1qoh - Revision history

OCA at 12:50, 13 December 2023

OCA — Wed, 13 Dec 2023 12:50:19 GMT

←Older revision		Revision as of 12:50, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='1qoh' size='340' side='right'caption='[[1qoh]], [[Resolution\|resolution]] 2.35Å' scene=''>		<StructureSection load='1qoh' size='340' side='right'caption='[[1qoh]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1qoh]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QOH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QOH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1qoh]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QOH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QOH FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[1bos\|1bos]]~~, [[~~1bov~~\|~~1bov~~]]~~, [[2bos\|2bos]]</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.35Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qoh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qoh OCA], [https://pdbe.org/1qoh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qoh RCSB], [https://www.ebi.ac.uk/pdbsum/1qoh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qoh ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qoh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qoh OCA], [https://pdbe.org/1qoh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qoh RCSB], [https://www.ebi.ac.uk/pdbsum/1qoh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qoh ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q47644_ECOLX Q47644_ECOLX]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
-	*[[Shiga toxin\|Shiga toxin]]	+	*[[Shiga toxin 3D structures\|Shiga toxin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ coli ~~migula 1895~~]]	+	[[Category: Escherichia coli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Armstrong~~, G D~~]]	+	[[Category: Armstrong GD]]
-	[[Category: Boodhoo, A]]	+	[[Category: Boodhoo A]]
-	[[Category: Brunton~~, J L~~]]	+	[[Category: Brunton JL]]
-	[[Category: Clark~~, C G~~]]	+	[[Category: Clark CG]]
-	[[Category: Pannu~~, N S~~]]	+	[[Category: Pannu NS]]
-	[[Category: Read~~, R J]]~~	+	[[Category: Read RJ]]
-	~~[[Category: Protein-carbohydrate recognition]]~~	+
-	~~[[Category: Receptor binding]]~~	+
-	~~[[Category: Specificity]]~~	+
-	~~[[Category: Toxin~~]]	+

OCA at 10:00, 15 September 2021

OCA — Wed, 15 Sep 2021 10:00:21 GMT

←Older revision		Revision as of 10:00, 15 September 2021
Line 3:		Line 3:
	<StructureSection load='1qoh' size='340' side='right'caption='[[1qoh]], [[Resolution\|resolution]] 2.35Å' scene=''>		<StructureSection load='1qoh' size='340' side='right'caption='[[1qoh]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1qoh]] is a 20 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QOH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1QOH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1qoh]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QOH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QOH FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bos\|1bos]], [[1bov\|1bov]], [[2bos\|2bos]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1bos\|1bos]], [[1bov\|1bov]], [[2bos\|2bos]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1qoh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qoh OCA], [~~http~~://pdbe.org/1qoh PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1qoh RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1qoh PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1qoh ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qoh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qoh OCA], [https://pdbe.org/1qoh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qoh RCSB], [https://www.ebi.ac.uk/pdbsum/1qoh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qoh ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 11:32, 4 December 2019

OCA — Wed, 04 Dec 2019 11:32:06 GMT

←Older revision		Revision as of 11:32, 4 December 2019
Line 1:		Line 1:

	==A MUTANT SHIGA-LIKE TOXIN IIE==		==A MUTANT SHIGA-LIKE TOXIN IIE==
-	<StructureSection load='1qoh' size='340' side='right' caption='[[1qoh]], [[Resolution\|resolution]] 2.35Å' scene=''>	+	<StructureSection load='1qoh' size='340' side='right'caption='[[1qoh]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1qoh]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QOH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QOH FirstGlance]. <br>		<table><tr><td colspan='2'>[[1qoh]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QOH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QOH FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
		+	[[Category: Large Structures]]
	[[Category: Armstrong, G D]]		[[Category: Armstrong, G D]]
	[[Category: Boodhoo, A]]		[[Category: Boodhoo, A]]

