1q3x - Revision history

OCA at 09:56, 16 August 2023

OCA — Wed, 16 Aug 2023 09:56:42 GMT

←Older revision		Revision as of 09:56, 16 August 2023
Line 3:		Line 3:
	<StructureSection load='1q3x' size='340' side='right'caption='[[1q3x]], [[Resolution\|resolution]] 2.23Å' scene=''>		<StructureSection load='1q3x' size='340' side='right'caption='[[1q3x]], [[Resolution\|resolution]] 2.23Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1q3x]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q3X OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1Q3X FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1q3x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q3X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q3X FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~, ~~<scene name='pdbligand=NA:SODIUM+ION'>NA</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.23Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~MASP2 ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1q3x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q3x OCA], [~~http~~://pdbe.org/1q3x PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1q3x RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1q3x PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1q3x ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q3x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q3x OCA], [https://pdbe.org/1q3x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q3x RCSB], [https://www.ebi.ac.uk/pdbsum/1q3x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q3x ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/MASP2_HUMAN MASP2_HUMAN]] Defects in MASP2 are the cause of MASP2 deficiency (MASPD) [MIM:[~~http~~://omim.org/entry/613791 613791]]. MASPD is a disorder that results in autoimmune manifestations, recurrent severe infections, and chronic inflammatory disease.<ref>PMID:12904520</ref> <ref>PMID:17252003</ref>	+	[https://www.uniprot.org/uniprot/MASP2_HUMAN MASP2_HUMAN] Defects in MASP2 are the cause of MASP2 deficiency (MASPD) [MIM:[https://omim.org/entry/613791 613791]. MASPD is a disorder that results in autoimmune manifestations, recurrent severe infections, and chronic inflammatory disease.<ref>PMID:12904520</ref> <ref>PMID:17252003</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/MASP2_HUMAN MASP2_HUMAN]] Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase.<ref>PMID:10946292</ref>	+	[https://www.uniprot.org/uniprot/MASP2_HUMAN MASP2_HUMAN] Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase.<ref>PMID:10946292</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ambrus, G]]	+	[[Category: Ambrus G]]
-	[[Category: Gal, P]]	+	[[Category: Gal P]]
-	[[Category: Harmat, V]]	+	[[Category: Harmat V]]
-	[[Category: Kardos, J]]	+	[[Category: Kardos J]]
-	[[Category: Naray-Szabo, G]]	+	[[Category: Naray-Szabo G]]
-	[[Category: Szilagyi, K]]	+	[[Category: Szilagyi K]]
-	[[Category: Zavodszky, P]]	+	[[Category: Zavodszky P]]
-	~~[[Category: Autoactivation]]~~	+
-	~~[[Category: Complement]]~~	+
-	~~[[Category: Hinge bending]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Modular structure]]~~	+
-	~~[[Category: Serine protease~~]]	+

OCA at 07:42, 9 December 2020

OCA — Wed, 09 Dec 2020 07:42:49 GMT

←Older revision		Revision as of 07:42, 9 December 2020
Line 1:		Line 1:

	==Crystal structure of the catalytic region of human MASP-2==		==Crystal structure of the catalytic region of human MASP-2==
-	<StructureSection load='1q3x' size='340' side='right' caption='[[1q3x]], [[Resolution\|resolution]] 2.23Å' scene=''>	+	<StructureSection load='1q3x' size='340' side='right'caption='[[1q3x]], [[Resolution\|resolution]] 2.23Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1q3x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q3X OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1Q3X FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1q3x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q3X OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1Q3X FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MASP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MASP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1q3x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q3x OCA], [http://pdbe.org/1q3x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1q3x RCSB], [http://www.ebi.ac.uk/pdbsum/1q3x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1q3x ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1q3x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q3x OCA], [http://pdbe.org/1q3x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1q3x RCSB], [http://www.ebi.ac.uk/pdbsum/1q3x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1q3x ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 31:		Line 31:
	</div>		</div>
	<div class="pdbe-citations 1q3x" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1q3x" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Mannan-binding lectin serine protease\|Mannan-binding lectin serine protease]]
	== References ==		== References ==
	<references/>		<references/>
Line 36:		Line 39:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Ambrus, G]]		[[Category: Ambrus, G]]
	[[Category: Gal, P]]		[[Category: Gal, P]]

