1qz3 - Revision history

OCA at 05:58, 23 August 2023

OCA — Wed, 23 Aug 2023 05:58:17 GMT

←Older revision		Revision as of 05:58, 23 August 2023
Line 3:		Line 3:
	<StructureSection load='1qz3' size='340' side='right'caption='[[1qz3]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='1qz3' size='340' side='right'caption='[[1qz3]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1qz3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_27009 Atcc 27009~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QZ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QZ3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1qz3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Alicyclobacillus_acidocaldarius Alicyclobacillus acidocaldarius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QZ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QZ3 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=HDS:1~~-~~HEXADECANOSULFONIC+ACID'>HDS</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[1evq\|1evq]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HDS:1-HEXADECANOSULFONIC+ACID'>HDS</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qz3 OCA], [https://pdbe.org/1qz3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qz3 RCSB], [https://www.ebi.ac.uk/pdbsum/1qz3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qz3 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qz3 OCA], [https://pdbe.org/1qz3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qz3 RCSB], [https://www.ebi.ac.uk/pdbsum/1qz3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qz3 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q7SIG1_ALIAC Q7SIG1_ALIAC]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Atcc 27009~~]]	+	[[Category: Alicyclobacillus acidocaldarius]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Febbraio, F]]	+	[[Category: De Simone G]]
-	[[Category: Giordano, V]]	+	[[Category: Febbraio F]]
-	[[Category: Manco, G]]	+	[[Category: Giordano V]]
-	[[Category: Mandrich, L]]	+	[[Category: Manco G]]
-	[[Category: Menchise, V]]	+	[[Category: Mandrich L]]
-	[[Category: Pedone, C]]	+	[[Category: Menchise V]]
-	[[Category: Rossi, M]]	+	[[Category: Pedone C]]
-	~~[[Category: Simone, G De]]~~	+	[[Category: Rossi M]]
-	~~[[Category: Alpha/beta hydrolase fold]]~~	+
-	~~[[Category: Hydrolase~~]]	+

OCA at 09:00, 21 April 2021

OCA — Wed, 21 Apr 2021 09:00:25 GMT

←Older revision		Revision as of 09:00, 21 April 2021
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	<StructureSection load='1qz3' size='340' side='right'caption='[[1qz3]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='1qz3' size='340' side='right'caption='[[1qz3]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1qz3]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_27009 Atcc 27009]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QZ3 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1QZ3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1qz3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_27009 Atcc 27009]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QZ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QZ3 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HDS:1-HEXADECANOSULFONIC+ACID'>HDS</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HDS:1-HEXADECANOSULFONIC+ACID'>HDS</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1evq\|1evq]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1evq\|1evq]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1qz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qz3 OCA], [~~http~~://pdbe.org/1qz3 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1qz3 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1qz3 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1qz3 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qz3 OCA], [https://pdbe.org/1qz3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qz3 RCSB], [https://www.ebi.ac.uk/pdbsum/1qz3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qz3 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 30:		Line 30:
	==See Also==		==See Also==
	*[[Carboxylesterase 3D structures\|Carboxylesterase 3D structures]]		*[[Carboxylesterase 3D structures\|Carboxylesterase 3D structures]]
-	*[[Lipase\|Lipase]]	+	*[[Lipase 3D Structures\|Lipase 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:23, 17 July 2019

OCA — Wed, 17 Jul 2019 13:23:12 GMT

←Older revision		Revision as of 13:23, 17 July 2019
Line 1:		Line 1:

