1qr9 - Revision history

OCA at 08:16, 14 February 2024

OCA — Wed, 14 Feb 2024 08:16:26 GMT

←Older revision		Revision as of 08:16, 14 February 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1qr9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QR9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QR9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1qr9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QR9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QR9 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qr9 OCA], [https://pdbe.org/1qr9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qr9 RCSB], [https://www.ebi.ac.uk/pdbsum/1qr9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qr9 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.6Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qr9 OCA], [https://pdbe.org/1qr9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qr9 RCSB], [https://www.ebi.ac.uk/pdbsum/1qr9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qr9 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q76270_9HIV1 Q76270_9HIV1]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 16:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qr9 ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qr9 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The gp41 envelope protein of human immunodeficiency virus type 1 (HIV-1) contains an alpha-helical core structure responsible for mediating membrane fusion during viral entry. Recent studies suggest that a conserved hydrophobic cavity in the coiled coil of this core plays a distinctive structural role in maintaining the fusogenic conformation of the gp41 molecule. Here we investigated the importance of this cavity in determining the structure and biological activity of the gp41 core by using the N34(L6)C28 model. The high-resolution crystal structures of N34(L6)C28 of two HIV-1 gp41 fusion-defective mutants reveal that each mutant sequence is accommodated in the six-helix bundle structure by forming the cavity with different sets of atoms. Remarkably, the mutant N34(L6)C28 cores are highly effective inhibitors of HIV-1 infection, with 5- to 16-fold greater activity than the wild-type molecule. The enhanced inhibitory activity by fusion-defective mutations correlates with local structural perturbations close to the cavity that destabilize the six-helix bundle. Taken together, these results indicate that the conserved hydrophobic coiled-coil cavity in the gp41 core is critical for HIV-1 entry and its inhibition and provides a potential antiviral drug target.
-
-	Inhibition of human immunodeficiency virus type 1 infectivity by the gp41 core: role of a conserved hydrophobic cavity in membrane fusion.,Ji H, Shu W, Burling FT, Jiang S, Lu M J Virol. 1999 Oct;73(10):8578-86. PMID:10482611<ref>PMID:10482611</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1qr9" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Gp41 3D Structures\|Gp41 3D Structures]]		*[[Gp41 3D Structures\|Gp41 3D Structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Human immunodeficiency virus 1]]		[[Category: Human immunodeficiency virus 1]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Burling~~, F T~~]]	+	[[Category: Burling FT]]
-	[[Category: Ji, H]]	+	[[Category: Ji H]]
-	[[Category: Jiang~~, S B~~]]	+	[[Category: Jiang SB]]
-	[[Category: Lu, M]]	+	[[Category: Lu M]]
-	[[Category: Shu, W]]	+	[[Category: Shu W]]
-	~~[[Category: Gp41]]~~	+
-	~~[[Category: Hiv-1 envelope protein]]~~	+
-	~~[[Category: Hiv-1 inhibition]]~~	+
-	~~[[Category: Membrane fusion]]~~	+
-	~~[[Category: Viral protein~~]]	+

OCA at 10:02, 15 September 2021

OCA — Wed, 15 Sep 2021 10:02:03 GMT

←Older revision		Revision as of 10:02, 15 September 2021
Line 3:		Line 3:
	<StructureSection load='1qr9' size='340' side='right'caption='[[1qr9]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='1qr9' size='340' side='right'caption='[[1qr9]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1qr9]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QR9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1QR9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1qr9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QR9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QR9 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1qr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qr9 OCA], [~~http~~://pdbe.org/1qr9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1qr9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1qr9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1qr9 ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qr9 OCA], [https://pdbe.org/1qr9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qr9 RCSB], [https://www.ebi.ac.uk/pdbsum/1qr9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qr9 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 11:46, 4 December 2019

OCA — Wed, 04 Dec 2019 11:46:34 GMT

←Older revision		Revision as of 11:46, 4 December 2019
Line 1:		Line 1:

	==INHIBITION OF HIV-1 INFECTIVITY BY THE GP41 CORE: ROLE OF A CONSERVED HYDROPHOBIC CAVITY IN MEMBRANE FUSION==		==INHIBITION OF HIV-1 INFECTIVITY BY THE GP41 CORE: ROLE OF A CONSERVED HYDROPHOBIC CAVITY IN MEMBRANE FUSION==
-	<StructureSection load='1qr9' size='340' side='right' caption='[[1qr9]], [[Resolution\|resolution]] 1.60Å' scene=''>	+	<StructureSection load='1qr9' size='340' side='right'caption='[[1qr9]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1qr9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QR9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QR9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1qr9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QR9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QR9 FirstGlance]. <br>
Line 27:		Line 27:

	==See Also==		==See Also==
-	*[[Gp41\|Gp41]]	+	*[[Gp41 3D Structures\|Gp41 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Human immunodeficiency virus 1]]		[[Category: Human immunodeficiency virus 1]]
		+	[[Category: Large Structures]]
	[[Category: Burling, F T]]		[[Category: Burling, F T]]
	[[Category: Ji, H]]		[[Category: Ji, H]]

OCA at 08:10, 28 February 2018

OCA — Wed, 28 Feb 2018 08:10:54 GMT

←Older revision		Revision as of 08:10, 28 February 2018
Line 1:		Line 1:
		+
	==INHIBITION OF HIV-1 INFECTIVITY BY THE GP41 CORE: ROLE OF A CONSERVED HYDROPHOBIC CAVITY IN MEMBRANE FUSION==		==INHIBITION OF HIV-1 INFECTIVITY BY THE GP41 CORE: ROLE OF A CONSERVED HYDROPHOBIC CAVITY IN MEMBRANE FUSION==
	<StructureSection load='1qr9' size='340' side='right' caption='[[1qr9]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='1qr9' size='340' side='right' caption='[[1qr9]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1qr9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~9hiv1 9hiv1~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QR9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QR9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1qr9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QR9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QR9 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qr9 OCA], [http://pdbe.org/1qr9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1qr9 RCSB], [http://www.ebi.ac.uk/pdbsum/1qr9 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qr9 OCA], [http://pdbe.org/1qr9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1qr9 RCSB], [http://www.ebi.ac.uk/pdbsum/1qr9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1qr9 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 9:		Line 10:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qr/1qr9_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qr/1qr9_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 31:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human immunodeficiency virus 1]]
	[[Category: Burling, F T]]		[[Category: Burling, F T]]
	[[Category: Ji, H]]		[[Category: Ji, H]]

OCA at 01:35, 8 February 2016

OCA — Mon, 08 Feb 2016 01:35:23 GMT

←Older revision		Revision as of 01:35, 8 February 2016
Line 13:		Line 13:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qr9 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:39, 10 September 2015

OCA — Thu, 10 Sep 2015 06:39:13 GMT

←Older revision		Revision as of 06:39, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1qr9' size='340' side='right' caption='[[1qr9]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='1qr9' size='340' side='right' caption='[[1qr9]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1qr9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Human_immunodeficiency_virus_1 Human immunodeficiency virus 1~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QR9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QR9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1qr9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QR9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QR9 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qr9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qr9 RCSB], [http://www.ebi.ac.uk/pdbsum/1qr9 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qr9 OCA], [http://pdbe.org/1qr9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1qr9 RCSB], [http://www.ebi.ac.uk/pdbsum/1qr9 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 23:		Line 23:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1qr9" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 30:		Line 31:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Human immunodeficiency virus 1]]
	[[Category: Burling, F T]]		[[Category: Burling, F T]]
	[[Category: Ji, H]]		[[Category: Ji, H]]

OCA at 08:25, 6 January 2015

OCA — Tue, 06 Jan 2015 08:25:40 GMT

←Older revision		Revision as of 08:25, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1qr9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QR9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QR9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1qr9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QR9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QR9 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qr9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qr9 RCSB], [http://www.ebi.ac.uk/pdbsum/1qr9 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qr9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qr9 RCSB], [http://www.ebi.ac.uk/pdbsum/1qr9 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Human immunodeficiency virus 1]]		[[Category: Human immunodeficiency virus 1]]
-	[[Category: Burling, F T.]]	+	[[Category: Burling, F T]]
-	[[Category: Ji, H.]]	+	[[Category: Ji, H]]
-	[[Category: Jiang, S B.]]	+	[[Category: Jiang, S B]]
-	[[Category: Lu, M.]]	+	[[Category: Lu, M]]
-	[[Category: Shu, W.]]	+	[[Category: Shu, W]]
	[[Category: Gp41]]		[[Category: Gp41]]
	[[Category: Hiv-1 envelope protein]]		[[Category: Hiv-1 envelope protein]]

