1qk6 - Revision history

OCA at 08:21, 1 May 2024

OCA — Wed, 01 May 2024 08:21:11 GMT

←Older revision		Revision as of 08:21, 1 May 2024
Line 1:		Line 1:

	==Solution structure of huwentoxin-I by NMR==		==Solution structure of huwentoxin-I by NMR==
-	<StructureSection load='1qk6' size='340' side='right'caption='[[1qk6~~]], [[NMR_Ensembles_of_Models \| 10 NMR models~~]]' scene=''>	+	<StructureSection load='1qk6' size='340' side='right'caption='[[1qk6]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1qk6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Selenocosmia_huwena Selenocosmia huwena~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QK6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QK6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1qk6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cyriopagopus_schmidti Cyriopagopus schmidti]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QK6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QK6 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qk6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qk6 OCA], [https://pdbe.org/1qk6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qk6 RCSB], [https://www.ebi.ac.uk/pdbsum/1qk6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qk6 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qk6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qk6 OCA], [https://pdbe.org/1qk6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qk6 RCSB], [https://www.ebi.ac.uk/pdbsum/1qk6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qk6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~TXH1_HAPSC TXH1_HAPSC]~~] Lethal ~~neurotoxin that blocks neuromuscular transmission by binding to the nicotinic acetylcholine receptor~~. ~~Possess presynaptic activity that affects the release of neurotransmitters from autonomic nerve endings of both cholinergic and adrenergic neuroeffector junctions. Selectively inhibits N~~-~~type calcium channel~~ (~~Cav2.2/CACNA1B~~) and ~~has only very weak effect~~ on ~~L-type calcium channel~~ (~~Cav1/CACNA1~~).~~<ref>PMID:10736477</ref> <ref>PMID:11024489</ref>~~	+	[https://www.uniprot.org/uniprot/TXH1_CYRSC TXH1_CYRSC] Lethal toxin with multiple biological activities. Inhibits voltage-gated TTX-sensitive sodium channels in DRG neurons (IC(50)=55 nM) and also shows activity when directly tested on Nav1.7/SCN9A (IC(50)=25.1-630 nM) (PubMed:17451655, PubMed:21731778, PubMed:31234412). Inhibits N-type calcium channels (Cav2.2/CACNA1B (IC(50)=100 nM)) (PubMed:11024489, PubMed:17451655). Also blocks neuromuscular transmission (PubMed:8212049, PubMed:9028007, PubMed:10736477). In vivo, intrathecal injected toxin shows analgesic activity in the rat formalin-induced pain model, without induction of motor dysfunction in rats.<ref>PMID:15581678</ref>
-	~~<div style="background~~-~~color~~:~~#fffaf0;">~~	+
-	~~== Publication Abstract from~~ PubMed ==	+
-	~~The three-dimensional structure in aqueous solution of native huwentoxin-I~~, ~~a neurotoxin from the venom of the spider Selenocosmia huwena, has been determined from two-dimensional H NMR data recorded at 500 and 600 MHz~~. ~~Structural constraints consisting of interproton distances inferred from NOEs and dihedral angles from spin~~-~~spin coupling constants were used as input for distance geometry calculation with the program XPLOR 3~~.~~1. The best 10 structures have NOE violations < 0.3 A, dihedral violations <~~ 2 ~~degrees, and pairwise root-mean-square differences of 1.08~~ (~~+/- 0.20~~) ~~A over backbone atoms~~ (N, ~~C alpha, C~~). ~~The molecule adopts a compact structure consisting of a small triple-stranded antiparallel beta-sheet and five beta-turns. A small hydrophobic patch consisting of Phe 6~~, ~~Trp 28~~, ~~and Trp 31 is located on one side of the molecule~~. ~~All six lysine residues are distributed on~~ the ~~molecular surface. The three disulfide bridges are buried within the molecule. The structure contains an "inhibitor cystine knot motif" which is adopted by several other small proteins, such as omega~~-~~conotoxin~~, ~~agatoxin IVA, and gurmarin.~~	+
-		+
-	~~Proton nuclear magnetic resonance studies on huwentoxin-I from the venom~~ of ~~the spider Selenocosmia huwena: 2. Three-dimensional structure~~ in ~~solution~~.~~,Qu Y, Liang S, Ding J, Liu X, Zhang R, Gu X J Protein Chem. 1997 Aug;16(6):565-74. PMID:9263120~~<ref>PMID:~~9263120~~</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 1qk6" style="background-color:#fffaf0;"></div~~>	+
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Cyriopagopus schmidti]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Selenocosmia huwena]]~~	+	[[Category: Ding J]]
-	[[Category: Ding, J]]	+	[[Category: Gu X]]
-	[[Category: Gu, X]]	+	[[Category: Liang S]]
-	[[Category: Liang, S]]	+	[[Category: Liu X]]
-	[[Category: Liu, X]]	+	[[Category: Qu Y]]
-	[[Category: Qu, Y]]	+	[[Category: Zhang R]]
-	[[Category: Zhang, R]]	+
-	~~[[Category: Cystine knot]]~~	+
-	~~[[Category: Huwentoxin-i]]~~	+
-	~~[[Category: Spider]]~~	+
-	~~[[Category: Toxin~~]]	+

