1qiu - Revision history

OCA at 07:46, 7 February 2024

OCA — Wed, 07 Feb 2024 07:46:41 GMT

←Older revision		Revision as of 07:46, 7 February 2024
Line 19:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qiu ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qiu ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Human adenoviruses are responsible for respiratory, gastroenteric and ocular infections and can serve as gene therapy vectors. They form icosahedral particles with 240 copies of the trimeric hexon protein arranged on the planes and a penton complex at each of the twelve vertices. The penton consists of a pentameric base, implicated in virus internalization, and a protruding trimeric fibre, responsible for receptor attachment. The fibres are homo-trimeric proteins containing an amino-terminal penton base attachment domain, a long, thin central shaft and a carboxy-terminal cell attachment or head domain. The shaft domain contains a repeating sequence motif with an invariant glycine or proline and a conserved pattern of hydrophobic residues. Here we describe the crystal structure at 2.4 A resolution of a recombinant protein containing the four distal repeats of the adenovirus type 2 fibre shaft plus the receptor-binding head domain. The structure reveals a novel triple beta-spiral fibrous fold for the shaft. Implications for folding of fibrous proteins (misfolding of shaft peptides leads to amyloid-like fibrils) and for the design of a new class of artificial, silk-like fibrous materials are discussed.
-
-	A triple beta-spiral in the adenovirus fibre shaft reveals a new structural motif for a fibrous protein.,van Raaij MJ, Mitraki A, Lavigne G, Cusack S Nature. 1999 Oct 28;401(6756):935-8. PMID:10553913<ref>PMID:10553913</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1qiu" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:46, 13 December 2023

OCA — Wed, 13 Dec 2023 12:46:15 GMT

←Older revision		Revision as of 12:46, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='1qiu' size='340' side='right'caption='[[1qiu]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='1qiu' size='340' side='right'caption='[[1qiu]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1qiu]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Ade02 Ade02~~]. The December 2010 RCSB PDB [~~http~~://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Adenovirus'' by David Goodsell is [~~http~~://dx.doi.org/10.2210/rcsb_pdb/mom_2010_12 10.2210/rcsb_pdb/mom_2010_12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QIU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1QIU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1qiu]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_adenovirus_2 Human adenovirus 2]. The December 2010 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Adenovirus'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2010_12 10.2210/rcsb_pdb/mom_2010_12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QIU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QIU FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[1qhv\|1qhv]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">LOCUS AD2H2 ([http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=10515 ADE02])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qiu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qiu OCA], [https://pdbe.org/1qiu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qiu RCSB], [https://www.ebi.ac.uk/pdbsum/1qiu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qiu ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1qiu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qiu OCA], [~~http~~://pdbe.org/1qiu PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1qiu RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1qiu PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1qiu ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/SPIKE_ADE02 SPIKE_ADE02]] Forms spikes that protrude from each vertex of the icosahedral capsid. Interacts with host coxsackievirus and adenovirus receptor CXADR located at the cell tight junctions to provide virion initial attachment to target cell. The fiber protein binds to CXADR with a higher affinity than CXADR binds to itself, thereby blocking the cell-cell adhesion function of CXADR dimers and leading to local disruption of the tight junction. Fiber protein present on neo-synthesized particles may thus disrupt the junctional integrity in order to facilitate further neighboring cells infection. Fiber proteins are shed during virus entry, when virus is still at the cell surface. Fiber shedding is dependent on viral CXADR drifting motion and subsequent binding to immobile integrins. Heparan sulfate might also play a role in virus binding.<ref>PMID:10704346</ref> <ref>PMID:12297051</ref> <ref>PMID:21843868</ref> <ref>PMID:9525681</ref>	+	[https://www.uniprot.org/uniprot/SPIKE_ADE02 SPIKE_ADE02] Forms spikes that protrude from each vertex of the icosahedral capsid. Interacts with host coxsackievirus and adenovirus receptor CXADR located at the cell tight junctions to provide virion initial attachment to target cell. The fiber protein binds to CXADR with a higher affinity than CXADR binds to itself, thereby blocking the cell-cell adhesion function of CXADR dimers and leading to local disruption of the tight junction. Fiber protein present on neo-synthesized particles may thus disrupt the junctional integrity in order to facilitate further neighboring cells infection. Fiber proteins are shed during virus entry, when virus is still at the cell surface. Fiber shedding is dependent on viral CXADR drifting motion and subsequent binding to immobile integrins. Heparan sulfate might also play a role in virus binding.<ref>PMID:10704346</ref> <ref>PMID:12297051</ref> <ref>PMID:21843868</ref> <ref>PMID:9525681</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Ade02]]
	[[Category: Adenovirus]]		[[Category: Adenovirus]]
		+	[[Category: Human adenovirus 2]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: RCSB PDB Molecule of the Month]]		[[Category: RCSB PDB Molecule of the Month]]
-	[[Category: Cusack, S]]	+	[[Category: Cusack S]]
-	[[Category: Lavigne, G]]	+	[[Category: Lavigne G]]
-	[[Category: Mitraki, A]]	+	[[Category: Mitraki A]]
-	[[Category: Raaij~~, M J.van]]~~	+	[[Category: Van Raaij MJ]]
-	~~[[Category: Fibre protein]]~~	+
-	~~[[Category: Triple beta-spiral~~]]	+