	==CRYSTAL STRUCTURE OF MUTANT M211S/R215L OF CARBOXYLESTERASE EST2 COMPLEXED WITH HEXADECANESULFONATE==		==CRYSTAL STRUCTURE OF MUTANT M211S/R215L OF CARBOXYLESTERASE EST2 COMPLEXED WITH HEXADECANESULFONATE==
-	<StructureSection load='1qz3' size='340' side='right' caption='[[1qz3]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='1qz3' size='340' side='right'caption='[[1qz3]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1qz3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_27009 Atcc 27009]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QZ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QZ3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1qz3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_27009 Atcc 27009]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QZ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QZ3 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HDS:1-HEXADECANOSULFONIC+ACID'>HDS</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HDS:1-HEXADECANOSULFONIC+ACID'>HDS</scene></td></tr>
-	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=X:2-DEOXY-N7-(8,9-DIHYDRO-9-HYDROXY-10-DEHYDROXY-AFLATOXIN)GUANOSINE+MONOPHOSPHATE'>X</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1evq\|1evq]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1evq\|1evq]]</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carboxylesterase Carboxylesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.1 3.1.1.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qz3 OCA], [http://pdbe.org/1qz3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1qz3 RCSB], [http://www.ebi.ac.uk/pdbsum/1qz3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1qz3 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qz3 OCA], [http://pdbe.org/1qz3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1qz3 RCSB], [http://www.ebi.ac.uk/pdbsum/1qz3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1qz3 ProSAT]</span></td></tr>
	</table>		</table>
Line 14:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qz/1qz3_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qz/1qz3_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 31:		Line 29:

	==See Also==		==See Also==
-	*[[Carboxylesterase\|Carboxylesterase]]	+	*[[Carboxylesterase 3D structures\|Carboxylesterase 3D structures]]
		+	*[[Lipase\|Lipase]]
	== References ==		== References ==
	<references/>		<references/>
Line 37:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 27009]]		[[Category: Atcc 27009]]
-	[[Category: ~~Carboxylesterase~~]]	+	[[Category: Large Structures]]
	[[Category: Febbraio, F]]		[[Category: Febbraio, F]]
	[[Category: Giordano, V]]		[[Category: Giordano, V]]

OCA at 15:53, 12 October 2017

OCA — Thu, 12 Oct 2017 15:53:29 GMT

←Older revision		Revision as of 15:53, 12 October 2017
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF MUTANT M211S/R215L OF CARBOXYLESTERASE EST2 COMPLEXED WITH HEXADECANESULFONATE==		==CRYSTAL STRUCTURE OF MUTANT M211S/R215L OF CARBOXYLESTERASE EST2 COMPLEXED WITH HEXADECANESULFONATE==
	<StructureSection load='1qz3' size='340' side='right' caption='[[1qz3]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='1qz3' size='340' side='right' caption='[[1qz3]], [[Resolution\|resolution]] 2.30Å' scene=''>
Line 7:		Line 8:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1evq\|1evq]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1evq\|1evq]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carboxylesterase Carboxylesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.1 3.1.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carboxylesterase Carboxylesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.1 3.1.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qz3 OCA], [http://pdbe.org/1qz3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1qz3 RCSB], [http://www.ebi.ac.uk/pdbsum/1qz3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qz3 OCA], [http://pdbe.org/1qz3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1qz3 RCSB], [http://www.ebi.ac.uk/pdbsum/1qz3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1qz3 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 31:		Line 32:
	==See Also==		==See Also==
	*[[Carboxylesterase\|Carboxylesterase]]		*[[Carboxylesterase\|Carboxylesterase]]
-	*[[Lipase\|Lipase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 04:42, 9 February 2016

OCA — Tue, 09 Feb 2016 04:42:07 GMT

←Older revision		Revision as of 04:42, 9 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qz3 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 18:43, 10 September 2015

OCA — Thu, 10 Sep 2015 18:43:43 GMT

←Older revision		Revision as of 18:43, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1qz3' size='340' side='right' caption='[[1qz3]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='1qz3' size='340' side='right' caption='[[1qz3]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1qz3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Alicyclobacillus_acidocaldarius Alicyclobacillus acidocaldarius~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QZ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QZ3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1qz3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_27009 Atcc 27009]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QZ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QZ3 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HDS:1-HEXADECANOSULFONIC+ACID'>HDS</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HDS:1-HEXADECANOSULFONIC+ACID'>HDS</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=X:2-DEOXY-N7-(8,9-DIHYDRO-9-HYDROXY-10-DEHYDROXY-AFLATOXIN)GUANOSINE+MONOPHOSPHATE'>X</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=X:2-DEOXY-N7-(8,9-DIHYDRO-9-HYDROXY-10-DEHYDROXY-AFLATOXIN)GUANOSINE+MONOPHOSPHATE'>X</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1evq\|1evq]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1evq\|1evq]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carboxylesterase Carboxylesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.1 3.1.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carboxylesterase Carboxylesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.1 3.1.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qz3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qz3 RCSB], [http://www.ebi.ac.uk/pdbsum/1qz3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qz3 OCA], [http://pdbe.org/1qz3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1qz3 RCSB], [http://www.ebi.ac.uk/pdbsum/1qz3 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1qz3" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Alicyclobacillus acidocaldarius~~]]	+	[[Category: Atcc 27009]]
	[[Category: Carboxylesterase]]		[[Category: Carboxylesterase]]
	[[Category: Febbraio, F]]		[[Category: Febbraio, F]]

