1qnw - Revision history

OCA at 06:05, 17 April 2024

OCA — Wed, 17 Apr 2024 06:05:42 GMT

←Older revision		Revision as of 06:05, 17 April 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1qnw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Ulex_europaeus Ulex europaeus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QNW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QNW FirstGlance]. <br>		<table><tr><td colspan='2'>[[1qnw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Ulex_europaeus Ulex europaeus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QNW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QNW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.35Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1qoo\|1qoo]], [[1qos\|1qos]], [[1qot\|1qot]]</div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qnw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qnw OCA], [https://pdbe.org/1qnw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qnw RCSB], [https://www.ebi.ac.uk/pdbsum/1qnw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qnw ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qnw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qnw OCA], [https://pdbe.org/1qnw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qnw RCSB], [https://www.ebi.ac.uk/pdbsum/1qnw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qnw ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/LEC2_ULEEU LEC2_ULEEU] Di-N-acetylchitobiose specific lectin.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 18:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qnw ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qnw ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Protein-carbohydrate interactions are the language of choice for inter- cellular communication. The legume lectins form a large family of homologous proteins that exhibit a wide variety of carbohydrate specificities. The legume lectin family is therefore highly suitable as a model system to study the structural principles of protein-carbohydrate recognition. Until now, structural data are only available for two specificity families: Man/Glc and Gal/GalNAc. No structural data are available for any of the fucose or chitobiose specific lectins.The crystal structure of Ulex europaeus (UEA-II) is the first of a legume lectin belonging to the chitobiose specificity group. The complexes with N-acetylglucosamine, galactose and fucosylgalactose show a promiscuous primary binding site capable of accommodating both N-acetylglucos amine or galactose in the primary binding site. The hydrogen bonding network in these complexes can be considered suboptimal, in agreement with the low affinities of these sugars. In the complexes with chitobiose, lactose and fucosyllactose this suboptimal hydrogen bonding network is compensated by extensive hydrophobic interactions in a Glc/GlcNAc binding subsite. UEA-II thus forms the first example of a legume lectin with a promiscuous binding site and illustrates the importance of hydrophobic interactions in protein-carbohydrate complexes. Together with other known legume lectin crystal structures, it shows how different specificities can be grafted upon a conserved structural framework.
-
-	Structural basis of carbohydrate recognition by lectin II from Ulex europaeus, a protein with a promiscuous carbohydrate-binding site.,Loris R, De Greve H, Dao-Thi MH, Messens J, Imberty A, Wyns L J Mol Biol. 2000 Aug 25;301(4):987-1002. PMID:10966800<ref>PMID:10966800</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1qnw" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Ulex europaeus]]		[[Category: Ulex europaeus]]
-	[[Category: Dao-Thi, M H]]	+	[[Category: Dao-Thi M-H]]
-	[[Category: Greve, H De]]	+	[[Category: De Greve H]]
-	[[Category: Imberty, A]]	+	[[Category: Imberty A]]
-	[[Category: Loris, R]]	+	[[Category: Loris R]]
-	[[Category: Messens, J]]	+	[[Category: Messens J]]
-	[[Category: Wyns, L]]	+	[[Category: Wyns L]]
-	~~[[Category: Carbohydrate binding]]~~	+
-	~~[[Category: Lectin~~]]	+

OCA at 10:00, 15 September 2021

OCA — Wed, 15 Sep 2021 10:00:05 GMT

←Older revision		Revision as of 10:00, 15 September 2021
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	<StructureSection load='1qnw' size='340' side='right'caption='[[1qnw]], [[Resolution\|resolution]] 2.35Å' scene=''>		<StructureSection load='1qnw' size='340' side='right'caption='[[1qnw]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1qnw]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Ulex_europaeus Ulex europaeus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QNW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1QNW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1qnw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Ulex_europaeus Ulex europaeus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QNW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QNW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qoo\|1qoo]], [[1qos\|1qos]], [[1qot\|1qot]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1qoo\|1qoo]], [[1qos\|1qos]], [[1qot\|1qot]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1qnw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qnw OCA], [~~http~~://pdbe.org/1qnw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1qnw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1qnw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1qnw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qnw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qnw OCA], [https://pdbe.org/1qnw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qnw RCSB], [https://www.ebi.ac.uk/pdbsum/1qnw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qnw ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 11:33, 4 December 2019

OCA — Wed, 04 Dec 2019 11:33:54 GMT

←Older revision		Revision as of 11:33, 4 December 2019
Line 1:		Line 1:

