1r02 - Revision history

OCA at 10:02, 21 June 2023

OCA — Wed, 21 Jun 2023 10:02:21 GMT

←Older revision		Revision as of 10:02, 21 June 2023
Line 1:		Line 1:

	==Solution structure of Human Orexin-A:Regulator of Appetite and Wakefulness==		==Solution structure of Human Orexin-A:Regulator of Appetite and Wakefulness==
-	<StructureSection load='1r02' size='340' side='right'caption='[[1r02~~]], [[NMR_Ensembles_of_Models \| 1 NMR models~~]]' scene=''>	+	<StructureSection load='1r02' size='340' side='right'caption='[[1r02]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1r02]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R02 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R02 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1r02]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R02 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R02 FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1cq0\|1cq0]]</div></td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r02 OCA], [https://pdbe.org/1r02 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r02 RCSB], [https://www.ebi.ac.uk/pdbsum/1r02 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r02 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r02 OCA], [https://pdbe.org/1r02 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r02 RCSB], [https://www.ebi.ac.uk/pdbsum/1r02 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r02 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/OREX_HUMAN OREX_HUMAN]] Defects in HCRT are the cause of narcolepsy type 1 (NRCLP1) [MIM:[https://omim.org/entry/161400 161400]]. Narcolepsy is a neurological disabling sleep disorder, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, such as cataplexy, hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions, which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is primarily a sporadically occurring disorder but familial clustering has been observed. Note=Human narcolepsy is associated with a deficient orexin system. Orexins are absent and/or greatly diminished in the brain and cerebrospinal fluid (CSF) of most narcoleptic patients.<ref>PMID:10973318</ref>	+	[https://www.uniprot.org/uniprot/OREX_HUMAN OREX_HUMAN] Defects in HCRT are the cause of narcolepsy type 1 (NRCLP1) [MIM:[https://omim.org/entry/161400 161400]. Narcolepsy is a neurological disabling sleep disorder, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, such as cataplexy, hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions, which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is primarily a sporadically occurring disorder but familial clustering has been observed. Note=Human narcolepsy is associated with a deficient orexin system. Orexins are absent and/or greatly diminished in the brain and cerebrospinal fluid (CSF) of most narcoleptic patients.<ref>PMID:10973318</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/OREX_HUMAN OREX_HUMAN]] Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity.	+	[https://www.uniprot.org/uniprot/OREX_HUMAN OREX_HUMAN] Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hong, E]]	+	[[Category: Hong E]]
-	[[Category: Kim, H Y]]	+	[[Category: Kim H-Y]]
-	[[Category: Kim, J I]]	+	[[Category: Kim J-I]]
-	[[Category: Lee, W]]	+	[[Category: Lee W]]
-	~~[[Category: Helix-loop-helix]]~~	+
-	~~[[Category: Neuropeptide]]~~	+
-	~~[[Category: Turn~~]]	+

OCA at 10:06, 15 September 2021

OCA — Wed, 15 Sep 2021 10:06:42 GMT

←Older revision		Revision as of 10:06, 15 September 2021
Line 3:		Line 3:
	<StructureSection load='1r02' size='340' side='right'caption='[[1r02]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='1r02' size='340' side='right'caption='[[1r02]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1r02]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R02 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1R02 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1r02]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R02 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R02 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cq0\|1cq0]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1cq0\|1cq0]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1r02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r02 OCA], [~~http~~://pdbe.org/1r02 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1r02 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1r02 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1r02 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r02 OCA], [https://pdbe.org/1r02 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r02 RCSB], [https://www.ebi.ac.uk/pdbsum/1r02 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r02 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/OREX_HUMAN OREX_HUMAN]] Defects in HCRT are the cause of narcolepsy type 1 (NRCLP1) [MIM:[~~http~~://omim.org/entry/161400 161400]]. Narcolepsy is a neurological disabling sleep disorder, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, such as cataplexy, hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions, which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is primarily a sporadically occurring disorder but familial clustering has been observed. Note=Human narcolepsy is associated with a deficient orexin system. Orexins are absent and/or greatly diminished in the brain and cerebrospinal fluid (CSF) of most narcoleptic patients.<ref>PMID:10973318</ref>	+	[[https://www.uniprot.org/uniprot/OREX_HUMAN OREX_HUMAN]] Defects in HCRT are the cause of narcolepsy type 1 (NRCLP1) [MIM:[https://omim.org/entry/161400 161400]]. Narcolepsy is a neurological disabling sleep disorder, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, such as cataplexy, hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions, which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is primarily a sporadically occurring disorder but familial clustering has been observed. Note=Human narcolepsy is associated with a deficient orexin system. Orexins are absent and/or greatly diminished in the brain and cerebrospinal fluid (CSF) of most narcoleptic patients.<ref>PMID:10973318</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/OREX_HUMAN OREX_HUMAN]] Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity.	+	[[https://www.uniprot.org/uniprot/OREX_HUMAN OREX_HUMAN]] Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 05:33, 10 October 2019

