1qnk - Revision history

OCA at 06:05, 17 April 2024

OCA — Wed, 17 Apr 2024 06:05:29 GMT

←Older revision		Revision as of 06:05, 17 April 2024
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	==TRUNCATED HUMAN GROB[5-73], NMR, 20 STRUCTURES==		==TRUNCATED HUMAN GROB[5-73], NMR, 20 STRUCTURES==
-	<StructureSection load='1qnk' size='340' side='right'caption='[[1qnk~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='1qnk' size='340' side='right'caption='[[1qnk]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1qnk]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QNK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1QNK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1qnk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QNK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QNK FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>CXCL2, GRO2, GROB, MIP2A, SCYB2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~9606 HUMAN])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1qnk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qnk OCA], [~~http~~://pdbe.org/1qnk PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1qnk RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1qnk PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1qnk ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qnk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qnk OCA], [https://pdbe.org/1qnk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qnk RCSB], [https://www.ebi.ac.uk/pdbsum/1qnk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qnk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CXCL2_HUMAN CXCL2_HUMAN]] Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity.<ref>PMID:10725737</ref>	+	[https://www.uniprot.org/uniprot/CXCL2_HUMAN CXCL2_HUMAN] Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity.<ref>PMID:10725737</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 19:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qnk ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qnk ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The three-dimensional structure of a novel four amino acid truncated form of the CXC chemokine GRObeta [5-73] isolated from bone marrow stromal cells with potent hematopoietic and anti-infective activities has been determined by two-dimensional (1)H nuclear magnetic resonance (NMR) spectroscopy in solution. On the basis of 1878 upper distance constraints derived from nuclear Overhauser effects (NOE) and 314 dihedral angle constraints, a group of 20 conformers representing the solution structure of the human GRObeta [5-73] was computed with the program DYANA. At the concentrations used for NMR study, GRObeta [5-73] forms a dimer in solution that is architectured by a six-stranded antiparallel beta-sheet (residues 25 to 29, 39 to 44, 49 to 52) and a pair of helices (residues 58 to 68) with 2-fold symmetry, while the C terminus of the protein is disordered. The average of the pairwise root-mean-square deviations of individual NMR conformers relative to the mean coordinates for the backbone atoms N, C(alpha) and C' of residues 5 to 68 is 0.47 A. Overall, the global fold of GRObeta [5-73] is similar to that of the previously reported NMR structure of GROalpha and the NMR and X-ray structures of interleukin-8. Among these three CXC chemokines, GRObeta [5-73] is most similar in structure to GROalpha. Significant differences between GRObeta [5-73], GROalpha and interleukin-8 are in the N-terminal loop comprising residues 12 to 19. The N-terminal arm containing the conserved ELR motif and the loop of residues 30 to 38 containing the GPH motif are different among these three CXC chemokines. The structural differences in these two regions may be responsible for the specificity of the receptor binding and biological activity of different chemokines.
-
-	Nuclear magnetic resonance solution structure of truncated human GRObeta [5-73] and its structural comparison with CXC chemokine family members GROalpha and IL-8.,Qian YQ, Johanson KO, McDevitt P J Mol Biol. 1999 Dec 17;294(5):1065-72. PMID:10600366<ref>PMID:10600366</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1qnk" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Johanson, K]]	+	[[Category: Johanson K]]
-	[[Category: McDevitt, P]]	+	[[Category: McDevitt P]]
-	[[Category: Qian~~, Y Q]]~~	+	[[Category: Qian YQ]]
-	~~[[Category: Chemokine]]~~	+
-	~~[[Category: Chemokine 15-o]]~~	+
-	~~[[Category: Cxc chemokine~~]]	+

OCA at 13:11, 16 December 2020

OCA — Wed, 16 Dec 2020 13:11:06 GMT

←Older revision		Revision as of 13:11, 16 December 2020
Line 1:		Line 1:

	==TRUNCATED HUMAN GROB[5-73], NMR, 20 STRUCTURES==		==TRUNCATED HUMAN GROB[5-73], NMR, 20 STRUCTURES==
-	<StructureSection load='1qnk' size='340' side='right' caption='[[1qnk]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='1qnk' size='340' side='right'caption='[[1qnk]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1qnk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QNK OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1QNK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1qnk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QNK OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1QNK FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CXCL2, GRO2, GROB, MIP2A, SCYB2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CXCL2, GRO2, GROB, MIP2A, SCYB2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1qnk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qnk OCA], [http://pdbe.org/1qnk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1qnk RCSB], [http://www.ebi.ac.uk/pdbsum/1qnk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1qnk ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1qnk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qnk OCA], [http://pdbe.org/1qnk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1qnk RCSB], [http://www.ebi.ac.uk/pdbsum/1qnk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1qnk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 1qnk" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1qnk" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[C-X-C motif chemokine 3D structures\|C-X-C motif chemokine 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 33:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Johanson, K]]		[[Category: Johanson, K]]
	[[Category: McDevitt, P]]		[[Category: McDevitt, P]]

