1qmw - Revision history

OCA at 08:24, 14 June 2023

OCA — Wed, 14 Jun 2023 08:24:22 GMT

←Older revision		Revision as of 08:24, 14 June 2023
Line 1:		Line 1:

	==Solution structure of alpha-conotoxin SI==		==Solution structure of alpha-conotoxin SI==
-	<StructureSection load='1qmw' size='340' side='right'caption='[[1qmw~~]], [[NMR_Ensembles_of_Models \| 36 NMR models~~]]' scene=''>	+	<StructureSection load='1qmw' size='340' side='right'caption='[[1qmw]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1qmw]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QMW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QMW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1qmw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_striatus Conus striatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QMW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QMW FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qmw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qmw OCA], [https://pdbe.org/1qmw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qmw RCSB], [https://www.ebi.ac.uk/pdbsum/1qmw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qmw ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qmw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qmw OCA], [https://pdbe.org/1qmw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qmw RCSB], [https://www.ebi.ac.uk/pdbsum/1qmw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qmw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CAS1_CONST CAS1_CONST]] Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin blocks muscular nAChRs alpha-1/gamma and alpha-1/delta subunits.	+	[https://www.uniprot.org/uniprot/CAS1_CONST CAS1_CONST] Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin blocks muscular nAChRs alpha-1/gamma and alpha-1/delta subunits.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Conus striatus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Barany, G]]	+	[[Category: Barany G]]
-	[[Category: Benie~~, A J~~]]	+	[[Category: Benie AJ]]
-	[[Category: Hargittai, B]]	+	[[Category: Hargittai B]]
-	[[Category: Janes~~, R W~~]]	+	[[Category: Janes RW]]
-	[[Category: Whitford, D]]	+	[[Category: Whitford D]]
-	~~[[Category: Conotoxin]]~~	+
-	~~[[Category: Nicotinic acetylcholine receptor]]~~	+
-	~~[[Category: Toxin]]~~	+
-	~~[[Category: Venom~~]]	+

OCA at 09:59, 15 September 2021

OCA — Wed, 15 Sep 2021 09:59:30 GMT

←Older revision		Revision as of 09:59, 15 September 2021
Line 3:		Line 3:
	<StructureSection load='1qmw' size='340' side='right'caption='[[1qmw]], [[NMR_Ensembles_of_Models \| 36 NMR models]]' scene=''>		<StructureSection load='1qmw' size='340' side='right'caption='[[1qmw]], [[NMR_Ensembles_of_Models \| 36 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1qmw]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QMW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1QMW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1qmw]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QMW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QMW FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1qmw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qmw OCA], [~~http~~://pdbe.org/1qmw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1qmw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1qmw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1qmw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qmw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qmw OCA], [https://pdbe.org/1qmw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qmw RCSB], [https://www.ebi.ac.uk/pdbsum/1qmw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qmw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CAS1_CONST CAS1_CONST]] Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin blocks muscular nAChRs alpha-1/gamma and alpha-1/delta subunits.	+	[[https://www.uniprot.org/uniprot/CAS1_CONST CAS1_CONST]] Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin blocks muscular nAChRs alpha-1/gamma and alpha-1/delta subunits.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 11:15, 4 December 2019

OCA — Wed, 04 Dec 2019 11:15:30 GMT

←Older revision		Revision as of 11:15, 4 December 2019
Line 1:		Line 1:

	==Solution structure of alpha-conotoxin SI==		==Solution structure of alpha-conotoxin SI==
-	<StructureSection load='1qmw' size='340' side='right' caption='[[1qmw]], [[NMR_Ensembles_of_Models \| 36 NMR models]]' scene=''>	+	<StructureSection load='1qmw' size='340' side='right'caption='[[1qmw]], [[NMR_Ensembles_of_Models \| 36 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1qmw]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QMW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QMW FirstGlance]. <br>		<table><tr><td colspan='2'>[[1qmw]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QMW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QMW FirstGlance]. <br>
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Barany, G]]		[[Category: Barany, G]]
	[[Category: Benie, A J]]		[[Category: Benie, A J]]

