1q6x - Revision history

OCA at 09:58, 16 August 2023

OCA — Wed, 16 Aug 2023 09:58:42 GMT

←Older revision		Revision as of 09:58, 16 August 2023
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	<StructureSection load='1q6x' size='340' side='right'caption='[[1q6x]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1q6x' size='340' side='right'caption='[[1q6x]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1q6x]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q6X OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1Q6X FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1q6x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q6X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q6X FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=NA:SODIUM+ION'>NA</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>cholinergic gene locus ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~10116 Buffalo rat])</td~~><~~/tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[http://en.wikipedia.org/wiki/Choline_O-acetyltransferase Choline O-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.6 2.3.1.6]~~ </~~span~~></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q6x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q6x OCA], [https://pdbe.org/1q6x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q6x RCSB], [https://www.ebi.ac.uk/pdbsum/1q6x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q6x ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1q6x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q6x OCA], [~~http~~://pdbe.org/1q6x PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1q6x RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1q6x PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1q6x ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CLAT_RAT CLAT_RAT]] Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.	+	[https://www.uniprot.org/uniprot/CLAT_RAT CLAT_RAT] Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Buffalo rat]]
-	[[Category: Choline O-acetyltransferase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Cai, Y~~]]	+	[[Category: Rattus norvegicus]]
-	[[Category: ~~Rodgers, D W~~]]	+	[[Category: Cai Y]]
-	[[Category: ~~Alpha beta sandwich]]~~	+	[[Category: Rodgers DW]]
-	~~[[Category: Extended loop]]~~	+
-	~~[[Category: Transferase]]~~	+
-	~~[[Category: Two domain~~]]	+

OCA at 07:44, 9 December 2020

OCA — Wed, 09 Dec 2020 07:44:51 GMT

←Older revision		Revision as of 07:44, 9 December 2020
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	==Crystal structure of rat choline acetyltransferase==		==Crystal structure of rat choline acetyltransferase==
-	<StructureSection load='1q6x' size='340' side='right' caption='[[1q6x]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='1q6x' size='340' side='right'caption='[[1q6x]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1q6x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q6X OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1Q6X FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1q6x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q6X OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1Q6X FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cholinergic gene locus ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cholinergic gene locus ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Choline_O-acetyltransferase Choline O-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.6 2.3.1.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Choline_O-acetyltransferase Choline O-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.6 2.3.1.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1q6x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q6x OCA], [http://pdbe.org/1q6x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1q6x RCSB], [http://www.ebi.ac.uk/pdbsum/1q6x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1q6x ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1q6x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q6x OCA], [http://pdbe.org/1q6x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1q6x RCSB], [http://www.ebi.ac.uk/pdbsum/1q6x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1q6x ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 1q6x" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1q6x" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Choline O-acetyltransferase\|Choline O-acetyltransferase]]
	== References ==		== References ==
	<references/>		<references/>
Line 36:		Line 39:
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
	[[Category: Choline O-acetyltransferase]]		[[Category: Choline O-acetyltransferase]]
		+	[[Category: Large Structures]]
	[[Category: Cai, Y]]		[[Category: Cai, Y]]
	[[Category: Rodgers, D W]]		[[Category: Rodgers, D W]]

OCA at 08:17, 24 February 2018

OCA — Sat, 24 Feb 2018 08:17:29 GMT

←Older revision		Revision as of 08:17, 24 February 2018
Line 1:		Line 1:
		+
	==Crystal structure of rat choline acetyltransferase==		==Crystal structure of rat choline acetyltransferase==
	<StructureSection load='1q6x' size='340' side='right' caption='[[1q6x]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1q6x' size='340' side='right' caption='[[1q6x]], [[Resolution\|resolution]] 2.50Å' scene=''>
Line 6:		Line 7:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cholinergic gene locus ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cholinergic gene locus ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Choline_O-acetyltransferase Choline O-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.6 2.3.1.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Choline_O-acetyltransferase Choline O-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.6 2.3.1.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q6x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q6x OCA], [http://pdbe.org/1q6x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1q6x RCSB], [http://www.ebi.ac.uk/pdbsum/1q6x PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q6x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q6x OCA], [http://pdbe.org/1q6x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1q6x RCSB], [http://www.ebi.ac.uk/pdbsum/1q6x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1q6x ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q6/1q6x_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q6/1q6x_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 29:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 1q6x" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1q6x" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Choline O-acetyltransferase\|Choline O-acetyltransferase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 00:07, 10 February 2016

