1qqe - Revision history

OCA at 08:16, 14 February 2024

OCA — Wed, 14 Feb 2024 08:16:08 GMT

←Older revision		Revision as of 08:16, 14 February 2024
Line 3:		Line 3:
	<StructureSection load='1qqe' size='340' side='right'caption='[[1qqe]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='1qqe' size='340' side='right'caption='[[1qqe]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1qqe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_18824 Atcc 18824~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QQE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QQE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1qqe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QQE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QQE FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qqe OCA], [https://pdbe.org/1qqe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qqe RCSB], [https://www.ebi.ac.uk/pdbsum/1qqe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qqe ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.9Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qqe OCA], [https://pdbe.org/1qqe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qqe RCSB], [https://www.ebi.ac.uk/pdbsum/1qqe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qqe ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/SEC17_YEAST SEC17_YEAST]] SNARE complex protein that binds to cis-SNARE complexes on membranes and is required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus and for homotypic vacuole fusion. During the priming step of membrane fusion, is released from cis-SNARE complexes by SEC18 to establish a pool of unpaired SNAREs, which are required for interactions in trans during docking and fusion steps. Can displace HOPS from SNARE complexes, which may be a prerequisite for trans-SNARE complex disassembly and subsequent rounds of priming, docking and fusion.<ref>PMID:8620540</ref> <ref>PMID:8670830</ref> <ref>PMID:9144293</ref> <ref>PMID:15889152</ref>	+	[https://www.uniprot.org/uniprot/SEC17_YEAST SEC17_YEAST] SNARE complex protein that binds to cis-SNARE complexes on membranes and is required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus and for homotypic vacuole fusion. During the priming step of membrane fusion, is released from cis-SNARE complexes by SEC18 to establish a pool of unpaired SNAREs, which are required for interactions in trans during docking and fusion steps. Can displace HOPS from SNARE complexes, which may be a prerequisite for trans-SNARE complex disassembly and subsequent rounds of priming, docking and fusion.<ref>PMID:8620540</ref> <ref>PMID:8670830</ref> <ref>PMID:9144293</ref> <ref>PMID:15889152</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 18:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qqe ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qqe ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	SNAP proteins play an essential role in membrane trafficking in eukaryotic cells. They activate and recycle SNARE proteins by serving as adaptors between SNAREs and the cytosolic chaperone NSF. We have determined the crystal structure of Sec17, the yeast homolog of alpha-SNAP, to 2.9 A resolution. Sec17 is composed of an N-terminal twisted sheet of alpha-helical hairpins and a C-terminal alpha-helical bundle. The N-terminal sheet has local similarity to the tetratricopeptide repeats from protein phosphatase 5 but has a different overall twist. Sec17 also shares structural features with HEAT and clathrin heavy chain repeats. Possible models of SNAP:SNARE binding suggest that SNAPs may function as lever arms, transmitting forces generated by conformational changes in NSF/Sec18 to drive disassembly of SNARE complexes.
-
-	Crystal structure of the vesicular transport protein Sec17: implications for SNAP function in SNARE complex disassembly.,Rice LM, Brunger AT Mol Cell. 1999 Jul;4(1):85-95. PMID:10445030<ref>PMID:10445030</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1qqe" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 18824]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Brunger, A T~~]]	+	[[Category: Saccharomyces cerevisiae]]
-	[[Category: ~~Rice, L M~~]]	+	[[Category: Brunger AT]]
-	[[Category: ~~Helix-turn-helix tpr-like repeat]]~~	+	[[Category: Rice LM]]
-	~~[[Category: Protein transport~~]]	+

OCA at 10:01, 15 September 2021

OCA — Wed, 15 Sep 2021 10:01:23 GMT

←Older revision		Revision as of 10:01, 15 September 2021
Line 3:		Line 3:
	<StructureSection load='1qqe' size='340' side='right'caption='[[1qqe]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='1qqe' size='340' side='right'caption='[[1qqe]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1qqe]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QQE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1QQE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1qqe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QQE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QQE FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1qqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qqe OCA], [~~http~~://pdbe.org/1qqe PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1qqe RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1qqe PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1qqe ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qqe OCA], [https://pdbe.org/1qqe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qqe RCSB], [https://www.ebi.ac.uk/pdbsum/1qqe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qqe ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/SEC17_YEAST SEC17_YEAST]] SNARE complex protein that binds to cis-SNARE complexes on membranes and is required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus and for homotypic vacuole fusion. During the priming step of membrane fusion, is released from cis-SNARE complexes by SEC18 to establish a pool of unpaired SNAREs, which are required for interactions in trans during docking and fusion steps. Can displace HOPS from SNARE complexes, which may be a prerequisite for trans-SNARE complex disassembly and subsequent rounds of priming, docking and fusion.<ref>PMID:8620540</ref> <ref>PMID:8670830</ref> <ref>PMID:9144293</ref> <ref>PMID:15889152</ref>	+	[[https://www.uniprot.org/uniprot/SEC17_YEAST SEC17_YEAST]] SNARE complex protein that binds to cis-SNARE complexes on membranes and is required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus and for homotypic vacuole fusion. During the priming step of membrane fusion, is released from cis-SNARE complexes by SEC18 to establish a pool of unpaired SNAREs, which are required for interactions in trans during docking and fusion steps. Can displace HOPS from SNARE complexes, which may be a prerequisite for trans-SNARE complex disassembly and subsequent rounds of priming, docking and fusion.<ref>PMID:8620540</ref> <ref>PMID:8670830</ref> <ref>PMID:9144293</ref> <ref>PMID:15889152</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 11:21, 4 December 2019

