1q8s - Revision history

OCA at 06:02, 17 April 2024

OCA — Wed, 17 Apr 2024 06:02:23 GMT

←Older revision		Revision as of 06:02, 17 April 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1q8s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pterocarpus_angolensis Pterocarpus angolensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q8S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q8S FirstGlance]. <br>		<table><tr><td colspan='2'>[[1q8s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pterocarpus_angolensis Pterocarpus angolensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q8S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q8S FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~"><~~scene name~~='~~pdbligand~~=CA:~~CALCIUM+ION'~~>CA</~~scene~~>, <scene name='pdbligand=MN:~~MANGANESE+(II)~~+ION'>MN</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MMA:O1-METHYL-MANNOSE'>MMA</scene><~~/td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.05Å</td></tr>
-	~~<tr id~~='~~NonStdRes'><td class~~=~~"sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res~~:~~]]</b~~></~~td><td class="sblockDat"~~><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene~~></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MMA:O1-METHYL-MANNOSE'>MMA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1n3o\|1n3o]], [[1n3p\|1n3p]], [[1n3q\|1n3q]], [[1ukg\|1ukg]], [[1q8o\|1q8o]], [[1q8p\|1q8p]], [[1q8q\|1q8q]], [[1q8v\|1q8v]]</div></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q8s OCA], [https://pdbe.org/1q8s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q8s RCSB], [https://www.ebi.ac.uk/pdbsum/1q8s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q8s ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q8s OCA], [https://pdbe.org/1q8s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q8s RCSB], [https://www.ebi.ac.uk/pdbsum/1q8s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q8s ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q8GSD2_PTEAG Q8GSD2_PTEAG]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 19:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1q8s ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1q8s ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The crystal structure of a Man/Glc-specific lectin from the seeds of the bloodwood tree (Pterocarpus angolensis), a leguminous plant from central Africa, has been determined in complex with mannose and five manno-oligosaccharides. The lectin contains a classical mannose-specificity loop, but its metal-binding loop resembles that of lectins of unrelated specificity from Ulex europaeus and Maackia amurensis. As a consequence, the interactions with mannose in the primary binding site are conserved, but details of carbohydrate-binding outside the primary binding site differ from those seen in the equivalent carbohydrate complexes of concanavalin A. These observations explain the differences in their respective fine specificity profiles for oligomannoses. While Man(alpha1-3)Man and Man(alpha1-3)[Man(alpha1-6)]Man bind to PAL in low-energy conformations identical with that of ConA, Man(alpha1-6)Man is required to adopt a different conformation. Man(alpha1-2)Man can bind only in a single binding mode, in sharp contrast to ConA, which creates a higher affinity for this disaccharide by allowing two binding modes.
-
-	Structural basis of oligomannose recognition by the Pterocarpus angolensis seed lectin.,Loris R, Van Walle I, De Greve H, Beeckmans S, Deboeck F, Wyns L, Bouckaert J J Mol Biol. 2004 Jan 30;335(5):1227-40. PMID:14729339<ref>PMID:14729339</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1q8s" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Pal\|Pal]]		*[[Pal\|Pal]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Pterocarpus angolensis]]		[[Category: Pterocarpus angolensis]]
-	[[Category: Beeckmans, S]]	+	[[Category: Beeckmans S]]
-	[[Category: Bouckaert, J]]	+	[[Category: Bouckaert J]]
-	[[Category: ~~DeBoeck, F~~]]	+	[[Category: De Greve H]]
-	[[Category: ~~Greve, H De~~]]	+	[[Category: DeBoeck F]]
-	[[Category: Loris, R]]	+	[[Category: Loris R]]
-	[[Category: Walle, I ~~Van~~]]	+	[[Category: Van Walle I]]
-	[[Category: Wyns, L]]	+	[[Category: Wyns L]]
-	~~[[Category: Carbohydrate]]~~	+
-	~~[[Category: Lectin]]~~	+
-	~~[[Category: Mannose]]~~	+
-	~~[[Category: Sugar binding protein~~]]	+