OCA at 08:25, 24 February 2018

OCA — Sat, 24 Feb 2018 08:25:53 GMT

←Older revision		Revision as of 08:25, 24 February 2018
Line 1:		Line 1:
		+
	==Crystal structure of the catalytic region of human MASP-2==		==Crystal structure of the catalytic region of human MASP-2==
	<StructureSection load='1q3x' size='340' side='right' caption='[[1q3x]], [[Resolution\|resolution]] 2.23Å' scene=''>		<StructureSection load='1q3x' size='340' side='right' caption='[[1q3x]], [[Resolution\|resolution]] 2.23Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MASP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MASP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q3x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q3x OCA], [http://pdbe.org/1q3x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1q3x RCSB], [http://www.ebi.ac.uk/pdbsum/1q3x PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q3x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q3x OCA], [http://pdbe.org/1q3x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1q3x RCSB], [http://www.ebi.ac.uk/pdbsum/1q3x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1q3x ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 15:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q3/1q3x_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q3/1q3x_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 03:40, 10 February 2016

OCA — Wed, 10 Feb 2016 03:40:37 GMT

←Older revision		Revision as of 03:40, 10 February 2016
Line 19:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1q3x ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 05:01, 11 September 2015

OCA — Fri, 11 Sep 2015 05:01:07 GMT

←Older revision		Revision as of 05:01, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1q3x' size='340' side='right' caption='[[1q3x]], [[Resolution\|resolution]] 2.23Å' scene=''>		<StructureSection load='1q3x' size='340' side='right' caption='[[1q3x]], [[Resolution\|resolution]] 2.23Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1q3x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q3X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Q3X FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1q3x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q3X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Q3X FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MASP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MASP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q3x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q3x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1q3x RCSB], [http://www.ebi.ac.uk/pdbsum/1q3x PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q3x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q3x OCA], [http://pdbe.org/1q3x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1q3x RCSB], [http://www.ebi.ac.uk/pdbsum/1q3x PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1q3x" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Ambrus, G]]		[[Category: Ambrus, G]]
	[[Category: Gal, P]]		[[Category: Gal, P]]

OCA at 07:25, 6 January 2015

OCA — Tue, 06 Jan 2015 07:25:52 GMT

←Older revision		Revision as of 07:25, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1q3x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q3X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Q3X FirstGlance]. <br>		<table><tr><td colspan='2'>[[1q3x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q3X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Q3X FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MASP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MASP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q3x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q3x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1q3x RCSB], [http://www.ebi.ac.uk/pdbsum/1q3x PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q3x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q3x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1q3x RCSB], [http://www.ebi.ac.uk/pdbsum/1q3x PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/MASP2_HUMAN MASP2_HUMAN]] Defects in MASP2 are the cause of MASP2 deficiency (MASPD) [MIM:[http://omim.org/entry/613791 613791]]. MASPD is a disorder that results in autoimmune manifestations, recurrent severe infections, and chronic inflammatory disease.<ref>PMID:12904520</ref> <ref>PMID:17252003</ref>		[[http://www.uniprot.org/uniprot/MASP2_HUMAN MASP2_HUMAN]] Defects in MASP2 are the cause of MASP2 deficiency (MASPD) [MIM:[http://omim.org/entry/613791 613791]]. MASPD is a disorder that results in autoimmune manifestations, recurrent severe infections, and chronic inflammatory disease.<ref>PMID:12904520</ref> <ref>PMID:17252003</ref>
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Ambrus, G.]]	+	[[Category: Ambrus, G]]
-	[[Category: Gal, P.]]	+	[[Category: Gal, P]]
-	[[Category: Harmat, V.]]	+	[[Category: Harmat, V]]
-	[[Category: Kardos, J.]]	+	[[Category: Kardos, J]]
-	[[Category: Naray-Szabo, G.]]	+	[[Category: Naray-Szabo, G]]
-	[[Category: Szilagyi, K.]]	+	[[Category: Szilagyi, K]]
-	[[Category: Zavodszky, P.]]	+	[[Category: Zavodszky, P]]
	[[Category: Autoactivation]]		[[Category: Autoactivation]]
	[[Category: Complement]]		[[Category: Complement]]

