1q9v - Revision history

OCA: Protected "1q9v" [edit=sysop:move=sysop]

OCA — Wed, 03 Aug 2011 08:39:23 GMT

Protected "1q9v" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:39, 3 August 2011

OCA: Redirecting to 3t4y

OCA — Wed, 03 Aug 2011 08:39:22 GMT

Redirecting to 3t4y

←Older revision		Revision as of 08:39, 3 August 2011
Line 1:		Line 1:
-	~~{{Seed}}~~	+	#REDIRECT [[3t4y]] This PDB entry is obsolete and replaced by 3t4y
-	[[~~Image:1q9v.png\|left\|200px~~]]	+
-		+
-	~~<!--~~	+
-	~~The line below this paragraph, containing "STRUCTURE_1q9v", creates the "Structure Box" on the page.~~	+
-	~~You may change the~~ PDB ~~parameter (which sets the PDB file loaded into the applet)~~	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page~~ is ~~loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display.~~	+
-	~~-->~~	+
-	~~{{STRUCTURE_1q9v\| PDB=1q9v \| SCENE= }}~~	+
-		+
-	~~===S25-2- Kdo monosaccharide complex===~~	+
-		+
-		+
-	~~<!--~~	+
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_14625588}}, adds the Publication Abstract to the page~~	+
-	~~(as it appears on PubMed at http://www.pubmed.gov), where 14625588 is the PubMed ID number.~~	+
-	~~-->~~	+
-	~~{{ABSTRACT_PUBMED_14625588}}~~	+
-		+
-	~~==About this Structure==~~	+
-	1Q9V is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q9V OCA].	+
-		+
-	~~==Reference==~~	+
-	~~<ref group="xtra">PMID:14625588</ref><references group="xtra"/>~~	+
-	~~[[Category: Mus musculus]]~~	+
-	~~[[Category: Brade, H.]]~~	+
-	~~[[Category: Brade, L.]]~~	+
-	~~[[Category: Evans, S V.]]~~	+
-	~~[[Category: Kosma, P.]]~~	+
-	~~[[Category: MacKenzie, C R.]]~~	+
-	~~[[Category: Nguyen, H P.]]~~	+
-	~~[[Category: Seto, N O.]]~~	+
-	~~[[Category: Anti-carbohydrate]]~~	+
-	~~[[Category: Anti-lp]]~~	+
-	~~[[Category: Antibody]]~~	+
-	~~[[Category: Antigen-binding fragment]]~~	+
-	~~[[Category: Fab]]~~	+
-	~~[[Category: Immunoglobulin]]~~	+
-	~~[[Category: Kdo]]~~	+
-	~~[[Category: Protein-carbohydrate complex]]~~	+
-		+
-	~~''Page seeded~~ by ~~[http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 14:39:02 2009''~~	+

OCA at 12:39, 17 February 2009

OCA — Tue, 17 Feb 2009 12:39:03 GMT

←Older revision		Revision as of 12:39, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q9V OCA].	+	1Q9V is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q9V OCA].

	==Reference==		==Reference==
-	~~Germline antibody recognition of distinct carbohydrate epitopes., Nguyen HP, Seto NO, MacKenzie CR, Brade L, Kosma P, Brade H, Evans SV, Nat Struct Biol. 2003 Dec;10(12):1019-25. Epub 2003 Nov 16.~~ PMID:[~~http~~:~~//www.ncbi.nlm.nih.gov/pubmed/14625588 14625588~~]	+	<ref group="xtra">PMID:14625588</ref><references group="xtra"/>
		+	[[Category: Mus musculus]]
	[[Category: Brade, H.]]		[[Category: Brade, H.]]
	[[Category: Brade, L.]]		[[Category: Brade, L.]]
Line 40:		Line 41:
	[[Category: Protein-carbohydrate complex]]		[[Category: Protein-carbohydrate complex]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Jul 28 20~~:06:~~48 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 14:39:02 2009''

OCA at 17:06, 28 July 2008

OCA — Mon, 28 Jul 2008 17:06:50 GMT

←Older revision		Revision as of 17:06, 28 July 2008
Line 1:		Line 1:
-	[[Image:1q9v.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:1q9v.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_1q9v\| PDB=1q9v \| SCENE= }}		{{STRUCTURE_1q9v\| PDB=1q9v \| SCENE= }}