OCA at 07:56, 28 February 2018

OCA — Wed, 28 Feb 2018 07:56:37 GMT

←Older revision		Revision as of 07:56, 28 February 2018
Line 1:		Line 1:
		+
	==A MUTANT SHIGA-LIKE TOXIN IIE==		==A MUTANT SHIGA-LIKE TOXIN IIE==
	<StructureSection load='1qoh' size='340' side='right' caption='[[1qoh]], [[Resolution\|resolution]] 2.35Å' scene=''>		<StructureSection load='1qoh' size='340' side='right' caption='[[1qoh]], [[Resolution\|resolution]] 2.35Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1qoh]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QOH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QOH FirstGlance]. <br>		<table><tr><td colspan='2'>[[1qoh]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QOH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QOH FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bos\|1bos]], [[1bov\|1bov]], [[2bos\|2bos]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bos\|1bos]], [[1bov\|1bov]], [[2bos\|2bos]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qoh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qoh OCA], [http://pdbe.org/1qoh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1qoh RCSB], [http://www.ebi.ac.uk/pdbsum/1qoh PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qoh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qoh OCA], [http://pdbe.org/1qoh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1qoh RCSB], [http://www.ebi.ac.uk/pdbsum/1qoh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1qoh ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 10:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qo/1qoh_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qo/1qoh_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qoh ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 16:08, 11 September 2015

OCA — Fri, 11 Sep 2015 16:08:44 GMT

←Older revision		Revision as of 16:08, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1qoh' size='340' side='right' caption='[[1qoh]], [[Resolution\|resolution]] 2.35Å' scene=''>		<StructureSection load='1qoh' size='340' side='right' caption='[[1qoh]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1qoh]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia~~ coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QOH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QOH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1qoh]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QOH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QOH FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bos\|1bos]], [[1bov\|1bov]], [[2bos\|2bos]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bos\|1bos]], [[1bov\|1bov]], [[2bos\|2bos]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qoh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qoh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qoh RCSB], [http://www.ebi.ac.uk/pdbsum/1qoh PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qoh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qoh OCA], [http://pdbe.org/1qoh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1qoh RCSB], [http://www.ebi.ac.uk/pdbsum/1qoh PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1qoh" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 31:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Escherichia~~ coli]]	+	[[Category: Bacillus coli migula 1895]]
	[[Category: Armstrong, G D]]		[[Category: Armstrong, G D]]
	[[Category: Boodhoo, A]]		[[Category: Boodhoo, A]]

OCA at 08:08, 6 January 2015

OCA — Tue, 06 Jan 2015 08:08:27 GMT

←Older revision		Revision as of 08:08, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1qoh]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QOH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QOH FirstGlance]. <br>		<table><tr><td colspan='2'>[[1qoh]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QOH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QOH FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bos\|1bos]], [[1bov\|1bov]], [[2bos\|2bos]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bos\|1bos]], [[1bov\|1bov]], [[2bos\|2bos]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qoh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qoh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qoh RCSB], [http://www.ebi.ac.uk/pdbsum/1qoh PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qoh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qoh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qoh RCSB], [http://www.ebi.ac.uk/pdbsum/1qoh PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: Armstrong, G D.]]	+	[[Category: Armstrong, G D]]
-	[[Category: Boodhoo, A.]]	+	[[Category: Boodhoo, A]]
-	[[Category: Brunton, J L.]]	+	[[Category: Brunton, J L]]
-	[[Category: Clark, C G.]]	+	[[Category: Clark, C G]]
-	[[Category: Pannu, N S.]]	+	[[Category: Pannu, N S]]
-	[[Category: Read, R J.]]	+	[[Category: Read, R J]]
	[[Category: Protein-carbohydrate recognition]]		[[Category: Protein-carbohydrate recognition]]
	[[Category: Receptor binding]]		[[Category: Receptor binding]]
	[[Category: Specificity]]		[[Category: Specificity]]
	[[Category: Toxin]]		[[Category: Toxin]]

