1r9p - Revision history

OCA at 06:34, 1 May 2024

OCA — Wed, 01 May 2024 06:34:34 GMT

←Older revision		Revision as of 06:34, 1 May 2024
Line 1:		Line 1:

	==Solution NMR Structure Of The Haemophilus Influenzae Iron-Sulfur Cluster Assembly Protein U (IscU) with Zinc Bound at the Active Site. Northeast Structural Genomics Consortium Target IR24.==		==Solution NMR Structure Of The Haemophilus Influenzae Iron-Sulfur Cluster Assembly Protein U (IscU) with Zinc Bound at the Active Site. Northeast Structural Genomics Consortium Target IR24.==
-	<StructureSection load='1r9p' size='340' side='right'caption='[[1r9p~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='1r9p' size='340' side='right'caption='[[1r9p]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1r9p]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacterium_influenzae"_lehmann_and_neumann_1896 "bacterium~~ influenzae~~" lehmann and neumann 1896~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R9P OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1R9P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1r9p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R9P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R9P FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'~~>~~[[1q48\|1q48]]~~<~~/div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">HI0377 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=727 "Bacterium influenzae" Lehmann and Neumann 1896])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r9p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r9p OCA], [https://pdbe.org/1r9p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r9p RCSB], [https://www.ebi.ac.uk/pdbsum/1r9p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r9p ProSAT], [https://www.topsan.org/Proteins/NESGC/1r9p TOPSAN]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1r9p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r9p OCA], [~~http~~://pdbe.org/1r9p PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1r9p RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1r9p PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1r9p ProSAT], [~~http~~://www.topsan.org/Proteins/NESGC/1r9p TOPSAN]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/ISCU_HAEIN ISCU_HAEIN]] A scaffold on which IscS assembles Fe-S clusters. Subsequently gives the nascent cluster to other proteins. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters (By similarity).	+	[https://www.uniprot.org/uniprot/ISCU_HAEIN ISCU_HAEIN] A scaffold on which IscS assembles Fe-S clusters. Subsequently gives the nascent cluster to other proteins. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 21:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r9p ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r9p ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	IscU is a highly conserved protein that serves as the scaffold for IscS-mediated assembly of iron-sulfur ([Fe-S]) clusters. We report the NMR solution structure of monomeric Haemophilus influenzae IscU with zinc bound at the [Fe-S] cluster assembly site. The compact core of the globular structure has an alpha-beta sandwich architecture with a three-stranded antiparallel beta-sheet and four alpha-helices. A nascent helix is located N-terminal to the core structure. The zinc is ligated by three cysteine residues and one histidine residue that are located in and near conformationally dynamic loops at one end of the IscU structure. Removal of the zinc metal by chelation results in widespread loss of structure in the apo form. The zinc-bound IscU may be a good model for iron-loaded IscU and may demonstrate structural features found in the [Fe-S] cluster bound form. Structural and functional similarities, genomic context in operons containing other homologous genes, and distributions of conserved surface residues support the hypothesis that IscU protein domains are homologous (i.e. derived from a common ancestor) with the SufE/YgdK family of [Fe-S] cluster assembly proteins.
-
-	Solution NMR structure of the iron-sulfur cluster assembly protein U (IscU) with zinc bound at the active site.,Ramelot TA, Cort JR, Goldsmith-Fischman S, Kornhaber GJ, Xiao R, Shastry R, Acton TB, Honig B, Montelione GT, Kennedy MA J Mol Biol. 2004 Nov 19;344(2):567-83. PMID:15522305<ref>PMID:15522305</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1r9p" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacterium~~ influenzae ~~lehmann and neumann 1896~~]]	+	[[Category: Haemophilus influenzae]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Acton~~, T B~~]]	+	[[Category: Acton TB]]
-	[[Category: Cort~~, J R~~]]	+	[[Category: Cort JR]]
-	[[Category: Kennedy~~, M A~~]]	+	[[Category: Kennedy MA]]
-	[[Category: Montelione~~, G T]]~~	+	[[Category: Montelione GT]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Ramelot TA]]
-	[[Category: Ramelot~~, T A~~]]	+	[[Category: Shastry R]]
-	[[Category: Shastry, R]]	+	[[Category: Xiao R]]
-	[[Category: Xiao, R]]	+
-	~~[[Category: 3beta strand]]~~	+
-	~~[[Category: Alpha helix]]~~	+
-	~~[[Category: Iron-sulfur cluster binding]]~~	+
-	~~[[Category: Nesg]]~~	+
-	~~[[Category: PSI, Protein structure initiative]]~~	+
-	~~[[Category: Three conserved cy]]~~	+
-	~~[[Category: Unknown function]]~~	+
-	~~[[Category: Zinc binding~~]]	+

