1qbd - Revision history

OCA at 09:40, 8 September 2021

OCA — Wed, 08 Sep 2021 09:40:13 GMT

←Older revision		Revision as of 09:40, 8 September 2021
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	<StructureSection load='1qbd' size='340' side='right'caption='[[1qbd]]' scene=''>		<StructureSection load='1qbd' size='340' side='right'caption='[[1qbd]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1QBD FirstGlance]. <br>	+	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QBD FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1qbd FirstGlance], [~~http~~://www.ebi.ac.uk/pdbsum/1qbd PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1qbd ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qbd FirstGlance], [https://www.ebi.ac.uk/pdbsum/1qbd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qbd ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 10:03, 27 November 2019

OCA — Wed, 27 Nov 2019 10:03:34 GMT

←Older revision		Revision as of 10:03, 27 November 2019
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	==HEXOSAMINIDASE BETA CHAIN, GLYCOSYL HYDROLASE FAMILY 20, THEORETICAL MODEL==		==HEXOSAMINIDASE BETA CHAIN, GLYCOSYL HYDROLASE FAMILY 20, THEORETICAL MODEL==
-	<StructureSection load='1qbd' size='340' side='right' caption='[[1qbd]]' scene=''>	+	<StructureSection load='1qbd' size='340' side='right'caption='[[1qbd]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QBD FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QBD FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Theoretical Model]]		[[Category: Theoretical Model]]
		+	[[Category: Large Structures]]
	[[Category: Dauter, Z]]		[[Category: Dauter, Z]]
	[[Category: Oppenheim, A]]		[[Category: Oppenheim, A]]

OCA at 08:04, 24 February 2018

OCA — Sat, 24 Feb 2018 08:04:50 GMT

←Older revision		Revision as of 08:04, 24 February 2018
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QBD FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QBD FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qbd FirstGlance], [http://www.ebi.ac.uk/pdbsum/1qbd PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qbd FirstGlance], [http://www.ebi.ac.uk/pdbsum/1qbd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1qbd ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 09:43, 11 February 2016

OCA — Thu, 11 Feb 2016 09:43:27 GMT

←Older revision		Revision as of 09:43, 11 February 2016
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		+	{{Theoretical_model}}
		+
	==HEXOSAMINIDASE BETA CHAIN, GLYCOSYL HYDROLASE FAMILY 20, THEORETICAL MODEL==		==HEXOSAMINIDASE BETA CHAIN, GLYCOSYL HYDROLASE FAMILY 20, THEORETICAL MODEL==
	<StructureSection load='1qbd' size='340' side='right' caption='[[1qbd]]' scene=''>		<StructureSection load='1qbd' size='340' side='right' caption='[[1qbd]]' scene=''>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Theoretical Model]]
	[[Category: Dauter, Z]]		[[Category: Dauter, Z]]
	[[Category: Oppenheim, A]]		[[Category: Oppenheim, A]]

OCA at 20:04, 10 September 2015

OCA — Thu, 10 Sep 2015 20:04:35 GMT

←Older revision		Revision as of 20:04, 10 September 2015
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1qbd" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:00, 18 December 2014

OCA — Thu, 18 Dec 2014 12:00:05 GMT

←Older revision		Revision as of 12:00, 18 December 2014
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-	~~{{Theoretical_model}}~~	+	==HEXOSAMINIDASE BETA CHAIN, GLYCOSYL HYDROLASE FAMILY 20, THEORETICAL MODEL==
		+	<StructureSection load='1qbd' size='340' side='right' caption='[[1qbd]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QBD FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qbd FirstGlance], [http://www.ebi.ac.uk/pdbsum/1qbd PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Chitin, the second most abundant polysaccharide on earth, is degraded by chitinases and chitobiases. The structure of Serratia marcescens chitobiase has been refined at 1.9 A resolution. The mature protein is folded into four domains and its active site is situated at the C-terminal end of the central (beta alpha)8-barrel. Based on the structure of the complex with the substrate disaccharide chitobiose, we propose an acid-base reaction mechanism, in which only one protein carboxylate acts as catalytic acid, while the nucleophile is the polar acetamido group of the sugar in a substrate-assisted reaction. The structural data lead to the hypothesis that the reaction proceeds with retention of anomeric configuration. The structure allows us to model the catalytic domain of the homologous hexosaminidases to give a structural rationale to pathogenic mutations that underlie Tay-Sachs and Sandhoff disease.

