1r1u - Revision history

OCA at 05:59, 23 August 2023

OCA — Wed, 23 Aug 2023 05:59:19 GMT

←Older revision		Revision as of 05:59, 23 August 2023
Line 3:		Line 3:
	<StructureSection load='1r1u' size='340' side='right'caption='[[1r1u]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1r1u' size='340' side='right'caption='[[1r1u]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1r1u]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus~~ aureus~~" (rosenbach 1884) zopf 1885~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R1U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R1U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1r1u]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R1U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R1U FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[1smt\|1smt]]~~, [[~~1r1t~~\|~~1r1t~~]]~~, [[1r1v\|1r1v]], [[1r22\|1r22]], [[1r23\|1r23]]</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r1u OCA], [https://pdbe.org/1r1u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r1u RCSB], [https://www.ebi.ac.uk/pdbsum/1r1u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r1u ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r1u OCA], [https://pdbe.org/1r1u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r1u RCSB], [https://www.ebi.ac.uk/pdbsum/1r1u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r1u ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/O85142_STAAU O85142_STAAU]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chen, X]]	+	[[Category: Staphylococcus aureus]]
-	[[Category: Eicken, C]]	+	[[Category: Chen X]]
-	[[Category: Giedroc~~, D P~~]]	+	[[Category: Eicken C]]
-	[[Category: Koshlap~~, K M~~]]	+	[[Category: Giedroc DP]]
-	[[Category: Pennella~~, M A~~]]	+	[[Category: Koshlap KM]]
-	[[Category: Sacchettini~~, J C~~]]	+	[[Category: Pennella MA]]
-	[[Category: VanZile~~, M L]]~~	+	[[Category: Sacchettini JC]]
-	~~[[Category: Dna binding]]~~	+	[[Category: VanZile ML]]
-	~~[[Category: Transcription repressor]]~~	+
-	~~[[Category: Transcriptional regulation]]~~	+
-	~~[[Category: Winged hth protein]]~~	+
-	~~[[Category: Zinc~~]]	+

OCA at 10:07, 15 September 2021

OCA — Wed, 15 Sep 2021 10:07:18 GMT

←Older revision		Revision as of 10:07, 15 September 2021
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	<StructureSection load='1r1u' size='340' side='right'caption='[[1r1u]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1r1u' size='340' side='right'caption='[[1r1u]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1r1u]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R1U OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1R1U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1r1u]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R1U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R1U FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1smt\|1smt]], [[1r1t\|1r1t]], [[1r1v\|1r1v]], [[1r22\|1r22]], [[1r23\|1r23]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1smt\|1smt]], [[1r1t\|1r1t]], [[1r1v\|1r1v]], [[1r22\|1r22]], [[1r23\|1r23]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1r1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r1u OCA], [~~http~~://pdbe.org/1r1u PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1r1u RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1r1u PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1r1u ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r1u OCA], [https://pdbe.org/1r1u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r1u RCSB], [https://www.ebi.ac.uk/pdbsum/1r1u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r1u ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 26:		Line 26:
	</div>		</div>
	<div class="pdbe-citations 1r1u" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1r1u" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[CzrA 3D structures\|CzrA 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:37, 4 December 2019

OCA — Wed, 04 Dec 2019 11:37:19 GMT

←Older revision		Revision as of 11:37, 4 December 2019
Line 1:		Line 1:

	==Crystal structure of the metal-sensing transcriptional repressor CzrA from Staphylococcus aureus in the apo-form==		==Crystal structure of the metal-sensing transcriptional repressor CzrA from Staphylococcus aureus in the apo-form==
-	<StructureSection load='1r1u' size='340' side='right' caption='[[1r1u]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='1r1u' size='340' side='right'caption='[[1r1u]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1r1u]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R1U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1R1U FirstGlance]. <br>		<table><tr><td colspan='2'>[[1r1u]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R1U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1R1U FirstGlance]. <br>
Line 26:		Line 26:
	</div>		</div>
	<div class="pdbe-citations 1r1u" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1r1u" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[CzrA 3D structures\|CzrA 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Chen, X]]		[[Category: Chen, X]]
	[[Category: Eicken, C]]		[[Category: Eicken, C]]

