1r6z - Revision history

OCA at 06:01, 23 August 2023

OCA — Wed, 23 Aug 2023 06:01:40 GMT

←Older revision		Revision as of 06:01, 23 August 2023
Line 3:		Line 3:
	<StructureSection load='1r6z' size='340' side='right'caption='[[1r6z]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='1r6z' size='340' side='right'caption='[[1r6z]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1r6z]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Drome Drome~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R6Z OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1R6Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1r6z]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster] and [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R6Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R6Z FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene><~~/td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">MALE, Argonaute 2 CG7439-PB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=PRD_900001:alpha-maltose'>PRD_900001</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1r6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r6z OCA], [~~http~~://pdbe.org/1r6z PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1r6z RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1r6z PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1r6z ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r6z OCA], [https://pdbe.org/1r6z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r6z RCSB], [https://www.ebi.ac.uk/pdbsum/1r6z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r6z ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.	+	[https://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.[https://www.uniprot.org/uniprot/AGO2_DROME AGO2_DROME] Essential for RNA interference (RNAi); double-stranded RNA induces potent and specific gene silencing. RNAi is mediated by the RNA-induced silencing complex (RISC), a sequence-specific, multicomponent nuclease that destroys or silences messenger RNAs homologous to the silencing trigger.<ref>PMID:11498593</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Drome~~]]	+	[[Category: Drosophila melanogaster]]
		+	[[Category: Escherichia coli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hannon~~, G J~~]]	+	[[Category: Hannon GJ]]
-	[[Category: Joshua-Tor, L]]	+	[[Category: Joshua-Tor L]]
-	[[Category: Liu, J]]	+	[[Category: Liu J]]
-	[[Category: Martienssen~~, R A~~]]	+	[[Category: Martienssen RA]]
-	[[Category: Schneiderman, J]]	+	[[Category: Schneiderman J]]
-	[[Category: Smith~~, S K~~]]	+	[[Category: Smith SK]]
-	[[Category: Song~~, J J~~]]	+	[[Category: Song JJ]]
-	[[Category: Tolia~~, N H]]~~	+	[[Category: Tolia NH]]
-	~~[[Category: Deviant ob fold]]~~	+
-	~~[[Category: Gene regulation]]~~	+
-	~~[[Category: Rnai~~]]	+

OCA at 13:20, 16 December 2020

OCA — Wed, 16 Dec 2020 13:20:25 GMT

←Older revision		Revision as of 13:20, 16 December 2020
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	==The Crystal Structure of the Argonaute2 PAZ domain (as a MBP fusion)==		==The Crystal Structure of the Argonaute2 PAZ domain (as a MBP fusion)==
-	<StructureSection load='1r6z' size='340' side='right' caption='[[1r6z]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='1r6z' size='340' side='right'caption='[[1r6z]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1r6z]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R6Z OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1R6Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1r6z]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R6Z OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1R6Z FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~MAL~~:~~MALTOSE~~'>~~MAL~~</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MALE, Argonaute 2 CG7439-PB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MALE, Argonaute 2 CG7439-PB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1r6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r6z OCA], [http://pdbe.org/1r6z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1r6z RCSB], [http://www.ebi.ac.uk/pdbsum/1r6z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1r6z ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1r6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r6z OCA], [http://pdbe.org/1r6z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1r6z RCSB], [http://www.ebi.ac.uk/pdbsum/1r6z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1r6z ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r6/1r6z_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r6/1r6z_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 29:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 1r6z" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1r6z" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Argonaute 3D structures\|Argonaute 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 34:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Drome]]		[[Category: Drome]]
		+	[[Category: Large Structures]]
	[[Category: Hannon, G J]]		[[Category: Hannon, G J]]
	[[Category: Joshua-Tor, L]]		[[Category: Joshua-Tor, L]]

OCA at 00:27, 16 November 2017

OCA — Thu, 16 Nov 2017 00:27:40 GMT

←Older revision		Revision as of 00:27, 16 November 2017
Line 1:		Line 1:
		+
	==The Crystal Structure of the Argonaute2 PAZ domain (as a MBP fusion)==		==The Crystal Structure of the Argonaute2 PAZ domain (as a MBP fusion)==
	<StructureSection load='1r6z' size='340' side='right' caption='[[1r6z]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='1r6z' size='340' side='right' caption='[[1r6z]], [[Resolution\|resolution]] 2.80Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAL:MALTOSE'>MAL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAL:MALTOSE'>MAL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MALE, Argonaute 2 CG7439-PB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MALE, Argonaute 2 CG7439-PB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r6z OCA], [http://pdbe.org/1r6z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1r6z RCSB], [http://www.ebi.ac.uk/pdbsum/1r6z PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r6z OCA], [http://pdbe.org/1r6z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1r6z RCSB], [http://www.ebi.ac.uk/pdbsum/1r6z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1r6z ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r6z ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 1r6z" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1r6z" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Argonaute\|Argonaute]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 01:16, 12 September 2015