-	~~{{STRUCTURE_1qbd\| PDB=1qbd \| SCENE= }}~~	+	Bacterial chitobiase structure provides insight into catalytic mechanism and the basis of Tay-Sachs disease.,Tews I, Perrakis A, Oppenheim A, Dauter Z, Wilson KS, Vorgias CE Nat Struct Biol. 1996 Jul;3(7):638-48. PMID:8673609<ref>PMID:8673609</ref>
-	~~===HEXOSAMINIDASE BETA CHAIN~~, ~~GLYCOSYL HYDROLASE FAMILY 20~~, ~~THEORETICAL MODEL===~~	+
-	~~{{ABSTRACT_PUBMED_8673609}}~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:008673609</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Dauter, Z]]		[[Category: Dauter, Z]]
	[[Category: Oppenheim, A]]		[[Category: Oppenheim, A]]

OCA at 04:32, 25 March 2013

OCA — Mon, 25 Mar 2013 04:32:20 GMT

←Older revision		Revision as of 04:32, 25 March 2013
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	{{Theoretical_model}}		{{Theoretical_model}}
-
-	[[Image:1qbd.png\|left\|200px]]

	{{STRUCTURE_1qbd\| PDB=1qbd \| SCENE= }}		{{STRUCTURE_1qbd\| PDB=1qbd \| SCENE= }}
-
	===HEXOSAMINIDASE BETA CHAIN, GLYCOSYL HYDROLASE FAMILY 20, THEORETICAL MODEL===		===HEXOSAMINIDASE BETA CHAIN, GLYCOSYL HYDROLASE FAMILY 20, THEORETICAL MODEL===
-
	{{ABSTRACT_PUBMED_8673609}}		{{ABSTRACT_PUBMED_8673609}}

	==Reference==		==Reference==
-	<ref group="xtra">PMID:008673609</ref><references group="xtra"/>	+	<ref group="xtra">PMID:008673609</ref><references group="xtra"/><references/>
	[[Category: Dauter, Z]]		[[Category: Dauter, Z]]
	[[Category: Oppenheim, A]]		[[Category: Oppenheim, A]]

OCA: Protected "1qbd" [edit=sysop:move=sysop]

OCA — Sun, 21 Oct 2012 09:38:05 GMT

Protected "1qbd" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:38, 21 October 2012

OCA at 09:38, 21 October 2012

OCA — Sun, 21 Oct 2012 09:38:00 GMT

←Older revision		Revision as of 09:38, 21 October 2012
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	{{Theoretical_model}}		{{Theoretical_model}}
-	~~{{Seed}}~~	+
	[[Image:1qbd.png\|left\|200px]]		[[Image:1qbd.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1qbd", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1qbd\| PDB=1qbd \| SCENE= }}		{{STRUCTURE_1qbd\| PDB=1qbd \| SCENE= }}

	===HEXOSAMINIDASE BETA CHAIN, GLYCOSYL HYDROLASE FAMILY 20, THEORETICAL MODEL===		===HEXOSAMINIDASE BETA CHAIN, GLYCOSYL HYDROLASE FAMILY 20, THEORETICAL MODEL===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_8673609}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 8673609 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_8673609}}		{{ABSTRACT_PUBMED_8673609}}
-
-	==About this Structure==
-	Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QBD OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~8673609~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:008673609</ref><references group="xtra"/>
	[[Category: Dauter, Z]]		[[Category: Dauter, Z]]
	[[Category: Oppenheim, A]]		[[Category: Oppenheim, A]]
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	[[Category: Vorgias, C E]]		[[Category: Vorgias, C E]]
	[[Category: Wilson, K S]]		[[Category: Wilson, K S]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 08:41:49 2010''

OCA at 05:41, 8 April 2010

OCA — Thu, 08 Apr 2010 05:41:49 GMT

←Older revision		Revision as of 05:41, 8 April 2010
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-	~~'''Theoretical Model'''~~	+	{{Theoretical_model}}
		+	{{Seed}}
		+	[[Image:1qbd.png\|left\|200px]]

-	The ~~entry 1QBD is a Theoretical Model titled 'HEXOSAMINIDASE BETA CHAIN~~, ~~GLYCOSYL HYDROLASE FAMILY 20~~, ~~THEORETICAL MODEL'~~.	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_1qbd", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_1qbd\| PDB=1qbd \| SCENE= }}

-	~~[[Category:Theoretical Model]]~~	+	===HEXOSAMINIDASE BETA CHAIN, GLYCOSYL HYDROLASE FAMILY 20, THEORETICAL MODEL===


-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Jul 30 09~~:52:~~51 2008~~''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_8673609}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 8673609 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_8673609}}
		+
		+	==About this Structure==
		+	Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QBD OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:8673609</ref><references group="xtra"/>
		+	[[Category: Dauter, Z]]
		+	[[Category: Oppenheim, A]]
		+	[[Category: Perrakis, A]]
		+	[[Category: Tews, I]]
		+	[[Category: Vorgias, C E]]
		+	[[Category: Wilson, K S]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 08:41:49 2010''