OCA — Thu, 10 Oct 2019 05:33:19 GMT

←Older revision		Revision as of 05:33, 10 October 2019
Line 1:		Line 1:

	==Solution structure of Human Orexin-A:Regulator of Appetite and Wakefulness==		==Solution structure of Human Orexin-A:Regulator of Appetite and Wakefulness==
-	<StructureSection load='1r02' size='340' side='right' caption='[[1r02]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>	+	<StructureSection load='1r02' size='340' side='right'caption='[[1r02]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1r02]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R02 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1R02 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1r02]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R02 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1R02 FirstGlance]. <br>
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 1r02" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1r02" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Orexin and Orexin receptor\|Orexin and Orexin receptor]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Hong, E]]		[[Category: Hong, E]]
	[[Category: Kim, H Y]]		[[Category: Kim, H Y]]

OCA at 07:43, 28 February 2018

OCA — Wed, 28 Feb 2018 07:43:56 GMT

←Older revision		Revision as of 07:43, 28 February 2018
Line 1:		Line 1:
		+
	==Solution structure of Human Orexin-A:Regulator of Appetite and Wakefulness==		==Solution structure of Human Orexin-A:Regulator of Appetite and Wakefulness==
	<StructureSection load='1r02' size='340' side='right' caption='[[1r02]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='1r02' size='340' side='right' caption='[[1r02]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1r02]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R02 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1R02 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1r02]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R02 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1R02 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cq0\|1cq0]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cq0\|1cq0]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r02 OCA], [http://pdbe.org/1r02 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1r02 RCSB], [http://www.ebi.ac.uk/pdbsum/1r02 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r02 OCA], [http://pdbe.org/1r02 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1r02 RCSB], [http://www.ebi.ac.uk/pdbsum/1r02 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1r02 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==

OCA at 15:34, 10 September 2015

OCA — Thu, 10 Sep 2015 15:34:49 GMT

←Older revision		Revision as of 15:34, 10 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[1r02]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R02 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1R02 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1r02]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R02 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1R02 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cq0\|1cq0]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cq0\|1cq0]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r02 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1r02 RCSB], [http://www.ebi.ac.uk/pdbsum/1r02 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r02 OCA], [http://pdbe.org/1r02 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1r02 RCSB], [http://www.ebi.ac.uk/pdbsum/1r02 PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 18:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1r02" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:51, 18 December 2014