OCA at 08:01, 28 February 2018

OCA — Wed, 28 Feb 2018 08:01:40 GMT

←Older revision		Revision as of 08:01, 28 February 2018
Line 1:		Line 1:
		+
	==Crystal structure of the metal-sensing transcriptional repressor CzrA from Staphylococcus aureus in the apo-form==		==Crystal structure of the metal-sensing transcriptional repressor CzrA from Staphylococcus aureus in the apo-form==
	<StructureSection load='1r1u' size='340' side='right' caption='[[1r1u]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1r1u' size='340' side='right' caption='[[1r1u]], [[Resolution\|resolution]] 2.00Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1r1u]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R1U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1R1U FirstGlance]. <br>		<table><tr><td colspan='2'>[[1r1u]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R1U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1R1U FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1smt\|1smt]], [[1r1t\|1r1t]], [[1r1v\|1r1v]], [[1r22\|1r22]], [[1r23\|1r23]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1smt\|1smt]], [[1r1t\|1r1t]], [[1r1v\|1r1v]], [[1r22\|1r22]], [[1r23\|1r23]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r1u OCA], [http://pdbe.org/1r1u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1r1u RCSB], [http://www.ebi.ac.uk/pdbsum/1r1u PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r1u OCA], [http://pdbe.org/1r1u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1r1u RCSB], [http://www.ebi.ac.uk/pdbsum/1r1u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1r1u ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 10:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r1/1r1u_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r1/1r1u_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 40:		Line 41:
	[[Category: Transcriptional regulation]]		[[Category: Transcriptional regulation]]
	[[Category: Winged hth protein]]		[[Category: Winged hth protein]]
		+	[[Category: Zinc]]

OCA at 22:33, 9 February 2016

OCA — Tue, 09 Feb 2016 22:33:51 GMT

←Older revision		Revision as of 22:33, 9 February 2016
Line 14:		Line 14:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r1u ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 02:41, 11 September 2015

OCA — Fri, 11 Sep 2015 02:41:56 GMT

←Older revision		Revision as of 02:41, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1r1u' size='340' side='right' caption='[[1r1u]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1r1u' size='340' side='right' caption='[[1r1u]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1r1u]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Staphylococcus_aureus Staphylococcus~~ aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R1U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1R1U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1r1u]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R1U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1R1U FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1smt\|1smt]], [[1r1t\|1r1t]], [[1r1v\|1r1v]], [[1r22\|1r22]], [[1r23\|1r23]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1smt\|1smt]], [[1r1t\|1r1t]], [[1r1v\|1r1v]], [[1r22\|1r22]], [[1r23\|1r23]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r1u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1r1u RCSB], [http://www.ebi.ac.uk/pdbsum/1r1u PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r1u OCA], [http://pdbe.org/1r1u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1r1u RCSB], [http://www.ebi.ac.uk/pdbsum/1r1u PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 24:		Line 24:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1r1u" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Staphylococcus aureus]]
	[[Category: Chen, X]]		[[Category: Chen, X]]
	[[Category: Eicken, C]]		[[Category: Eicken, C]]

OCA at 08:13, 6 January 2015

OCA — Tue, 06 Jan 2015 08:13:59 GMT

←Older revision		Revision as of 08:13, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1r1u]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R1U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1R1U FirstGlance]. <br>		<table><tr><td colspan='2'>[[1r1u]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R1U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1R1U FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1smt\|1smt]], [[1r1t\|1r1t]], [[1r1v\|1r1v]], [[1r22\|1r22]], [[1r23\|1r23]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1smt\|1smt]], [[1r1t\|1r1t]], [[1r1v\|1r1v]], [[1r22\|1r22]], [[1r23\|1r23]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r1u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1r1u RCSB], [http://www.ebi.ac.uk/pdbsum/1r1u PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r1u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1r1u RCSB], [http://www.ebi.ac.uk/pdbsum/1r1u PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
-	[[Category: Chen, X.]]	+	[[Category: Chen, X]]
-	[[Category: Eicken, C.]]	+	[[Category: Eicken, C]]
-	[[Category: Giedroc, D P.]]	+	[[Category: Giedroc, D P]]
-	[[Category: Koshlap, K M.]]	+	[[Category: Koshlap, K M]]
-	[[Category: Pennella, M A.]]	+	[[Category: Pennella, M A]]
-	[[Category: Sacchettini, J C.]]	+	[[Category: Sacchettini, J C]]
-	[[Category: VanZile, M L.]]	+	[[Category: VanZile, M L]]
	[[Category: Dna binding]]		[[Category: Dna binding]]
	[[Category: Transcription repressor]]		[[Category: Transcription repressor]]
	[[Category: Transcriptional regulation]]		[[Category: Transcriptional regulation]]
	[[Category: Winged hth protein]]		[[Category: Winged hth protein]]