OCA at 13:22, 16 December 2020

OCA — Wed, 16 Dec 2020 13:22:09 GMT

←Older revision		Revision as of 13:22, 16 December 2020
Line 1:		Line 1:

	==Solution NMR Structure Of The Haemophilus Influenzae Iron-Sulfur Cluster Assembly Protein U (IscU) with Zinc Bound at the Active Site. Northeast Structural Genomics Consortium Target IR24.==		==Solution NMR Structure Of The Haemophilus Influenzae Iron-Sulfur Cluster Assembly Protein U (IscU) with Zinc Bound at the Active Site. Northeast Structural Genomics Consortium Target IR24.==
-	<StructureSection load='1r9p' size='340' side='right' caption='[[1r9p]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='1r9p' size='340' side='right'caption='[[1r9p]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1r9p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacterium_influenzae"_lehmann_and_neumann_1896 "bacterium influenzae" lehmann and neumann 1896]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R9P OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1R9P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1r9p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacterium_influenzae"_lehmann_and_neumann_1896 "bacterium influenzae" lehmann and neumann 1896]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R9P OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1R9P FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1q48\|1q48]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1q48\|1q48]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HI0377 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=727 "Bacterium influenzae" Lehmann and Neumann 1896])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HI0377 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=727 "Bacterium influenzae" Lehmann and Neumann 1896])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1r9p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r9p OCA], [http://pdbe.org/1r9p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1r9p RCSB], [http://www.ebi.ac.uk/pdbsum/1r9p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1r9p ProSAT], [http://www.topsan.org/Proteins/NESGC/1r9p TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1r9p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r9p OCA], [http://pdbe.org/1r9p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1r9p RCSB], [http://www.ebi.ac.uk/pdbsum/1r9p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1r9p ProSAT], [http://www.topsan.org/Proteins/NESGC/1r9p TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 35:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Bacterium influenzae lehmann and neumann 1896]]		[[Category: Bacterium influenzae lehmann and neumann 1896]]
		+	[[Category: Large Structures]]
	[[Category: Acton, T B]]		[[Category: Acton, T B]]
	[[Category: Cort, J R]]		[[Category: Cort, J R]]

OCA at 08:08, 28 February 2018

OCA — Wed, 28 Feb 2018 08:08:46 GMT

←Older revision		Revision as of 08:08, 28 February 2018
Line 1:		Line 1:
		+
	==Solution NMR Structure Of The Haemophilus Influenzae Iron-Sulfur Cluster Assembly Protein U (IscU) with Zinc Bound at the Active Site. Northeast Structural Genomics Consortium Target IR24.==		==Solution NMR Structure Of The Haemophilus Influenzae Iron-Sulfur Cluster Assembly Protein U (IscU) with Zinc Bound at the Active Site. Northeast Structural Genomics Consortium Target IR24.==
	<StructureSection load='1r9p' size='340' side='right' caption='[[1r9p]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1r9p' size='340' side='right' caption='[[1r9p]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1q48\|1q48]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1q48\|1q48]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HI0377 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=727 "Bacterium influenzae" Lehmann and Neumann 1896])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HI0377 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=727 "Bacterium influenzae" Lehmann and Neumann 1896])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r9p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r9p OCA], [http://pdbe.org/1r9p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1r9p RCSB], [http://www.ebi.ac.uk/pdbsum/1r9p PDBsum], [http://www.topsan.org/Proteins/NESGC/1r9p TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r9p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r9p OCA], [http://pdbe.org/1r9p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1r9p RCSB], [http://www.ebi.ac.uk/pdbsum/1r9p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1r9p ProSAT], [http://www.topsan.org/Proteins/NESGC/1r9p TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r9/1r9p_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r9/1r9p_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r9p ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 16:20, 11 September 2015