OCA at 09:22, 29 September 2021

OCA — Wed, 29 Sep 2021 09:22:07 GMT

←Older revision		Revision as of 09:22, 29 September 2021
Line 3:		Line 3:
	<StructureSection load='1q8s' size='340' side='right'caption='[[1q8s]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='1q8s' size='340' side='right'caption='[[1q8s]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1q8s]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Pterocarpus_angolensis Pterocarpus angolensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q8S OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1Q8S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1q8s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pterocarpus_angolensis Pterocarpus angolensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q8S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q8S FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=~~MAN~~:~~ALPHA-D-MANNOSE~~'>~~MAN~~</scene>, <scene name='pdbligand=~~MMA~~:O1-~~METHYL~~-MANNOSE'>~~MMA~~</scene>, <scene name='pdbligand=MN:~~MANGANESE+(II)+ION~~'>MN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MMA:O1-METHYL-MANNOSE'>MMA</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1n3o\|1n3o]], [[1n3p\|1n3p]], [[1n3q\|1n3q]], [[1ukg\|1ukg]], [[1q8o\|1q8o]], [[1q8p\|1q8p]], [[1q8q\|1q8q]], [[1q8v\|1q8v]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1n3o\|1n3o]], [[1n3p\|1n3p]], [[1n3q\|1n3q]], [[1ukg\|1ukg]], [[1q8o\|1q8o]], [[1q8p\|1q8p]], [[1q8q\|1q8q]], [[1q8v\|1q8v]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1q8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q8s OCA], [~~http~~://pdbe.org/1q8s PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1q8s RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1q8s PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1q8s ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q8s OCA], [https://pdbe.org/1q8s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q8s RCSB], [https://www.ebi.ac.uk/pdbsum/1q8s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q8s ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 10:27, 27 November 2019

OCA — Wed, 27 Nov 2019 10:27:04 GMT

←Older revision		Revision as of 10:27, 27 November 2019
Line 1:		Line 1:

	==Pterocarpus angolensis lectin (PAL) in complex with the dimannoside Man(alpha1-6)Man==		==Pterocarpus angolensis lectin (PAL) in complex with the dimannoside Man(alpha1-6)Man==
-	<StructureSection load='1q8s' size='340' side='right' caption='[[1q8s]], [[Resolution\|resolution]] 2.05Å' scene=''>	+	<StructureSection load='1q8s' size='340' side='right'caption='[[1q8s]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1q8s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pterocarpus_angolensis Pterocarpus angolensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q8S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Q8S FirstGlance]. <br>		<table><tr><td colspan='2'>[[1q8s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pterocarpus_angolensis Pterocarpus angolensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q8S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Q8S FirstGlance]. <br>
Line 28:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 1q8s" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1q8s" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Pal\|Pal]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Pterocarpus angolensis]]		[[Category: Pterocarpus angolensis]]
	[[Category: Beeckmans, S]]		[[Category: Beeckmans, S]]

OCA at 08:26, 24 February 2018

OCA — Sat, 24 Feb 2018 08:26:47 GMT

←Older revision		Revision as of 08:26, 24 February 2018
Line 1:		Line 1:
		+
	==Pterocarpus angolensis lectin (PAL) in complex with the dimannoside Man(alpha1-6)Man==		==Pterocarpus angolensis lectin (PAL) in complex with the dimannoside Man(alpha1-6)Man==
	<StructureSection load='1q8s' size='340' side='right' caption='[[1q8s]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='1q8s' size='340' side='right' caption='[[1q8s]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1q8s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pterocarpus_angolensis Pterocarpus angolensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q8S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Q8S FirstGlance]. <br>		<table><tr><td colspan='2'>[[1q8s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pterocarpus_angolensis Pterocarpus angolensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q8S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Q8S FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:~~MANGANESE+(II)+ION~~'>MN</scene>, <scene name='pdbligand=~~MAN~~:~~ALPHA~~-D-MANNOSE'>~~MAN~~</scene>, <scene name='pdbligand=~~MMA~~:~~O1-METHYL-MANNOSE~~'>~~MMA~~</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MMA:O1-METHYL-MANNOSE'>MMA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1n3o\|1n3o]], [[1n3p\|1n3p]], [[1n3q\|1n3q]], [[1ukg\|1ukg]], [[1q8o\|1q8o]], [[1q8p\|1q8p]], [[1q8q\|1q8q]], [[1q8v\|1q8v]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1n3o\|1n3o]], [[1n3p\|1n3p]], [[1n3q\|1n3q]], [[1ukg\|1ukg]], [[1q8o\|1q8o]], [[1q8p\|1q8p]], [[1q8q\|1q8q]], [[1q8v\|1q8v]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q8s OCA], [http://pdbe.org/1q8s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1q8s RCSB], [http://www.ebi.ac.uk/pdbsum/1q8s PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q8s OCA], [http://pdbe.org/1q8s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1q8s RCSB], [http://www.ebi.ac.uk/pdbsum/1q8s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1q8s ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q8/1q8s_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q8/1q8s_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1q8s ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 1q8s" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1q8s" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Pal\|Pal]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:41, 11 September 2015