OCA at 16:35, 29 September 2014

OCA — Mon, 29 Sep 2014 16:35:20 GMT

←Older revision		Revision as of 16:35, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1r1u.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of the metal-sensing transcriptional repressor CzrA from Staphylococcus aureus in the apo-form==
		+	<StructureSection load='1r1u' size='340' side='right' caption='[[1r1u]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1r1u]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R1U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1R1U FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1smt\|1smt]], [[1r1t\|1r1t]], [[1r1v\|1r1v]], [[1r22\|1r22]], [[1r23\|1r23]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r1u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1r1u RCSB], [http://www.ebi.ac.uk/pdbsum/1r1u PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r1/1r1u_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The origin of metal ion selectivity by members of the SmtB/ArsR family of bacterial metal-sensing transcriptional repressors and the mechanism of negative allosteric regulation of DNA binding is poorly understood. Here, we report that two homologous zinc sensors, Staphylococcus aureus CzrA and cyanobacterial SmtB, are "winged" helix homodimeric DNA-binding proteins that bind Zn(II) to a pair of tetrahedral, interhelical binding sites, with two ligands derived from the alpha5 helix of one subunit, Asp84 O(delta1) (Asp104 in SmtB), His86 N(delta1) (His106), and two derived from the alpha5 helix of the other, His97' N(delta1) (His117') and His100' N(epsilon2) (Glu120'). Formation of the metal chelate drives a quaternary structural switch mediated by an intersubunit hydrogen-binding network that originates with the non-liganding N(epsilon2) face of His97 in CzrA (His117 in SmtB) that stabilizes a low-affinity, DNA-binding conformation. The structure of the Zn(1) SmtB homodimer shows that both metal-binding sites of the dimer must be occupied for the quaternary structural switch to occur. Thus, a critical zinc-ligating histidine residue obligatorily couples formation of the metal-sensing coordination chelate to changes in the conformation and dynamics of the putative DNA-binding helices.

-	~~{{STRUCTURE_1r1u\| PDB=1r1u \| SCENE= }}~~	+	A metal-ligand-mediated intersubunit allosteric switch in related SmtB/ArsR zinc sensor proteins.,Eicken C, Pennella MA, Chen X, Koshlap KM, VanZile ML, Sacchettini JC, Giedroc DP J Mol Biol. 2003 Oct 31;333(4):683-95. PMID:14568530<ref>PMID:14568530</ref>

-	~~===Crystal structure~~ of the ~~metal-sensing transcriptional repressor CzrA from Staphylococcus aureus in the apo-form===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_14568530}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1r1u]] is a 4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Staphylococcus_aureus Staphylococcus aureus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1R1U OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:014568530<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
	[[Category: Chen, X.]]		[[Category: Chen, X.]]

OCA: Protected "1r1u" [edit=sysop:move=sysop]

OCA — Fri, 04 Jan 2013 10:35:44 GMT

Protected "1r1u" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:35, 4 January 2013

OCA at 10:35, 4 January 2013

OCA — Fri, 04 Jan 2013 10:35:41 GMT

←Older revision		Revision as of 10:35, 4 January 2013
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-	{{Seed}}
	[[Image:1r1u.png\|left\|200px]]		[[Image:1r1u.png\|left\|200px]]

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	{{STRUCTURE_1r1u\| PDB=1r1u \| SCENE= }}		{{STRUCTURE_1r1u\| PDB=1r1u \| SCENE= }}

	===Crystal structure of the metal-sensing transcriptional repressor CzrA from Staphylococcus aureus in the apo-form===		===Crystal structure of the metal-sensing transcriptional repressor CzrA from Staphylococcus aureus in the apo-form===

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	{{ABSTRACT_PUBMED_14568530}}		{{ABSTRACT_PUBMED_14568530}}

	==About this Structure==		==About this Structure==
-	~~1R1U~~ is a 4 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R1U OCA].	+	[[1r1u]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R1U OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~14568530~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:014568530</ref><references group="xtra"/>
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
	[[Category: Chen, X.]]		[[Category: Chen, X.]]
Line 33:		Line 21:
	[[Category: VanZile, M L.]]		[[Category: VanZile, M L.]]
	[[Category: Dna binding]]		[[Category: Dna binding]]
		+	[[Category: Transcription repressor]]
	[[Category: Transcriptional regulation]]		[[Category: Transcriptional regulation]]
	[[Category: Winged hth protein]]		[[Category: Winged hth protein]]
-	[[Category: Zinc]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 13:16:08 2009''