OCA at 07:40, 28 February 2018

OCA — Wed, 28 Feb 2018 07:40:49 GMT

←Older revision		Revision as of 07:40, 28 February 2018
Line 1:		Line 1:
-	==~~SOLUTION STRUCTURE OF ALPHA~~-~~CONOTOXIN~~ SI==	+
		+	==Solution structure of alpha-conotoxin SI==
	<StructureSection load='1qmw' size='340' side='right' caption='[[1qmw]], [[NMR_Ensembles_of_Models \| 36 NMR models]]' scene=''>		<StructureSection load='1qmw' size='340' side='right' caption='[[1qmw]], [[NMR_Ensembles_of_Models \| 36 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1qmw]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QMW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QMW FirstGlance]. <br>		<table><tr><td colspan='2'>[[1qmw]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QMW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QMW FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qmw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qmw OCA], [http://pdbe.org/1qmw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1qmw RCSB], [http://www.ebi.ac.uk/pdbsum/1qmw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qmw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qmw OCA], [http://pdbe.org/1qmw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1qmw RCSB], [http://www.ebi.ac.uk/pdbsum/1qmw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1qmw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 20:36, 9 September 2015

OCA — Wed, 09 Sep 2015 20:36:54 GMT

←Older revision		Revision as of 20:36, 9 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[1qmw]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QMW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QMW FirstGlance]. <br>		<table><tr><td colspan='2'>[[1qmw]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QMW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QMW FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qmw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qmw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qmw RCSB], [http://www.ebi.ac.uk/pdbsum/1qmw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qmw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qmw OCA], [http://pdbe.org/1qmw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1qmw RCSB], [http://www.ebi.ac.uk/pdbsum/1qmw PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CAS1_CONST CAS1_CONST]] Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin blocks muscular nAChRs alpha-1/gamma and alpha-1/delta subunits.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 14:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1qmw" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 05:01, 22 December 2014

OCA — Mon, 22 Dec 2014 05:01:49 GMT

←Older revision		Revision as of 05:01, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1qmw]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QMW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QMW FirstGlance]. <br>		<table><tr><td colspan='2'>[[1qmw]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QMW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QMW FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qmw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qmw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qmw RCSB], [http://www.ebi.ac.uk/pdbsum/1qmw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qmw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qmw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qmw RCSB], [http://www.ebi.ac.uk/pdbsum/1qmw PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 18:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Barany, G.]]	+	[[Category: Barany, G]]
-	[[Category: Benie, A J.]]	+	[[Category: Benie, A J]]
-	[[Category: Hargittai, B.]]	+	[[Category: Hargittai, B]]
-	[[Category: Janes, R W.]]	+	[[Category: Janes, R W]]
-	[[Category: Whitford, D.]]	+	[[Category: Whitford, D]]
	[[Category: Conotoxin]]		[[Category: Conotoxin]]
	[[Category: Nicotinic acetylcholine receptor]]		[[Category: Nicotinic acetylcholine receptor]]
	[[Category: Toxin]]		[[Category: Toxin]]
	[[Category: Venom]]		[[Category: Venom]]

OCA at 06:51, 9 June 2014

OCA — Mon, 09 Jun 2014 06:51:03 GMT

←Older revision		Revision as of 06:51, 9 June 2014
Line 1:		Line 1:
-	[[~~Image:~~1qmw.~~png~~\|~~left\|200px~~]]	+	==SOLUTION STRUCTURE OF ALPHA-CONOTOXIN SI==
		+	<StructureSection load='1qmw' size='340' side='right' caption='[[1qmw]], [[NMR_Ensembles_of_Models \| 36 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1qmw]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QMW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QMW FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qmw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qmw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qmw RCSB], [http://www.ebi.ac.uk/pdbsum/1qmw PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The nuclear magnetic resonance solution structure of alpha-conotoxin SI has been determined at pH 4.2. The 36 lowest energy structures show that alpha-conotoxin SI exists in a single major solution conformation and is stabilized by six hydrogen bonds. Comparisons are made between the SI solution structure and the solution and crystal structures of alpha-conotoxin GI. Surprisingly, a high degree of similarity between the backbone conformations of the GI crystal and the SI solution structures is seen in the region of lowest sequence homology, namely residues Gly-8 to Ser-12. This similarity is more surprising when considering that in SI a proline replaces the Arg-9 found in GI. The correspondence in conformation in this region provides the definitive evidence that it is the loss of the arginine basic charge at residue 9 which determines the differences in toxicity between GI and SI, rather than any changes in conformation induced by the cyclic proline residue.