OCA — Wed, 10 Feb 2016 00:07:49 GMT

←Older revision		Revision as of 00:07, 10 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1q6x ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 03:24, 11 September 2015

OCA — Fri, 11 Sep 2015 03:24:32 GMT

←Older revision		Revision as of 03:24, 11 September 2015
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	<StructureSection load='1q6x' size='340' side='right' caption='[[1q6x]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1q6x' size='340' side='right' caption='[[1q6x]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1q6x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rattus_norvegicus Rattus norvegicus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q6X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Q6X FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1q6x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q6X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Q6X FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cholinergic gene locus ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 ~~Rattus norvegicus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cholinergic gene locus ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Choline_O-acetyltransferase Choline O-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.6 2.3.1.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Choline_O-acetyltransferase Choline O-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.6 2.3.1.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q6x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q6x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1q6x RCSB], [http://www.ebi.ac.uk/pdbsum/1q6x PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q6x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q6x OCA], [http://pdbe.org/1q6x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1q6x RCSB], [http://www.ebi.ac.uk/pdbsum/1q6x PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1q6x" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Buffalo rat]]
	[[Category: Choline O-acetyltransferase]]		[[Category: Choline O-acetyltransferase]]
-	[[Category: Rattus norvegicus]]
	[[Category: Cai, Y]]		[[Category: Cai, Y]]
	[[Category: Rodgers, D W]]		[[Category: Rodgers, D W]]

OCA at 10:26, 25 December 2014

OCA — Thu, 25 Dec 2014 10:26:51 GMT

←Older revision		Revision as of 10:26, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1q6x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q6X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Q6X FirstGlance]. <br>		<table><tr><td colspan='2'>[[1q6x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q6X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Q6X FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cholinergic gene locus ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cholinergic gene locus ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Choline_O-acetyltransferase Choline O-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.6 2.3.1.6] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Choline_O-acetyltransferase Choline O-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.6 2.3.1.6] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q6x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q6x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1q6x RCSB], [http://www.ebi.ac.uk/pdbsum/1q6x PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q6x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q6x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1q6x RCSB], [http://www.ebi.ac.uk/pdbsum/1q6x PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CLAT_RAT CLAT_RAT]] Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 37:
	[[Category: Choline O-acetyltransferase]]		[[Category: Choline O-acetyltransferase]]
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
-	[[Category: Cai, Y.]]	+	[[Category: Cai, Y]]
-	[[Category: Rodgers, D W.]]	+	[[Category: Rodgers, D W]]
	[[Category: Alpha beta sandwich]]		[[Category: Alpha beta sandwich]]
	[[Category: Extended loop]]		[[Category: Extended loop]]
	[[Category: Transferase]]		[[Category: Transferase]]
	[[Category: Two domain]]		[[Category: Two domain]]