OCA at 13:10, 16 December 2020

OCA — Wed, 16 Dec 2020 13:10:15 GMT

←Older revision		Revision as of 13:10, 16 December 2020
Line 1:		Line 1:

	==A triple beta-spiral in the adenovirus fibre shaft reveals a new structural motif for biological fibres==		==A triple beta-spiral in the adenovirus fibre shaft reveals a new structural motif for biological fibres==
-	<StructureSection load='1qiu' size='340' side='right' caption='[[1qiu]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='1qiu' size='340' side='right'caption='[[1qiu]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1qiu]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Ade02 Ade02]. The December 2010 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Adenovirus'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2010_12 10.2210/rcsb_pdb/mom_2010_12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QIU OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1QIU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1qiu]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Ade02 Ade02]. The December 2010 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Adenovirus'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2010_12 10.2210/rcsb_pdb/mom_2010_12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QIU OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1QIU FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qhv\|1qhv]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1qhv\|1qhv]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LOCUS AD2H2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10515 ADE02])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LOCUS AD2H2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10515 ADE02])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1qiu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qiu OCA], [http://pdbe.org/1qiu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1qiu RCSB], [http://www.ebi.ac.uk/pdbsum/1qiu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1qiu ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1qiu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qiu OCA], [http://pdbe.org/1qiu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1qiu RCSB], [http://www.ebi.ac.uk/pdbsum/1qiu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1qiu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 35:		Line 35:
	[[Category: Ade02]]		[[Category: Ade02]]
	[[Category: Adenovirus]]		[[Category: Adenovirus]]
		+	[[Category: Large Structures]]
	[[Category: RCSB PDB Molecule of the Month]]		[[Category: RCSB PDB Molecule of the Month]]
	[[Category: Cusack, S]]		[[Category: Cusack, S]]

OCA at 07:15, 17 January 2018

OCA — Wed, 17 Jan 2018 07:15:18 GMT

←Older revision		Revision as of 07:15, 17 January 2018
Line 1:		Line 1:
-	==A ~~TRIPLE BETA~~-~~SPIRAL IN THE ADENOVIRUS FIBRE SHAFT REVEALS A NEW STRUCTURAL MOTIF FOR BIOLOGICAL FIBRES~~==	+
		+	==A triple beta-spiral in the adenovirus fibre shaft reveals a new structural motif for biological fibres==
	<StructureSection load='1qiu' size='340' side='right' caption='[[1qiu]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='1qiu' size='340' side='right' caption='[[1qiu]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qhv\|1qhv]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qhv\|1qhv]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LOCUS AD2H2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10515 ADE02])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LOCUS AD2H2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10515 ADE02])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qiu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qiu OCA], [http://pdbe.org/1qiu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1qiu RCSB], [http://www.ebi.ac.uk/pdbsum/1qiu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qiu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qiu OCA], [http://pdbe.org/1qiu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1qiu RCSB], [http://www.ebi.ac.uk/pdbsum/1qiu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1qiu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qi/1qiu_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qi/1qiu_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 38:		Line 39:
	[[Category: Lavigne, G]]		[[Category: Lavigne, G]]
	[[Category: Mitraki, A]]		[[Category: Mitraki, A]]
-	[[Category: Raaij, M J.~~Van~~]]	+	[[Category: Raaij, M J.van]]
	[[Category: Fibre protein]]		[[Category: Fibre protein]]
	[[Category: Triple beta-spiral]]		[[Category: Triple beta-spiral]]