	==lectin II from Ulex europaeus==		==lectin II from Ulex europaeus==
-	<StructureSection load='1qnw' size='340' side='right' caption='[[1qnw]], [[Resolution\|resolution]] 2.35Å' scene=''>	+	<StructureSection load='1qnw' size='340' side='right'caption='[[1qnw]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1qnw]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Ulex_europaeus Ulex europaeus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QNW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QNW FirstGlance]. <br>		<table><tr><td colspan='2'>[[1qnw]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Ulex_europaeus Ulex europaeus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QNW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QNW FirstGlance]. <br>
Line 31:		Line 31:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Ulex europaeus]]		[[Category: Ulex europaeus]]
	[[Category: Dao-Thi, M H]]		[[Category: Dao-Thi, M H]]

OCA at 07:58, 28 February 2018

OCA — Wed, 28 Feb 2018 07:58:51 GMT

←Older revision		Revision as of 07:58, 28 February 2018
Line 1:		Line 1:
-	==~~LECTIN~~ II ~~FROM ULEX EUROPAEUS~~==	+
		+	==lectin II from Ulex europaeus==
	<StructureSection load='1qnw' size='340' side='right' caption='[[1qnw]], [[Resolution\|resolution]] 2.35Å' scene=''>		<StructureSection load='1qnw' size='340' side='right' caption='[[1qnw]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qoo\|1qoo]], [[1qos\|1qos]], [[1qot\|1qot]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qoo\|1qoo]], [[1qos\|1qos]], [[1qot\|1qot]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qnw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qnw OCA], [http://pdbe.org/1qnw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1qnw RCSB], [http://www.ebi.ac.uk/pdbsum/1qnw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qnw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qnw OCA], [http://pdbe.org/1qnw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1qnw RCSB], [http://www.ebi.ac.uk/pdbsum/1qnw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1qnw ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qn/1qnw_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qn/1qnw_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qnw ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 00:49, 12 September 2015

OCA — Sat, 12 Sep 2015 00:49:46 GMT

←Older revision		Revision as of 00:49, 12 September 2015
Line 5:		Line 5:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qoo\|1qoo]], [[1qos\|1qos]], [[1qot\|1qot]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qoo\|1qoo]], [[1qos\|1qos]], [[1qot\|1qot]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qnw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qnw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qnw RCSB], [http://www.ebi.ac.uk/pdbsum/1qnw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qnw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qnw OCA], [http://pdbe.org/1qnw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1qnw RCSB], [http://www.ebi.ac.uk/pdbsum/1qnw PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1qnw" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:10, 6 January 2015

OCA — Tue, 06 Jan 2015 08:10:38 GMT

←Older revision		Revision as of 08:10, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1qnw]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Ulex_europaeus Ulex europaeus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QNW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QNW FirstGlance]. <br>		<table><tr><td colspan='2'>[[1qnw]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Ulex_europaeus Ulex europaeus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QNW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QNW FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qoo\|1qoo]], [[1qos\|1qos]], [[1qot\|1qot]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qoo\|1qoo]], [[1qos\|1qos]], [[1qot\|1qot]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qnw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qnw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qnw RCSB], [http://www.ebi.ac.uk/pdbsum/1qnw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qnw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qnw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qnw RCSB], [http://www.ebi.ac.uk/pdbsum/1qnw PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Ulex europaeus]]		[[Category: Ulex europaeus]]
-	[[Category: Dao-Thi, M H.]]	+	[[Category: Dao-Thi, M H]]
-	[[Category: Greve, H De.]]	+	[[Category: Greve, H De]]
-	[[Category: Imberty, A.]]	+	[[Category: Imberty, A]]
-	[[Category: Loris, R.]]	+	[[Category: Loris, R]]
-	[[Category: Messens, J.]]	+	[[Category: Messens, J]]
-	[[Category: Wyns, L.]]	+	[[Category: Wyns, L]]
	[[Category: Carbohydrate binding]]		[[Category: Carbohydrate binding]]
	[[Category: Lectin]]		[[Category: Lectin]]

