1r44 - Revision history

OCA at 08:20, 14 February 2024

OCA — Wed, 14 Feb 2024 08:20:20 GMT

←Older revision		Revision as of 08:20, 14 February 2024
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	<StructureSection load='1r44' size='340' side='right'caption='[[1r44]], [[Resolution\|resolution]] 2.25Å' scene=''>		<StructureSection load='1r44' size='340' side='right'caption='[[1r44]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1r44]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_19434 Atcc 19434~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R44 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1R44 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1r44]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecium Enterococcus faecium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R44 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R44 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.25Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~VANX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=1352 ATCC 19434])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1r44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r44 OCA], [~~http~~://pdbe.org/1r44 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1r44 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1r44 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1r44 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r44 OCA], [https://pdbe.org/1r44 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r44 RCSB], [https://www.ebi.ac.uk/pdbsum/1r44 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r44 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/VANX_ENTFC VANX_ENTFC]] Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide.	+	[https://www.uniprot.org/uniprot/VANX_ENTFC VANX_ENTFC] Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 20:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r44 ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r44 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	VanX is a zinc-dependent D-alanyl-D-alanine dipeptidase that is a critical component in a system that mediates transposon-based vancomycin resistance in enterococci. It is also a key drug target in circumventing clinical vancomycin resistance. The structure of VanX from E. faecium has been solved by X-ray crystallography and reveals a Zn(2+)-dipeptidase with a unique overall fold and a well-defined active site confined within a cavity of limited size. The crystal structures of VanX, the VanX:D-alanyl-D-alanine complex, the VanX:D-alanine complex, and VanX in complex with phosphonate and phosphinate transition-state analog inhibitors, are also presented at high resolution. Structural homology searches of known structures revealed that the fold of VanX is similar to those of two proteins: the N-terminal fragment of murine Sonic hedgehog and the Zn(2+)-dependent N-acyl-D-alanyl-D-alanine carboxypeptidase of S. albus G.
-
-	The structure of VanX reveals a novel amino-dipeptidase involved in mediating transposon-based vancomycin resistance.,Bussiere DE, Pratt SD, Katz L, Severin JM, Holzman T, Park CH Mol Cell. 1998 Jul;2(1):75-84. PMID:9702193<ref>PMID:9702193</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1r44" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Atcc 19434~~]]	+	[[Category: Enterococcus faecium]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Holzman, T]]	+	[[Category: Holzman T]]
-	[[Category: Katz, L]]	+	[[Category: Katz L]]
-	[[Category: Park~~, C H~~]]	+	[[Category: Park CH]]
-	[[Category: Pratt~~, S D~~]]	+	[[Category: Pratt SD]]
-	[[Category: Severin~~, J M]]~~	+	[[Category: Severin JM]]
-	~~[[Category: Dipeptidase]]~~	+
-	~~[[Category: E faecium]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Vanx~~]]	+

OCA at 13:18, 16 December 2020

OCA — Wed, 16 Dec 2020 13:18:08 GMT

←Older revision		Revision as of 13:18, 16 December 2020
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	==Crystal Structure of VanX==		==Crystal Structure of VanX==
-	<StructureSection load='1r44' size='340' side='right' caption='[[1r44]], [[Resolution\|resolution]] 2.25Å' scene=''>	+	<StructureSection load='1r44' size='340' side='right'caption='[[1r44]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1r44]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_19434 Atcc 19434]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R44 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1R44 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1r44]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_19434 Atcc 19434]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R44 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1R44 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VANX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1352 ATCC 19434])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VANX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1352 ATCC 19434])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1r44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r44 OCA], [http://pdbe.org/1r44 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1r44 RCSB], [http://www.ebi.ac.uk/pdbsum/1r44 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1r44 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1r44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r44 OCA], [http://pdbe.org/1r44 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1r44 RCSB], [http://www.ebi.ac.uk/pdbsum/1r44 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1r44 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r4/1r44_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r4/1r44_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 19434]]		[[Category: Atcc 19434]]
		+	[[Category: Large Structures]]
	[[Category: Holzman, T]]		[[Category: Holzman, T]]
	[[Category: Katz, L]]		[[Category: Katz, L]]