OCA at 08:09, 6 January 2015

OCA — Tue, 06 Jan 2015 08:09:04 GMT

←Older revision		Revision as of 08:09, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1qz3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Alicyclobacillus_acidocaldarius Alicyclobacillus acidocaldarius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QZ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QZ3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1qz3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Alicyclobacillus_acidocaldarius Alicyclobacillus acidocaldarius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QZ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QZ3 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HDS:1-HEXADECANOSULFONIC+ACID'>HDS</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HDS:1-HEXADECANOSULFONIC+ACID'>HDS</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=X:2-DEOXY-N7-(8,9-DIHYDRO-9-HYDROXY-10-DEHYDROXY-AFLATOXIN)GUANOSINE+MONOPHOSPHATE'>X</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=X:2-DEOXY-N7-(8,9-DIHYDRO-9-HYDROXY-10-DEHYDROXY-AFLATOXIN)GUANOSINE+MONOPHOSPHATE'>X</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1evq\|1evq]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1evq\|1evq]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carboxylesterase Carboxylesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.1 3.1.1.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carboxylesterase Carboxylesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.1 3.1.1.1] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qz3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qz3 RCSB], [http://www.ebi.ac.uk/pdbsum/1qz3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qz3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qz3 RCSB], [http://www.ebi.ac.uk/pdbsum/1qz3 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 37:		Line 37:
	[[Category: Alicyclobacillus acidocaldarius]]		[[Category: Alicyclobacillus acidocaldarius]]
	[[Category: Carboxylesterase]]		[[Category: Carboxylesterase]]
-	[[Category: Febbraio, F.]]	+	[[Category: Febbraio, F]]
-	[[Category: Giordano, V.]]	+	[[Category: Giordano, V]]
-	[[Category: Manco, G.]]	+	[[Category: Manco, G]]
-	[[Category: Mandrich, L.]]	+	[[Category: Mandrich, L]]
-	[[Category: Menchise, V.]]	+	[[Category: Menchise, V]]
-	[[Category: Pedone, C.]]	+	[[Category: Pedone, C]]
-	[[Category: Rossi, M.]]	+	[[Category: Rossi, M]]
-	[[Category: Simone, G De.]]	+	[[Category: Simone, G De]]
	[[Category: Alpha/beta hydrolase fold]]		[[Category: Alpha/beta hydrolase fold]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 15:36, 29 September 2014