OCA at 10:06, 3 October 2014

OCA — Fri, 03 Oct 2014 10:06:46 GMT

←Older revision		Revision as of 10:06, 3 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1qr9\| PDB=1qr9 \| SCENE= }}~~	+	==INHIBITION OF HIV-1 INFECTIVITY BY THE GP41 CORE: ROLE OF A CONSERVED HYDROPHOBIC CAVITY IN MEMBRANE FUSION==
-	===INHIBITION OF HIV-1 INFECTIVITY BY THE GP41 CORE: ROLE OF A CONSERVED HYDROPHOBIC CAVITY IN MEMBRANE FUSION===	+	<StructureSection load='1qr9' size='340' side='right' caption='[[1qr9]], [[Resolution\|resolution]] 1.60Å' scene=''>
-	~~{{ABSTRACT_PUBMED_10482611}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1qr9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QR9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QR9 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qr9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qr9 RCSB], [http://www.ebi.ac.uk/pdbsum/1qr9 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qr/1qr9_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The gp41 envelope protein of human immunodeficiency virus type 1 (HIV-1) contains an alpha-helical core structure responsible for mediating membrane fusion during viral entry. Recent studies suggest that a conserved hydrophobic cavity in the coiled coil of this core plays a distinctive structural role in maintaining the fusogenic conformation of the gp41 molecule. Here we investigated the importance of this cavity in determining the structure and biological activity of the gp41 core by using the N34(L6)C28 model. The high-resolution crystal structures of N34(L6)C28 of two HIV-1 gp41 fusion-defective mutants reveal that each mutant sequence is accommodated in the six-helix bundle structure by forming the cavity with different sets of atoms. Remarkably, the mutant N34(L6)C28 cores are highly effective inhibitors of HIV-1 infection, with 5- to 16-fold greater activity than the wild-type molecule. The enhanced inhibitory activity by fusion-defective mutations correlates with local structural perturbations close to the cavity that destabilize the six-helix bundle. Taken together, these results indicate that the conserved hydrophobic coiled-coil cavity in the gp41 core is critical for HIV-1 entry and its inhibition and provides a potential antiviral drug target.

-	~~==About this Structure==~~	+	Inhibition of human immunodeficiency virus type 1 infectivity by the gp41 core: role of a conserved hydrophobic cavity in membrane fusion.,Ji H, Shu W, Burling FT, Jiang S, Lu M J Virol. 1999 Oct;73(10):8578-86. PMID:10482611<ref>PMID:10482611</ref>
-	~~[[1qr9]] is a~~ 1 ~~chain structure with sequence from [http~~:~~//en~~.~~wikipedia~~.~~org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=1QR9 OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Gp41\|Gp41]]		*[[Gp41\|Gp41]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:010482611</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Human immunodeficiency virus 1]]		[[Category: Human immunodeficiency virus 1]]
	[[Category: Burling, F T.]]		[[Category: Burling, F T.]]

OCA at 10:55, 16 April 2014

OCA — Wed, 16 Apr 2014 10:55:47 GMT

←Older revision		Revision as of 10:55, 16 April 2014
Line 1:		Line 1:
-	[[Image:1qr9.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_1qr9", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1qr9\| PDB=1qr9 \| SCENE= }}		{{STRUCTURE_1qr9\| PDB=1qr9 \| SCENE= }}
-
	===INHIBITION OF HIV-1 INFECTIVITY BY THE GP41 CORE: ROLE OF A CONSERVED HYDROPHOBIC CAVITY IN MEMBRANE FUSION===		===INHIBITION OF HIV-1 INFECTIVITY BY THE GP41 CORE: ROLE OF A CONSERVED HYDROPHOBIC CAVITY IN MEMBRANE FUSION===
-
-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_10482611}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 10482611 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_10482611}}		{{ABSTRACT_PUBMED_10482611}}

	==About this Structure==		==About this Structure==
	[[1qr9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QR9 OCA].		[[1qr9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QR9 OCA].
		+
		+	==See Also==
		+	*[[Gp41\|Gp41]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:010482611</ref><references group="xtra"/>	+	<ref group="xtra">PMID:010482611</ref><references group="xtra"/><references/>
	[[Category: Human immunodeficiency virus 1]]		[[Category: Human immunodeficiency virus 1]]
	[[Category: Burling, F T.]]		[[Category: Burling, F T.]]

OCA: Protected "1qr9" [edit=sysop:move=sysop]

OCA — Wed, 16 Nov 2011 11:18:56 GMT

Protected "1qr9" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:18, 16 November 2011