-	~~'''~~S25-2- Kdo monosaccharide complex~~'''~~	+	===S25-2- Kdo monosaccharide complex===


-	~~==Overview==~~	+	<!--
-	~~High-resolution structures reveal how a germline antibody can recognize a range of clinically relevant carbohydrate epitopes.~~ The ~~germline response to a carbohydrate immunogen can be critical to survivability~~, ~~with selection for antibody gene segments that both confer protection against common pathogens and retain~~ the ~~flexibility~~ to ~~adapt to new disease organisms~~. ~~We show here that antibody S25-2 binds several distinct inner-core epitopes of bacterial lipopolysaccharides (LPSs~~) by linking an inherited monosaccharide residue binding site with a subset of complementarity-determining regions (CDRs) of limited flexibility positioned to recognize the remainder of an array of different epitopes. This strategy allows germline antibodies to adapt to different epitopes while minimizing entropic penalties associated with the immobilization of labile CDRs upon binding of antigen, ~~and provides insight into~~ the ~~link between the genetic origin of individual CDRs and their respective roles in antigen recognition~~.	+	The line below this paragraph, {{ABSTRACT_PUBMED_14625588}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 14625588 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_14625588}}

	==About this Structure==		==About this Structure==
Line 35:		Line 39:
	[[Category: Kdo]]		[[Category: Kdo]]
	[[Category: Protein-carbohydrate complex]]		[[Category: Protein-carbohydrate complex]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 06~~:03:09 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:06:48 2008''

OCA at 03:03, 3 May 2008

OCA — Sat, 03 May 2008 03:03:12 GMT

←Older revision		Revision as of 03:03, 3 May 2008
Line 1:		Line 1:
	[[Image:1q9v.gif\|left\|200px]]		[[Image:1q9v.gif\|left\|200px]]

-	{{Structure	+	<!--
-	\|PDB~~= 1q9v \|SIZE=350\|CAPTION= <~~scene ~~name='initialview01'>1q9v</scene>~~, ~~resolution 1~~.~~73Å~~	+	The line below this paragraph, containing "STRUCTURE_1q9v", creates the "Structure Box" on the page.
-	~~\|SITE=~~	+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	~~\|LIGAND= <scene name='pdbligand=KDO:3~~-~~DEOXY~~-~~D-MANNO-OCT-2-ULOSONIC+ACID'>KDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~>	+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	\|~~ACTIVITY~~=	+	or leave the SCENE parameter empty for the default display.
-	\|~~GENE~~=	+	-->
-	~~\|DOMAIN=~~	+	{{STRUCTURE_1q9v\| PDB=1q9v \| SCENE= }}
-	~~\|RELATEDENTRY=[[1q9t\|1q9t]], [[1q9r\|1q9r]], [[1q9q\|1q9q]], [[1q9l\|1q9l]], [[1q9k\|1q9k]], [[1q9o\|1q9o]], [[1q9w\|1q9w]]~~	+
-	\|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q9v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q9v OCA], [http://www.ebi.ac.uk/pdbsum/1q9v PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1q9v RCSB]</span>	+
-	}}	+

	'''S25-2- Kdo monosaccharide complex'''		'''S25-2- Kdo monosaccharide complex'''
Line 19:		Line 16:

	==About this Structure==		==About this Structure==
-	~~1Q9V is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus].~~ Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q9V OCA].	+	Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q9V OCA].