-	~~{{STRUCTURE_1qmw\| PDB=1qmw \| SCENE= }}~~	+	Solution structure of alpha-conotoxin SI.,Benie AJ, Whitford D, Hargittai B, Barany G, Janes RW FEBS Lett. 2000 Jul 7;476(3):287-95. PMID:10913630<ref>PMID:10913630</ref>

-	~~===SOLUTION STRUCTURE OF ALPHA-CONOTOXIN SI===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_10913630}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1qmw]] is~~ a ~~1 chain structure~~. ~~Full experimental information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=1QMW OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:010913630<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Barany, G.]]		[[Category: Barany, G.]]
	[[Category: Benie, A J.]]		[[Category: Benie, A J.]]

OCA: Protected "1qmw" [edit=sysop:move=sysop]

OCA — Tue, 14 Aug 2012 14:59:29 GMT

Protected "1qmw" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:59, 14 August 2012

OCA at 14:59, 14 August 2012

OCA — Tue, 14 Aug 2012 14:59:28 GMT

←Older revision		Revision as of 14:59, 14 August 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1qmw.png\|left\|200px]]		[[Image:1qmw.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1qmw", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1qmw\| PDB=1qmw \| SCENE= }}		{{STRUCTURE_1qmw\| PDB=1qmw \| SCENE= }}

	===SOLUTION STRUCTURE OF ALPHA-CONOTOXIN SI===		===SOLUTION STRUCTURE OF ALPHA-CONOTOXIN SI===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_10913630}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 10913630 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_10913630}}		{{ABSTRACT_PUBMED_10913630}}

	==About this Structure==		==About this Structure==
-	~~1QMW is a~~ [[~~Single protein~~]] structure ~~of sequence from [http://en.wikipedia.org/wiki/Conus_striatus Conus striatus]~~. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QMW OCA].	+	[[1qmw]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QMW OCA].

	==Reference==		==Reference==
-	~~Solution structure of alpha-conotoxin SI., Benie AJ, Whitford D, Hargittai B, Barany G, Janes RW, FEBS Lett. 2000 Jul 7;476(3):287-95.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/10913630 10913630]~~	+	<ref group="xtra">PMID:010913630</ref><references group="xtra"/>
-	~~[[Category: Conus striatus]]~~	+
-	~~[[Category: Single protein]]~~	+
	[[Category: Barany, G.]]		[[Category: Barany, G.]]
	[[Category: Benie, A J.]]		[[Category: Benie, A J.]]
Line 35:		Line 21:
	[[Category: Toxin]]		[[Category: Toxin]]
	[[Category: Venom]]		[[Category: Venom]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:25:54 2008''

OCA at 09:26, 27 July 2008

OCA — Sun, 27 Jul 2008 09:26:01 GMT

←Older revision		Revision as of 09:26, 27 July 2008
Line 1:		Line 1:
-	[[Image:1qmw.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:1qmw.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_1qmw\| PDB=1qmw \| SCENE= }}		{{STRUCTURE_1qmw\| PDB=1qmw \| SCENE= }}

-	~~'''~~SOLUTION STRUCTURE OF ALPHA-CONOTOXIN SI~~'''~~	+	===SOLUTION STRUCTURE OF ALPHA-CONOTOXIN SI===


-	~~==Overview==~~	+	<!--
-	The nuclear magnetic resonance solution structure of alpha-conotoxin SI has been determined at pH 4.2. The 36 lowest energy structures show that alpha-conotoxin SI exists in a single major solution conformation and is stabilized by six hydrogen bonds. Comparisons are made between the SI solution structure and the solution and crystal structures of alpha-conotoxin GI. Surprisingly, ~~a high degree of similarity between~~ the ~~backbone conformations of the GI crystal and the SI solution structures is seen in the region of lowest sequence homology, namely residues Gly-8~~ to ~~Ser-12. This similarity is more surprising when considering that in SI a proline replaces~~ the ~~Arg-9 found in GI. The correspondence in conformation in this region provides the definitive evidence that~~ it ~~is the loss of the arginine basic charge~~ at ~~residue 9 which determines the differences in toxicity between GI and SI~~, ~~rather than any changes in conformation induced by~~ the ~~cyclic proline residue~~.	+	The line below this paragraph, {{ABSTRACT_PUBMED_10913630}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 10913630 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_10913630}}

	==About this Structure==		==About this Structure==
-	1QMW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Conus_striatus Conus striatus]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QMW OCA].	+	1QMW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Conus_striatus Conus striatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QMW OCA].

	==Reference==		==Reference==
Line 31:		Line 35:
	[[Category: Toxin]]		[[Category: Toxin]]
	[[Category: Venom]]		[[Category: Venom]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 06:~~27:57 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:25:54 2008''