OCA — Mon, 29 Sep 2014 15:36:13 GMT

←Older revision		Revision as of 15:36, 29 September 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1qz3\| PDB=1qz3 \| SCENE= }}~~	+	==CRYSTAL STRUCTURE OF MUTANT M211S/R215L OF CARBOXYLESTERASE EST2 COMPLEXED WITH HEXADECANESULFONATE==
-	===CRYSTAL STRUCTURE OF MUTANT M211S/R215L OF CARBOXYLESTERASE EST2 COMPLEXED WITH HEXADECANESULFONATE===	+	<StructureSection load='1qz3' size='340' side='right' caption='[[1qz3]], [[Resolution\|resolution]] 2.30Å' scene=''>
-	~~{{ABSTRACT_PUBMED_14617621}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1qz3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Alicyclobacillus_acidocaldarius Alicyclobacillus acidocaldarius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QZ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QZ3 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HDS:1-HEXADECANOSULFONIC+ACID'>HDS</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=X:2-DEOXY-N7-(8,9-DIHYDRO-9-HYDROXY-10-DEHYDROXY-AFLATOXIN)GUANOSINE+MONOPHOSPHATE'>X</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1evq\|1evq]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carboxylesterase Carboxylesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.1 3.1.1.1] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qz3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qz3 RCSB], [http://www.ebi.ac.uk/pdbsum/1qz3 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qz/1qz3_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The reaction mechanism of the esterase 2 (EST2) from Alicyclobacillus acidocaldarius was studied at the kinetic and structural level to shed light on the mechanism of activity and substrate specificity increase previously observed in its double mutant M211S/R215L. In particular, the values of kinetic constants (k1, k(-1), k2, and k3) along with activation energies (E1, E(-1), E2, and E3) were measured for wild type and mutant enzyme. The previously suggested substrate-induced switch in the reaction mechanism from kcat=k3 with a short acyl chain substrate (p-nitrophenyl hexanoate) to kcat=k2 with a long acyl chain substrate (p-nitrophenyl dodecanoate) was validated. The inhibition afforded by an irreversible inhibitor (1-hexadecanesulfonyl chloride), structurally related to p-nitrophenyl dodecanoate, was studied by kinetic analysis. Moreover the three-dimensional structure of the double mutant bound to this inhibitor was determined, providing essential information on the enzyme mechanism. In fact, structural analysis explained the observed substrate-induced switch because of an inversion in the binding mode of the long acyl chain derivatives with respect to the acyl- and alcohol-binding sites.

-	~~==About this Structure==~~	+	A substrate-induced switch in the reaction mechanism of a thermophilic esterase: kinetic evidences and structural basis.,De Simone G, Mandrich L, Menchise V, Giordano V, Febbraio F, Rossi M, Pedone C, Manco G J Biol Chem. 2004 Feb 20;279(8):6815-23. Epub 2003 Nov 15. PMID:14617621<ref>PMID:14617621</ref>
-	~~[[1qz3]] is~~ a ~~1 chain structure with sequence from [http~~:~~//en~~.~~wikipedia~~.~~org/wiki/Alicyclobacillus_acidocaldarius Alicyclobacillus acidocaldarius]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=1QZ3 OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Carboxylesterase\|Carboxylesterase]]		*[[Carboxylesterase\|Carboxylesterase]]
	*[[Lipase\|Lipase]]		*[[Lipase\|Lipase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:014617621<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Alicyclobacillus acidocaldarius]]		[[Category: Alicyclobacillus acidocaldarius]]
	[[Category: Carboxylesterase]]		[[Category: Carboxylesterase]]

OCA at 11:02, 11 March 2013

OCA — Mon, 11 Mar 2013 11:02:28 GMT

←Older revision		Revision as of 11:02, 11 March 2013
Line 1:		Line 1:
-	[[Image:1qz3.png\|left\|200px]]
-
	{{STRUCTURE_1qz3\| PDB=1qz3 \| SCENE= }}		{{STRUCTURE_1qz3\| PDB=1qz3 \| SCENE= }}
-
	===CRYSTAL STRUCTURE OF MUTANT M211S/R215L OF CARBOXYLESTERASE EST2 COMPLEXED WITH HEXADECANESULFONATE===		===CRYSTAL STRUCTURE OF MUTANT M211S/R215L OF CARBOXYLESTERASE EST2 COMPLEXED WITH HEXADECANESULFONATE===
-
	{{ABSTRACT_PUBMED_14617621}}		{{ABSTRACT_PUBMED_14617621}}

OCA at 12:40, 20 October 2012

OCA — Sat, 20 Oct 2012 12:40:42 GMT

←Older revision		Revision as of 12:40, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1qz3]] is a 1 chain structure ~~of [[Lipase]]~~ with sequence from [http://en.wikipedia.org/wiki/Alicyclobacillus_acidocaldarius Alicyclobacillus acidocaldarius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QZ3 OCA].	+	[[1qz3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Alicyclobacillus_acidocaldarius Alicyclobacillus acidocaldarius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QZ3 OCA].

	==See Also==		==See Also==