OCA at 14:15, 29 September 2014

OCA — Mon, 29 Sep 2014 14:15:08 GMT

←Older revision		Revision as of 14:15, 29 September 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1q3x~~\| ~~PDB~~=1q3x \| ~~SCENE~~= }}	+	==Crystal structure of the catalytic region of human MASP-2==
-	===~~Crystal structure~~ of the catalytic ~~region~~ of ~~human MASP~~-2===	+	<StructureSection load='1q3x' size='340' side='right' caption='[[1q3x]], [[Resolution\|resolution]] 2.23Å' scene=''>
-	~~{{ABSTRACT_PUBMED_15364579}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1q3x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q3X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Q3X FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MASP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q3x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q3x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1q3x RCSB], [http://www.ebi.ac.uk/pdbsum/1q3x PDBsum]</span></td></tr>
		+	<table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/MASP2_HUMAN MASP2_HUMAN]] Defects in MASP2 are the cause of MASP2 deficiency (MASPD) [MIM:[http://omim.org/entry/613791 613791]]. MASPD is a disorder that results in autoimmune manifestations, recurrent severe infections, and chronic inflammatory disease.<ref>PMID:12904520</ref> <ref>PMID:17252003</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MASP2_HUMAN MASP2_HUMAN]] Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase.<ref>PMID:10946292</ref>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q3/1q3x_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A family of serine proteases mediates the proteolytic cascades of several defense mechanisms in vertebrates, such as the complement system, blood coagulation and fibrinolysis. These proteases usually form large complexes with other glycoproteins. Their common features are their modular structures and restricted substrate specificities. The lectin pathway of complement, where mannose-binding lectin (MBL) recognizes the carbohydrate structures on pathogens, is activated by mannose-binding lectin-associated serine protease-2 (MASP-2). We present the 2.25A resolution structure of the catalytic fragment of MASP-2 encompassing the second complement control protein module (CCP2) and the serine protease (SP) domain. The CCP2 module stabilizes the structure of the SP domain as demonstrated by differential scanning calorimetry measurements. The asymmetric unit contains two molecules with different CCP-SP domain orientations, reflecting increased modular flexibility at the CCP2/SP joint. This flexibility may partly explain the ability of the MASP-2 dimer to perform all of its functions alone, whereas the same functions are mediated by the much larger C1r2-C1s2 tetramer in the C1 complex of the classical pathway. The main scaffold of the MASP-2 SP domain is chymotrypsin-like. Eight surface loops determine the S1 and other subsite specificities. Surprisingly, some surface loops of MASP-2, e.g. loop 1 and loop 2, which form the S1 pocket are similar to those of trypsin, and show significant differences if compared with those of C1s, indicating that the nearly identical substrate specificities of C1s and MASP-2 are realized through different sets of enzyme-substrate interactions.

