1qqg - Revision history

OCA at 08:16, 14 February 2024

OCA — Wed, 14 Feb 2024 08:16:08 GMT

←Older revision		Revision as of 08:16, 14 February 2024
Line 3:		Line 3:
	<StructureSection load='1qqg' size='340' side='right'caption='[[1qqg]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='1qqg' size='340' side='right'caption='[[1qqg]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1qqg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QQG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QQG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1qqg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QQG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QQG FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qqg OCA], [https://pdbe.org/1qqg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qqg RCSB], [https://www.ebi.ac.uk/pdbsum/1qqg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qqg ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qqg OCA], [https://pdbe.org/1qqg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qqg RCSB], [https://www.ebi.ac.uk/pdbsum/1qqg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qqg ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/IRS1_HUMAN IRS1_HUMAN]] Polymorphisms in IRS1 may be involved in the etiology of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:[https://omim.org/entry/125853 125853]].<ref>PMID:14707024</ref> <ref>PMID:8723689</ref> <ref>PMID:10206679</ref> <ref>PMID:12843189</ref> <ref>PMID:15590636</ref>	+	[https://www.uniprot.org/uniprot/IRS1_HUMAN IRS1_HUMAN] Polymorphisms in IRS1 may be involved in the etiology of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:[https://omim.org/entry/125853 125853].<ref>PMID:14707024</ref> <ref>PMID:8723689</ref> <ref>PMID:10206679</ref> <ref>PMID:12843189</ref> <ref>PMID:15590636</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/IRS1_HUMAN IRS1_HUMAN]] May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).<ref>PMID:16878150</ref> <ref>PMID:14707024</ref>	+	[https://www.uniprot.org/uniprot/IRS1_HUMAN IRS1_HUMAN] May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).<ref>PMID:16878150</ref> <ref>PMID:14707024</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 20:		Line 21:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qqg ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qqg ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	We have determined the crystal structure at 2.3-A resolution of an amino-terminal segment of human insulin receptor substrate 1 that encompasses its pleckstrin homology (PH) and phosphotyrosine binding (PTB) domains. Both domains adopt the canonical seven-stranded beta-sandwich PH domain fold. The domains are closely associated, with a 720-A(2) contact surface buried between them that appears to be stabilized by ionic, hydrophobic, and hydrogen bonding interactions. The nonconserved 46-residue linker between the domains is disordered. The PTB domain peptide binding site is fully exposed on the molecular surface, as is a large cationic patch at the base of the PH domain that is a likely binding site for the head groups of phosphatidylinositol phosphates. Binding assays confirm that phosphatidylinositol phosphates bind the PH domain, but not the PTB domain. Ligand binding to the PH domain does not alter PTB domain interactions, and vice versa. The structural and accompanying functional data illustrate how the two binding domains might act cooperatively to effectively increase local insulin receptor substrate 1 concentration at the membrane and transiently fix the receptor and substrate, to allow multiple phosphorylation reactions to occur during each union.
-
-	Crystal structure of the pleckstrin homology-phosphotyrosine binding (PH-PTB) targeting region of insulin receptor substrate 1.,Dhe-Paganon S, Ottinger EA, Nolte RT, Eck MJ, Shoelson SE Proc Natl Acad Sci U S A. 1999 Jul 20;96(15):8378-83. PMID:10411883<ref>PMID:10411883</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1qqg" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Dhe-Paganon, S]]	+	[[Category: Dhe-Paganon S]]
-	[[Category: Shoelson~~, S E]]~~	+	[[Category: Shoelson SE]]
-	~~[[Category: Beta-sandwhich]]~~	+
-	~~[[Category: Signal transduction~~]]	+