	==Reference==		==Reference==
	Germline antibody recognition of distinct carbohydrate epitopes., Nguyen HP, Seto NO, MacKenzie CR, Brade L, Kosma P, Brade H, Evans SV, Nat Struct Biol. 2003 Dec;10(12):1019-25. Epub 2003 Nov 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14625588 14625588]		Germline antibody recognition of distinct carbohydrate epitopes., Nguyen HP, Seto NO, MacKenzie CR, Brade L, Kosma P, Brade H, Evans SV, Nat Struct Biol. 2003 Dec;10(12):1019-25. Epub 2003 Nov 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14625588 14625588]
-	[[Category: Mus musculus]]
-	[[Category: Protein complex]]
	[[Category: Brade, H.]]		[[Category: Brade, H.]]
	[[Category: Brade, L.]]		[[Category: Brade, L.]]
Line 32:		Line 27:
	[[Category: Nguyen, H P.]]		[[Category: Nguyen, H P.]]
	[[Category: Seto, N O.]]		[[Category: Seto, N O.]]
-	[[Category: ~~anti~~-carbohydrate]]	+	[[Category: Anti-carbohydrate]]
-	[[Category: ~~anti~~-lp]]	+	[[Category: Anti-lp]]
-	[[Category: ~~antibody~~]]	+	[[Category: Antibody]]
-	[[Category: ~~antigen~~-binding fragment]]	+	[[Category: Antigen-binding fragment]]
-	[[Category: ~~fab~~]]	+	[[Category: Fab]]
-	[[Category: ~~immunoglobulin~~]]	+	[[Category: Immunoglobulin]]
-	[[Category: ~~kdo~~]]	+	[[Category: Kdo]]
-	[[Category: ~~protein~~-carbohydrate complex]]	+	[[Category: Protein-carbohydrate complex]]
-		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:03:09 2008''
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun Mar 30 23~~:10:47 2008''	+

OCA at 20:10, 30 March 2008

OCA — Sun, 30 Mar 2008 20:10:49 GMT

←Older revision		Revision as of 20:10, 30 March 2008
Line 4:		Line 4:
	\|PDB= 1q9v \|SIZE=350\|CAPTION= <scene name='initialview01'>1q9v</scene>, resolution 1.73Å		\|PDB= 1q9v \|SIZE=350\|CAPTION= <scene name='initialview01'>1q9v</scene>, resolution 1.73Å
	\|SITE=		\|SITE=
-	\|LIGAND= <scene name='pdbligand=KDO:3-DEOXY-D-MANNO-OCT-2-ULOSONIC+ACID'>KDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> ~~and~~ <scene name='pdbligand=ZN:ZINC ION'>ZN</scene>	+	\|LIGAND= <scene name='pdbligand=KDO:3-DEOXY-D-MANNO-OCT-2-ULOSONIC+ACID'>KDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
	\|ACTIVITY=		\|ACTIVITY=
	\|GENE=		\|GENE=
		+	\|DOMAIN=
		+	\|RELATEDENTRY=[[1q9t\|1q9t]], [[1q9r\|1q9r]], [[1q9q\|1q9q]], [[1q9l\|1q9l]], [[1q9k\|1q9k]], [[1q9o\|1q9o]], [[1q9w\|1q9w]]
		+	\|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q9v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q9v OCA], [http://www.ebi.ac.uk/pdbsum/1q9v PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1q9v RCSB]</span>
	}}		}}

Line 29:		Line 32:
	[[Category: Nguyen, H P.]]		[[Category: Nguyen, H P.]]
	[[Category: Seto, N O.]]		[[Category: Seto, N O.]]
-	[[Category: KDO]]
-	[[Category: MG]]
-	[[Category: ZN]]
	[[Category: anti-carbohydrate]]		[[Category: anti-carbohydrate]]
	[[Category: anti-lp]]		[[Category: anti-lp]]
Line 41:		Line 41:
	[[Category: protein-carbohydrate complex]]		[[Category: protein-carbohydrate complex]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu~~ Mar ~~20 13~~:34:51 2008''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:10:47 2008''

OCA at 11:34, 20 March 2008

OCA — Thu, 20 Mar 2008 11:34:54 GMT

←Older revision		Revision as of 11:34, 20 March 2008
Line 1:		Line 1:
-	[[Image:1q9v.gif\|left\|200px]]~~<br /><applet load~~="1q9v~~" size~~="350~~" color~~=~~"white" frame="true" align~~=~~"right" spinBox="true"~~	+	[[Image:1q9v.gif\|left\|200px]]
-	~~caption="~~1q9v, resolution 1.73Å" />	+
-	'''S25-2- Kdo monosaccharide complex'''~~<br />~~	+	{{Structure
		+	\|PDB= 1q9v \|SIZE=350\|CAPTION= <scene name='initialview01'>1q9v</scene>, resolution 1.73Å
		+	\|SITE=
		+	\|LIGAND= <scene name='pdbligand=KDO:3-DEOXY-D-MANNO-OCT-2-ULOSONIC+ACID'>KDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> and <scene name='pdbligand=ZN:ZINC ION'>ZN</scene>
		+	\|ACTIVITY=
		+	\|GENE=
		+	}}
		+
		+	'''S25-2- Kdo monosaccharide complex'''
		+