OCA at 18:30, 27 July 2022

OCA — Wed, 27 Jul 2022 18:30:18 GMT

←Older revision		Revision as of 18:30, 27 July 2022
Line 3:		Line 3:
	<StructureSection load='1qk6' size='340' side='right'caption='[[1qk6]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='1qk6' size='340' side='right'caption='[[1qk6]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1qk6]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Selenocosmia_huwena Selenocosmia huwena]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QK6 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1QK6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1qk6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Selenocosmia_huwena Selenocosmia huwena]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QK6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QK6 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1qk6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qk6 OCA], [~~http~~://pdbe.org/1qk6 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1qk6 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1qk6 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1qk6 ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qk6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qk6 OCA], [https://pdbe.org/1qk6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qk6 RCSB], [https://www.ebi.ac.uk/pdbsum/1qk6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qk6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/TXH1_HAPSC TXH1_HAPSC]] Lethal neurotoxin that blocks neuromuscular transmission by binding to the nicotinic acetylcholine receptor. Possess presynaptic activity that affects the release of neurotransmitters from autonomic nerve endings of both cholinergic and adrenergic neuroeffector junctions. Selectively inhibits N-type calcium channel (Cav2.2/CACNA1B) and has only very weak effect on L-type calcium channel (Cav1/CACNA1).<ref>PMID:10736477</ref> <ref>PMID:11024489</ref>	+	[[https://www.uniprot.org/uniprot/TXH1_HAPSC TXH1_HAPSC]] Lethal neurotoxin that blocks neuromuscular transmission by binding to the nicotinic acetylcholine receptor. Possess presynaptic activity that affects the release of neurotransmitters from autonomic nerve endings of both cholinergic and adrenergic neuroeffector junctions. Selectively inhibits N-type calcium channel (Cav2.2/CACNA1B) and has only very weak effect on L-type calcium channel (Cav1/CACNA1).<ref>PMID:10736477</ref> <ref>PMID:11024489</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 08:52, 21 October 2020

OCA — Wed, 21 Oct 2020 08:52:58 GMT

←Older revision		Revision as of 08:52, 21 October 2020
Line 1:		Line 1:

	==Solution structure of huwentoxin-I by NMR==		==Solution structure of huwentoxin-I by NMR==
-	<StructureSection load='1qk6' size='340' side='right' caption='[[1qk6]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>	+	<StructureSection load='1qk6' size='340' side='right'caption='[[1qk6]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1qk6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Selenocosmia_huwena Selenocosmia huwena]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QK6 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1QK6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1qk6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Selenocosmia_huwena Selenocosmia huwena]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QK6 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1QK6 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1qk6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qk6 OCA], [http://pdbe.org/1qk6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1qk6 RCSB], [http://www.ebi.ac.uk/pdbsum/1qk6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1qk6 ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1qk6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qk6 OCA], [http://pdbe.org/1qk6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1qk6 RCSB], [http://www.ebi.ac.uk/pdbsum/1qk6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1qk6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Selenocosmia huwena]]		[[Category: Selenocosmia huwena]]
	[[Category: Ding, J]]		[[Category: Ding, J]]

