1q7s - Revision history

OCA at 08:13, 14 February 2024

OCA — Wed, 14 Feb 2024 08:13:36 GMT

←Older revision		Revision as of 08:13, 14 February 2024
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	<StructureSection load='1q7s' size='340' side='right'caption='[[1q7s]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1q7s' size='340' side='right'caption='[[1q7s]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1q7s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q7S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q7S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1q7s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q7S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q7S FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q7s OCA], [https://pdbe.org/1q7s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q7s RCSB], [https://www.ebi.ac.uk/pdbsum/1q7s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q7s ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q7s OCA], [https://pdbe.org/1q7s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q7s RCSB], [https://www.ebi.ac.uk/pdbsum/1q7s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q7s ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PTH2_HUMAN PTH2_HUMAN]] The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis (By similarity).<ref>PMID:15006356</ref> Promotes caspase-independent apoptosis by regulating the function of two transcriptional regulators, AES and TLE1.<ref>PMID:15006356</ref>	+	[https://www.uniprot.org/uniprot/PTH2_HUMAN PTH2_HUMAN] The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis (By similarity).<ref>PMID:15006356</ref> Promotes caspase-independent apoptosis by regulating the function of two transcriptional regulators, AES and TLE1.<ref>PMID:15006356</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 18:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1q7s ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1q7s ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Peptidyl-tRNA hydrolase (Pth) activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two different enzymes have been reported to encode such activity, Pth present in bacteria and eukaryotes and Pth2 present in archaea and eukaryotes. Here we report the crystallographic structure of the Homo sapiens Pth2 at a 2.0-A resolution as well as its catalytic properties. In contrast to the structure of Escherichia coli Pth, H. sapiens Pth2 has an alpha/beta fold with a four-stranded antiparallel beta-sheet in its core surrounded by two alpha-helices on each side. This arrangement of secondary structure elements generates a fold not previously reported. Its catalytic efficiency is comparable with that reported for the archaeal Sulfolobus solfataricus Pth2 and higher than that of the bacterial E. coli Pth. Several lines of evidence target the active site to two close loops with highly conserved residues. This active site architecture is unrelated to that of E. coli Pth. In addition, intermolecular contacts in the crystal asymmetric unit cell suggest a likely surface for protein-protein interactions related to the Pth2-mediated apoptosis.
-
-	Crystal structure of a human peptidyl-tRNA hydrolase reveals a new fold and suggests basis for a bifunctional activity.,De Pereda JM, Waas WF, Jan Y, Ruoslahti E, Schimmel P, Pascual J J Biol Chem. 2004 Feb 27;279(9):8111-5. Epub 2003 Dec 5. PMID:14660562<ref>PMID:14660562</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1q7s" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Jan, Y~~]]	+	[[Category: De Pereda JM]]
-	[[Category: ~~Pascual, J~~]]	+	[[Category: Jan Y]]
-	[[Category: ~~Pereda,~~ J ~~M.De~~]]	+	[[Category: Pascual J]]
-	[[Category: Ruoslahti, E]]	+	[[Category: Ruoslahti E]]
-	[[Category: Schimmel, P]]	+	[[Category: Schimmel P]]
-	[[Category: Waas~~, W F]]~~	+	[[Category: Waas WF]]
-	~~[[Category: Apoptosis~~]]	+