OCA at 10:01, 15 September 2021

OCA — Wed, 15 Sep 2021 10:01:28 GMT

←Older revision		Revision as of 10:01, 15 September 2021
Line 3:		Line 3:
	<StructureSection load='1qqg' size='340' side='right'caption='[[1qqg]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='1qqg' size='340' side='right'caption='[[1qqg]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1qqg]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QQG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1QQG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1qqg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QQG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QQG FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1qqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qqg OCA], [~~http~~://pdbe.org/1qqg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1qqg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1qqg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1qqg ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qqg OCA], [https://pdbe.org/1qqg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qqg RCSB], [https://www.ebi.ac.uk/pdbsum/1qqg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qqg ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/IRS1_HUMAN IRS1_HUMAN]] Polymorphisms in IRS1 may be involved in the etiology of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:[~~http~~://omim.org/entry/125853 125853]].<ref>PMID:14707024</ref> <ref>PMID:8723689</ref> <ref>PMID:10206679</ref> <ref>PMID:12843189</ref> <ref>PMID:15590636</ref>	+	[[https://www.uniprot.org/uniprot/IRS1_HUMAN IRS1_HUMAN]] Polymorphisms in IRS1 may be involved in the etiology of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:[https://omim.org/entry/125853 125853]].<ref>PMID:14707024</ref> <ref>PMID:8723689</ref> <ref>PMID:10206679</ref> <ref>PMID:12843189</ref> <ref>PMID:15590636</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/IRS1_HUMAN IRS1_HUMAN]] May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).<ref>PMID:16878150</ref> <ref>PMID:14707024</ref>	+	[[https://www.uniprot.org/uniprot/IRS1_HUMAN IRS1_HUMAN]] May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).<ref>PMID:16878150</ref> <ref>PMID:14707024</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 10:15, 27 November 2019

OCA — Wed, 27 Nov 2019 10:15:47 GMT

←Older revision		Revision as of 10:15, 27 November 2019
Line 1:		Line 1:

	==CRYSTAL STRUCTURE OF THE PH-PTB TARGETING REGION OF IRS-1==		==CRYSTAL STRUCTURE OF THE PH-PTB TARGETING REGION OF IRS-1==
-	<StructureSection load='1qqg' size='340' side='right' caption='[[1qqg]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='1qqg' size='340' side='right'caption='[[1qqg]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1qqg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QQG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QQG FirstGlance]. <br>		<table><tr><td colspan='2'>[[1qqg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QQG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QQG FirstGlance]. <br>
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Dhe-Paganon, S]]		[[Category: Dhe-Paganon, S]]
	[[Category: Shoelson, S E]]		[[Category: Shoelson, S E]]
	[[Category: Beta-sandwhich]]		[[Category: Beta-sandwhich]]
	[[Category: Signal transduction]]		[[Category: Signal transduction]]

OCA at 06:29, 31 January 2018

OCA — Wed, 31 Jan 2018 06:29:26 GMT

←Older revision		Revision as of 06:29, 31 January 2018
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF THE PH-PTB TARGETING REGION OF IRS-1==		==CRYSTAL STRUCTURE OF THE PH-PTB TARGETING REGION OF IRS-1==
	<StructureSection load='1qqg' size='340' side='right' caption='[[1qqg]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='1qqg' size='340' side='right' caption='[[1qqg]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1qqg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QQG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QQG FirstGlance]. <br>		<table><tr><td colspan='2'>[[1qqg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QQG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QQG FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qqg OCA], [http://pdbe.org/1qqg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1qqg RCSB], [http://www.ebi.ac.uk/pdbsum/1qqg PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qqg OCA], [http://pdbe.org/1qqg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1qqg RCSB], [http://www.ebi.ac.uk/pdbsum/1qqg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1qqg ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qq/1qqg_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qq/1qqg_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 18:41, 8 February 2016

OCA — Mon, 08 Feb 2016 18:41:54 GMT

←Older revision		Revision as of 18:41, 8 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qqg ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 14:20, 10 September 2015