	==Overview==		==Overview==
Line 7:		Line 16:

	==About this Structure==		==About this Structure==
-	1Q9V is a [~~http://en.wikipedia.org/wiki/Protein_complex~~ Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus~~] with <scene name='pdbligand=KDO:'>KDO</scene>, <scene name='pdbligand=MG:'>MG</scene> and <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligands ligands~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q9V OCA].	+	1Q9V is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q9V OCA].

	==Reference==		==Reference==
-	Germline antibody recognition of distinct carbohydrate epitopes., Nguyen HP, Seto NO, MacKenzie CR, Brade L, Kosma P, Brade H, Evans SV, Nat Struct Biol. 2003 Dec;10(12):1019-25. Epub 2003 Nov 16. PMID:[http://~~ispc~~.~~weizmann~~.ac.~~il/~~/~~pmbin~~/~~getpm?pmid=~~14625588 14625588]	+	Germline antibody recognition of distinct carbohydrate epitopes., Nguyen HP, Seto NO, MacKenzie CR, Brade L, Kosma P, Brade H, Evans SV, Nat Struct Biol. 2003 Dec;10(12):1019-25. Epub 2003 Nov 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14625588 14625588]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Protein complex]]		[[Category: Protein complex]]
Line 24:		Line 33:
	[[Category: ZN]]		[[Category: ZN]]
	[[Category: anti-carbohydrate]]		[[Category: anti-carbohydrate]]
-	[[Category: anti-~~lps~~]]	+	[[Category: anti-lp]]
	[[Category: antibody]]		[[Category: antibody]]
	[[Category: antigen-binding fragment]]		[[Category: antigen-binding fragment]]
Line 32:		Line 41:
	[[Category: protein-carbohydrate complex]]		[[Category: protein-carbohydrate complex]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu ~~Feb 21 14~~:37:23 2008''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:34:51 2008''

OCA at 12:37, 21 February 2008

OCA — Thu, 21 Feb 2008 12:37:24 GMT

←Older revision		Revision as of 12:37, 21 February 2008
Line 1:		Line 1:
-	[[Image:1q9v.gif\|left\|200px]]<br />	+	[[Image:1q9v.gif\|left\|200px]]<br /><applet load="1q9v" size="350" color="white" frame="true" align="right" spinBox="true"
-	<applet load="1q9v" size="~~450~~" color="white" frame="true" align="right" spinBox="true"	+
	caption="1q9v, resolution 1.73Å" />		caption="1q9v, resolution 1.73Å" />
	'''S25-2- Kdo monosaccharide complex'''<br />		'''S25-2- Kdo monosaccharide complex'''<br />

	==Overview==		==Overview==
-	High-resolution structures reveal how a germline antibody can recognize a, range of clinically relevant carbohydrate epitopes. The germline response, to a carbohydrate immunogen can be critical to survivability, with, selection for antibody gene segments that both confer protection against, common pathogens and retain the flexibility to adapt to new disease, organisms. We show here that antibody S25-2 binds several distinct, inner-core epitopes of bacterial lipopolysaccharides (LPSs) by linking an, inherited monosaccharide residue binding site with a subset of, complementarity-determining regions (CDRs) of limited flexibility, positioned to recognize the remainder of an array of different epitopes., This strategy allows germline antibodies to adapt to different epitopes, while minimizing entropic penalties associated with the immobilization of, labile CDRs upon binding of antigen, and provides insight into the link, between the genetic origin of individual CDRs and their respective roles, in antigen recognition.	+	High-resolution structures reveal how a germline antibody can recognize a range of clinically relevant carbohydrate epitopes. The germline response to a carbohydrate immunogen can be critical to survivability, with selection for antibody gene segments that both confer protection against common pathogens and retain the flexibility to adapt to new disease organisms. We show here that antibody S25-2 binds several distinct inner-core epitopes of bacterial lipopolysaccharides (LPSs) by linking an inherited monosaccharide residue binding site with a subset of complementarity-determining regions (CDRs) of limited flexibility positioned to recognize the remainder of an array of different epitopes. This strategy allows germline antibodies to adapt to different epitopes while minimizing entropic penalties associated with the immobilization of labile CDRs upon binding of antigen, and provides insight into the link between the genetic origin of individual CDRs and their respective roles in antigen recognition.