OCA — Sat, 12 Sep 2015 01:16:18 GMT

←Older revision		Revision as of 01:16, 12 September 2015
Line 2:		Line 2:
	<StructureSection load='1r6z' size='340' side='right' caption='[[1r6z]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='1r6z' size='340' side='right' caption='[[1r6z]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1r6z]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia coli~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R6Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1R6Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1r6z]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R6Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1R6Z FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAL:MALTOSE'>MAL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAL:MALTOSE'>MAL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MALE, Argonaute 2 CG7439-PB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~562 Escherichia coli~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MALE, Argonaute 2 CG7439-PB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r6z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1r6z RCSB], [http://www.ebi.ac.uk/pdbsum/1r6z PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r6z OCA], [http://pdbe.org/1r6z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1r6z RCSB], [http://www.ebi.ac.uk/pdbsum/1r6z PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1r6z" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Escherichia coli~~]]	+	[[Category: Drome]]
	[[Category: Hannon, G J]]		[[Category: Hannon, G J]]
	[[Category: Joshua-Tor, L]]		[[Category: Joshua-Tor, L]]

OCA at 21:53, 25 December 2014

OCA — Thu, 25 Dec 2014 21:53:05 GMT

←Older revision		Revision as of 21:53, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1r6z]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R6Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1R6Z FirstGlance]. <br>		<table><tr><td colspan='2'>[[1r6z]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R6Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1R6Z FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAL:MALTOSE'>MAL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAL:MALTOSE'>MAL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MALE, Argonaute 2 CG7439-PB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MALE, Argonaute 2 CG7439-PB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r6z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1r6z RCSB], [http://www.ebi.ac.uk/pdbsum/1r6z PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r6z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1r6z RCSB], [http://www.ebi.ac.uk/pdbsum/1r6z PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: Hannon, G J.]]	+	[[Category: Hannon, G J]]
-	[[Category: Joshua-Tor, L.]]	+	[[Category: Joshua-Tor, L]]
-	[[Category: Liu, J.]]	+	[[Category: Liu, J]]
-	[[Category: Martienssen, R A.]]	+	[[Category: Martienssen, R A]]
-	[[Category: Schneiderman, J.]]	+	[[Category: Schneiderman, J]]
-	[[Category: Smith, S K.]]	+	[[Category: Smith, S K]]
-	[[Category: Song, J J.]]	+	[[Category: Song, J J]]
-	[[Category: Tolia, N H.]]	+	[[Category: Tolia, N H]]
	[[Category: Deviant ob fold]]		[[Category: Deviant ob fold]]
	[[Category: Gene regulation]]		[[Category: Gene regulation]]
	[[Category: Rnai]]		[[Category: Rnai]]

OCA at 23:11, 28 September 2014

OCA — Sun, 28 Sep 2014 23:11:15 GMT

←Older revision		Revision as of 23:11, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1r6z.~~png~~\|~~left~~\|200px]]	+	==The Crystal Structure of the Argonaute2 PAZ domain (as a MBP fusion)==
		+	<StructureSection load='1r6z' size='340' side='right' caption='[[1r6z]], [[Resolution\|resolution]] 2.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1r6z]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R6Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1R6Z FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAL:MALTOSE'>MAL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MALE, Argonaute 2 CG7439-PB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r6z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1r6z RCSB], [http://www.ebi.ac.uk/pdbsum/1r6z PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r6/1r6z_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	RISC, the RNA-induced silencing complex, uses short interfering RNAs (siRNAs) or micro RNAs (miRNAs) to select its targets in a sequence-dependent manner. Key RISC components are Argonaute proteins, which contain two characteristic domains, PAZ and PIWI. PAZ is highly conserved and is found only in Argonaute proteins and Dicer. We have solved the crystal structure of the PAZ domain of Drosophila Argonaute2. The PAZ domain contains a variant of the OB fold, a module that often binds single-stranded nucleic acids. PAZ domains show low-affinity nucleic acid binding, probably interacting with the 3' ends of single-stranded regions of RNA. PAZ can bind the characteristic two-base 3' overhangs of siRNAs, indicating that although PAZ may not be a primary nucleic acid binding site in Dicer or RISC, it may contribute to the specific and productive incorporation of siRNAs and miRNAs into the RNAi pathway.

