1r7t - Revision history

OCA at 18:15, 29 May 2024

OCA — Wed, 29 May 2024 18:15:45 GMT

←Older revision		Revision as of 18:15, 29 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1r7t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R7T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R7T FirstGlance]. <br>		<table><tr><td colspan='2'>[[1r7t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R7T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R7T FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DLG:HEXYL+3-DEOXY-BETA-D-GALACTOPYRANOSE'>DLG</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.09Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DLG:HEXYL+3-DEOXY-BETA-D-GALACTOPYRANOSE'>DLG</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r7t OCA], [https://pdbe.org/1r7t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r7t RCSB], [https://www.ebi.ac.uk/pdbsum/1r7t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r7t ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r7t OCA], [https://pdbe.org/1r7t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r7t RCSB], [https://www.ebi.ac.uk/pdbsum/1r7t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r7t ProSAT]</span></td></tr>
	</table>		</table>

OCA at 09:51, 21 December 2022

OCA — Wed, 21 Dec 2022 09:51:00 GMT

←Older revision		Revision as of 09:51, 21 December 2022
Line 3:		Line 3:
	<StructureSection load='1r7t' size='340' side='right'caption='[[1r7t]], [[Resolution\|resolution]] 2.09Å' scene=''>		<StructureSection load='1r7t' size='340' side='right'caption='[[1r7t]], [[Resolution\|resolution]] 2.09Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1r7t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R7T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R7T FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1r7t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R7T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R7T FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat">~~<scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>,~~ <scene name='pdbligand=DLG:HEXYL+3-DEOXY-BETA-D-GALACTOPYRANOSE'>DLG</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DLG:HEXYL+3-DEOXY-BETA-D-GALACTOPYRANOSE'>DLG</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1r7u\|1r7u]]~~, ~~[[1r7v\|1r7v]], [[1r7x\|1r7x]], [[1r7y\|1r7y]], [[1r80\|1r80]], [[1r81\|1r81]], [[1r82\|1r82]]~~<~~/div></td></tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>[https://en.wikipedia.org/wiki/Glycoprotein-fucosylgalactoside_alpha-N-acetylgalactosaminyltransferase Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.40 2.4.1.40] </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r7t OCA], [https://pdbe.org/1r7t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r7t RCSB], [https://www.ebi.ac.uk/pdbsum/1r7t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r7t ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r7t OCA], [https://pdbe.org/1r7t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r7t RCSB], [https://www.ebi.ac.uk/pdbsum/1r7t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r7t ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/BGAT_HUMAN BGAT_HUMAN]] This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.	+	[https://www.uniprot.org/uniprot/BGAT_HUMAN BGAT_HUMAN] This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Borisova~~, S N~~]]	+	[[Category: Borisova SN]]
-	[[Category: Cai, Y]]	+	[[Category: Cai Y]]
-	[[Category: Evans~~, S V~~]]	+	[[Category: Evans SV]]
-	[[Category: Leinala~~, E K~~]]	+	[[Category: Leinala EK]]
-	[[Category: Nguyen~~, H P~~]]	+	[[Category: Nguyen HP]]
-	[[Category: Palcic~~, M M~~]]	+	[[Category: Palcic MM]]
-	[[Category: Seto~~, N O.L]]~~	+	[[Category: Seto NOL]]
-	~~[[Category: Blood group antigen]]~~	+
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Signal-anchor]]~~	+
-	~~[[Category: Transferase]]~~	+
-	~~[[Category: Transmembrane~~]]	+

