1qvl - Revision history

OCA at 09:19, 6 December 2023

OCA — Wed, 06 Dec 2023 09:19:42 GMT

←Older revision		Revision as of 09:19, 6 December 2023
Line 1:		Line 1:

	==Structure of the antimicrobial hexapeptide cyc-(RRWWRF) bound to SDS micelles==		==Structure of the antimicrobial hexapeptide cyc-(RRWWRF) bound to SDS micelles==
-	<StructureSection load='1qvl' size='340' side='right'caption='[[1qvl~~]], [[NMR_Ensembles_of_Models \| 10 NMR models~~]]' scene=''>	+	<StructureSection load='1qvl' size='340' side='right'caption='[[1qvl]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1qvl]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QVL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QVL FirstGlance]. <br>		<table><tr><td colspan='2'>[[1qvl]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QVL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QVL FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qvl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qvl OCA], [https://pdbe.org/1qvl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qvl RCSB], [https://www.ebi.ac.uk/pdbsum/1qvl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qvl ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PRD_000105:CYCLIC+HEXAPEPTIDE+CYC-(RRWWRF)'>PRD_000105</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qvl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qvl OCA], [https://pdbe.org/1qvl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qvl RCSB], [https://www.ebi.ac.uk/pdbsum/1qvl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qvl ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Appelt, C]]	+	[[Category: Appelt C]]
-	[[Category: Bienert, M]]	+	[[Category: Bienert M]]
-	[[Category: Dathe, M]]	+	[[Category: Dathe M]]
-	[[Category: Schmieder, P]]	+	[[Category: Schmieder P]]
-	[[Category: Soderhall~~, J A]]~~	+	[[Category: Soderhall JA]]
-	~~[[Category: Antimicrobial protein~~]]	+

OCA at 10:05, 15 September 2021

OCA — Wed, 15 Sep 2021 10:05:21 GMT

←Older revision		Revision as of 10:05, 15 September 2021
Line 3:		Line 3:
	<StructureSection load='1qvl' size='340' side='right'caption='[[1qvl]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='1qvl' size='340' side='right'caption='[[1qvl]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1qvl]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QVL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1QVL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1qvl]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QVL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QVL FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1qvl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qvl OCA], [~~http~~://pdbe.org/1qvl PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1qvl RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1qvl PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1qvl ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qvl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qvl OCA], [https://pdbe.org/1qvl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qvl RCSB], [https://www.ebi.ac.uk/pdbsum/1qvl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qvl ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 11:26, 4 December 2019

OCA — Wed, 04 Dec 2019 11:26:54 GMT

←Older revision		Revision as of 11:26, 4 December 2019
Line 1:		Line 1:

	==Structure of the antimicrobial hexapeptide cyc-(RRWWRF) bound to SDS micelles==		==Structure of the antimicrobial hexapeptide cyc-(RRWWRF) bound to SDS micelles==
-	<StructureSection load='1qvl' size='340' side='right' caption='[[1qvl]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>	+	<StructureSection load='1qvl' size='340' side='right'caption='[[1qvl]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1qvl]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QVL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QVL FirstGlance]. <br>		<table><tr><td colspan='2'>[[1qvl]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QVL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QVL FirstGlance]. <br>
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Appelt, C]]		[[Category: Appelt, C]]
	[[Category: Bienert, M]]		[[Category: Bienert, M]]

OCA at 07:51, 28 February 2018

OCA — Wed, 28 Feb 2018 07:51:47 GMT

←Older revision		Revision as of 07:51, 28 February 2018
Line 1:		Line 1:
		+
	==Structure of the antimicrobial hexapeptide cyc-(RRWWRF) bound to SDS micelles==		==Structure of the antimicrobial hexapeptide cyc-(RRWWRF) bound to SDS micelles==
	<StructureSection load='1qvl' size='340' side='right' caption='[[1qvl]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='1qvl' size='340' side='right' caption='[[1qvl]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1qvl]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QVL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QVL FirstGlance]. <br>		<table><tr><td colspan='2'>[[1qvl]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QVL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QVL FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qvl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qvl OCA], [http://pdbe.org/1qvl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1qvl RCSB], [http://www.ebi.ac.uk/pdbsum/1qvl PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qvl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qvl OCA], [http://pdbe.org/1qvl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1qvl RCSB], [http://www.ebi.ac.uk/pdbsum/1qvl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1qvl ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:45, 11 September 2015