OCA at 16:33, 29 September 2014

OCA — Mon, 29 Sep 2014 16:33:25 GMT

←Older revision		Revision as of 16:33, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1qnw.~~png~~\|~~left~~\|200px]]	+	==LECTIN II FROM ULEX EUROPAEUS==
		+	<StructureSection load='1qnw' size='340' side='right' caption='[[1qnw]], [[Resolution\|resolution]] 2.35Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1qnw]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Ulex_europaeus Ulex europaeus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QNW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QNW FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qoo\|1qoo]], [[1qos\|1qos]], [[1qot\|1qot]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qnw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qnw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qnw RCSB], [http://www.ebi.ac.uk/pdbsum/1qnw PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qn/1qnw_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Protein-carbohydrate interactions are the language of choice for inter- cellular communication. The legume lectins form a large family of homologous proteins that exhibit a wide variety of carbohydrate specificities. The legume lectin family is therefore highly suitable as a model system to study the structural principles of protein-carbohydrate recognition. Until now, structural data are only available for two specificity families: Man/Glc and Gal/GalNAc. No structural data are available for any of the fucose or chitobiose specific lectins.The crystal structure of Ulex europaeus (UEA-II) is the first of a legume lectin belonging to the chitobiose specificity group. The complexes with N-acetylglucosamine, galactose and fucosylgalactose show a promiscuous primary binding site capable of accommodating both N-acetylglucos amine or galactose in the primary binding site. The hydrogen bonding network in these complexes can be considered suboptimal, in agreement with the low affinities of these sugars. In the complexes with chitobiose, lactose and fucosyllactose this suboptimal hydrogen bonding network is compensated by extensive hydrophobic interactions in a Glc/GlcNAc binding subsite. UEA-II thus forms the first example of a legume lectin with a promiscuous binding site and illustrates the importance of hydrophobic interactions in protein-carbohydrate complexes. Together with other known legume lectin crystal structures, it shows how different specificities can be grafted upon a conserved structural framework.

-	~~{{STRUCTURE_1qnw\| PDB=1qnw \| SCENE= }}~~	+	Structural basis of carbohydrate recognition by lectin II from Ulex europaeus, a protein with a promiscuous carbohydrate-binding site.,Loris R, De Greve H, Dao-Thi MH, Messens J, Imberty A, Wyns L J Mol Biol. 2000 Aug 25;301(4):987-1002. PMID:10966800<ref>PMID:10966800</ref>

-	~~===LECTIN II FROM ULEX EUROPAEUS===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_10966800}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1qnw]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Ulex_europaeus Ulex europaeus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1QNW OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:010966800<~~/~~ref~~><~~ref group="xtra">PMID:010508764</ref><ref group="xtra">PMID:011491289</ref><references group="xtra"~~/>	+
	[[Category: Ulex europaeus]]		[[Category: Ulex europaeus]]
	[[Category: Dao-Thi, M H.]]		[[Category: Dao-Thi, M H.]]

OCA at 09:29, 16 January 2013

OCA — Wed, 16 Jan 2013 09:29:15 GMT

←Older revision		Revision as of 09:29, 16 January 2013
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	[[Image:1qnw.png\|left\|200px]]		[[Image:1qnw.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_1qnw\| PDB=1qnw \| SCENE= }}		{{STRUCTURE_1qnw\| PDB=1qnw \| SCENE= }}

	===LECTIN II FROM ULEX EUROPAEUS===		===LECTIN II FROM ULEX EUROPAEUS===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_10966800}}, adds the Publication Abstract to the page
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	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~10966800~~</ref><ref group="xtra">PMID:~~10508764~~</ref><ref group="xtra">PMID:~~9757099</ref><ref group="xtra">PMID:9546043~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:010966800</ref><ref group="xtra">PMID:010508764</ref><ref group="xtra">PMID:011491289</ref><references group="xtra"/>
	[[Category: Ulex europaeus]]		[[Category: Ulex europaeus]]
	[[Category: Dao-Thi, M H.]]		[[Category: Dao-Thi, M H.]]

OCA: Protected "1qnw" [edit=sysop:move=sysop]

OCA — Mon, 14 Mar 2011 20:33:18 GMT

Protected "1qnw" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:33, 14 March 2011

OCA at 20:33, 14 March 2011

OCA — Mon, 14 Mar 2011 20:33:16 GMT

←Older revision		Revision as of 20:33, 14 March 2011
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-	{{Seed}}
	[[Image:1qnw.png\|left\|200px]]		[[Image:1qnw.png\|left\|200px]]

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	==About this Structure==		==About this Structure==
-	~~1QNW~~ is a 4 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Ulex_europaeus Ulex europaeus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QNW OCA].	+	[[1qnw]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Ulex_europaeus Ulex europaeus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QNW OCA].

	==Reference==		==Reference==
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	[[Category: Carbohydrate binding]]		[[Category: Carbohydrate binding]]
	[[Category: Lectin]]		[[Category: Lectin]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 22 20:20:11 2009''