OCA at 15:15, 9 February 2016

OCA — Tue, 09 Feb 2016 15:15:10 GMT

←Older revision		Revision as of 15:15, 9 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qiu ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 23:29, 10 September 2015

OCA — Thu, 10 Sep 2015 23:29:10 GMT

←Older revision		Revision as of 23:29, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1qiu' size='340' side='right' caption='[[1qiu]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='1qiu' size='340' side='right' caption='[[1qiu]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1qiu]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Human_adenovirus_2 Human adenovirus 2~~]. The December 2010 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Adenovirus'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2010_12 10.2210/rcsb_pdb/mom_2010_12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QIU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QIU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1qiu]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Ade02 Ade02]. The December 2010 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Adenovirus'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2010_12 10.2210/rcsb_pdb/mom_2010_12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QIU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QIU FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qhv\|1qhv]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qhv\|1qhv]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LOCUS AD2H2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10515 ~~Human adenovirus 2~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LOCUS AD2H2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10515 ADE02])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qiu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qiu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qiu RCSB], [http://www.ebi.ac.uk/pdbsum/1qiu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qiu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qiu OCA], [http://pdbe.org/1qiu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1qiu RCSB], [http://www.ebi.ac.uk/pdbsum/1qiu PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~FIBP_ADE02 FIBP_ADE02~~]] Forms spikes that protrude from each vertex of the icosahedral capsid. Interacts with host coxsackievirus and adenovirus receptor CXADR located at the cell tight junctions to provide virion initial attachment to target cell. The fiber protein binds to CXADR with a higher affinity than CXADR binds to itself, thereby blocking the cell-cell adhesion function of CXADR dimers and leading to local disruption of the tight junction. Fiber protein present on neo-synthesized particles may thus disrupt the junctional integrity in order to facilitate further neighboring cells infection. Fiber proteins are shed during virus entry, when virus is still at the cell surface. Fiber shedding is dependent on viral CXADR drifting motion and subsequent binding to immobile integrins. Heparan sulfate might also play a role in virus binding.<ref>PMID:~~9525681~~</ref> <ref>PMID:~~10704346~~</ref> <ref>PMID:~~12297051~~</ref> <ref>PMID:~~21843868~~</ref>	+	[[http://www.uniprot.org/uniprot/SPIKE_ADE02 SPIKE_ADE02]] Forms spikes that protrude from each vertex of the icosahedral capsid. Interacts with host coxsackievirus and adenovirus receptor CXADR located at the cell tight junctions to provide virion initial attachment to target cell. The fiber protein binds to CXADR with a higher affinity than CXADR binds to itself, thereby blocking the cell-cell adhesion function of CXADR dimers and leading to local disruption of the tight junction. Fiber protein present on neo-synthesized particles may thus disrupt the junctional integrity in order to facilitate further neighboring cells infection. Fiber proteins are shed during virus entry, when virus is still at the cell surface. Fiber shedding is dependent on viral CXADR drifting motion and subsequent binding to immobile integrins. Heparan sulfate might also play a role in virus binding.<ref>PMID:10704346</ref> <ref>PMID:12297051</ref> <ref>PMID:21843868</ref> <ref>PMID:9525681</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1qiu" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Ade02]]
	[[Category: Adenovirus]]		[[Category: Adenovirus]]
-	[[Category: Human adenovirus 2]]
	[[Category: RCSB PDB Molecule of the Month]]		[[Category: RCSB PDB Molecule of the Month]]
	[[Category: Cusack, S]]		[[Category: Cusack, S]]