OCA — Thu, 10 Sep 2015 14:20:53 GMT

←Older revision		Revision as of 14:20, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1qqg' size='340' side='right' caption='[[1qqg]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='1qqg' size='340' side='right' caption='[[1qqg]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1qqg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QQG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QQG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1qqg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QQG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QQG FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qqg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qqg RCSB], [http://www.ebi.ac.uk/pdbsum/1qqg PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qqg OCA], [http://pdbe.org/1qqg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1qqg RCSB], [http://www.ebi.ac.uk/pdbsum/1qqg PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1qqg" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Dhe-Paganon, S]]		[[Category: Dhe-Paganon, S]]
	[[Category: Shoelson, S E]]		[[Category: Shoelson, S E]]
	[[Category: Beta-sandwhich]]		[[Category: Beta-sandwhich]]
	[[Category: Signal transduction]]		[[Category: Signal transduction]]

OCA at 08:10, 6 January 2015

OCA — Tue, 06 Jan 2015 08:10:53 GMT

←Older revision		Revision as of 08:10, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1qqg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QQG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QQG FirstGlance]. <br>		<table><tr><td colspan='2'>[[1qqg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QQG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QQG FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qqg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qqg RCSB], [http://www.ebi.ac.uk/pdbsum/1qqg PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qqg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qqg RCSB], [http://www.ebi.ac.uk/pdbsum/1qqg PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/IRS1_HUMAN IRS1_HUMAN]] Polymorphisms in IRS1 may be involved in the etiology of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:[http://omim.org/entry/125853 125853]].<ref>PMID:14707024</ref> <ref>PMID:8723689</ref> <ref>PMID:10206679</ref> <ref>PMID:12843189</ref> <ref>PMID:15590636</ref>		[[http://www.uniprot.org/uniprot/IRS1_HUMAN IRS1_HUMAN]] Polymorphisms in IRS1 may be involved in the etiology of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:[http://omim.org/entry/125853 125853]].<ref>PMID:14707024</ref> <ref>PMID:8723689</ref> <ref>PMID:10206679</ref> <ref>PMID:12843189</ref> <ref>PMID:15590636</ref>
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Dhe-Paganon, S.]]	+	[[Category: Dhe-Paganon, S]]
-	[[Category: Shoelson, S E.]]	+	[[Category: Shoelson, S E]]
	[[Category: Beta-sandwhich]]		[[Category: Beta-sandwhich]]
	[[Category: Signal transduction]]		[[Category: Signal transduction]]

OCA at 16:33, 29 September 2014

OCA — Mon, 29 Sep 2014 16:33:34 GMT

←Older revision		Revision as of 16:33, 29 September 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1qqg\| PDB=1qqg \| SCENE= }}~~	+	==CRYSTAL STRUCTURE OF THE PH-PTB TARGETING REGION OF IRS-1==
-	===CRYSTAL STRUCTURE OF THE PH-PTB TARGETING REGION OF IRS-1===	+	<StructureSection load='1qqg' size='340' side='right' caption='[[1qqg]], [[Resolution\|resolution]] 2.30Å' scene=''>
-	~~{{ABSTRACT_PUBMED_10411883}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1qqg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QQG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QQG FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qqg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qqg RCSB], [http://www.ebi.ac.uk/pdbsum/1qqg PDBsum]</span></td></tr>
		+	<table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/IRS1_HUMAN IRS1_HUMAN]] Polymorphisms in IRS1 may be involved in the etiology of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:[http://omim.org/entry/125853 125853]].<ref>PMID:14707024</ref> <ref>PMID:8723689</ref> <ref>PMID:10206679</ref> <ref>PMID:12843189</ref> <ref>PMID:15590636</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/IRS1_HUMAN IRS1_HUMAN]] May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).<ref>PMID:16878150</ref> <ref>PMID:14707024</ref>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qq/1qqg_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	We have determined the crystal structure at 2.3-A resolution of an amino-terminal segment of human insulin receptor substrate 1 that encompasses its pleckstrin homology (PH) and phosphotyrosine binding (PTB) domains. Both domains adopt the canonical seven-stranded beta-sandwich PH domain fold. The domains are closely associated, with a 720-A(2) contact surface buried between them that appears to be stabilized by ionic, hydrophobic, and hydrogen bonding interactions. The nonconserved 46-residue linker between the domains is disordered. The PTB domain peptide binding site is fully exposed on the molecular surface, as is a large cationic patch at the base of the PH domain that is a likely binding site for the head groups of phosphatidylinositol phosphates. Binding assays confirm that phosphatidylinositol phosphates bind the PH domain, but not the PTB domain. Ligand binding to the PH domain does not alter PTB domain interactions, and vice versa. The structural and accompanying functional data illustrate how the two binding domains might act cooperatively to effectively increase local insulin receptor substrate 1 concentration at the membrane and transiently fix the receptor and substrate, to allow multiple phosphorylation reactions to occur during each union.