OCA — Fri, 11 Sep 2015 07:45:29 GMT

←Older revision		Revision as of 07:45, 11 September 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1qvl]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QVL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QVL FirstGlance]. <br>		<table><tr><td colspan='2'>[[1qvl]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QVL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QVL FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qvl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qvl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qvl RCSB], [http://www.ebi.ac.uk/pdbsum/1qvl PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qvl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qvl OCA], [http://pdbe.org/1qvl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1qvl RCSB], [http://www.ebi.ac.uk/pdbsum/1qvl PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 13:		Line 13:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1qvl" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 05:23, 22 December 2014

OCA — Mon, 22 Dec 2014 05:23:57 GMT

←Older revision		Revision as of 05:23, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1qvl]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QVL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QVL FirstGlance]. <br>		<table><tr><td colspan='2'>[[1qvl]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QVL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QVL FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qvl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qvl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qvl RCSB], [http://www.ebi.ac.uk/pdbsum/1qvl PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qvl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qvl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qvl RCSB], [http://www.ebi.ac.uk/pdbsum/1qvl PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 17:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Appelt, C.]]	+	[[Category: Appelt, C]]
-	[[Category: Bienert, M.]]	+	[[Category: Bienert, M]]
-	[[Category: Dathe, M.]]	+	[[Category: Dathe, M]]
-	[[Category: Schmieder, P.]]	+	[[Category: Schmieder, P]]
-	[[Category: Soderhall, J A.]]	+	[[Category: Soderhall, J A]]
	[[Category: Antimicrobial protein]]		[[Category: Antimicrobial protein]]

OCA at 06:58, 9 June 2014

OCA — Mon, 09 Jun 2014 06:58:22 GMT

←Older revision		Revision as of 06:58, 9 June 2014
Line 1:		Line 1:
-	[[~~Image~~:1qvl.~~png\|left\|200px~~]]	+	==Structure of the antimicrobial hexapeptide cyc-(RRWWRF) bound to SDS micelles==
		+	<StructureSection load='1qvl' size='340' side='right' caption='[[1qvl]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1qvl]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QVL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QVL FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qvl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qvl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qvl RCSB], [http://www.ebi.ac.uk/pdbsum/1qvl PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Antimicrobial, cationic peptides are abundant throughout nature as part of many organisms' defence against microorganisms. They exhibit a large variety of sequences and structural motifs and are thought to act by rupturing the bacterial membrane. Several models based on biophysical experiments have been proposed for their mechanism of action. Here we present the NMR-determined structure of the cyclic, cationic antimicrobial peptide cyclo(RRWWRF) both free in aqueous solution and bound to detergent micelles. The peptide has a rather flexible but ordered structure in water. A distinct structure is formed when the peptide is bound to a detergent micelle. The structures in neutral and negatively charged micelles are nearly identical but differ from that in aqueous solution. The orientation of the amino acid side chains creates an amphipathic molecule with the peptide backbone forming the hydrophilic part. The orientation of the peptide in the micelle was determined by using NOEs and paramagnetic agents. The peptide is oriented mainly parallel to the micelle surface in both detergents. Substitution of the arginine and tryptophan residues is known to influence the antimicrobial activity. Therefore the structure of the micelle-bound analogues cyclo(RRYYRF), cyclo(KKWWKF) and cyclo(RRNalNalRF) were also determined. They exhibit remarkable similarities in backbone conformation and side-chain orientation. The structure of these peptides allows the side-chain properties to be correlated to biological activity.

-	~~{{STRUCTURE_1qvl\| PDB=1qvl \| SCENE= }}~~	+	Structure of the antimicrobial, cationic hexapeptide cyclo(RRWWRF) and its analogues in solution and bound to detergent micelles.,Appelt C, Wessolowski A, Soderhall JA, Dathe M, Schmieder P Chembiochem. 2005 Sep;6(9):1654-62. PMID:16075425<ref>PMID:16075425</ref>

-	~~===Structure~~ of the ~~antimicrobial hexapeptide cyc-(RRWWRF) bound to SDS micelles===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16075425}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1qvl]] is a 1 chain structure~~. ~~Full experimental information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=1QVL OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:016075425<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Appelt, C.]]		[[Category: Appelt, C.]]
	[[Category: Bienert, M.]]		[[Category: Bienert, M.]]