OCA at 07:39, 25 December 2014

OCA — Thu, 25 Dec 2014 07:39:07 GMT

←Older revision		Revision as of 07:39, 25 December 2014
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1qiu]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_adenovirus_2 Human adenovirus 2]. The December 2010 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Adenovirus'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2010_12 10.2210/rcsb_pdb/mom_2010_12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QIU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QIU FirstGlance]. <br>		<table><tr><td colspan='2'>[[1qiu]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_adenovirus_2 Human adenovirus 2]. The December 2010 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Adenovirus'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2010_12 10.2210/rcsb_pdb/mom_2010_12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QIU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QIU FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qhv\|1qhv]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qhv\|1qhv]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LOCUS AD2H2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10515 Human adenovirus 2])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LOCUS AD2H2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10515 Human adenovirus 2])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qiu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qiu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qiu RCSB], [http://www.ebi.ac.uk/pdbsum/1qiu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qiu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qiu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qiu RCSB], [http://www.ebi.ac.uk/pdbsum/1qiu PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FIBP_ADE02 FIBP_ADE02]] Forms spikes that protrude from each vertex of the icosahedral capsid. Interacts with host coxsackievirus and adenovirus receptor CXADR located at the cell tight junctions to provide virion initial attachment to target cell. The fiber protein binds to CXADR with a higher affinity than CXADR binds to itself, thereby blocking the cell-cell adhesion function of CXADR dimers and leading to local disruption of the tight junction. Fiber protein present on neo-synthesized particles may thus disrupt the junctional integrity in order to facilitate further neighboring cells infection. Fiber proteins are shed during virus entry, when virus is still at the cell surface. Fiber shedding is dependent on viral CXADR drifting motion and subsequent binding to immobile integrins. Heparan sulfate might also play a role in virus binding.<ref>PMID:9525681</ref> <ref>PMID:10704346</ref> <ref>PMID:12297051</ref> <ref>PMID:21843868</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	[[Category: Human adenovirus 2]]		[[Category: Human adenovirus 2]]
	[[Category: RCSB PDB Molecule of the Month]]		[[Category: RCSB PDB Molecule of the Month]]
-	[[Category: Cusack, S.]]	+	[[Category: Cusack, S]]
-	[[Category: Lavigne, G.]]	+	[[Category: Lavigne, G]]
-	[[Category: Mitraki, A.]]	+	[[Category: Mitraki, A]]
-	[[Category: Raaij, M J.Van~~.]]~~	+	[[Category: Raaij, M J.Van]]
-	~~[[Category: Adenovirus~~]]	+
	[[Category: Fibre protein]]		[[Category: Fibre protein]]
	[[Category: Triple beta-spiral]]		[[Category: Triple beta-spiral]]

OCA at 14:38, 29 September 2014

OCA — Mon, 29 Sep 2014 14:38:37 GMT

←Older revision		Revision as of 14:38, 29 September 2014
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-	[[~~Image:~~1qiu.~~png~~\|~~left~~\|200px]]	+	==A TRIPLE BETA-SPIRAL IN THE ADENOVIRUS FIBRE SHAFT REVEALS A NEW STRUCTURAL MOTIF FOR BIOLOGICAL FIBRES==
		+	<StructureSection load='1qiu' size='340' side='right' caption='[[1qiu]], [[Resolution\|resolution]] 2.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1qiu]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_adenovirus_2 Human adenovirus 2]. The December 2010 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Adenovirus'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2010_12 10.2210/rcsb_pdb/mom_2010_12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QIU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QIU FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qhv\|1qhv]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LOCUS AD2H2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10515 Human adenovirus 2])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qiu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qiu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qiu RCSB], [http://www.ebi.ac.uk/pdbsum/1qiu PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qi/1qiu_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human adenoviruses are responsible for respiratory, gastroenteric and ocular infections and can serve as gene therapy vectors. They form icosahedral particles with 240 copies of the trimeric hexon protein arranged on the planes and a penton complex at each of the twelve vertices. The penton consists of a pentameric base, implicated in virus internalization, and a protruding trimeric fibre, responsible for receptor attachment. The fibres are homo-trimeric proteins containing an amino-terminal penton base attachment domain, a long, thin central shaft and a carboxy-terminal cell attachment or head domain. The shaft domain contains a repeating sequence motif with an invariant glycine or proline and a conserved pattern of hydrophobic residues. Here we describe the crystal structure at 2.4 A resolution of a recombinant protein containing the four distal repeats of the adenovirus type 2 fibre shaft plus the receptor-binding head domain. The structure reveals a novel triple beta-spiral fibrous fold for the shaft. Implications for folding of fibrous proteins (misfolding of shaft peptides leads to amyloid-like fibrils) and for the design of a new class of artificial, silk-like fibrous materials are discussed.

