1qkq - Revision history

OCA at 12:47, 13 December 2023

OCA — Wed, 13 Dec 2023 12:47:28 GMT

←Older revision		Revision as of 12:47, 13 December 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1qkq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QKQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QKQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1qkq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QKQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QKQ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=MAN:ALPHA~~-~~D-MANNOSE'>MAN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[1lcl\|1lcl]]</div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
-	~~<tr~~ id~~='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/Lysophospholipase Lysophospholipase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.5 3.1.1.5]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qkq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qkq OCA], [https://pdbe.org/1qkq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qkq RCSB], [https://www.ebi.ac.uk/pdbsum/1qkq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qkq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qkq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qkq OCA], [https://pdbe.org/1qkq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qkq RCSB], [https://www.ebi.ac.uk/pdbsum/1qkq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qkq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~LPPL_HUMAN LPPL_HUMAN~~]~~] May have both lysophospholipase~~ and ~~carbohydrate~~-~~binding activities~~.	+	[https://www.uniprot.org/uniprot/LEG10_HUMAN LEG10_HUMAN] Regulates immune responses through the recognition of cell-surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg).<ref>PMID:17502455</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Lysophospholipase]]~~	+	[[Category: Acharya KR]]
-	[[Category: Acharya~~, K R~~]]	+	[[Category: Leonidas DD]]
-	[[Category: Leonidas~~, D D~~]]	+	[[Category: Swaminathan GJ]]
-	[[Category: Swaminathan~~, G J]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Serine esterase~~]]	+

OCA at 09:58, 15 September 2021

OCA — Wed, 15 Sep 2021 09:58:33 GMT

←Older revision		Revision as of 09:58, 15 September 2021
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	<StructureSection load='1qkq' size='340' side='right'caption='[[1qkq]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1qkq' size='340' side='right'caption='[[1qkq]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1qkq]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QKQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1QKQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1qkq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QKQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QKQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lcl\|1lcl]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1lcl\|1lcl]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Lysophospholipase Lysophospholipase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.5 3.1.1.5] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Lysophospholipase Lysophospholipase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.5 3.1.1.5] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1qkq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qkq OCA], [~~http~~://pdbe.org/1qkq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1qkq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1qkq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1qkq ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qkq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qkq OCA], [https://pdbe.org/1qkq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qkq RCSB], [https://www.ebi.ac.uk/pdbsum/1qkq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qkq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/LPPL_HUMAN LPPL_HUMAN]] May have both lysophospholipase and carbohydrate-binding activities.	+	[[https://www.uniprot.org/uniprot/LPPL_HUMAN LPPL_HUMAN]] May have both lysophospholipase and carbohydrate-binding activities.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 11:36, 4 December 2019

OCA — Wed, 04 Dec 2019 11:36:42 GMT

←Older revision		Revision as of 11:36, 4 December 2019
Line 1:		Line 1:

	==CHARCOT-LEYDEN CRYSTAL PROTEIN - MANNOSE COMPLEX==		==CHARCOT-LEYDEN CRYSTAL PROTEIN - MANNOSE COMPLEX==
-	<StructureSection load='1qkq' size='340' side='right' caption='[[1qkq]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='1qkq' size='340' side='right'caption='[[1qkq]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1qkq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QKQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QKQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1qkq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QKQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QKQ FirstGlance]. <br>
Line 21:		Line 21:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qkq ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qkq ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The role(s) of the eosinophil Charcot-Leyden crystal (CLC) protein in eosinophil or basophil function or associated inflammatory processes is yet to be established. Although the CLC protein has been reported to exhibit weak lysophospholipase activity, it shows virtually no sequence homology to any known member of this family of enzymes. The X-ray crystal structure of the CLC protein is very similar to the structure of the galectins, members of a beta-galactoside-specific animal lectin family, including a partially conserved galectin carbohydrate recognition domain (CRD). In the absence of any known natural carbohydrate ligand for this protein, the functional role of the CLC protein (galectin-10) has remained speculative. Here we describe structural studies on the carbohydrate binding properties of the CLC protein and report the first structure of a carbohydrate in complex with the protein. Interestingly, the CLC protein demonstrates no affinity for beta-galactosides and binds mannose in a manner very different from those of other related galectins that have been shown to bind lactosamine. The partial conservation of residues involved in carbohydrate binding led to significant changes in the topology and chemical nature of the CRD, and has implications for carbohydrate recognition by the CLC protein in vivo and its functional role in the biology of inflammation.
		+
		+	Selective recognition of mannose by the human eosinophil Charcot-Leyden crystal protein (galectin-10): a crystallographic study at 1.8 A resolution.,Swaminathan GJ, Leonidas DD, Savage MP, Ackerman SJ, Acharya KR Biochemistry. 1999 Oct 19;38(42):13837-43. PMID:10529229<ref>PMID:10529229</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 1qkq" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
	[[Category: Lysophospholipase]]		[[Category: Lysophospholipase]]
	[[Category: Acharya, K R]]		[[Category: Acharya, K R]]