OCA at 08:18, 24 February 2018

OCA — Sat, 24 Feb 2018 08:18:44 GMT

←Older revision		Revision as of 08:18, 24 February 2018
Line 1:		Line 1:
-	==~~SOLUTION STRUCTURE OF HUWENTOXIN~~-I BY NMR==	+
		+	==Solution structure of huwentoxin-I by NMR==
	<StructureSection load='1qk6' size='340' side='right' caption='[[1qk6]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='1qk6' size='340' side='right' caption='[[1qk6]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1qk6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Haplopelma_schmidti Haplopelma schmidti~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QK6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QK6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1qk6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Selenocosmia_huwena Selenocosmia huwena]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QK6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QK6 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qk6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qk6 OCA], [http://pdbe.org/1qk6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1qk6 RCSB], [http://www.ebi.ac.uk/pdbsum/1qk6 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qk6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qk6 OCA], [http://pdbe.org/1qk6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1qk6 RCSB], [http://www.ebi.ac.uk/pdbsum/1qk6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1qk6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 20:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Haplopelma schmidti~~]]	+	[[Category: Selenocosmia huwena]]
	[[Category: Ding, J]]		[[Category: Ding, J]]
	[[Category: Gu, X]]		[[Category: Gu, X]]

OCA at 22:23, 11 September 2015

OCA — Fri, 11 Sep 2015 22:23:30 GMT

←Older revision		Revision as of 22:23, 11 September 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1qk6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Haplopelma_schmidti Haplopelma schmidti]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QK6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QK6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1qk6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Haplopelma_schmidti Haplopelma schmidti]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QK6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QK6 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qk6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qk6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qk6 RCSB], [http://www.ebi.ac.uk/pdbsum/1qk6 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qk6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qk6 OCA], [http://pdbe.org/1qk6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1qk6 RCSB], [http://www.ebi.ac.uk/pdbsum/1qk6 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TXH1_HAPSC TXH1_HAPSC]] Lethal neurotoxin that blocks neuromuscular transmission by binding to the nicotinic acetylcholine receptor. Possess presynaptic activity that affects the release of neurotransmitters from autonomic nerve endings of both cholinergic and adrenergic neuroeffector junctions. Selectively inhibits N-type calcium channel (Cav2.2/CACNA1B) and has only very weak effect on L-type calcium channel (Cav1/CACNA1).<ref>PMID:10736477</ref> <ref>PMID:11024489</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 13:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1qk6" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 05:45, 22 December 2014

OCA — Mon, 22 Dec 2014 05:45:15 GMT

←Older revision		Revision as of 05:45, 22 December 2014
Line 1:		Line 1:
-	[[~~Image~~:1qk6.~~png\|left\|200px~~]]	+	==SOLUTION STRUCTURE OF HUWENTOXIN-I BY NMR==
		+	<StructureSection load='1qk6' size='340' side='right' caption='[[1qk6]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1qk6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Haplopelma_schmidti Haplopelma schmidti]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QK6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QK6 FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qk6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qk6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qk6 RCSB], [http://www.ebi.ac.uk/pdbsum/1qk6 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The three-dimensional structure in aqueous solution of native huwentoxin-I, a neurotoxin from the venom of the spider Selenocosmia huwena, has been determined from two-dimensional H NMR data recorded at 500 and 600 MHz. Structural constraints consisting of interproton distances inferred from NOEs and dihedral angles from spin-spin coupling constants were used as input for distance geometry calculation with the program XPLOR 3.1. The best 10 structures have NOE violations < 0.3 A, dihedral violations < 2 degrees, and pairwise root-mean-square differences of 1.08 (+/- 0.20) A over backbone atoms (N, C alpha, C). The molecule adopts a compact structure consisting of a small triple-stranded antiparallel beta-sheet and five beta-turns. A small hydrophobic patch consisting of Phe 6, Trp 28, and Trp 31 is located on one side of the molecule. All six lysine residues are distributed on the molecular surface. The three disulfide bridges are buried within the molecule. The structure contains an "inhibitor cystine knot motif" which is adopted by several other small proteins, such as omega-conotoxin, agatoxin IVA, and gurmarin.