OCA — Wed, 04 Dec 2019 11:21:03 GMT

←Older revision		Revision as of 11:21, 4 December 2019
Line 1:		Line 1:

	==CRYSTAL STRUCTURE OF THE VESICULAR TRANSPORT PROTEIN SEC17==		==CRYSTAL STRUCTURE OF THE VESICULAR TRANSPORT PROTEIN SEC17==
-	<StructureSection load='1qqe' size='340' side='right' caption='[[1qqe]], [[Resolution\|resolution]] 2.90Å' scene=''>	+	<StructureSection load='1qqe' size='340' side='right'caption='[[1qqe]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1qqe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QQE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QQE FirstGlance]. <br>		<table><tr><td colspan='2'>[[1qqe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QQE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QQE FirstGlance]. <br>
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 18824]]		[[Category: Atcc 18824]]
		+	[[Category: Large Structures]]
	[[Category: Brunger, A T]]		[[Category: Brunger, A T]]
	[[Category: Rice, L M]]		[[Category: Rice, L M]]
	[[Category: Helix-turn-helix tpr-like repeat]]		[[Category: Helix-turn-helix tpr-like repeat]]
	[[Category: Protein transport]]		[[Category: Protein transport]]

OCA at 07:46, 28 February 2018

OCA — Wed, 28 Feb 2018 07:46:11 GMT

←Older revision		Revision as of 07:46, 28 February 2018
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF THE VESICULAR TRANSPORT PROTEIN SEC17==		==CRYSTAL STRUCTURE OF THE VESICULAR TRANSPORT PROTEIN SEC17==
	<StructureSection load='1qqe' size='340' side='right' caption='[[1qqe]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='1qqe' size='340' side='right' caption='[[1qqe]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1qqe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QQE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QQE FirstGlance]. <br>		<table><tr><td colspan='2'>[[1qqe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QQE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QQE FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qqe OCA], [http://pdbe.org/1qqe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1qqe RCSB], [http://www.ebi.ac.uk/pdbsum/1qqe PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qqe OCA], [http://pdbe.org/1qqe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1qqe RCSB], [http://www.ebi.ac.uk/pdbsum/1qqe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1qqe ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qq/1qqe_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qq/1qqe_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 01:19, 10 February 2016

OCA — Wed, 10 Feb 2016 01:19:31 GMT

←Older revision		Revision as of 01:19, 10 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qqe ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 03:56, 11 September 2015

OCA — Fri, 11 Sep 2015 03:56:26 GMT

←Older revision		Revision as of 03:56, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1qqe' size='340' side='right' caption='[[1qqe]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='1qqe' size='340' side='right' caption='[[1qqe]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1qqe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae Saccharomyces cerevisiae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QQE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QQE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1qqe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QQE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QQE FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qqe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qqe RCSB], [http://www.ebi.ac.uk/pdbsum/1qqe PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qqe OCA], [http://pdbe.org/1qqe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1qqe RCSB], [http://www.ebi.ac.uk/pdbsum/1qqe PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1qqe" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Saccharomyces cerevisiae~~]]	+	[[Category: Atcc 18824]]
	[[Category: Brunger, A T]]		[[Category: Brunger, A T]]
	[[Category: Rice, L M]]		[[Category: Rice, L M]]
	[[Category: Helix-turn-helix tpr-like repeat]]		[[Category: Helix-turn-helix tpr-like repeat]]
	[[Category: Protein transport]]		[[Category: Protein transport]]

