1q8m - Revision history

OCA at 09:48, 21 December 2022

OCA — Wed, 21 Dec 2022 09:48:22 GMT

←Older revision		Revision as of 09:48, 21 December 2022
Line 3:		Line 3:
	<StructureSection load='1q8m' size='340' side='right'caption='[[1q8m]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='1q8m' size='340' side='right'caption='[[1q8m]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1q8m]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q8M OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1Q8M FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1q8m]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q8M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q8M FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1hkf\|1hkf]], [[3hfl\|3hfl]], [[1tvd\|1tvd]], [[1i85\|1i85]]</div></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q8m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q8m OCA], [https://pdbe.org/1q8m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q8m RCSB], [https://www.ebi.ac.uk/pdbsum/1q8m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q8m ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TREM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1q8m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q8m OCA], [~~http~~://pdbe.org/1q8m PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1q8m RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1q8m PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1q8m ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/TREM1_HUMAN TREM1_HUMAN]] Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock.<ref>PMID:10799849</ref> <ref>PMID:11323674</ref>	+	[https://www.uniprot.org/uniprot/TREM1_HUMAN TREM1_HUMAN] Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock.<ref>PMID:10799849</ref> <ref>PMID:11323674</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Colonna, M]]	+	[[Category: Colonna M]]
-	[[Category: Kattah, M]]	+	[[Category: Kattah M]]
-	[[Category: Radaev, S]]	+	[[Category: Radaev S]]
-	[[Category: Rostro, B]]	+	[[Category: Rostro B]]
-	[[Category: Sun~~, P D]]~~	+	[[Category: Sun PD]]
-	~~[[Category: Immune system receptor]]~~	+
-	~~[[Category: Immunoglobulin-like]]~~	+
-	~~[[Category: V-type ig-like domain~~]]	+

OCA at 07:45, 9 December 2020

OCA — Wed, 09 Dec 2020 07:45:50 GMT

←Older revision		Revision as of 07:45, 9 December 2020
Line 1:		Line 1:

	==Crystal structure of the human myeloid cell activating receptor TREM-1==		==Crystal structure of the human myeloid cell activating receptor TREM-1==
-	<StructureSection load='1q8m' size='340' side='right' caption='[[1q8m]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='1q8m' size='340' side='right'caption='[[1q8m]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1q8m]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q8M OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1Q8M FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1q8m]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q8M OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1Q8M FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hkf\|1hkf]], [[3hfl\|3hfl]], [[1tvd\|1tvd]], [[1i85\|1i85]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1hkf\|1hkf]], [[3hfl\|3hfl]], [[1tvd\|1tvd]], [[1i85\|1i85]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TREM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TREM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1q8m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q8m OCA], [http://pdbe.org/1q8m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1q8m RCSB], [http://www.ebi.ac.uk/pdbsum/1q8m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1q8m ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1q8m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q8m OCA], [http://pdbe.org/1q8m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1q8m RCSB], [http://www.ebi.ac.uk/pdbsum/1q8m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1q8m ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 35:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Colonna, M]]		[[Category: Colonna, M]]
	[[Category: Kattah, M]]		[[Category: Kattah, M]]

OCA at 07:52, 24 February 2018

OCA — Sat, 24 Feb 2018 07:52:10 GMT

←Older revision		Revision as of 07:52, 24 February 2018
Line 1:		Line 1:
		+
	==Crystal structure of the human myeloid cell activating receptor TREM-1==		==Crystal structure of the human myeloid cell activating receptor TREM-1==
	<StructureSection load='1q8m' size='340' side='right' caption='[[1q8m]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='1q8m' size='340' side='right' caption='[[1q8m]], [[Resolution\|resolution]] 2.60Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hkf\|1hkf]], [[3hfl\|3hfl]], [[1tvd\|1tvd]], [[1i85\|1i85]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hkf\|1hkf]], [[3hfl\|3hfl]], [[1tvd\|1tvd]], [[1i85\|1i85]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TREM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TREM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q8m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q8m OCA], [http://pdbe.org/1q8m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1q8m RCSB], [http://www.ebi.ac.uk/pdbsum/1q8m PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q8m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q8m OCA], [http://pdbe.org/1q8m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1q8m RCSB], [http://www.ebi.ac.uk/pdbsum/1q8m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1q8m ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q8/1q8m_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q8/1q8m_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 05:29, 9 February 2016