OCA at 09:11, 12 October 2017

OCA — Thu, 12 Oct 2017 09:11:24 GMT

←Older revision		Revision as of 09:11, 12 October 2017
Line 1:		Line 1:
		+
	==Crystal Structure of VanX==		==Crystal Structure of VanX==
	<StructureSection load='1r44' size='340' side='right' caption='[[1r44]], [[Resolution\|resolution]] 2.25Å' scene=''>		<StructureSection load='1r44' size='340' side='right' caption='[[1r44]], [[Resolution\|resolution]] 2.25Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VANX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1352 ATCC 19434])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VANX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1352 ATCC 19434])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r44 OCA], [http://pdbe.org/1r44 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1r44 RCSB], [http://www.ebi.ac.uk/pdbsum/1r44 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r44 OCA], [http://pdbe.org/1r44 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1r44 RCSB], [http://www.ebi.ac.uk/pdbsum/1r44 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1r44 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 03:18, 10 February 2016

OCA — Wed, 10 Feb 2016 03:18:31 GMT

←Older revision		Revision as of 03:18, 10 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r44 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 04:51, 11 September 2015

OCA — Fri, 11 Sep 2015 04:51:15 GMT

←Older revision		Revision as of 04:51, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1r44' size='340' side='right' caption='[[1r44]], [[Resolution\|resolution]] 2.25Å' scene=''>		<StructureSection load='1r44' size='340' side='right' caption='[[1r44]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1r44]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Enterococcus_faecium Enterococcus faecium~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R44 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1R44 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1r44]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_19434 Atcc 19434]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R44 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1R44 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VANX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1352 ~~Enterococcus faecium~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VANX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1352 ATCC 19434])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r44 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1r44 RCSB], [http://www.ebi.ac.uk/pdbsum/1r44 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r44 OCA], [http://pdbe.org/1r44 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1r44 RCSB], [http://www.ebi.ac.uk/pdbsum/1r44 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1r44" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Enterococcus faecium~~]]	+	[[Category: Atcc 19434]]
	[[Category: Holzman, T]]		[[Category: Holzman, T]]
	[[Category: Katz, L]]		[[Category: Katz, L]]

OCA at 11:25, 25 December 2014

OCA — Thu, 25 Dec 2014 11:25:53 GMT

←Older revision		Revision as of 11:25, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1r44]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterococcus_faecium Enterococcus faecium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R44 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1R44 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1r44]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterococcus_faecium Enterococcus faecium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R44 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1R44 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VANX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1352 Enterococcus faecium])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VANX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1352 Enterococcus faecium])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r44 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1r44 RCSB], [http://www.ebi.ac.uk/pdbsum/1r44 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r44 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1r44 RCSB], [http://www.ebi.ac.uk/pdbsum/1r44 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/VANX_ENTFC VANX_ENTFC]] Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Enterococcus faecium]]		[[Category: Enterococcus faecium]]
-	[[Category: Holzman, T.]]	+	[[Category: Holzman, T]]
-	[[Category: Katz, L.]]	+	[[Category: Katz, L]]
-	[[Category: Park, C H.]]	+	[[Category: Park, C H]]
-	[[Category: Pratt, S D.]]	+	[[Category: Pratt, S D]]
-	[[Category: Severin, J M.]]	+	[[Category: Severin, J M]]
	[[Category: Dipeptidase]]		[[Category: Dipeptidase]]
	[[Category: E faecium]]		[[Category: E faecium]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Vanx]]		[[Category: Vanx]]