OCA — Thu, 18 Dec 2014 11:51:59 GMT

←Older revision		Revision as of 11:51, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1r02\| PDB=1r02 \| SCENE= }}~~	+	==Solution structure of Human Orexin-A:Regulator of Appetite and Wakefulness==
-	===Solution structure of Human Orexin-A:Regulator of Appetite and Wakefulness===	+	<StructureSection load='1r02' size='340' side='right' caption='[[1r02]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
-	~~{{ABSTRACT_PUBMED_15479620}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[1r02]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R02 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1R02 FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cq0\|1cq0]]</td></tr>
-	[[http://www.uniprot.org/uniprot/OREX_HUMAN OREX_HUMAN]] Defects in HCRT are the cause of narcolepsy type 1 (NRCLP1) [MIM:[http://omim.org/entry/161400 161400]]. Narcolepsy is a neurological disabling sleep disorder, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, such as cataplexy, hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions, which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is primarily a sporadically occurring disorder but familial clustering has been observed. Note=Human narcolepsy is associated with a deficient orexin system. Orexins are absent and/or greatly diminished in the brain and cerebrospinal fluid (CSF) of most narcoleptic patients.<ref>PMID:10973318</ref>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r02 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1r02 RCSB], [http://www.ebi.ac.uk/pdbsum/1r02 PDBsum]</span></td></tr>
-		+	</table>
-	==Function==	+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/OREX_HUMAN OREX_HUMAN]] Defects in HCRT are the cause of narcolepsy type 1 (NRCLP1) [MIM:[http://omim.org/entry/161400 161400]]. Narcolepsy is a neurological disabling sleep disorder, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, such as cataplexy, hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions, which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is primarily a sporadically occurring disorder but familial clustering has been observed. Note=Human narcolepsy is associated with a deficient orexin system. Orexins are absent and/or greatly diminished in the brain and cerebrospinal fluid (CSF) of most narcoleptic patients.<ref>PMID:10973318</ref>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/OREX_HUMAN OREX_HUMAN]] Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity.		[[http://www.uniprot.org/uniprot/OREX_HUMAN OREX_HUMAN]] Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Orexin-A and orexin-B (hypocretin-1 and hypocretin-2, respectively) are important hypothalamic neuro-peptides, which are encoded by a single mRNA transcript and stimulate food intake as well as regulate wakefulness. Here we determined the solution structure of orexin-A by NMR spectroscopy and by simulated-annealing calculation. The structural features of orexin-A involve two alpha-helices, with the hydrophobic residues disposed to on one side of helix, and hydrophilic residues to the other. A hydrophilic turn induced by two disulfide bonds provides the key difference between orexin-A and -B. With previous mutagenic studies, the derived structure of orexin-A provides us with a structure-functional view for novel drug design.

-	~~==About this Structure==~~	+	Solution structure of human orexin-A: regulator of appetite and wakefulness.,Kim HY, Hong E, Kim JI, Lee W J Biochem Mol Biol. 2004 Sep 30;37(5):565-73. PMID:15479620<ref>PMID:15479620</ref>
-	~~[[1r02]] is a 1 chain~~ structure~~. Full experimental information is available from [http~~:~~//oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=1R02 OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	<references ~~group="xtra"~~/><~~references~~/>	+	</div>
-	[[Category: Hong, E.]]	+	== References ==
-	[[Category: Kim, H Y.]]	+	<references/>
-	[[Category: Kim, J I.]]	+	__TOC__
-	[[Category: Lee, W.]]	+	</StructureSection>
		+	[[Category: Hong, E]]
		+	[[Category: Kim, H Y]]
		+	[[Category: Kim, J I]]
		+	[[Category: Lee, W]]
	[[Category: Helix-loop-helix]]		[[Category: Helix-loop-helix]]
	[[Category: Neuropeptide]]		[[Category: Neuropeptide]]
	[[Category: Turn]]		[[Category: Turn]]

OCA at 21:49, 24 March 2013

OCA — Sun, 24 Mar 2013 21:49:08 GMT

←Older revision		Revision as of 21:49, 24 March 2013
Line 1:		Line 1:
-	[[Image:1r02.png\|left\|200px]]
-
	{{STRUCTURE_1r02\| PDB=1r02 \| SCENE= }}		{{STRUCTURE_1r02\| PDB=1r02 \| SCENE= }}
-
	===Solution structure of Human Orexin-A:Regulator of Appetite and Wakefulness===		===Solution structure of Human Orexin-A:Regulator of Appetite and Wakefulness===
-
	{{ABSTRACT_PUBMED_15479620}}		{{ABSTRACT_PUBMED_15479620}}
		+
		+	==Disease==
		+	[[http://www.uniprot.org/uniprot/OREX_HUMAN OREX_HUMAN]] Defects in HCRT are the cause of narcolepsy type 1 (NRCLP1) [MIM:[http://omim.org/entry/161400 161400]]. Narcolepsy is a neurological disabling sleep disorder, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, such as cataplexy, hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions, which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is primarily a sporadically occurring disorder but familial clustering has been observed. Note=Human narcolepsy is associated with a deficient orexin system. Orexins are absent and/or greatly diminished in the brain and cerebrospinal fluid (CSF) of most narcoleptic patients.<ref>PMID:10973318</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/OREX_HUMAN OREX_HUMAN]] Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity.

