1qct - Revision history

OCA at 09:53, 15 September 2021

OCA — Wed, 15 Sep 2021 09:53:51 GMT

←Older revision		Revision as of 09:53, 15 September 2021
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	<StructureSection load='1qct' size='340' side='right'caption='[[1qct]]' scene=''>		<StructureSection load='1qct' size='340' side='right'caption='[[1qct]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1QCT FirstGlance]. <br>	+	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QCT FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1qct FirstGlance], [~~http~~://www.ebi.ac.uk/pdbsum/1qct PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1qct ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qct FirstGlance], [https://www.ebi.ac.uk/pdbsum/1qct PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qct ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 10:37, 27 November 2019

OCA — Wed, 27 Nov 2019 10:37:48 GMT

←Older revision		Revision as of 10:37, 27 November 2019
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	==AN 'ELECTROSTATIC SANDWICH' MODEL FOR THE (FIBROBLAST GROWTH FACTOR RECEPTOR-HEPARIN-FIBROBLAST GROWTH FACTOR) DIMER==		==AN 'ELECTROSTATIC SANDWICH' MODEL FOR THE (FIBROBLAST GROWTH FACTOR RECEPTOR-HEPARIN-FIBROBLAST GROWTH FACTOR) DIMER==
-	<StructureSection load='1qct' size='340' side='right' caption='[[1qct]]' scene=''>	+	<StructureSection load='1qct' size='340' side='right'caption='[[1qct]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QCT FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QCT FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Theoretical Model]]		[[Category: Theoretical Model]]
		+	[[Category: Large Structures]]
	[[Category: Huhtala, M T]]		[[Category: Huhtala, M T]]
	[[Category: Johnson, M S]]		[[Category: Johnson, M S]]
	[[Category: Pentikainen, O T]]		[[Category: Pentikainen, O T]]

OCA at 08:35, 24 February 2018

OCA — Sat, 24 Feb 2018 08:35:22 GMT

←Older revision		Revision as of 08:35, 24 February 2018
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QCT FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QCT FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qct FirstGlance], [http://www.ebi.ac.uk/pdbsum/1qct PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qct FirstGlance], [http://www.ebi.ac.uk/pdbsum/1qct PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1qct ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 09:43, 11 February 2016

OCA — Thu, 11 Feb 2016 09:43:40 GMT

←Older revision		Revision as of 09:43, 11 February 2016
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		+	{{Theoretical_model}}
		+
	==AN 'ELECTROSTATIC SANDWICH' MODEL FOR THE (FIBROBLAST GROWTH FACTOR RECEPTOR-HEPARIN-FIBROBLAST GROWTH FACTOR) DIMER==		==AN 'ELECTROSTATIC SANDWICH' MODEL FOR THE (FIBROBLAST GROWTH FACTOR RECEPTOR-HEPARIN-FIBROBLAST GROWTH FACTOR) DIMER==
	<StructureSection load='1qct' size='340' side='right' caption='[[1qct]]' scene=''>		<StructureSection load='1qct' size='340' side='right' caption='[[1qct]]' scene=''>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Theoretical Model]]
	[[Category: Huhtala, M T]]		[[Category: Huhtala, M T]]
	[[Category: Johnson, M S]]		[[Category: Johnson, M S]]
	[[Category: Pentikainen, O T]]		[[Category: Pentikainen, O T]]

OCA at 04:32, 10 September 2015

OCA — Thu, 10 Sep 2015 04:32:53 GMT

←Older revision		Revision as of 04:32, 10 September 2015
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1qct" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:36, 6 January 2015

OCA — Tue, 06 Jan 2015 07:36:07 GMT

←Older revision		Revision as of 07:36, 6 January 2015
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QCT FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QCT FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qct FirstGlance], [http://www.ebi.ac.uk/pdbsum/1qct PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qct FirstGlance], [http://www.ebi.ac.uk/pdbsum/1qct PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 20:01, 28 September 2014

OCA — Sun, 28 Sep 2014 20:01:18 GMT

←Older revision		Revision as of 20:01, 28 September 2014
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-	~~{{Theoretical_model}}~~	+	==AN 'ELECTROSTATIC SANDWICH' MODEL FOR THE (FIBROBLAST GROWTH FACTOR RECEPTOR-HEPARIN-FIBROBLAST GROWTH FACTOR) DIMER==
		+	<StructureSection load='1qct' size='340' side='right' caption='[[1qct]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QCT FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qct FirstGlance], [http://www.ebi.ac.uk/pdbsum/1qct PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	BACKGROUND: Fibroblastic growth factors (FGFs) are a family of cytokines involved in regulation of cell growth, differentiation and chemotaxis in a variety of tissue types. High-affinity FGF receptors (FGFRs) are transmembrane proteins that consist of three extracellular immunoglobulin-like domains, a transmembrane helix and an intracellular protein tyrosine kinase signalling domain. FGFRs are activated through ligand-dependent dimerization that allows trans-autophosphorylation of the tyrosine kinase domains. Heparin or heparin-like molecules, such as heparan sulphate proteoglycans, bind to both FGFs and FGFRs and are required for FGF signal transduction. At present no structure of the ternary complex for FGFR, FGF and heparin exists. RESULTS: We have used the type-1 interleukin-1 receptor-interleukin-1 beta complex crystal structure, in which both the ligand and the receptor are homologous to those of the FGF-FGFR pair, to identify potential interactions in the FGFR-heparin-FGF ternary complex. A key feature of the modelled complex is the 'electrostatic sandwich' that is formed between the positively charged surfaces of FGF and the receptor, with the negatively charged heparin captured in between. The ternary complex places limits on the range of likely modes of receptor dimerization: one of five different dimeric receptor complexes built from the ternary complex correlates best with the experimental data. CONCLUSIONS: The ternary complex of FGFR, FGF and heparin, derived on the basis of the homologous interleukin-1 receptor complex, is in agreement with much of the published experimental data, as is the dimeric receptor complex (FGFR-heparin-FGF)2. This work suggests that the FGF interactions seen in crystal structures, which have previously been used to predict the mode of FGF dimerization, might not be relevant to the biologically active dimeric FGFR-heparin-FGF complex.