OCA at 09:38, 8 September 2021

OCA — Wed, 08 Sep 2021 09:38:58 GMT

←Older revision		Revision as of 09:38, 8 September 2021
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	<StructureSection load='1q7s' size='340' side='right'caption='[[1q7s]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1q7s' size='340' side='right'caption='[[1q7s]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1q7s]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q7S OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1Q7S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1q7s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q7S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q7S FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1q7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q7s OCA], [~~http~~://pdbe.org/1q7s PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1q7s RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1q7s PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1q7s ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q7s OCA], [https://pdbe.org/1q7s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q7s RCSB], [https://www.ebi.ac.uk/pdbsum/1q7s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q7s ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PTH2_HUMAN PTH2_HUMAN]] The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis (By similarity).<ref>PMID:15006356</ref> Promotes caspase-independent apoptosis by regulating the function of two transcriptional regulators, AES and TLE1.<ref>PMID:15006356</ref>	+	[[https://www.uniprot.org/uniprot/PTH2_HUMAN PTH2_HUMAN]] The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis (By similarity).<ref>PMID:15006356</ref> Promotes caspase-independent apoptosis by regulating the function of two transcriptional regulators, AES and TLE1.<ref>PMID:15006356</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 09:58, 27 November 2019

OCA — Wed, 27 Nov 2019 09:58:24 GMT

←Older revision		Revision as of 09:58, 27 November 2019
Line 1:		Line 1:

	==Crystal structure of bit1==		==Crystal structure of bit1==
-	<StructureSection load='1q7s' size='340' side='right' caption='[[1q7s]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='1q7s' size='340' side='right'caption='[[1q7s]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1q7s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q7S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Q7S FirstGlance]. <br>		<table><tr><td colspan='2'>[[1q7s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q7S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Q7S FirstGlance]. <br>
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Jan, Y]]		[[Category: Jan, Y]]
	[[Category: Pascual, J]]		[[Category: Pascual, J]]

OCA at 08:00, 24 February 2018

OCA — Sat, 24 Feb 2018 08:00:25 GMT

←Older revision		Revision as of 08:00, 24 February 2018
Line 1:		Line 1:
		+
	==Crystal structure of bit1==		==Crystal structure of bit1==
	<StructureSection load='1q7s' size='340' side='right' caption='[[1q7s]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1q7s' size='340' side='right' caption='[[1q7s]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1q7s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q7S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Q7S FirstGlance]. <br>		<table><tr><td colspan='2'>[[1q7s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q7S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Q7S FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q7s OCA], [http://pdbe.org/1q7s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1q7s RCSB], [http://www.ebi.ac.uk/pdbsum/1q7s PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q7s OCA], [http://pdbe.org/1q7s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1q7s RCSB], [http://www.ebi.ac.uk/pdbsum/1q7s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1q7s ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q7/1q7s_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q7/1q7s_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 11:04, 8 February 2016

OCA — Mon, 08 Feb 2016 11:04:12 GMT

←Older revision		Revision as of 11:04, 8 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1q7s ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 10:53, 10 September 2015

OCA — Thu, 10 Sep 2015 10:53:40 GMT

←Older revision		Revision as of 10:53, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1q7s' size='340' side='right' caption='[[1q7s]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1q7s' size='340' side='right' caption='[[1q7s]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1q7s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q7S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Q7S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1q7s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q7S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Q7S FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q7s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1q7s RCSB], [http://www.ebi.ac.uk/pdbsum/1q7s PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q7s OCA], [http://pdbe.org/1q7s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1q7s RCSB], [http://www.ebi.ac.uk/pdbsum/1q7s PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1q7s" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Jan, Y]]		[[Category: Jan, Y]]
	[[Category: Pascual, J]]		[[Category: Pascual, J]]

OCA at 22:51, 24 December 2014

OCA — Wed, 24 Dec 2014 22:51:38 GMT

←Older revision		Revision as of 22:51, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1q7s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q7S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Q7S FirstGlance]. <br>		<table><tr><td colspan='2'>[[1q7s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q7S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Q7S FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q7s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1q7s RCSB], [http://www.ebi.ac.uk/pdbsum/1q7s PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q7s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1q7s RCSB], [http://www.ebi.ac.uk/pdbsum/1q7s PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PTH2_HUMAN PTH2_HUMAN]] The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis (By similarity).<ref>PMID:15006356</ref> Promotes caspase-independent apoptosis by regulating the function of two transcriptional regulators, AES and TLE1.<ref>PMID:15006356</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Jan, Y.]]	+	[[Category: Jan, Y]]
-	[[Category: Pascual, J.]]	+	[[Category: Pascual, J]]
-	[[Category: Pereda, J M.De.]]	+	[[Category: Pereda, J M.De]]
-	[[Category: Ruoslahti, E.]]	+	[[Category: Ruoslahti, E]]
-	[[Category: Schimmel, P.]]	+	[[Category: Schimmel, P]]
-	[[Category: Waas, W F.]]	+	[[Category: Waas, W F]]
	[[Category: Apoptosis]]		[[Category: Apoptosis]]