-	~~{{STRUCTURE_1qk6\| PDB=1qk6 \| SCENE= }}~~	+	Proton nuclear magnetic resonance studies on huwentoxin-I from the venom of the spider Selenocosmia huwena: 2. Three-dimensional structure in solution.,Qu Y, Liang S, Ding J, Liu X, Zhang R, Gu X J Protein Chem. 1997 Aug;16(6):565-74. PMID:9263120<ref>PMID:9263120</ref>

-	~~===SOLUTION STRUCTURE OF HUWENTOXIN-I BY NMR===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_9263120}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1qk6]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Haplopelma_schmidti Haplopelma schmidti]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1QK6 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:009263120<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Haplopelma schmidti]]		[[Category: Haplopelma schmidti]]
-	[[Category: Ding, J.]]	+	[[Category: Ding, J]]
-	[[Category: Gu, X.]]	+	[[Category: Gu, X]]
-	[[Category: Liang, S.]]	+	[[Category: Liang, S]]
-	[[Category: Liu, X.]]	+	[[Category: Liu, X]]
-	[[Category: Qu, Y.]]	+	[[Category: Qu, Y]]
-	[[Category: Zhang, R.]]	+	[[Category: Zhang, R]]
	[[Category: Cystine knot]]		[[Category: Cystine knot]]
	[[Category: Huwentoxin-i]]		[[Category: Huwentoxin-i]]
	[[Category: Spider]]		[[Category: Spider]]
	[[Category: Toxin]]		[[Category: Toxin]]

OCA at 09:33, 16 January 2013

OCA — Wed, 16 Jan 2013 09:33:17 GMT

←Older revision		Revision as of 09:33, 16 January 2013
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	[[Image:1qk6.png\|left\|200px]]		[[Image:1qk6.png\|left\|200px]]

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-	-->
	{{STRUCTURE_1qk6\| PDB=1qk6 \| SCENE= }}		{{STRUCTURE_1qk6\| PDB=1qk6 \| SCENE= }}

	===SOLUTION STRUCTURE OF HUWENTOXIN-I BY NMR===		===SOLUTION STRUCTURE OF HUWENTOXIN-I BY NMR===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_9263120}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 9263120 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_9263120}}		{{ABSTRACT_PUBMED_9263120}}

	==About this Structure==		==About this Structure==
-	[[1qk6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Ornithoctonus_huwena Ornithoctonus huwena~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QK6 OCA].	+	[[1qk6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Haplopelma_schmidti Haplopelma schmidti]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QK6 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~9263120</ref><ref group="xtra">PMID:8561851</ref><ref group="xtra">PMID:8212049</ref><ref group="xtra">PMID:8136023~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:009263120</ref><references group="xtra"/>
-	[[Category: ~~Ornithoctonus huwena~~]]	+	[[Category: Haplopelma schmidti]]
	[[Category: Ding, J.]]		[[Category: Ding, J.]]
	[[Category: Gu, X.]]		[[Category: Gu, X.]]

OCA: Protected "1qk6" [edit=sysop:move=sysop]

OCA — Mon, 14 Mar 2011 22:26:02 GMT

Protected "1qk6" [edit=sysop:move=sysop]

←Older revision

Revision as of 22:26, 14 March 2011

OCA at 22:25, 14 March 2011

OCA — Mon, 14 Mar 2011 22:25:59 GMT

←Older revision		Revision as of 22:25, 14 March 2011
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-	{{Seed}}
	[[Image:1qk6.png\|left\|200px]]		[[Image:1qk6.png\|left\|200px]]

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	==About this Structure==		==About this Structure==
-	~~1QK6 is a~~ [[~~Single protein~~]] structure of sequence from [http://en.wikipedia.org/wiki/Ornithoctonus_huwena Ornithoctonus huwena]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QK6 OCA].	+	[[1qk6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ornithoctonus_huwena Ornithoctonus huwena]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QK6 OCA].