	==About this Structure==		==About this Structure==
-	1Q9V is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with KDO, MG and ZN as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1Q9V OCA].	+	1Q9V is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=KDO:'>KDO</scene>, <scene name='pdbligand=MG:'>MG</scene> and <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q9V OCA].

	==Reference==		==Reference==
Line 16:		Line 15:
	[[Category: Brade, H.]]		[[Category: Brade, H.]]
	[[Category: Brade, L.]]		[[Category: Brade, L.]]
-	[[Category: Evans, S.V.]]	+	[[Category: Evans, S V.]]
	[[Category: Kosma, P.]]		[[Category: Kosma, P.]]
-	[[Category: MacKenzie, C.R.]]	+	[[Category: MacKenzie, C R.]]
-	[[Category: Nguyen, H.P.]]	+	[[Category: Nguyen, H P.]]
-	[[Category: Seto, N.O.]]	+	[[Category: Seto, N O.]]
	[[Category: KDO]]		[[Category: KDO]]
	[[Category: MG]]		[[Category: MG]]
Line 33:		Line 32:
	[[Category: protein-carbohydrate complex]]		[[Category: protein-carbohydrate complex]]

-	''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Sun Nov 18 09~~:40:~~16 2007~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:37:23 2008''

OCA: New page: 200px
'''S25-2- Kdo monosacc...
OCA — Sun, 18 Nov 2007 07:33:17 GMT

New page: 200px<br /> <applet load="1q9v" size="450" color="white" frame="true" align="right" spinBox="true" caption="1q9v, resolution 1.73Å" /> '''S25-2- Kdo monosacc...

New page
[[Image:1q9v.gif|left|200px]]<br />
<applet load="1q9v" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1q9v, resolution 1.73Å" />
'''S25-2- Kdo monosaccharide complex'''<br />

==Overview==
High-resolution structures reveal how a germline antibody can recognize a, range of clinically relevant carbohydrate epitopes. The germline response, to a carbohydrate immunogen can be critical to survivability, with, selection for antibody gene segments that both confer protection against, common pathogens and retain the flexibility to adapt to new disease, organisms. We show here that antibody S25-2 binds several distinct, inner-core epitopes of bacterial lipopolysaccharides (LPSs) by linking an, inherited monosaccharide residue binding site with a subset of, complementarity-determining regions (CDRs) of limited flexibility, positioned to recognize the remainder of an array of different epitopes., This strategy allows germline antibodies to adapt to different epitopes, while minimizing entropic penalties associated with the immobilization of, labile CDRs upon binding of antigen, and provides insight into the link, between the genetic origin of individual CDRs and their respective roles, in antigen recognition.

==About this Structure==
1Q9V is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with KDO, MG and ZN as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1Q9V OCA].

==Reference==
Germline antibody recognition of distinct carbohydrate epitopes., Nguyen HP, Seto NO, MacKenzie CR, Brade L, Kosma P, Brade H, Evans SV, Nat Struct Biol. 2003 Dec;10(12):1019-25. Epub 2003 Nov 16. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=14625588 14625588]
[[Category: Mus musculus]]
[[Category: Protein complex]]
[[Category: Brade, H.]]
[[Category: Brade, L.]]
[[Category: Evans, S.V.]]
[[Category: Kosma, P.]]
[[Category: MacKenzie, C.R.]]
[[Category: Nguyen, H.P.]]
[[Category: Seto, N.O.]]
[[Category: KDO]]
[[Category: MG]]
[[Category: ZN]]
[[Category: anti-carbohydrate]]
[[Category: anti-lps]]
[[Category: antibody]]
[[Category: antigen-binding fragment]]
[[Category: fab]]
[[Category: immunoglobulin]]
[[Category: kdo]]
[[Category: protein-carbohydrate complex]]

''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 18 09:40:16 2007''