OCA at 14:29, 29 September 2014

OCA — Mon, 29 Sep 2014 14:29:14 GMT

←Older revision		Revision as of 14:29, 29 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1q7s.~~png\|left~~\|200px]]	+	==Crystal structure of bit1==
		+	<StructureSection load='1q7s' size='340' side='right' caption='[[1q7s]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1q7s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q7S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Q7S FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q7s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1q7s RCSB], [http://www.ebi.ac.uk/pdbsum/1q7s PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q7/1q7s_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Peptidyl-tRNA hydrolase (Pth) activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two different enzymes have been reported to encode such activity, Pth present in bacteria and eukaryotes and Pth2 present in archaea and eukaryotes. Here we report the crystallographic structure of the Homo sapiens Pth2 at a 2.0-A resolution as well as its catalytic properties. In contrast to the structure of Escherichia coli Pth, H. sapiens Pth2 has an alpha/beta fold with a four-stranded antiparallel beta-sheet in its core surrounded by two alpha-helices on each side. This arrangement of secondary structure elements generates a fold not previously reported. Its catalytic efficiency is comparable with that reported for the archaeal Sulfolobus solfataricus Pth2 and higher than that of the bacterial E. coli Pth. Several lines of evidence target the active site to two close loops with highly conserved residues. This active site architecture is unrelated to that of E. coli Pth. In addition, intermolecular contacts in the crystal asymmetric unit cell suggest a likely surface for protein-protein interactions related to the Pth2-mediated apoptosis.

-	~~{{STRUCTURE_1q7s\| PDB=1q7s \| SCENE= }}~~	+	Crystal structure of a human peptidyl-tRNA hydrolase reveals a new fold and suggests basis for a bifunctional activity.,De Pereda JM, Waas WF, Jan Y, Ruoslahti E, Schimmel P, Pascual J J Biol Chem. 2004 Feb 27;279(9):8111-5. Epub 2003 Dec 5. PMID:14660562<ref>PMID:14660562</ref>

-	~~===Crystal structure~~ of ~~bit1===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_14660562}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1q7s]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1Q7S OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:014660562<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Jan, Y.]]		[[Category: Jan, Y.]]

OCA: Protected "1q7s" [edit=sysop:move=sysop]

OCA — Wed, 02 Jan 2013 09:57:43 GMT

Protected "1q7s" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:57, 2 January 2013

OCA at 09:57, 2 January 2013

OCA — Wed, 02 Jan 2013 09:57:39 GMT

←Older revision		Revision as of 09:57, 2 January 2013
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-	{{Seed}}
	[[Image:1q7s.png\|left\|200px]]		[[Image:1q7s.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_1q7s\| PDB=1q7s \| SCENE= }}		{{STRUCTURE_1q7s\| PDB=1q7s \| SCENE= }}

	===Crystal structure of bit1===		===Crystal structure of bit1===

-
-	<!--
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	{{ABSTRACT_PUBMED_14660562}}		{{ABSTRACT_PUBMED_14660562}}

	==About this Structure==		==About this Structure==
-	~~1Q7S~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q7S OCA].	+	[[1q7s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q7S OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~14660562~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:014660562</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Jan, Y.]]		[[Category: Jan, Y.]]
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	[[Category: Waas, W F.]]		[[Category: Waas, W F.]]
	[[Category: Apoptosis]]		[[Category: Apoptosis]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 21:31:14 2009''