OCA at 08:00, 28 February 2018

OCA — Wed, 28 Feb 2018 08:00:55 GMT

←Older revision		Revision as of 08:00, 28 February 2018
Line 1:		Line 1:
		+
	==CHARCOT-LEYDEN CRYSTAL PROTEIN - MANNOSE COMPLEX==		==CHARCOT-LEYDEN CRYSTAL PROTEIN - MANNOSE COMPLEX==
	<StructureSection load='1qkq' size='340' side='right' caption='[[1qkq]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1qkq' size='340' side='right' caption='[[1qkq]], [[Resolution\|resolution]] 1.80Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lcl\|1lcl]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lcl\|1lcl]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysophospholipase Lysophospholipase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.5 3.1.1.5] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysophospholipase Lysophospholipase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.5 3.1.1.5] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qkq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qkq OCA], [http://pdbe.org/1qkq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1qkq RCSB], [http://www.ebi.ac.uk/pdbsum/1qkq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qkq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qkq OCA], [http://pdbe.org/1qkq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1qkq RCSB], [http://www.ebi.ac.uk/pdbsum/1qkq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1qkq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qk/1qkq_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qk/1qkq_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qkq ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	__TOC__		__TOC__

OCA at 13:09, 11 September 2015

OCA — Fri, 11 Sep 2015 13:09:02 GMT

←Older revision		Revision as of 13:09, 11 September 2015
Line 6:		Line 6:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lcl\|1lcl]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lcl\|1lcl]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysophospholipase Lysophospholipase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.5 3.1.1.5] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysophospholipase Lysophospholipase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.5 3.1.1.5] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qkq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qkq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qkq RCSB], [http://www.ebi.ac.uk/pdbsum/1qkq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qkq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qkq OCA], [http://pdbe.org/1qkq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1qkq RCSB], [http://www.ebi.ac.uk/pdbsum/1qkq PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 16:52, 25 December 2014

OCA — Thu, 25 Dec 2014 16:52:36 GMT

←Older revision		Revision as of 16:52, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1qkq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QKQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QKQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1qkq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QKQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QKQ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lcl\|1lcl]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lcl\|1lcl]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysophospholipase Lysophospholipase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.5 3.1.1.5] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysophospholipase Lysophospholipase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.5 3.1.1.5] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qkq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qkq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qkq RCSB], [http://www.ebi.ac.uk/pdbsum/1qkq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qkq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qkq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qkq RCSB], [http://www.ebi.ac.uk/pdbsum/1qkq PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/LPPL_HUMAN LPPL_HUMAN]] May have both lysophospholipase and carbohydrate-binding activities.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 22:		Line 24:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Lysophospholipase]]		[[Category: Lysophospholipase]]
-	[[Category: Acharya, K R.]]	+	[[Category: Acharya, K R]]
-	[[Category: Leonidas, D D.]]	+	[[Category: Leonidas, D D]]
-	[[Category: Swaminathan, G J.]]	+	[[Category: Swaminathan, G J]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Serine esterase]]		[[Category: Serine esterase]]