-	[~~[Image~~:~~1qct~~.~~png\|left\|200px]]~~	+	A dimeric ternary complex of FGFR [correction of FGFR1], heparin and FGF-1 leads to an 'electrostatic sandwich' model for heparin binding.,Huhtala MT, Pentikainen OT, Johnson MS Structure. 1999 Jun 15;7(6):699-709. PMID:10404599<ref>PMID:10404599</ref>

-	~~{{STRUCTURE_1qct\| PDB=1qct \| SCENE= }}~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	==~~=AN 'ELECTROSTATIC SANDWICH' MODEL FOR THE (FIBROBLAST GROWTH FACTOR RECEPTOR-HEPARIN-FIBROBLAST GROWTH FACTOR) DIMER===~~	+	== References ==
-		+	<references/>
-	~~{{ABSTRACT_PUBMED_10404599}}~~	+	__TOC__
-		+	</StructureSection>
-	~~==Reference~~==	+
-	<~~ref group="xtra">PMID:010404599<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Huhtala, M T]]		[[Category: Huhtala, M T]]
	[[Category: Johnson, M S]]		[[Category: Johnson, M S]]
	[[Category: Pentikainen, O T]]		[[Category: Pentikainen, O T]]

OCA: Protected "1qct" [edit=sysop:move=sysop]

OCA — Sun, 21 Oct 2012 09:23:46 GMT

Protected "1qct" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:23, 21 October 2012

OCA at 09:23, 21 October 2012

OCA — Sun, 21 Oct 2012 09:23:42 GMT

←Older revision		Revision as of 09:23, 21 October 2012
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	{{Theoretical_model}}		{{Theoretical_model}}
-	~~{{Seed}}~~	+
	[[Image:1qct.png\|left\|200px]]		[[Image:1qct.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1qct", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1qct\| PDB=1qct \| SCENE= }}		{{STRUCTURE_1qct\| PDB=1qct \| SCENE= }}

	===AN 'ELECTROSTATIC SANDWICH' MODEL FOR THE (FIBROBLAST GROWTH FACTOR RECEPTOR-HEPARIN-FIBROBLAST GROWTH FACTOR) DIMER===		===AN 'ELECTROSTATIC SANDWICH' MODEL FOR THE (FIBROBLAST GROWTH FACTOR RECEPTOR-HEPARIN-FIBROBLAST GROWTH FACTOR) DIMER===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_10404599}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 10404599 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_10404599}}		{{ABSTRACT_PUBMED_10404599}}
-
-	==About this Structure==
-	Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QCT OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~10404599~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:010404599</ref><references group="xtra"/>
	[[Category: Huhtala, M T]]		[[Category: Huhtala, M T]]
	[[Category: Johnson, M S]]		[[Category: Johnson, M S]]
	[[Category: Pentikainen, O T]]		[[Category: Pentikainen, O T]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 08:14:05 2010''

OCA at 05:14, 8 April 2010

OCA — Thu, 08 Apr 2010 05:14:06 GMT

←Older revision		Revision as of 05:14, 8 April 2010
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-	~~'''Theoretical Model'''~~	+	{{Theoretical_model}}
		+	{{Seed}}
		+	[[Image:1qct.png\|left\|200px]]

-	~~The entry 1QCT is a Theoretical Model titled 'AN 'ELECTROSTATIC SANDWICH' MODEL FOR THE (FIBROBLAST GROWTH FACTOR RECEPTOR~~-~~HEPARIN~~-~~FIBROBLAST GROWTH FACTOR~~) ~~DIMER'~~.	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_1qct", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_1qct\| PDB=1qct \| SCENE= }}

-	~~[[Category:Theoretical Model]]~~	+	===AN 'ELECTROSTATIC SANDWICH' MODEL FOR THE (FIBROBLAST GROWTH FACTOR RECEPTOR-HEPARIN-FIBROBLAST GROWTH FACTOR) DIMER===


-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Jul 30 09~~:52:~~52 2008~~''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_10404599}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 10404599 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_10404599}}
		+
		+	==About this Structure==
		+	Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QCT OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:10404599</ref><references group="xtra"/>
		+	[[Category: Huhtala, M T]]
		+	[[Category: Johnson, M S]]
		+	[[Category: Pentikainen, O T]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 08:14:05 2010''