliseenkova, A V]]		[[Category: Eliseenkova, A V]]
	[[Category: Garbi, M]]		[[Category: Garbi, M]]
Line 44:		Line 45:
	[[Category: Fgf-12]]		[[Category: Fgf-12]]
	[[Category: Hormone-growth factor complex]]		[[Category: Hormone-growth factor complex]]
-	[[Category: Human]]

OCA at 20:26, 25 December 2014

OCA — Thu, 25 Dec 2014 20:26:38 GMT

←Older revision		Revision as of 20:26, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1q1u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q1U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Q1U FirstGlance]. <br>		<table><tr><td colspan='2'>[[1q1u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q1U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Q1U FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q1u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1q1u RCSB], [http://www.ebi.ac.uk/pdbsum/1q1u PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q1u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1q1u RCSB], [http://www.ebi.ac.uk/pdbsum/1q1u PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FGF12_HUMAN FGF12_HUMAN]] Probably involved in nervous system development and function.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Eliseenkova, A V.]]	+	[[Category: Eliseenkova, A V]]
-	[[Category: Garbi, M.]]	+	[[Category: Garbi, M]]
-	[[Category: Goldfarb, M.]]	+	[[Category: Goldfarb, M]]
-	[[Category: Mohammadi, M.]]	+	[[Category: Mohammadi, M]]
-	[[Category: Olsen, S K.]]	+	[[Category: Olsen, S K]]
-	[[Category: Ornitz, D M.]]	+	[[Category: Ornitz, D M]]
-	[[Category: Zampieri, N.]]	+	[[Category: Zampieri, N]]
	[[Category: Crystal structure]]		[[Category: Crystal structure]]
	[[Category: Fgf-12]]		[[Category: Fgf-12]]
	[[Category: Hormone-growth factor complex]]		[[Category: Hormone-growth factor complex]]
	[[Category: Human]]		[[Category: Human]]

OCA at 15:20, 29 September 2014

OCA — Mon, 29 Sep 2014 15:20:32 GMT

←Older revision		Revision as of 15:20, 29 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1q1u.~~png\|left~~\|200px]]	+	==Crystal structure of human FHF1b (FGF12b)==
		+	<StructureSection load='1q1u' size='340' side='right' caption='[[1q1u]], [[Resolution\|resolution]] 1.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1q1u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q1U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Q1U FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q1u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1q1u RCSB], [http://www.ebi.ac.uk/pdbsum/1q1u PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q1/1q1u_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Fibroblast growth factors (FGFs) interact with heparan sulfate glycosaminoglycans and the extracellular domains of FGF cell surface receptors (FGFRs) to trigger receptor activation and biological responses. FGF homologous factors (FHF1-FHF4; also known as FGF11-FGF14) are related to FGFs by substantial sequence homology, yet their only documented interactions are with an intracellular kinase scaffold protein, islet brain-2 (IB2) and with voltage-gated sodium channels. In this report, we show that recombinant FHFs can bind heparin with high affinity like classical FGFs yet fail to activate any of the seven principal FGFRs. Instead, we demonstrate that FHFs bind IB2 directly, furthering the contention that FHFs and FGFs elicit their biological effects by binding to different protein partners. To understand the molecular basis for this differential target binding specificity, we elucidated the crystal structure of FHF1b to 1.7-A resolution. The FHF1b core domain assumes a beta-trefoil fold consisting of 12 antiparallel beta strands (beta 1 through beta 12). The FHF1b beta-trefoil core is remarkably similar to that of classical FGFs and exhibits an FGF-characteristic heparin-binding surface as attested to by the number of bound sulfate ions. Using molecular modeling and structure-based mutational analysis, we identified two surface residues, Arg52 in the beta 4-beta 5 loop and Val95 in the beta 9 strand of FHF1b that are required for the interaction of FHF1b with IB2. These two residues are unique to FHFs, and mutations of the corresponding residues of FGF1 to Arg and Val diminish the capacity of FGF1 to activate FGFRs, suggesting that these two FHF residues contribute to the inability of FHFs to activate FGFRs. Hence, FHFs and FGFs bear striking structural similarity but have diverged to direct related surfaces toward interaction with distinct protein targets.

-	~~{{STRUCTURE_1q1u\| PDB=1q1u \| SCENE= }}~~	+	Fibroblast growth factor (FGF) homologous factors share structural but not functional homology with FGFs.,Olsen SK, Garbi M, Zampieri N, Eliseenkova AV, Ornitz DM, Goldfarb M, Mohammadi M J Biol Chem. 2003 Sep 5;278(36):34226-36. Epub 2003 Jun 17. PMID:12815063<ref>PMID:12815063</ref>

-	~~===Crystal structure~~ of ~~human FHF1b (FGF12b)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_12815063}}~~	+	==See Also==
-		+	*[[Fibroblast growth factor\|Fibroblast growth factor]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~1q1u~~]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q1U OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:012815063<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Eliseenkova, A V.]]		[[Category: Eliseenkova, A V.]]

OCA: Protected "1q1u" [edit=sysop:move=sysop]

OCA — Wed, 02 Jan 2013 09:43:08 GMT

Protected "1q1u" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:43, 2 January 2013

OCA at 09:43, 2 January 2013

OCA — Wed, 02 Jan 2013 09:43:04 GMT

←Older revision		Revision as of 09:43, 2 January 2013
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-	{{Seed}}
	[[Image:1q1u.png\|left\|200px]]		[[Image:1q1u.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1q1u", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1q1u\| PDB=1q1u \| SCENE= }}		{{STRUCTURE_1q1u\| PDB=1q1u \| SCENE= }}

	===Crystal structure of human FHF1b (FGF12b)===		===Crystal structure of human FHF1b (FGF12b)===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_12815063}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 12815063 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_12815063}}		{{ABSTRACT_PUBMED_12815063}}

	==About this Structure==		==About this Structure==
-	~~1Q1U~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q1U OCA].	+	[[1q1u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q1U OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~12815063~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:012815063</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Eliseenkova, A V.]]		[[Category: Eliseenkova, A V.]]
Line 34:		Line 22:
	[[Category: Crystal structure]]		[[Category: Crystal structure]]
	[[Category: Fgf-12]]		[[Category: Fgf-12]]
		+	[[Category: Hormone-growth factor complex]]
	[[Category: Human]]		[[Category: Human]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 06:12:20 2009''

OCA at 04:12, 18 February 2009

OCA — Wed, 18 Feb 2009 04:12:21 GMT

←Older revision		Revision as of 04:12, 18 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	1Q1U is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q1U OCA].	+	1Q1U is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q1U OCA].

	==Reference==		==Reference==
-	Fibroblast growth factor (FGF) homologous factors share structural but not functional homology with FGFs., Olsen SK, Garbi M, Zampieri N, Eliseenkova AV, Ornitz DM, Goldfarb M, Mohammadi M, J Biol Chem. 2003 Sep 5;278(36):34226-36. Epub 2003 Jun 17. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/12815063 12815063]~~	+	<ref group="xtra">PMID:12815063</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Single protein]]
	[[Category: Eliseenkova, A V.]]		[[Category: Eliseenkova, A V.]]
	[[Category: Garbi, M.]]		[[Category: Garbi, M.]]
Line 37:		Line 36:
	[[Category: Human]]		[[Category: Human]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 29 12~~:55:~~03 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 06:12:20 2009''