OCA — Tue, 09 Feb 2016 05:29:47 GMT

←Older revision		Revision as of 05:29, 9 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1q8m ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 19:05, 10 September 2015

OCA — Thu, 10 Sep 2015 19:05:52 GMT

←Older revision		Revision as of 19:05, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1q8m' size='340' side='right' caption='[[1q8m]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='1q8m' size='340' side='right' caption='[[1q8m]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1q8m]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q8M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Q8M FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1q8m]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q8M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Q8M FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hkf\|1hkf]], [[3hfl\|3hfl]], [[1tvd\|1tvd]], [[1i85\|1i85]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hkf\|1hkf]], [[3hfl\|3hfl]], [[1tvd\|1tvd]], [[1i85\|1i85]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TREM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TREM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q8m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q8m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1q8m RCSB], [http://www.ebi.ac.uk/pdbsum/1q8m PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q8m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q8m OCA], [http://pdbe.org/1q8m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1q8m RCSB], [http://www.ebi.ac.uk/pdbsum/1q8m PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1q8m" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Colonna, M]]		[[Category: Colonna, M]]
	[[Category: Kattah, M]]		[[Category: Kattah, M]]

OCA at 04:45, 25 December 2014

OCA — Thu, 25 Dec 2014 04:45:10 GMT

←Older revision		Revision as of 04:45, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1q8m]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q8M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Q8M FirstGlance]. <br>		<table><tr><td colspan='2'>[[1q8m]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q8M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Q8M FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hkf\|1hkf]], [[3hfl\|3hfl]], [[1tvd\|1tvd]], [[1i85\|1i85]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hkf\|1hkf]], [[3hfl\|3hfl]], [[1tvd\|1tvd]], [[1i85\|1i85]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TREM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TREM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q8m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q8m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1q8m RCSB], [http://www.ebi.ac.uk/pdbsum/1q8m PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q8m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q8m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1q8m RCSB], [http://www.ebi.ac.uk/pdbsum/1q8m PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TREM1_HUMAN TREM1_HUMAN]] Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock.<ref>PMID:10799849</ref> <ref>PMID:11323674</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Colonna, M.]]	+	[[Category: Colonna, M]]
-	[[Category: Kattah, M.]]	+	[[Category: Kattah, M]]
-	[[Category: Radaev, S.]]	+	[[Category: Radaev, S]]
-	[[Category: Rostro, B.]]	+	[[Category: Rostro, B]]
-	[[Category: Sun, P D.]]	+	[[Category: Sun, P D]]
	[[Category: Immune system receptor]]		[[Category: Immune system receptor]]
	[[Category: Immunoglobulin-like]]		[[Category: Immunoglobulin-like]]
	[[Category: V-type ig-like domain]]		[[Category: V-type ig-like domain]]