OCA at 10:47, 25 December 2014

OCA — Thu, 25 Dec 2014 10:47:53 GMT

←Older revision		Revision as of 10:47, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1qqe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QQE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QQE FirstGlance]. <br>		<table><tr><td colspan='2'>[[1qqe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QQE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QQE FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qqe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qqe RCSB], [http://www.ebi.ac.uk/pdbsum/1qqe PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qqe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qqe RCSB], [http://www.ebi.ac.uk/pdbsum/1qqe PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SEC17_YEAST SEC17_YEAST]] SNARE complex protein that binds to cis-SNARE complexes on membranes and is required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus and for homotypic vacuole fusion. During the priming step of membrane fusion, is released from cis-SNARE complexes by SEC18 to establish a pool of unpaired SNAREs, which are required for interactions in trans during docking and fusion steps. Can displace HOPS from SNARE complexes, which may be a prerequisite for trans-SNARE complex disassembly and subsequent rounds of priming, docking and fusion.<ref>PMID:8620540</ref> <ref>PMID:8670830</ref> <ref>PMID:9144293</ref> <ref>PMID:15889152</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 28:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
-	[[Category: Brunger, A T.]]	+	[[Category: Brunger, A T]]
-	[[Category: Rice, L M.]]	+	[[Category: Rice, L M]]
	[[Category: Helix-turn-helix tpr-like repeat]]		[[Category: Helix-turn-helix tpr-like repeat]]
	[[Category: Protein transport]]		[[Category: Protein transport]]

OCA at 17:22, 29 September 2014

OCA — Mon, 29 Sep 2014 17:22:56 GMT

←Older revision		Revision as of 17:22, 29 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1qqe.~~png\|left~~\|200px]]	+	==CRYSTAL STRUCTURE OF THE VESICULAR TRANSPORT PROTEIN SEC17==
		+	<StructureSection load='1qqe' size='340' side='right' caption='[[1qqe]], [[Resolution\|resolution]] 2.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1qqe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QQE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QQE FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qqe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qqe RCSB], [http://www.ebi.ac.uk/pdbsum/1qqe PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qq/1qqe_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	SNAP proteins play an essential role in membrane trafficking in eukaryotic cells. They activate and recycle SNARE proteins by serving as adaptors between SNAREs and the cytosolic chaperone NSF. We have determined the crystal structure of Sec17, the yeast homolog of alpha-SNAP, to 2.9 A resolution. Sec17 is composed of an N-terminal twisted sheet of alpha-helical hairpins and a C-terminal alpha-helical bundle. The N-terminal sheet has local similarity to the tetratricopeptide repeats from protein phosphatase 5 but has a different overall twist. Sec17 also shares structural features with HEAT and clathrin heavy chain repeats. Possible models of SNAP:SNARE binding suggest that SNAPs may function as lever arms, transmitting forces generated by conformational changes in NSF/Sec18 to drive disassembly of SNARE complexes.

-	~~{{STRUCTURE_1qqe\| PDB=1qqe \| SCENE= }}~~	+	Crystal structure of the vesicular transport protein Sec17: implications for SNAP function in SNARE complex disassembly.,Rice LM, Brunger AT Mol Cell. 1999 Jul;4(1):85-95. PMID:10445030<ref>PMID:10445030</ref>

-	~~===CRYSTAL STRUCTURE OF THE VESICULAR TRANSPORT PROTEIN SEC17===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_10445030}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1qqe]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1QQE OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:010445030<~~/~~ref~~><~~ref group="xtra">PMID:015906318</ref><references group="xtra"~~/>	+
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Brunger, A T.]]		[[Category: Brunger, A T.]]

OCA: Protected "1qqe" [edit=sysop:move=sysop]

OCA — Wed, 02 Jan 2013 10:02:05 GMT

Protected "1qqe" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:02, 2 January 2013

OCA at 10:02, 2 January 2013

OCA — Wed, 02 Jan 2013 10:02:02 GMT

←Older revision		Revision as of 10:02, 2 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1qqe.png\|left\|200px]]		[[Image:1qqe.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1qqe", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1qqe\| PDB=1qqe \| SCENE= }}		{{STRUCTURE_1qqe\| PDB=1qqe \| SCENE= }}

	===CRYSTAL STRUCTURE OF THE VESICULAR TRANSPORT PROTEIN SEC17===		===CRYSTAL STRUCTURE OF THE VESICULAR TRANSPORT PROTEIN SEC17===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_10445030}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 10445030 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_10445030}}		{{ABSTRACT_PUBMED_10445030}}

	==About this Structure==		==About this Structure==
-	~~1QQE~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QQE OCA].	+	[[1qqe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QQE OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~10445030~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:010445030</ref><ref group="xtra">PMID:015906318</ref><references group="xtra"/>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Brunger, A T.]]		[[Category: Brunger, A T.]]
	[[Category: Rice, L M.]]		[[Category: Rice, L M.]]
	[[Category: Helix-turn-helix tpr-like repeat]]		[[Category: Helix-turn-helix tpr-like repeat]]
-		+	[[Category: Protein transport]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 14:15:49 2009''~~	+