-	~~==Disease==~~	+	The structure of MBL-associated serine protease-2 reveals that identical substrate specificities of C1s and MASP-2 are realized through different sets of enzyme-substrate interactions.,Harmat V, Gal P, Kardos J, Szilagyi K, Ambrus G, Vegh B, Naray-Szabo G, Zavodszky P J Mol Biol. 2004 Oct 1;342(5):1533-46. PMID:15364579<ref>PMID:15364579</ref>
-	~~[[http://www~~.~~uniprot~~.~~org/uniprot/MASP2_HUMAN MASP2_HUMAN]] Defects in MASP2 are the cause of MASP2 deficiency~~ (~~MASPD~~) ~~[MIM~~:~~[http://omim~~.~~org/entry/613791 613791]]. MASPD is a disorder that results in autoimmune manifestations, recurrent severe infections, and chronic inflammatory disease.<ref>~~PMID:~~12904520</ref>~~<ref>PMID:~~17252003~~</ref>	+

-	~~==Function==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[http:~~/~~/www.uniprot.org/uniprot/MASP2_HUMAN MASP2_HUMAN]] Serum protease that plays an important role in the activation~~ of the ~~complement system via mannose-binding lectin~~. ~~After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation~~ of ~~C3 convertase~~.<~~ref~~>~~PMID:10946292~~</~~ref~~>	+	</div>
-		+	== References ==
-	==~~About this Structure==~~	+	<references/>
-	[[1q3x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q3X OCA].	+	__TOC__
-		+	</StructureSection>
-	~~==Reference~~==	+
-	~~<ref group="xtra">PMID:015364579</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Ambrus, G.]]		[[Category: Ambrus, G.]]

OCA at 23:31, 24 March 2013

OCA — Sun, 24 Mar 2013 23:31:13 GMT

←Older revision		Revision as of 23:31, 24 March 2013
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-	[[Image:1q3x.png\|left\|200px]]
-
	{{STRUCTURE_1q3x\| PDB=1q3x \| SCENE= }}		{{STRUCTURE_1q3x\| PDB=1q3x \| SCENE= }}
-
	===Crystal structure of the catalytic region of human MASP-2===		===Crystal structure of the catalytic region of human MASP-2===
		+	{{ABSTRACT_PUBMED_15364579}}

-	~~{{ABSTRACT_PUBMED_15364579}}~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/MASP2_HUMAN MASP2_HUMAN]] Defects in MASP2 are the cause of MASP2 deficiency (MASPD) [MIM:[http://omim.org/entry/613791 613791]]. MASPD is a disorder that results in autoimmune manifestations, recurrent severe infections, and chronic inflammatory disease.<ref>PMID:12904520</ref><ref>PMID:17252003</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/MASP2_HUMAN MASP2_HUMAN]] Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase.<ref>PMID:10946292</ref>

	==About this Structure==		==About this Structure==
Line 11:		Line 13:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:015364579</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015364579</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Ambrus, G.]]		[[Category: Ambrus, G.]]

OCA: Protected "1q3x" [edit=sysop:move=sysop]

OCA — Wed, 02 Jan 2013 10:01:30 GMT

Protected "1q3x" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:01, 2 January 2013

OCA at 10:01, 2 January 2013

OCA — Wed, 02 Jan 2013 10:01:28 GMT

←Older revision		Revision as of 10:01, 2 January 2013
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-	{{Seed}}
	[[Image:1q3x.png\|left\|200px]]		[[Image:1q3x.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1q3x", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1q3x\| PDB=1q3x \| SCENE= }}		{{STRUCTURE_1q3x\| PDB=1q3x \| SCENE= }}

	===Crystal structure of the catalytic region of human MASP-2===		===Crystal structure of the catalytic region of human MASP-2===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15364579}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15364579 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15364579}}		{{ABSTRACT_PUBMED_15364579}}
-
-	==Disease==
-	Known disease associated with this structure: MASP2 deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=605102 605102]]

	==About this Structure==		==About this Structure==
-	~~1Q3X~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q3X OCA].	+	[[1q3x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q3X OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15364579~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015364579</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Ambrus, G.]]		[[Category: Ambrus, G.]]
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	[[Category: Complement]]		[[Category: Complement]]
	[[Category: Hinge bending]]		[[Category: Hinge bending]]
		+	[[Category: Hydrolase]]
	[[Category: Modular structure]]		[[Category: Modular structure]]
	[[Category: Serine protease]]		[[Category: Serine protease]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 15:08:30 2009''