OCA at 15:50, 29 September 2014

OCA — Mon, 29 Sep 2014 15:50:14 GMT

←Older revision		Revision as of 15:50, 29 September 2014
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-	[[~~Image:~~1q8m.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of the human myeloid cell activating receptor TREM-1==
		+	<StructureSection load='1q8m' size='340' side='right' caption='[[1q8m]], [[Resolution\|resolution]] 2.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1q8m]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q8M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Q8M FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hkf\|1hkf]], [[3hfl\|3hfl]], [[1tvd\|1tvd]], [[1i85\|1i85]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TREM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q8m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q8m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1q8m RCSB], [http://www.ebi.ac.uk/pdbsum/1q8m PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q8/1q8m_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Triggering receptors expressed on myeloid cells (TREM) are a family of recently discovered receptors that play important roles in innate immune responses, such as to activate inflammatory responses and to contribute to septic shock in response to microbial-mediated infections. To date, two TREM receptors in human and several homologs in mice have been identified. We report the 2.6 A resolution crystal structure of the extracellular domain of human TREM-1. The overall fold of the receptor resembles that of a V-type immunoglobulin domain with differences primarily located in the N-terminal strand. TREM-1 forms a "head-to-tail" dimer with 4100 A(2) interface area that is partially mediated by a domain swapping between the first strands. This mode of dimer formation is different from the "head-to-head" dimerization that existed in V(H)V(L) domains of antibodies or V domains of T cell receptors. As a result, the dimeric TREM-1 most likely contains two distinct ligand binding sites.

-	~~{{STRUCTURE_1q8m\| PDB=1q8m \| SCENE= }}~~	+	Crystal structure of the human myeloid cell activating receptor TREM-1.,Radaev S, Kattah M, Rostro B, Colonna M, Sun PD Structure. 2003 Dec;11(12):1527-35. PMID:14656437<ref>PMID:14656437</ref>

-	~~===Crystal structure~~ of the ~~human myeloid cell activating receptor TREM-1===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_14656437}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1q8m]] is a 4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1Q8M OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:014656437<~~/~~ref~~><~~ref group="xtra">PMID:014752199</ref><references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Colonna, M.]]		[[Category: Colonna, M.]]

OCA: Protected "1q8m" [edit=sysop:move=sysop]

OCA — Wed, 02 Jan 2013 09:45:00 GMT

Protected "1q8m" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:45, 2 January 2013

OCA at 09:44, 2 January 2013

OCA — Wed, 02 Jan 2013 09:44:57 GMT

←Older revision		Revision as of 09:44, 2 January 2013
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-	{{Seed}}
	[[Image:1q8m.png\|left\|200px]]		[[Image:1q8m.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_1q8m\| PDB=1q8m \| SCENE= }}		{{STRUCTURE_1q8m\| PDB=1q8m \| SCENE= }}

	===Crystal structure of the human myeloid cell activating receptor TREM-1===		===Crystal structure of the human myeloid cell activating receptor TREM-1===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_14656437}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 14656437 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_14656437}}		{{ABSTRACT_PUBMED_14656437}}

	==About this Structure==		==About this Structure==
-	~~1Q8M~~ is a 4 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q8M OCA].	+	[[1q8m]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q8M OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~14656437~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:014656437</ref><ref group="xtra">PMID:014752199</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Colonna, M.]]		[[Category: Colonna, M.]]
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	[[Category: Rostro, B.]]		[[Category: Rostro, B.]]
	[[Category: Sun, P D.]]		[[Category: Sun, P D.]]
		+	[[Category: Immune system receptor]]
	[[Category: Immunoglobulin-like]]		[[Category: Immunoglobulin-like]]
	[[Category: V-type ig-like domain]]		[[Category: V-type ig-like domain]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 06:51:09 2009''

OCA at 04:51, 17 February 2009

OCA — Tue, 17 Feb 2009 04:51:09 GMT

←Older revision		Revision as of 04:51, 17 February 2009
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	==About this Structure==		==About this Structure==
-	1Q8M is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q8M OCA].	+	1Q8M is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q8M OCA].

	==Reference==		==Reference==
-	~~Crystal structure of the human myeloid cell activating receptor TREM-1., Radaev S, Kattah M, Rostro B, Colonna M, Sun PD, Structure. 2003 Dec;11(12):1527-35.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/14656437 14656437]~~	+	<ref group="xtra">PMID:14656437</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Single protein]]
	[[Category: Colonna, M.]]		[[Category: Colonna, M.]]
	[[Category: Kattah, M.]]		[[Category: Kattah, M.]]
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	[[Category: V-type ig-like domain]]		[[Category: V-type ig-like domain]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Jul 28 10~~:29:~~21 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 06:51:09 2009''