OCA at 10:09, 15 September 2021

OCA — Wed, 15 Sep 2021 10:09:20 GMT

←Older revision		Revision as of 10:09, 15 September 2021
Line 3:		Line 3:
	<StructureSection load='1r7t' size='340' side='right'caption='[[1r7t]], [[Resolution\|resolution]] 2.09Å' scene=''>		<StructureSection load='1r7t' size='340' side='right'caption='[[1r7t]], [[Resolution\|resolution]] 2.09Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1r7t]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R7T OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1R7T FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1r7t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R7T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R7T FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DLG:HEXYL+3-DEOXY-BETA-D-GALACTOPYRANOSE'>DLG</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC~~</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG~~</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=DLG:HEXYL+3-DEOXY-BETA-D-GALACTOPYRANOSE'>DLG</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1r7u\|1r7u]], [[1r7v\|1r7v]], [[1r7x\|1r7x]], [[1r7y\|1r7y]], [[1r80\|1r80]], [[1r81\|1r81]], [[1r82\|1r82]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1r7u\|1r7u]], [[1r7v\|1r7v]], [[1r7x\|1r7x]], [[1r7y\|1r7y]], [[1r80\|1r80]], [[1r81\|1r81]], [[1r82\|1r82]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Glycoprotein-fucosylgalactoside_alpha-N-acetylgalactosaminyltransferase Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.40 2.4.1.40] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Glycoprotein-fucosylgalactoside_alpha-N-acetylgalactosaminyltransferase Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.40 2.4.1.40] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1r7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r7t OCA], [~~http~~://pdbe.org/1r7t PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1r7t RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1r7t PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1r7t ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r7t OCA], [https://pdbe.org/1r7t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r7t RCSB], [https://www.ebi.ac.uk/pdbsum/1r7t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r7t ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/BGAT_HUMAN BGAT_HUMAN]] This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.	+	[[https://www.uniprot.org/uniprot/BGAT_HUMAN BGAT_HUMAN]] This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 11:43, 4 December 2019

OCA — Wed, 04 Dec 2019 11:43:08 GMT

←Older revision		Revision as of 11:43, 4 December 2019
Line 1:		Line 1:

	==Glycosyltransferase A in complex with 3-deoxy-acceptor analog inhibitor==		==Glycosyltransferase A in complex with 3-deoxy-acceptor analog inhibitor==
-	<StructureSection load='1r7t' size='340' side='right' caption='[[1r7t]], [[Resolution\|resolution]] 2.09Å' scene=''>	+	<StructureSection load='1r7t' size='340' side='right'caption='[[1r7t]], [[Resolution\|resolution]] 2.09Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1r7t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R7T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1R7T FirstGlance]. <br>		<table><tr><td colspan='2'>[[1r7t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R7T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1R7T FirstGlance]. <br>
Line 32:		Line 32:

	==See Also==		==See Also==
-	*[[Glycosyltransferase\|Glycosyltransferase]]	+	*[[Glycosyltransferase 3D structures\|Glycosyltransferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 39:		Line 39:
	[[Category: Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase]]		[[Category: Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Borisova, S N]]		[[Category: Borisova, S N]]
	[[Category: Cai, Y]]		[[Category: Cai, Y]]

OCA at 08:07, 28 February 2018

OCA — Wed, 28 Feb 2018 08:07:31 GMT

←Older revision		Revision as of 08:07, 28 February 2018
Line 1:		Line 1:
		+
	==Glycosyltransferase A in complex with 3-deoxy-acceptor analog inhibitor==		==Glycosyltransferase A in complex with 3-deoxy-acceptor analog inhibitor==
	<StructureSection load='1r7t' size='340' side='right' caption='[[1r7t]], [[Resolution\|resolution]] 2.09Å' scene=''>		<StructureSection load='1r7t' size='340' side='right' caption='[[1r7t]], [[Resolution\|resolution]] 2.09Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1r7t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R7T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1R7T FirstGlance]. <br>		<table><tr><td colspan='2'>[[1r7t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R7T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1R7T FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>,~~ <scene name='pdbligand=DLG:HEXYL+3-DEOXY-BETA-D-GALACTOPYRANOSE'>DLG</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DLG:HEXYL+3-DEOXY-BETA-D-GALACTOPYRANOSE'>DLG</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1r7u\|1r7u]], [[1r7v\|1r7v]], [[1r7x\|1r7x]], [[1r7y\|1r7y]], [[1r80\|1r80]], [[1r81\|1r81]], [[1r82\|1r82]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1r7u\|1r7u]], [[1r7v\|1r7v]], [[1r7x\|1r7x]], [[1r7y\|1r7y]], [[1r80\|1r80]], [[1r81\|1r81]], [[1r82\|1r82]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycoprotein-fucosylgalactoside_alpha-N-acetylgalactosaminyltransferase Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.40 2.4.1.40] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycoprotein-fucosylgalactoside_alpha-N-acetylgalactosaminyltransferase Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.40 2.4.1.40] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r7t OCA], [http://pdbe.org/1r7t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1r7t RCSB], [http://www.ebi.ac.uk/pdbsum/1r7t PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r7t OCA], [http://pdbe.org/1r7t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1r7t RCSB], [http://www.ebi.ac.uk/pdbsum/1r7t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1r7t ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r7/1r7t_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r7/1r7t_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 09:34, 7 February 2016