OCA at 07:04, 9 June 2014

OCA — Mon, 09 Jun 2014 07:04:08 GMT

←Older revision		Revision as of 07:04, 9 June 2014
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-	~~[[Image:1qkq.png\|left\|200px]]~~	+	==CHARCOT-LEYDEN CRYSTAL PROTEIN - MANNOSE COMPLEX==
-		+	<StructureSection load='1qkq' size='340' side='right' caption='[[1qkq]], [[Resolution\|resolution]] 1.80Å' scene=''>
-	~~{{STRUCTURE_1qkq\| PDB=1qkq \| SCENE= }}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[1qkq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QKQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QKQ FirstGlance]. <br>
-	===CHARCOT-LEYDEN CRYSTAL PROTEIN - MANNOSE COMPLEX===	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene><br>
-		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lcl\|1lcl]]</td></tr>
-		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysophospholipase Lysophospholipase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.5 3.1.1.5] </span></td></tr>
-	==~~About this Structure~~==	+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qkq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qkq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qkq RCSB], [http://www.ebi.ac.uk/pdbsum/1qkq PDBsum]</span></td></tr>
-	[[1qkq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QKQ OCA].	+	<table>
-		+	== Evolutionary Conservation ==
-	==~~Reference~~==	+	[[Image:Consurf_key_small.gif\|200px\|right]]
-	<~~ref group~~="~~xtra~~">~~PMID~~:~~010563827~~</~~ref~~><~~ref group~~="~~xtra~~">~~PMID~~:~~008747464~~</~~ref~~><~~ref group~~="~~xtra~~">~~PMID~~:~~010529229~~</~~ref~~><~~references group~~="~~xtra~~"/>	+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qk/1qkq_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Lysophospholipase]]		[[Category: Lysophospholipase]]

OCA: Protected "1qkq" [edit=sysop:move=sysop]

OCA — Wed, 29 Aug 2012 05:33:10 GMT

Protected "1qkq" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:33, 29 August 2012

OCA at 05:33, 29 August 2012

OCA — Wed, 29 Aug 2012 05:33:08 GMT

←Older revision		Revision as of 05:33, 29 August 2012
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-	{{Seed}}
	[[Image:1qkq.png\|left\|200px]]		[[Image:1qkq.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1qkq", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1qkq\| PDB=1qkq \| SCENE= }}		{{STRUCTURE_1qkq\| PDB=1qkq \| SCENE= }}

-	===CHARCOT-LEYDEN CRYSTAL PROTEIN-MANNOSE COMPLEX===	+	===CHARCOT-LEYDEN CRYSTAL PROTEIN - MANNOSE COMPLEX===


	==About this Structure==		==About this Structure==
-	~~1QKQ~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QKQ OCA].	+	[[1qkq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QKQ OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~10563827~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:010563827</ref><ref group="xtra">PMID:008747464</ref><ref group="xtra">PMID:010529229</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Lysophospholipase]]		[[Category: Lysophospholipase]]
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	[[Category: Leonidas, D D.]]		[[Category: Leonidas, D D.]]
	[[Category: Swaminathan, G J.]]		[[Category: Swaminathan, G J.]]
-	[[Category: ~~Charcot-leyden crystal protein]]~~	+	[[Category: Hydrolase]]
-	~~[[Category: Galectin-10~~]]	+
	[[Category: Serine esterase]]		[[Category: Serine esterase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 22:17:36 2009''

OCA at 20:17, 17 February 2009

OCA — Tue, 17 Feb 2009 20:17:37 GMT

←Older revision		Revision as of 20:17, 17 February 2009
Line 14:		Line 14:

	==About this Structure==		==About this Structure==
-	1QKQ is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QKQ OCA].	+	1QKQ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QKQ OCA].

	==Reference==		==Reference==
-	Selective Recognition of Mannose by the Human Eosinophil Charcot-Leyden Crystal Protein (Galectin-10): A Crystallographic Study at 1.8 A Resolution., Swaminathan GJ, Leonidas DD, Savage MP, Ackerman SJ, Acharya KR, Biochemistry. 1999 Nov 16;38(46):15406. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/10563827 10563827]~~	+	<ref group="xtra">PMID:10563827</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Lysophospholipase]]		[[Category: Lysophospholipase]]
-	[[Category: Single protein]]
	[[Category: Acharya, K R.]]		[[Category: Acharya, K R.]]
	[[Category: Leonidas, D D.]]		[[Category: Leonidas, D D.]]
Line 28:		Line 27:
	[[Category: Serine esterase]]		[[Category: Serine esterase]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue ~~Jul 29 06~~:33:~~29 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 22:17:36 2009''