	==About this Structure==		==About this Structure==
	[[1r02]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R02 OCA].		[[1r02]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R02 OCA].
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
	[[Category: Hong, E.]]		[[Category: Hong, E.]]
	[[Category: Kim, H Y.]]		[[Category: Kim, H Y.]]

OCA: Protected "1r02" [edit=sysop:move=sysop]

OCA — Fri, 04 Jan 2013 10:12:15 GMT

Protected "1r02" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:12, 4 January 2013

OCA at 10:12, 4 January 2013

OCA — Fri, 04 Jan 2013 10:12:13 GMT

←Older revision		Revision as of 10:12, 4 January 2013
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	[[Image:1r02.png\|left\|200px]]		[[Image:1r02.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_1r02\| PDB=1r02 \| SCENE= }}		{{STRUCTURE_1r02\| PDB=1r02 \| SCENE= }}

	===Solution structure of Human Orexin-A:Regulator of Appetite and Wakefulness===		===Solution structure of Human Orexin-A:Regulator of Appetite and Wakefulness===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15479620}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15479620 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_15479620}}		{{ABSTRACT_PUBMED_15479620}}

	==About this Structure==		==About this Structure==
-	~~1R02 is a~~ [[~~Single protein~~]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R02 OCA].	+	[[1r02]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R02 OCA].
-		+
-	~~==Reference==~~	+
-	Solution structure of human orexin-A: regulator of appetite and wakefulness., Kim HY, Hong E, Kim JI, Lee W, J Biochem Mol Biol. 2004 Sep 30;37(5):565-73. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15479620 15479620]	+
-	~~[[Category: Single protein]]~~	+
	[[Category: Hong, E.]]		[[Category: Hong, E.]]
	[[Category: Kim, H Y.]]		[[Category: Kim, H Y.]]
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	[[Category: Lee, W.]]		[[Category: Lee, W.]]
	[[Category: Helix-loop-helix]]		[[Category: Helix-loop-helix]]
		+	[[Category: Neuropeptide]]
	[[Category: Turn]]		[[Category: Turn]]
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-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:00:58 2008''

OCA at 04:01, 28 July 2008

OCA — Mon, 28 Jul 2008 04:01:02 GMT

←Older revision		Revision as of 04:01, 28 July 2008
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		+	[[Image:1r02.png\|left\|200px]]

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	{{STRUCTURE_1r02\| PDB=1r02 \| SCENE= }}		{{STRUCTURE_1r02\| PDB=1r02 \| SCENE= }}

-	~~'''~~Solution structure of Human Orexin-A:Regulator of Appetite and Wakefulness~~'''~~	+	===Solution structure of Human Orexin-A:Regulator of Appetite and Wakefulness===


-	~~==Overview==~~	+	<!--
-	~~Orexin~~-~~A and orexin~~-~~B (hypocretin-1 and hypocretin-2~~, ~~respectively) are important hypothalamic neuro-peptides~~, ~~which are encoded by a single mRNA transcript and stimulate food intake as well as regulate wakefulness. Here we determined~~ the ~~solution structure of orexin-A by NMR spectroscopy and by simulated-annealing calculation. The structural features of orexin-A involve two alpha-helices, with~~ the ~~hydrophobic residues disposed to~~ on ~~one side of helix, and hydrophilic residues to the other~~. ~~A hydrophilic turn induced by two disulfide bonds provides the key difference between orexin-A and -B~~. ~~With previous mutagenic studies~~, the ~~derived structure of orexin~~-~~A provides us with a structure~~-~~functional view for novel drug design.~~	+	The line below this paragraph, {{ABSTRACT_PUBMED_15479620}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 15479620 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_15479620}}

	==About this Structure==		==About this Structure==
-	1R02 is a [[Single protein]] structure. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R02 OCA].	+	1R02 is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R02 OCA].

	==Reference==		==Reference==
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	[[Category: Helix-loop-helix]]		[[Category: Helix-loop-helix]]
	[[Category: Turn]]		[[Category: Turn]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 06~~:54:39 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:00:58 2008''