-	~~{{STRUCTURE_1r6z\| PDB=1r6z \| SCENE= }}~~	+	The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes.,Song JJ, Liu J, Tolia NH, Schneiderman J, Smith SK, Martienssen RA, Hannon GJ, Joshua-Tor L Nat Struct Biol. 2003 Dec;10(12):1026-32. Epub 2003 Nov 16. PMID:14625589<ref>PMID:14625589</ref>

-	~~===The Crystal Structure~~ of the ~~Argonaute2 PAZ domain (as a MBP fusion)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_14625589}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1r6z]] is a 3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli Escherichia coli]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1R6Z OCA].~~	+

	==See Also==		==See Also==
-	*[[~~Maltose-binding protein~~\|~~Maltose-binding protein~~]]	+	*[[Argonaute\|Argonaute]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:014625589<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Hannon, G J.]]		[[Category: Hannon, G J.]]

OCA at 22:05, 20 October 2012

OCA — Sat, 20 Oct 2012 22:05:39 GMT

←Older revision		Revision as of 22:05, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1r6z]] is a 3 chain structure ~~of [[Maltose-binding protein]]~~ with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli~~,_drosophila_melanogaster~~ Escherichia coli~~, drosophila melanogaster~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R6Z OCA].	+	[[1r6z]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R6Z OCA].

	==See Also==		==See Also==
Line 15:		Line 15:
	==Reference==		==Reference==
	<ref group="xtra">PMID:014625589</ref><references group="xtra"/>		<ref group="xtra">PMID:014625589</ref><references group="xtra"/>
-	[[Category: Escherichia coli~~, drosophila melanogaster~~]]	+	[[Category: Escherichia coli]]
	[[Category: Hannon, G J.]]		[[Category: Hannon, G J.]]
	[[Category: Joshua-Tor, L.]]		[[Category: Joshua-Tor, L.]]

OCA: Protected "1r6z" [edit=sysop:move=sysop]

OCA — Fri, 27 Jul 2012 15:13:53 GMT

Protected "1r6z" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:13, 27 July 2012

OCA at 15:13, 27 July 2012

OCA — Fri, 27 Jul 2012 15:13:52 GMT

←Older revision		Revision as of 15:13, 27 July 2012
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-	{{Seed}}
	[[Image:1r6z.png\|left\|200px]]		[[Image:1r6z.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1r6z", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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	{{STRUCTURE_1r6z\| PDB=1r6z \| SCENE= }}		{{STRUCTURE_1r6z\| PDB=1r6z \| SCENE= }}

	===The Crystal Structure of the Argonaute2 PAZ domain (as a MBP fusion)===		===The Crystal Structure of the Argonaute2 PAZ domain (as a MBP fusion)===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_14625589}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 14625589 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_14625589}}		{{ABSTRACT_PUBMED_14625589}}

	==About this Structure==		==About this Structure==
-	~~1R6Z~~ is a 3 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Escherichia_coli,_drosophila_melanogaster Escherichia coli, drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R6Z OCA].	+	[[1r6z]] is a 3 chain structure of [[Maltose-binding protein]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli,_drosophila_melanogaster Escherichia coli, drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R6Z OCA].
		+
		+	==See Also==
		+	*[[Maltose-binding protein\|Maltose-binding protein]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~14625589~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:014625589</ref><references group="xtra"/>
	[[Category: Escherichia coli, drosophila melanogaster]]		[[Category: Escherichia coli, drosophila melanogaster]]
	[[Category: Hannon, G J.]]		[[Category: Hannon, G J.]]
Line 34:		Line 25:
	[[Category: Tolia, N H.]]		[[Category: Tolia, N H.]]
	[[Category: Deviant ob fold]]		[[Category: Deviant ob fold]]
		+	[[Category: Gene regulation]]
	[[Category: Rnai]]		[[Category: Rnai]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:00:47 2009''

OCA at 07:00, 18 February 2009

OCA — Wed, 18 Feb 2009 07:00:50 GMT

←Older revision		Revision as of 07:00, 18 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	1R6Z is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Escherichia_coli,_drosophila_melanogaster Escherichia coli, drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R6Z OCA].	+	1R6Z is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli,_drosophila_melanogaster Escherichia coli, drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R6Z OCA].

	==Reference==		==Reference==
-	The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes., Song JJ, Liu J, Tolia NH, Schneiderman J, Smith SK, Martienssen RA, Hannon GJ, Joshua-Tor L, Nat Struct Biol. 2003 Dec;10(12):1026-32. Epub 2003 Nov 16. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/14625589 14625589]~~	+	<ref group="xtra">PMID:14625589</ref><references group="xtra"/>
	[[Category: Escherichia coli, drosophila melanogaster]]		[[Category: Escherichia coli, drosophila melanogaster]]
-	[[Category: Single protein]]
	[[Category: Hannon, G J.]]		[[Category: Hannon, G J.]]
	[[Category: Joshua-Tor, L.]]		[[Category: Joshua-Tor, L.]]
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	[[Category: Rnai]]		[[Category: Rnai]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 29 15~~:13:~~55 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:00:47 2009''