OCA at 07:50, 14 June 2018

OCA — Thu, 14 Jun 2018 07:50:10 GMT

←Older revision		Revision as of 07:50, 14 June 2018
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1qnk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QNK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QNK FirstGlance]. <br>		<table><tr><td colspan='2'>[[1qnk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QNK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QNK FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qnk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qnk OCA], [http://pdbe.org/1qnk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1qnk RCSB], [http://www.ebi.ac.uk/pdbsum/1qnk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1qnk ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CXCL2, GRO2, GROB, MIP2A, SCYB2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qnk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qnk OCA], [http://pdbe.org/1qnk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1qnk RCSB], [http://www.ebi.ac.uk/pdbsum/1qnk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1qnk ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CXCL2_HUMAN CXCL2_HUMAN]] Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity.<ref>PMID:10725737</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 34:
	[[Category: Human]]		[[Category: Human]]
	[[Category: Johanson, K]]		[[Category: Johanson, K]]
-	[[Category: ~~Mcdevitt~~, P]]	+	[[Category: McDevitt, P]]
	[[Category: Qian, Y Q]]		[[Category: Qian, Y Q]]
	[[Category: Chemokine]]		[[Category: Chemokine]]
	[[Category: Chemokine 15-o]]		[[Category: Chemokine 15-o]]
	[[Category: Cxc chemokine]]		[[Category: Cxc chemokine]]

OCA at 08:06, 28 February 2018

OCA — Wed, 28 Feb 2018 08:06:24 GMT

←Older revision		Revision as of 08:06, 28 February 2018
Line 1:		Line 1:
		+
	==TRUNCATED HUMAN GROB[5-73], NMR, 20 STRUCTURES==		==TRUNCATED HUMAN GROB[5-73], NMR, 20 STRUCTURES==
	<StructureSection load='1qnk' size='340' side='right' caption='[[1qnk]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1qnk' size='340' side='right' caption='[[1qnk]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1qnk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QNK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QNK FirstGlance]. <br>		<table><tr><td colspan='2'>[[1qnk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QNK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QNK FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qnk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qnk OCA], [http://pdbe.org/1qnk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1qnk RCSB], [http://www.ebi.ac.uk/pdbsum/1qnk PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qnk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qnk OCA], [http://pdbe.org/1qnk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1qnk RCSB], [http://www.ebi.ac.uk/pdbsum/1qnk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1qnk ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 9:		Line 10:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qn/1qnk_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qn/1qnk_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 06:34, 8 February 2016

OCA — Mon, 08 Feb 2016 06:34:23 GMT

←Older revision		Revision as of 06:34, 8 February 2016
Line 13:		Line 13:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qnk ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 08:50, 10 September 2015

OCA — Thu, 10 Sep 2015 08:50:57 GMT

←Older revision		Revision as of 08:50, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1qnk' size='340' side='right' caption='[[1qnk]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1qnk' size='340' side='right' caption='[[1qnk]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1qnk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QNK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QNK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1qnk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QNK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QNK FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qnk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qnk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qnk RCSB], [http://www.ebi.ac.uk/pdbsum/1qnk PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qnk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qnk OCA], [http://pdbe.org/1qnk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1qnk RCSB], [http://www.ebi.ac.uk/pdbsum/1qnk PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 23:		Line 23:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1qnk" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Johanson, K]]		[[Category: Johanson, K]]
	[[Category: Mcdevitt, P]]		[[Category: Mcdevitt, P]]

OCA at 07:23, 6 January 2015

OCA — Tue, 06 Jan 2015 07:23:00 GMT

←Older revision		Revision as of 07:23, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1qnk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QNK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QNK FirstGlance]. <br>		<table><tr><td colspan='2'>[[1qnk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QNK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QNK FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qnk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qnk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qnk RCSB], [http://www.ebi.ac.uk/pdbsum/1qnk PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qnk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qnk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qnk RCSB], [http://www.ebi.ac.uk/pdbsum/1qnk PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Johanson, K.]]	+	[[Category: Johanson, K]]
-	[[Category: Mcdevitt, P.]]	+	[[Category: Mcdevitt, P]]
-	[[Category: Qian, Y Q.]]	+	[[Category: Qian, Y Q]]
	[[Category: Chemokine]]		[[Category: Chemokine]]
	[[Category: Chemokine 15-o]]		[[Category: Chemokine 15-o]]
	[[Category: Cxc chemokine]]		[[Category: Cxc chemokine]]