OCA: Protected "1qvl" [edit=sysop:move=sysop]

OCA — Tue, 14 Aug 2012 15:35:31 GMT

Protected "1qvl" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:35, 14 August 2012

OCA at 15:35, 14 August 2012

OCA — Tue, 14 Aug 2012 15:35:29 GMT

←Older revision		Revision as of 15:35, 14 August 2012
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:1qvl.png\|left\|200px]]
-	[[Image:1qvl.~~gif~~\|left\|200px]]	+

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1qvl", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1qvl\| PDB=1qvl \| SCENE= }}		{{STRUCTURE_1qvl\| PDB=1qvl \| SCENE= }}

	===Structure of the antimicrobial hexapeptide cyc-(RRWWRF) bound to SDS micelles===		===Structure of the antimicrobial hexapeptide cyc-(RRWWRF) bound to SDS micelles===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16075425}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16075425 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_16075425}}		{{ABSTRACT_PUBMED_16075425}}

	==About this Structure==		==About this Structure==
-	Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QVL OCA].	+	[[1qvl]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QVL OCA].

	==Reference==		==Reference==
-	Structure of the antimicrobial, cationic hexapeptide cyclo(RRWWRF) and its analogues in solution and bound to detergent micelles., Appelt C, Wessolowski A, Soderhall JA, Dathe M, Schmieder P, Chembiochem. 2005 Sep;6(9):1654-62. PMID:~~[http://www.ncbi.nlm.nih.gov~~/~~pubmed~~/~~16075425 16075425]~~	+	<ref group="xtra">PMID:016075425</ref><references group="xtra"/>
	[[Category: Appelt, C.]]		[[Category: Appelt, C.]]
	[[Category: Bienert, M.]]		[[Category: Bienert, M.]]
Line 30:		Line 18:
	[[Category: Soderhall, J A.]]		[[Category: Soderhall, J A.]]
	[[Category: Antimicrobial protein]]		[[Category: Antimicrobial protein]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:18:09 2008''

OCA at 21:18, 28 July 2008

OCA — Mon, 28 Jul 2008 21:18:10 GMT

←Older revision		Revision as of 21:18, 28 July 2008
Line 1:		Line 1:
		+	{{Seed}}
	[[Image:1qvl.gif\|left\|200px]]		[[Image:1qvl.gif\|left\|200px]]

Line 9:		Line 10:
	{{STRUCTURE_1qvl\| PDB=1qvl \| SCENE= }}		{{STRUCTURE_1qvl\| PDB=1qvl \| SCENE= }}

-	~~'''~~Structure of the antimicrobial hexapeptide cyc-(RRWWRF) bound to SDS micelles~~'''~~	+	===Structure of the antimicrobial hexapeptide cyc-(RRWWRF) bound to SDS micelles===


-	~~==Overview==~~	+	<!--
-	~~Antimicrobial~~, cationic peptides are abundant throughout nature as part of many organisms' defence against microorganisms. They exhibit a large variety of sequences and structural motifs and are thought to act by rupturing the bacterial membrane. Several models based on biophysical experiments have been proposed for their mechanism of action. Here we present the NMR-determined structure of the cyclic, cationic antimicrobial peptide cyclo(RRWWRF) both free in aqueous solution and bound to detergent micelles. The peptide has a rather flexible but ordered structure in water. A distinct structure is formed when the ~~peptide is bound~~ to ~~a detergent micelle. The structures in neutral and negatively charged micelles are nearly identical but differ from that in aqueous solution. The orientation of~~ the ~~amino acid side chains creates an amphipathic molecule with the peptide backbone forming the hydrophilic part~~. ~~The orientation of the peptide in the micelle was determined by using NOEs and paramagnetic agents~~. ~~The peptide~~ is ~~oriented mainly parallel to~~ the ~~micelle surface in both detergents~~. ~~Substitution of the arginine and tryptophan residues is known to influence the antimicrobial activity. Therefore the structure of the micelle~~-~~bound analogues cyclo(RRYYRF), cyclo(KKWWKF) and cyclo(RRNalNalRF) were also determined. They exhibit remarkable similarities in backbone conformation and side~~-~~chain orientation. The structure of these peptides allows the side-chain properties to be correlated to biological activity.~~	+	The line below this paragraph, {{ABSTRACT_PUBMED_16075425}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 16075425 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_16075425}}

	==About this Structure==		==About this Structure==
-	Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QVL OCA].	+	Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QVL OCA].

	==Reference==		==Reference==
Line 26:		Line 30:
	[[Category: Soderhall, J A.]]		[[Category: Soderhall, J A.]]
	[[Category: Antimicrobial protein]]		[[Category: Antimicrobial protein]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 06~~:45:05 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:18:09 2008''