OCA — Sun, 07 Feb 2016 09:34:48 GMT

←Older revision		Revision as of 09:34, 7 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r7t ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 00:06, 10 September 2015

OCA — Thu, 10 Sep 2015 00:06:25 GMT

←Older revision		Revision as of 00:06, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1r7t' size='340' side='right' caption='[[1r7t]], [[Resolution\|resolution]] 2.09Å' scene=''>		<StructureSection load='1r7t' size='340' side='right' caption='[[1r7t]], [[Resolution\|resolution]] 2.09Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1r7t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R7T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1R7T FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1r7t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R7T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1R7T FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=DLG:HEXYL+3-DEOXY-BETA-D-GALACTOPYRANOSE'>DLG</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=DLG:HEXYL+3-DEOXY-BETA-D-GALACTOPYRANOSE'>DLG</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1r7u\|1r7u]], [[1r7v\|1r7v]], [[1r7x\|1r7x]], [[1r7y\|1r7y]], [[1r80\|1r80]], [[1r81\|1r81]], [[1r82\|1r82]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1r7u\|1r7u]], [[1r7v\|1r7v]], [[1r7x\|1r7x]], [[1r7y\|1r7y]], [[1r80\|1r80]], [[1r81\|1r81]], [[1r82\|1r82]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycoprotein-fucosylgalactoside_alpha-N-acetylgalactosaminyltransferase Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.40 2.4.1.40] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycoprotein-fucosylgalactoside_alpha-N-acetylgalactosaminyltransferase Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.40 2.4.1.40] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r7t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1r7t RCSB], [http://www.ebi.ac.uk/pdbsum/1r7t PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r7t OCA], [http://pdbe.org/1r7t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1r7t RCSB], [http://www.ebi.ac.uk/pdbsum/1r7t PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1r7t" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 36:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase]]		[[Category: Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase]]
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Borisova, S N]]		[[Category: Borisova, S N]]
	[[Category: Cai, Y]]		[[Category: Cai, Y]]

OCA at 14:06, 24 December 2014

OCA — Wed, 24 Dec 2014 14:06:16 GMT

←Older revision		Revision as of 14:06, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1r7t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R7T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1R7T FirstGlance]. <br>		<table><tr><td colspan='2'>[[1r7t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R7T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1R7T FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=DLG:HEXYL+3-DEOXY-BETA-D-GALACTOPYRANOSE'>DLG</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=DLG:HEXYL+3-DEOXY-BETA-D-GALACTOPYRANOSE'>DLG</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1r7u\|1r7u]], [[1r7v\|1r7v]], [[1r7x\|1r7x]], [[1r7y\|1r7y]], [[1r80\|1r80]], [[1r81\|1r81]], [[1r82\|1r82]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1r7u\|1r7u]], [[1r7v\|1r7v]], [[1r7x\|1r7x]], [[1r7y\|1r7y]], [[1r80\|1r80]], [[1r81\|1r81]], [[1r82\|1r82]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycoprotein-fucosylgalactoside_alpha-N-acetylgalactosaminyltransferase Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.40 2.4.1.40] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycoprotein-fucosylgalactoside_alpha-N-acetylgalactosaminyltransferase Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.40 2.4.1.40] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r7t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1r7t RCSB], [http://www.ebi.ac.uk/pdbsum/1r7t PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r7t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1r7t RCSB], [http://www.ebi.ac.uk/pdbsum/1r7t PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BGAT_HUMAN BGAT_HUMAN]] This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 37:
	[[Category: Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase]]		[[Category: Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Borisova, S N.]]	+	[[Category: Borisova, S N]]
-	[[Category: Cai, Y.]]	+	[[Category: Cai, Y]]
-	[[Category: Evans, S V.]]	+	[[Category: Evans, S V]]
-	[[Category: Leinala, E K.]]	+	[[Category: Leinala, E K]]
-	[[Category: Nguyen, H P.]]	+	[[Category: Nguyen, H P]]
-	[[Category: Palcic, M M.]]	+	[[Category: Palcic, M M]]
-	[[Category: Seto, N O.L.]]	+	[[Category: Seto, N O.L]]
	[[Category: Blood group antigen]]		[[Category: Blood group antigen]]
	[[Category: Glycoprotein]]		[[Category: Glycoprotein]]