OCA at 23:28, 28 September 2014

OCA — Sun, 28 Sep 2014 23:28:22 GMT

←Older revision		Revision as of 23:28, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1q6x.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of rat choline acetyltransferase==
		+	<StructureSection load='1q6x' size='340' side='right' caption='[[1q6x]], [[Resolution\|resolution]] 2.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1q6x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q6X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Q6X FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cholinergic gene locus ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Choline_O-acetyltransferase Choline O-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.6 2.3.1.6] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q6x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q6x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1q6x RCSB], [http://www.ebi.ac.uk/pdbsum/1q6x PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q6/1q6x_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Choline acetyltransferase (ChAT) synthesizes acetylcholine in neurons and other cell types. Decreases in ChAT activity are associated with a number of disease states, and mutations in ChAT cause congenital neuromuscular disorders. The crystal structure of ChAT reported here shows the enzyme divided into two domains with the active site in a solvent accessible tunnel at the domain interface. A low-resolution view of the complex with one substrate, coenzyme A, defines its binding site and suggests an additional interaction not found in the related carnitine acetyltransferase. Also, the preference for choline over carnitine as an acetyl acceptor is seen to result from both electrostatic and steric blocks to carnitine binding at the active site. While half of the mutations that cause motor disorders are positioned to affect enzyme activity directly, the remaining changes are surprisingly distant from the active site and must exert indirect effects. The structure indicates how ChAT is regulated by phosphorylation and reveals an unusual pattern of basic surface patches that may mediate membrane association or macromolecular interactions.

-	~~{{STRUCTURE_1q6x\| PDB=1q6x \| SCENE= }}~~	+	Choline acetyltransferase structure reveals distribution of mutations that cause motor disorders.,Cai Y, Cronin CN, Engel AG, Ohno K, Hersh LB, Rodgers DW EMBO J. 2004 May 19;23(10):2047-58. Epub 2004 May 6. PMID:15131697<ref>PMID:15131697</ref>

-	~~===Crystal structure~~ of ~~rat choline acetyltransferase===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15131697}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1q6x]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Rattus_norvegicus Rattus norvegicus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1Q6X OCA].~~	+

	==See Also==		==See Also==
	*[[Choline O-acetyltransferase\|Choline O-acetyltransferase]]		*[[Choline O-acetyltransferase\|Choline O-acetyltransferase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:015131697<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Choline O-acetyltransferase]]		[[Category: Choline O-acetyltransferase]]
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]

OCA at 15:37, 20 October 2012

OCA — Sat, 20 Oct 2012 15:37:11 GMT

←Older revision		Revision as of 15:37, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1q6x]] is a 2 chain structure ~~of [[Choline O-acetyltransferase]]~~ with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q6X OCA].	+	[[1q6x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q6X OCA].

	==See Also==		==See Also==

OCA: Protected "1q6x" [edit=sysop:move=sysop]

OCA — Thu, 26 Jul 2012 18:57:12 GMT

Protected "1q6x" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:57, 26 July 2012

OCA at 18:57, 26 July 2012

OCA — Thu, 26 Jul 2012 18:57:11 GMT

←Older revision		Revision as of 18:57, 26 July 2012
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-	{{Seed}}
	[[Image:1q6x.png\|left\|200px]]		[[Image:1q6x.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1q6x", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1q6x\| PDB=1q6x \| SCENE= }}		{{STRUCTURE_1q6x\| PDB=1q6x \| SCENE= }}

	===Crystal structure of rat choline acetyltransferase===		===Crystal structure of rat choline acetyltransferase===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15131697}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15131697 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15131697}}		{{ABSTRACT_PUBMED_15131697}}

	==About this Structure==		==About this Structure==
-	~~1Q6X~~ is a 2 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q6X OCA].	+	[[1q6x]] is a 2 chain structure of [[Choline O-acetyltransferase]] with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q6X OCA].
		+
		+	==See Also==
		+	*[[Choline O-acetyltransferase\|Choline O-acetyltransferase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15131697~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015131697</ref><references group="xtra"/>
	[[Category: Choline O-acetyltransferase]]		[[Category: Choline O-acetyltransferase]]
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
Line 30:		Line 21:
	[[Category: Alpha beta sandwich]]		[[Category: Alpha beta sandwich]]
	[[Category: Extended loop]]		[[Category: Extended loop]]
		+	[[Category: Transferase]]
	[[Category: Two domain]]		[[Category: Two domain]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 13:50:13 2009''