OCA at 23:59, 28 September 2014

OCA — Sun, 28 Sep 2014 23:59:27 GMT

←Older revision		Revision as of 23:59, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1qoh.~~png~~\|~~left~~\|200px]]	+	==A MUTANT SHIGA-LIKE TOXIN IIE==
		+	<StructureSection load='1qoh' size='340' side='right' caption='[[1qoh]], [[Resolution\|resolution]] 2.35Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1qoh]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QOH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QOH FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bos\|1bos]], [[1bov\|1bov]], [[2bos\|2bos]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qoh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qoh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qoh RCSB], [http://www.ebi.ac.uk/pdbsum/1qoh PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qo/1qoh_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	BACKGROUND: Shiga-like toxins (SLTs) are produced by the pathogenic strains of Escherichia coli that cause hemorrhagic colitis and hemolytic uremic syndrome. These diseases in humans are generally associated with group II family members (SLT-II and SLT-IIc), whereas SLT-IIe (pig edema toxin) is central to edema disease of swine. The pentameric B-subunit component of the majority of family members binds to the cell-surface glycolipid globotriaosyl ceramide (Gb(3)), but globotetraosyl ceramide (Gb(4)) is the preferred receptor for SLT-IIe. A double-mutant of the SLT-IIe B subunit that reverses two sequence differences from SLT-II (GT3; Gln65-->Glu, Lys67-->Gln, SLT-I numbering) has been shown to bind more strongly to Gb(3) than to Gb(4). RESULTS: To understand the molecular basis of receptor binding and specificity, we have determined the structure of the GT3 mutant B pentamer, both in complex with a Gb(3) analogue (2.0 A resolution; R = 0.155, R(free) = 0.194) and in its native form (2.35 A resolution; R = 0.187, R(free) = 0.232). CONCLUSIONS: These are the first structures of a member of the medically important group II Shiga-like toxins to be reported. The structures confirm the previous observation of multiple binding sites on each SLT monomer, although binding site 3 is not occupied in the GT3 structure. Analysis of the binding properties of mutants suggests that site 3 is a secondary Gb(4)-binding site. The two mutated residues are located appropriately to interact with the extra betaGalNAc residue on Gb(4). Differences in the binding sites provide a molecular basis for understanding the tissue specificities and pathogenic mechanisms of members of the SLT family.

-	~~{{STRUCTURE_1qoh\| PDB=1qoh \| SCENE= }}~~	+	A mutant Shiga-like toxin IIe bound to its receptor Gb(3): structure of a group II Shiga-like toxin with altered binding specificity.,Ling H, Pannu NS, Boodhoo A, Armstrong GD, Clark CG, Brunton JL, Read RJ Structure. 2000 Mar 15;8(3):253-64. PMID:10745005<ref>PMID:10745005</ref>

-	~~===A MUTANT SHIGA-LIKE TOXIN IIE===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_10745005}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1qoh]] is~~ a ~~20 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli Escherichia coli]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1QOH OCA].~~	+

	==See Also==		==See Also==
	*[[Shiga toxin\|Shiga toxin]]		*[[Shiga toxin\|Shiga toxin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:010745005<~~/~~ref~~><~~ref group="xtra">PMID:009485303</ref><ref group="xtra">PMID:001741063</ref><references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Armstrong, G D.]]		[[Category: Armstrong, G D.]]

OCA at 20:10, 20 October 2012

OCA — Sat, 20 Oct 2012 20:10:38 GMT

←Older revision		Revision as of 20:10, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1qoh]] is a 20 chain structure ~~of [[Shiga toxin]]~~ with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QOH OCA].	+	[[1qoh]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QOH OCA].

	==See Also==		==See Also==

OCA at 09:38, 27 July 2012

OCA — Fri, 27 Jul 2012 09:38:58 GMT

←Older revision		Revision as of 09:38, 27 July 2012
Line 1:		Line 1:
	[[Image:1qoh.png\|left\|200px]]		[[Image:1qoh.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1qoh", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1qoh\| PDB=1qoh \| SCENE= }}		{{STRUCTURE_1qoh\| PDB=1qoh \| SCENE= }}

	===A MUTANT SHIGA-LIKE TOXIN IIE===		===A MUTANT SHIGA-LIKE TOXIN IIE===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_10745005}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 10745005 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_10745005}}		{{ABSTRACT_PUBMED_10745005}}

	==About this Structure==		==About this Structure==
-	[[1qoh]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QOH OCA].	+	[[1qoh]] is a 20 chain structure of [[Shiga toxin]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QOH OCA].
		+
		+	==See Also==
		+	*[[Shiga toxin\|Shiga toxin]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~10745005~~</ref><ref group="xtra">PMID:~~9485303~~</ref><ref group="xtra">PMID:~~1741063~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:010745005</ref><ref group="xtra">PMID:009485303</ref><ref group="xtra">PMID:001741063</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Armstrong, G D.]]		[[Category: Armstrong, G D.]]

OCA: Protected "1qoh" [edit=sysop:move=sysop]

OCA — Mon, 14 Mar 2011 23:56:31 GMT

Protected "1qoh" [edit=sysop:move=sysop]

←Older revision

Revision as of 23:56, 14 March 2011