OCA at 17:06, 29 September 2014

OCA — Mon, 29 Sep 2014 17:06:31 GMT

←Older revision		Revision as of 17:06, 29 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1qnk.~~png\|left~~\|200px]]	+	==TRUNCATED HUMAN GROB[5-73], NMR, 20 STRUCTURES==
		+	<StructureSection load='1qnk' size='340' side='right' caption='[[1qnk]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1qnk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QNK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QNK FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qnk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qnk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qnk RCSB], [http://www.ebi.ac.uk/pdbsum/1qnk PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qn/1qnk_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The three-dimensional structure of a novel four amino acid truncated form of the CXC chemokine GRObeta [5-73] isolated from bone marrow stromal cells with potent hematopoietic and anti-infective activities has been determined by two-dimensional (1)H nuclear magnetic resonance (NMR) spectroscopy in solution. On the basis of 1878 upper distance constraints derived from nuclear Overhauser effects (NOE) and 314 dihedral angle constraints, a group of 20 conformers representing the solution structure of the human GRObeta [5-73] was computed with the program DYANA. At the concentrations used for NMR study, GRObeta [5-73] forms a dimer in solution that is architectured by a six-stranded antiparallel beta-sheet (residues 25 to 29, 39 to 44, 49 to 52) and a pair of helices (residues 58 to 68) with 2-fold symmetry, while the C terminus of the protein is disordered. The average of the pairwise root-mean-square deviations of individual NMR conformers relative to the mean coordinates for the backbone atoms N, C(alpha) and C' of residues 5 to 68 is 0.47 A. Overall, the global fold of GRObeta [5-73] is similar to that of the previously reported NMR structure of GROalpha and the NMR and X-ray structures of interleukin-8. Among these three CXC chemokines, GRObeta [5-73] is most similar in structure to GROalpha. Significant differences between GRObeta [5-73], GROalpha and interleukin-8 are in the N-terminal loop comprising residues 12 to 19. The N-terminal arm containing the conserved ELR motif and the loop of residues 30 to 38 containing the GPH motif are different among these three CXC chemokines. The structural differences in these two regions may be responsible for the specificity of the receptor binding and biological activity of different chemokines.

-	~~{{STRUCTURE_1qnk\| PDB=1qnk \| SCENE= }}~~	+	Nuclear magnetic resonance solution structure of truncated human GRObeta [5-73] and its structural comparison with CXC chemokine family members GROalpha and IL-8.,Qian YQ, Johanson KO, McDevitt P J Mol Biol. 1999 Dec 17;294(5):1065-72. PMID:10600366<ref>PMID:10600366</ref>

-	~~===TRUNCATED HUMAN GROB[5-73]~~, ~~NMR, 20 STRUCTURES===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_10600366}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1qnk]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1QNK OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:010600366<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Johanson, K.]]		[[Category: Johanson, K.]]

OCA: Protected "1qnk" [edit=sysop:move=sysop]

OCA — Wed, 02 Jan 2013 09:58:26 GMT

Protected "1qnk" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:58, 2 January 2013

OCA at 09:58, 2 January 2013

OCA — Wed, 02 Jan 2013 09:58:22 GMT

←Older revision		Revision as of 09:58, 2 January 2013
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-	{{Seed}}
	[[Image:1qnk.png\|left\|200px]]		[[Image:1qnk.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1qnk", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1qnk\| PDB=1qnk \| SCENE= }}		{{STRUCTURE_1qnk\| PDB=1qnk \| SCENE= }}

	===TRUNCATED HUMAN GROB[5-73], NMR, 20 STRUCTURES===		===TRUNCATED HUMAN GROB[5-73], NMR, 20 STRUCTURES===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_10600366}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 10600366 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_10600366}}		{{ABSTRACT_PUBMED_10600366}}

	==About this Structure==		==About this Structure==
-	~~1QNK~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QNK OCA].	+	[[1qnk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QNK OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~10600366~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:010600366</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Johanson, K.]]		[[Category: Johanson, K.]]
	[[Category: Mcdevitt, P.]]		[[Category: Mcdevitt, P.]]
	[[Category: Qian, Y Q.]]		[[Category: Qian, Y Q.]]
		+	[[Category: Chemokine]]
	[[Category: Chemokine 15-o]]		[[Category: Chemokine 15-o]]
	[[Category: Cxc chemokine]]		[[Category: Cxc chemokine]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 19:50:11 2009''