OCA — Fri, 11 Sep 2015 11:41:02 GMT

←Older revision		Revision as of 11:41, 11 September 2015
Line 6:		Line 6:
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1n3o\|1n3o]], [[1n3p\|1n3p]], [[1n3q\|1n3q]], [[1ukg\|1ukg]], [[1q8o\|1q8o]], [[1q8p\|1q8p]], [[1q8q\|1q8q]], [[1q8v\|1q8v]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1n3o\|1n3o]], [[1n3p\|1n3p]], [[1n3q\|1n3q]], [[1ukg\|1ukg]], [[1q8o\|1q8o]], [[1q8p\|1q8p]], [[1q8q\|1q8q]], [[1q8v\|1q8v]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q8s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1q8s RCSB], [http://www.ebi.ac.uk/pdbsum/1q8s PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q8s OCA], [http://pdbe.org/1q8s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1q8s RCSB], [http://www.ebi.ac.uk/pdbsum/1q8s PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1q8s" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 08:23, 6 January 2015

OCA — Tue, 06 Jan 2015 08:23:29 GMT

←Older revision		Revision as of 08:23, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1q8s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pterocarpus_angolensis Pterocarpus angolensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q8S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Q8S FirstGlance]. <br>		<table><tr><td colspan='2'>[[1q8s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pterocarpus_angolensis Pterocarpus angolensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q8S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Q8S FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MMA:O1-METHYL-MANNOSE'>MMA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MMA:O1-METHYL-MANNOSE'>MMA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1n3o\|1n3o]], [[1n3p\|1n3p]], [[1n3q\|1n3q]], [[1ukg\|1ukg]], [[1q8o\|1q8o]], [[1q8p\|1q8p]], [[1q8q\|1q8q]], [[1q8v\|1q8v]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1n3o\|1n3o]], [[1n3p\|1n3p]], [[1n3q\|1n3q]], [[1ukg\|1ukg]], [[1q8o\|1q8o]], [[1q8p\|1q8p]], [[1q8q\|1q8q]], [[1q8v\|1q8v]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q8s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1q8s RCSB], [http://www.ebi.ac.uk/pdbsum/1q8s PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q8s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1q8s RCSB], [http://www.ebi.ac.uk/pdbsum/1q8s PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Pterocarpus angolensis]]		[[Category: Pterocarpus angolensis]]
-	[[Category: Beeckmans, S.]]	+	[[Category: Beeckmans, S]]
-	[[Category: Bouckaert, J.]]	+	[[Category: Bouckaert, J]]
-	[[Category: DeBoeck, F.]]	+	[[Category: DeBoeck, F]]
-	[[Category: Greve, H De.]]	+	[[Category: Greve, H De]]
-	[[Category: Loris, R.]]	+	[[Category: Loris, R]]
-	[[Category: Walle, I Van.]]	+	[[Category: Walle, I Van]]
-	[[Category: Wyns, L.]]	+	[[Category: Wyns, L]]
	[[Category: Carbohydrate]]		[[Category: Carbohydrate]]
	[[Category: Lectin]]		[[Category: Lectin]]
	[[Category: Mannose]]		[[Category: Mannose]]
	[[Category: Sugar binding protein]]		[[Category: Sugar binding protein]]

OCA at 14:46, 29 September 2014

OCA — Mon, 29 Sep 2014 14:46:24 GMT

←Older revision		Revision as of 14:46, 29 September 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1q8s\| PDB=1q8s \| SCENE= }}~~	+	==Pterocarpus angolensis lectin (PAL) in complex with the dimannoside Man(alpha1-6)Man==
-	===Pterocarpus angolensis lectin (PAL) in complex with the dimannoside Man(alpha1-6)Man===	+	<StructureSection load='1q8s' size='340' side='right' caption='[[1q8s]], [[Resolution\|resolution]] 2.05Å' scene=''>
-	~~{{ABSTRACT_PUBMED_14729339}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1q8s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pterocarpus_angolensis Pterocarpus angolensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q8S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Q8S FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MMA:O1-METHYL-MANNOSE'>MMA</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1n3o\|1n3o]], [[1n3p\|1n3p]], [[1n3q\|1n3q]], [[1ukg\|1ukg]], [[1q8o\|1q8o]], [[1q8p\|1q8p]], [[1q8q\|1q8q]], [[1q8v\|1q8v]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q8s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1q8s RCSB], [http://www.ebi.ac.uk/pdbsum/1q8s PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q8/1q8s_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The crystal structure of a Man/Glc-specific lectin from the seeds of the bloodwood tree (Pterocarpus angolensis), a leguminous plant from central Africa, has been determined in complex with mannose and five manno-oligosaccharides. The lectin contains a classical mannose-specificity loop, but its metal-binding loop resembles that of lectins of unrelated specificity from Ulex europaeus and Maackia amurensis. As a consequence, the interactions with mannose in the primary binding site are conserved, but details of carbohydrate-binding outside the primary binding site differ from those seen in the equivalent carbohydrate complexes of concanavalin A. These observations explain the differences in their respective fine specificity profiles for oligomannoses. While Man(alpha1-3)Man and Man(alpha1-3)[Man(alpha1-6)]Man bind to PAL in low-energy conformations identical with that of ConA, Man(alpha1-6)Man is required to adopt a different conformation. Man(alpha1-2)Man can bind only in a single binding mode, in sharp contrast to ConA, which creates a higher affinity for this disaccharide by allowing two binding modes.