OCA at 14:09, 29 September 2014

OCA — Mon, 29 Sep 2014 14:09:07 GMT

←Older revision		Revision as of 14:09, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1r44.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure of VanX==
		+	<StructureSection load='1r44' size='340' side='right' caption='[[1r44]], [[Resolution\|resolution]] 2.25Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1r44]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterococcus_faecium Enterococcus faecium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R44 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1R44 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VANX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1352 Enterococcus faecium])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r44 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1r44 RCSB], [http://www.ebi.ac.uk/pdbsum/1r44 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r4/1r44_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	VanX is a zinc-dependent D-alanyl-D-alanine dipeptidase that is a critical component in a system that mediates transposon-based vancomycin resistance in enterococci. It is also a key drug target in circumventing clinical vancomycin resistance. The structure of VanX from E. faecium has been solved by X-ray crystallography and reveals a Zn(2+)-dipeptidase with a unique overall fold and a well-defined active site confined within a cavity of limited size. The crystal structures of VanX, the VanX:D-alanyl-D-alanine complex, the VanX:D-alanine complex, and VanX in complex with phosphonate and phosphinate transition-state analog inhibitors, are also presented at high resolution. Structural homology searches of known structures revealed that the fold of VanX is similar to those of two proteins: the N-terminal fragment of murine Sonic hedgehog and the Zn(2+)-dependent N-acyl-D-alanyl-D-alanine carboxypeptidase of S. albus G.

-	~~{{STRUCTURE_1r44\| PDB=1r44 \| SCENE= }}~~	+	The structure of VanX reveals a novel amino-dipeptidase involved in mediating transposon-based vancomycin resistance.,Bussiere DE, Pratt SD, Katz L, Severin JM, Holzman T, Park CH Mol Cell. 1998 Jul;2(1):75-84. PMID:9702193<ref>PMID:9702193</ref>

-	~~===Crystal Structure~~ of ~~VanX===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_9702193}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1r44]] is a 6 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Enterococcus_faecium Enterococcus faecium]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1R44 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:009702193<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Enterococcus faecium]]		[[Category: Enterococcus faecium]]
	[[Category: Holzman, T.]]		[[Category: Holzman, T.]]

OCA: Protected "1r44" [edit=sysop:move=sysop]

OCA — Fri, 04 Jan 2013 10:32:36 GMT

Protected "1r44" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:32, 4 January 2013

OCA at 10:32, 4 January 2013

OCA — Fri, 04 Jan 2013 10:32:31 GMT

←Older revision		Revision as of 10:32, 4 January 2013
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-	{{Seed}}
	[[Image:1r44.png\|left\|200px]]		[[Image:1r44.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1r44", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
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	{{STRUCTURE_1r44\| PDB=1r44 \| SCENE= }}		{{STRUCTURE_1r44\| PDB=1r44 \| SCENE= }}

	===Crystal Structure of VanX===		===Crystal Structure of VanX===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_9702193}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 9702193 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_9702193}}		{{ABSTRACT_PUBMED_9702193}}

	==About this Structure==		==About this Structure==
-	~~1R44~~ is a 6 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Enterococcus_faecium Enterococcus faecium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R44 OCA].	+	[[1r44]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterococcus_faecium Enterococcus faecium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R44 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~9702193~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:009702193</ref><references group="xtra"/>
	[[Category: Enterococcus faecium]]		[[Category: Enterococcus faecium]]
	[[Category: Holzman, T.]]		[[Category: Holzman, T.]]
Line 32:		Line 20:
	[[Category: Dipeptidase]]		[[Category: Dipeptidase]]
	[[Category: E faecium]]		[[Category: E faecium]]
		+	[[Category: Hydrolase]]
	[[Category: Vanx]]		[[Category: Vanx]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 15:00:29 2009''

OCA at 13:00, 17 February 2009

OCA — Tue, 17 Feb 2009 13:00:30 GMT

←Older revision		Revision as of 13:00, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	1R44 is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Enterococcus_faecium Enterococcus faecium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R44 OCA].	+	1R44 is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Enterococcus_faecium Enterococcus faecium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R44 OCA].

	==Reference==		==Reference==
-	The structure of VanX reveals a novel amino-dipeptidase involved in mediating transposon-based vancomycin resistance., Bussiere DE, Pratt SD, Katz L, Severin JM, Holzman T, Park CH, Mol Cell. 1998 Jul;2(1):75-84. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/9702193 9702193]~~	+	<ref group="xtra">PMID:9702193</ref><references group="xtra"/>
	[[Category: Enterococcus faecium]]		[[Category: Enterococcus faecium]]
-	[[Category: Single protein]]
	[[Category: Holzman, T.]]		[[Category: Holzman, T.]]
	[[Category: Katz, L.]]		[[Category: Katz, L.]]
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	[[Category: Vanx]]		[[Category: Vanx]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Jul 28 20~~:34:~~20 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 15:00:29 2009''