	==Reference==		==Reference==
-	~~Proton nuclear magnetic resonance studies on huwentoxin-I from the venom of the spider Selenocosmia huwena~~: ~~2. Three-dimensional structure in solution., Qu Y, Liang S, Ding J, Liu X, Zhang R, Gu X, J Protein Chem. 1997 Aug;16(6)~~:~~565-74.~~ PMID:~~[http~~://~~www.ncbi.nlm.nih.gov/pubmed/9263120 9263120]~~	+	<ref group="xtra">PMID:9263120</ref><ref group="xtra">PMID:8561851</ref><ref group="xtra">PMID:8212049</ref><ref group="xtra">PMID:8136023</ref><references group="xtra"/>
	[[Category: Ornithoctonus huwena]]		[[Category: Ornithoctonus huwena]]
-	[[Category: Single protein]]
	[[Category: Ding, J.]]		[[Category: Ding, J.]]
	[[Category: Gu, X.]]		[[Category: Gu, X.]]
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	[[Category: Spider]]		[[Category: Spider]]
	[[Category: Toxin]]		[[Category: Toxin]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:38:00 2008''

OCA at 09:38, 29 July 2008

OCA — Tue, 29 Jul 2008 09:38:04 GMT

←Older revision		Revision as of 09:38, 29 July 2008
Line 1:		Line 1:
-	[[Image:1qk6.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:1qk6.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_1qk6\| PDB=1qk6 \| SCENE= }}		{{STRUCTURE_1qk6\| PDB=1qk6 \| SCENE= }}

-	~~'''~~SOLUTION STRUCTURE OF HUWENTOXIN-I BY NMR~~'''~~	+	===SOLUTION STRUCTURE OF HUWENTOXIN-I BY NMR===


-	~~==Overview==~~	+	<!--
-	The ~~three-dimensional structure in aqueous solution of native huwentoxin-I~~, ~~a neurotoxin from~~ the ~~venom of~~ the ~~spider Selenocosmia huwena, has been determined from two-dimensional H NMR data recorded~~ at ~~500 and 600 MHz~~. Structural constraints consisting of interproton distances inferred from NOEs and dihedral angles from spin-spin coupling constants were used as input for distance geometry calculation with the program XPLOR 3.~~1. The best 10 structures have NOE violations < 0.3 A, dihedral violations < 2 degrees, and pairwise root-mean-square differences of 1.08 (+/- 0.20~~) A over backbone atoms (N, C alpha, C). The molecule adopts a compact structure consisting of a small triple-stranded antiparallel beta-sheet and five beta-turns. A small hydrophobic patch consisting of Phe 6, Trp 28, ~~and Trp 31~~ is ~~located on one side of~~ the ~~molecule~~. All six lysine residues are distributed on the molecular surface. The three disulfide bridges are buried within the molecule. The structure contains an "inhibitor cystine knot motif" which is adopted by several other small proteins, such as omega-~~conotoxin, agatoxin IVA, and gurmarin.~~	+	The line below this paragraph, {{ABSTRACT_PUBMED_9263120}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 9263120 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_9263120}}

	==About this Structure==		==About this Structure==
-	1QK6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Ornithoctonus_huwena Ornithoctonus huwena]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QK6 OCA].	+	1QK6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Ornithoctonus_huwena Ornithoctonus huwena]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QK6 OCA].

	==Reference==		==Reference==
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	[[Category: Spider]]		[[Category: Spider]]
	[[Category: Toxin]]		[[Category: Toxin]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 06~~:22:13 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:38:00 2008''