-	~~{{STRUCTURE_1qiu\| PDB=1qiu \| SCENE= }}~~	+	A triple beta-spiral in the adenovirus fibre shaft reveals a new structural motif for a fibrous protein.,van Raaij MJ, Mitraki A, Lavigne G, Cusack S Nature. 1999 Oct 28;401(6756):935-8. PMID:10553913<ref>PMID:10553913</ref>

-	~~===A TRIPLE BETA-SPIRAL IN THE ADENOVIRUS FIBRE SHAFT REVEALS A NEW STRUCTURAL MOTIF FOR BIOLOGICAL FIBRES===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_10553913}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1qiu]] is~~ a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_adenovirus_2 Human adenovirus 2]. The December 2010 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the ~~Month] feature on ''Adenovirus'' by David Goodsell is [http://dx~~.~~doi~~.~~org/10~~.~~2210~~/~~rcsb_pdb/mom_2010_12 10.2210/rcsb_pdb/mom_2010_12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QIU OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:010553913<~~/~~ref~~><~~ref group="xtra">PMID:016375921</ref><references group="xtra"~~/>	+
	[[Category: Adenovirus]]		[[Category: Adenovirus]]
	[[Category: Human adenovirus 2]]		[[Category: Human adenovirus 2]]

OCA: Protected "1qiu" [edit=sysop:move=sysop]

OCA — Wed, 02 Jan 2013 09:44:38 GMT

Protected "1qiu" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:44, 2 January 2013

OCA at 09:44, 2 January 2013

OCA — Wed, 02 Jan 2013 09:44:35 GMT

←Older revision		Revision as of 09:44, 2 January 2013
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-	{{Seed}}
	[[Image:1qiu.png\|left\|200px]]		[[Image:1qiu.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_1qiu\| PDB=1qiu \| SCENE= }}		{{STRUCTURE_1qiu\| PDB=1qiu \| SCENE= }}

	===A TRIPLE BETA-SPIRAL IN THE ADENOVIRUS FIBRE SHAFT REVEALS A NEW STRUCTURAL MOTIF FOR BIOLOGICAL FIBRES===		===A TRIPLE BETA-SPIRAL IN THE ADENOVIRUS FIBRE SHAFT REVEALS A NEW STRUCTURAL MOTIF FOR BIOLOGICAL FIBRES===

-
-	<!--
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	{{ABSTRACT_PUBMED_10553913}}		{{ABSTRACT_PUBMED_10553913}}

	==About this Structure==		==About this Structure==
-	~~1QIU~~ is a 6 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Human_adenovirus_2 Human adenovirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QIU OCA].	+	[[1qiu]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_adenovirus_2 Human adenovirus 2]. The December 2010 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Adenovirus'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2010_12 10.2210/rcsb_pdb/mom_2010_12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QIU OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~10553913~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:010553913</ref><ref group="xtra">PMID:016375921</ref><references group="xtra"/>
		+	[[Category: Adenovirus]]
	[[Category: Human adenovirus 2]]		[[Category: Human adenovirus 2]]
		+	[[Category: RCSB PDB Molecule of the Month]]
	[[Category: Cusack, S.]]		[[Category: Cusack, S.]]
	[[Category: Lavigne, G.]]		[[Category: Lavigne, G.]]
Line 32:		Line 22:
	[[Category: Fibre protein]]		[[Category: Fibre protein]]
	[[Category: Triple beta-spiral]]		[[Category: Triple beta-spiral]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 10:45:13 2009''