-	~~==About this Structure==~~	+	Structural basis of oligomannose recognition by the Pterocarpus angolensis seed lectin.,Loris R, Van Walle I, De Greve H, Beeckmans S, Deboeck F, Wyns L, Bouckaert J J Mol Biol. 2004 Jan 30;335(5):1227-40. PMID:14729339<ref>PMID:14729339</ref>
-	~~[[1q8s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pterocarpus_angolensis~~ Pterocarpus angolensis]. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=1Q8S OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Pal\|Pal]]		*[[Pal\|Pal]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:014729339<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Pterocarpus angolensis]]		[[Category: Pterocarpus angolensis]]
	[[Category: Beeckmans, S.]]		[[Category: Beeckmans, S.]]

OCA at 10:06, 11 March 2013

OCA — Mon, 11 Mar 2013 10:06:48 GMT

←Older revision		Revision as of 10:06, 11 March 2013
Line 1:		Line 1:
-	[[Image:1q8s.png\|left\|200px]]
-
	{{STRUCTURE_1q8s\| PDB=1q8s \| SCENE= }}		{{STRUCTURE_1q8s\| PDB=1q8s \| SCENE= }}
-
	===Pterocarpus angolensis lectin (PAL) in complex with the dimannoside Man(alpha1-6)Man===		===Pterocarpus angolensis lectin (PAL) in complex with the dimannoside Man(alpha1-6)Man===
-
	{{ABSTRACT_PUBMED_14729339}}		{{ABSTRACT_PUBMED_14729339}}

	==About this Structure==		==About this Structure==
	[[1q8s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pterocarpus_angolensis Pterocarpus angolensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q8S OCA].		[[1q8s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pterocarpus_angolensis Pterocarpus angolensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q8S OCA].
		+
		+	==See Also==
		+	*[[Pal\|Pal]]

	==Reference==		==Reference==

OCA: Protected "1q8s" [edit=sysop:move=sysop]

OCA — Wed, 02 Jan 2013 10:02:53 GMT

Protected "1q8s" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:02, 2 January 2013

OCA at 10:02, 2 January 2013

OCA — Wed, 02 Jan 2013 10:02:49 GMT

←Older revision		Revision as of 10:02, 2 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1q8s.png\|left\|200px]]		[[Image:1q8s.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1q8s", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1q8s\| PDB=1q8s \| SCENE= }}		{{STRUCTURE_1q8s\| PDB=1q8s \| SCENE= }}

	===Pterocarpus angolensis lectin (PAL) in complex with the dimannoside Man(alpha1-6)Man===		===Pterocarpus angolensis lectin (PAL) in complex with the dimannoside Man(alpha1-6)Man===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_14729339}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 14729339 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_14729339}}		{{ABSTRACT_PUBMED_14729339}}

	==About this Structure==		==About this Structure==
-	~~1Q8S~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Pterocarpus_angolensis Pterocarpus angolensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q8S OCA].	+	[[1q8s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pterocarpus_angolensis Pterocarpus angolensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q8S OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~14729339~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:014729339</ref><references group="xtra"/>
	[[Category: Pterocarpus angolensis]]		[[Category: Pterocarpus angolensis]]
	[[Category: Beeckmans, S.]]		[[Category: Beeckmans, S.]]
Line 35:		Line 23:
	[[Category: Lectin]]		[[Category: Lectin]]
	[[Category: Mannose]]		[[Category: Mannose]]
-		+	[[Category: Sugar binding protein]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 21:06:29 2009''~~	+