OCA at 22:01, 28 September 2014

OCA — Sun, 28 Sep 2014 22:01:57 GMT

←Older revision		Revision as of 22:01, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1r7t.~~png~~\|~~left~~\|200px]]	+	==Glycosyltransferase A in complex with 3-deoxy-acceptor analog inhibitor==
		+	<StructureSection load='1r7t' size='340' side='right' caption='[[1r7t]], [[Resolution\|resolution]] 2.09Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1r7t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R7T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1R7T FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=DLG:HEXYL+3-DEOXY-BETA-D-GALACTOPYRANOSE'>DLG</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1r7u\|1r7u]], [[1r7v\|1r7v]], [[1r7x\|1r7x]], [[1r7y\|1r7y]], [[1r80\|1r80]], [[1r81\|1r81]], [[1r82\|1r82]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycoprotein-fucosylgalactoside_alpha-N-acetylgalactosaminyltransferase Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.40 2.4.1.40] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r7t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1r7t RCSB], [http://www.ebi.ac.uk/pdbsum/1r7t PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r7/1r7t_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human ABO(H) blood group glycosyltransferases GTA and GTB catalyze the final monosaccharide addition in the biosynthesis of the human A and B blood group antigens. GTA and GTB utilize a common acceptor, the H antigen disaccharide alpha-l-Fucp-(1-->2)-beta-d-Galp-OR, but different donors, where GTA transfers GalNAc from UDP-GalNAc and GTB transfers Gal from UDP-Gal. GTA and GTB are two of the most homologous enzymes known to transfer different donors and differ in only 4 amino acid residues, but one in particular (Leu/Met-266) has been shown to dominate the selection between donor sugars. The structures of the A and B glycosyltransferases have been determined to high resolution in complex with two inhibitory acceptor analogs alpha-l-Fucp(1-->2)-beta-d-(3-deoxy)-Galp-OR and alpha-l-Fucp-(1-->2)-beta-d-(3-amino)-Galp-OR, in which the 3-hydroxyl moiety of the Gal ring has been replaced by hydrogen or an amino group, respectively. Remarkably, although the 3-deoxy inhibitor occupies the same conformation and position observed for the native H antigen in GTA and GTB, the 3-amino analog is recognized differently by the two enzymes. The 3-amino substitution introduces a novel intramolecular hydrogen bond between O2' on Fuc and N3' on Gal, which alters the minimum-energy conformation of the inhibitor. In the absence of UDP, the 3-amino analog can be accommodated by either GTA or GTB with the l-Fuc residue partially occupying the vacant UDP binding site. However, in the presence of UDP, the analog is forced to abandon the intramolecular hydrogen bond, and the l-Fuc residue is shifted to a less ordered conformation. Further, the residue Leu/Met-266 that was thought important only in distinguishing between donor substrates is observed to interact differently with the 3-amino acceptor analog in GTA and GTB. These observations explain why the 3-deoxy analog acts as a competitive inhibitor of the glycosyltransferase reaction, whereas the 3-amino analog displays complex modes of inhibition.

-	~~{{STRUCTURE_1r7t\| PDB=1r7t \| SCENE= }}~~	+	The influence of an intramolecular hydrogen bond in differential recognition of inhibitory acceptor analogs by human ABO(H) blood group A and B glycosyltransferases.,Nguyen HP, Seto NO, Cai Y, Leinala EK, Borisova SN, Palcic MM, Evans SV J Biol Chem. 2003 Dec 5;278(49):49191-5. Epub 2003 Sep 11. PMID:12972418<ref>PMID:12972418</ref>

-	~~===Glycosyltransferase A in complex with 3-deoxy-acceptor analog inhibitor===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_12972418}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1r7t]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1R7T OCA].~~	+

	==See Also==		==See Also==
	*[[Glycosyltransferase\|Glycosyltransferase]]		*[[Glycosyltransferase\|Glycosyltransferase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:012972418<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase]]		[[Category: Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA at 06:15, 20 October 2012

OCA — Sat, 20 Oct 2012 06:15:33 GMT

←Older revision		Revision as of 06:15, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1r7t]] is a 1 chain structure ~~of [[Glycosyltransferase]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R7T OCA].	+	[[1r7t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R7T OCA].

	==See Also==		==See Also==