-	~~==Disease==~~	+	Crystal structure of the pleckstrin homology-phosphotyrosine binding (PH-PTB) targeting region of insulin receptor substrate 1.,Dhe-Paganon S, Ottinger EA, Nolte RT, Eck MJ, Shoelson SE Proc Natl Acad Sci U S A. 1999 Jul 20;96(15):8378-83. PMID:10411883<ref>PMID:10411883</ref>
-	~~[[http://www.uniprot.org/uniprot/IRS1_HUMAN IRS1_HUMAN]] Polymorphisms in IRS1 may be involved in~~ the ~~etiology~~ of ~~non-~~insulin-~~dependent diabetes mellitus~~ (~~NIDDM~~) ~~[MIM~~:~~[http://omim~~.~~org/entry/125853 125853]].<ref>~~PMID:~~14707024</ref><ref>PMID:8723689</ref><ref>PMID:10206679</ref><ref>PMID:12843189</ref>~~<ref>PMID:~~15590636~~</ref>	+

-	~~==Function==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[http:~~/~~/www~~.~~uniprot~~.~~org/uniprot/IRS1_HUMAN IRS1_HUMAN]] May mediate the control~~ of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).<~~ref~~>~~PMID:16878150~~</~~ref~~>~~<ref>PMID:14707024</ref>~~	+	</div>
-		+	== References ==
-	==~~About this Structure==~~	+	<references/>
-	[[1qqg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QQG OCA].	+	__TOC__
-		+	</StructureSection>
-	~~==Reference~~==	+
-	~~<ref group="xtra">PMID:010411883</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Dhe-Paganon, S.]]		[[Category: Dhe-Paganon, S.]]

OCA at 19:56, 24 March 2013

OCA — Sun, 24 Mar 2013 19:56:35 GMT

←Older revision		Revision as of 19:56, 24 March 2013
Line 1:		Line 1:
-	[[Image:1qqg.png\|left\|200px]]
-
	{{STRUCTURE_1qqg\| PDB=1qqg \| SCENE= }}		{{STRUCTURE_1qqg\| PDB=1qqg \| SCENE= }}
-
	===CRYSTAL STRUCTURE OF THE PH-PTB TARGETING REGION OF IRS-1===		===CRYSTAL STRUCTURE OF THE PH-PTB TARGETING REGION OF IRS-1===
		+	{{ABSTRACT_PUBMED_10411883}}

-	~~{{ABSTRACT_PUBMED_10411883}}~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/IRS1_HUMAN IRS1_HUMAN]] Polymorphisms in IRS1 may be involved in the etiology of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:[http://omim.org/entry/125853 125853]].<ref>PMID:14707024</ref><ref>PMID:8723689</ref><ref>PMID:10206679</ref><ref>PMID:12843189</ref><ref>PMID:15590636</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/IRS1_HUMAN IRS1_HUMAN]] May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).<ref>PMID:16878150</ref><ref>PMID:14707024</ref>

	==About this Structure==		==About this Structure==
Line 11:		Line 13:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:010411883</ref><references group="xtra"/>	+	<ref group="xtra">PMID:010411883</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Dhe-Paganon, S.]]		[[Category: Dhe-Paganon, S.]]

OCA: Protected "1qqg" [edit=sysop:move=sysop]

OCA — Wed, 02 Jan 2013 09:48:49 GMT

Protected "1qqg" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:48, 2 January 2013