OCA — Fri, 11 Sep 2015 16:20:47 GMT

←Older revision		Revision as of 16:20, 11 September 2015
Line 6:		Line 6:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1q48\|1q48]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1q48\|1q48]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HI0377 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=727 "Bacterium influenzae" Lehmann and Neumann 1896])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HI0377 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=727 "Bacterium influenzae" Lehmann and Neumann 1896])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r9p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r9p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1r9p RCSB], [http://www.ebi.ac.uk/pdbsum/1r9p PDBsum], [http://www.topsan.org/Proteins/NESGC/1r9p TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r9p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r9p OCA], [http://pdbe.org/1r9p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1r9p RCSB], [http://www.ebi.ac.uk/pdbsum/1r9p PDBsum], [http://www.topsan.org/Proteins/NESGC/1r9p TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1r9p" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 18:56, 25 December 2014

OCA — Thu, 25 Dec 2014 18:56:05 GMT

←Older revision		Revision as of 18:56, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1r9p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacterium_influenzae"_lehmann_and_neumann_1896 "bacterium influenzae" lehmann and neumann 1896]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R9P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1R9P FirstGlance]. <br>		<table><tr><td colspan='2'>[[1r9p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacterium_influenzae"_lehmann_and_neumann_1896 "bacterium influenzae" lehmann and neumann 1896]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R9P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1R9P FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1q48\|1q48]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1q48\|1q48]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HI0377 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=727 "Bacterium influenzae" Lehmann and Neumann 1896])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HI0377 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=727 "Bacterium influenzae" Lehmann and Neumann 1896])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r9p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r9p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1r9p RCSB], [http://www.ebi.ac.uk/pdbsum/1r9p PDBsum], [http://www.topsan.org/Proteins/NESGC/1r9p TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r9p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r9p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1r9p RCSB], [http://www.ebi.ac.uk/pdbsum/1r9p PDBsum], [http://www.topsan.org/Proteins/NESGC/1r9p TOPSAN]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ISCU_HAEIN ISCU_HAEIN]] A scaffold on which IscS assembles Fe-S clusters. Subsequently gives the nascent cluster to other proteins. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Bacterium influenzae lehmann and neumann 1896]]		[[Category: Bacterium influenzae lehmann and neumann 1896]]
-	[[Category: Acton, T B.]]	+	[[Category: Acton, T B]]
-	[[Category: Cort, J R.]]	+	[[Category: Cort, J R]]
-	[[Category: Kennedy, M A.]]	+	[[Category: Kennedy, M A]]
-	[[Category: Montelione, G T.]]	+	[[Category: Montelione, G T]]
-	[[Category: ~~NESG, Northeast~~ Structural ~~Genomics Consortium.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Ramelot, T A.]]	+	[[Category: Ramelot, T A]]
-	[[Category: Shastry, R.]]	+	[[Category: Shastry, R]]
-	[[Category: Xiao, R.]]	+	[[Category: Xiao, R]]
	[[Category: 3beta strand]]		[[Category: 3beta strand]]
-	[[Category: ~~4 alpha~~ helix]]	+	[[Category: Alpha helix]]
	[[Category: Iron-sulfur cluster binding]]		[[Category: Iron-sulfur cluster binding]]
	[[Category: Nesg]]		[[Category: Nesg]]
-	[[Category: ~~Northeast structural genomics consortium]]~~	+	[[Category: PSI, Protein structure initiative]]
-	~~[[Category:~~ Protein structure initiative]]	+
-	~~[[Category: Psi-2]]~~	+
-	~~[[Category: Structural genomic~~]]	+
	[[Category: Three conserved cy]]		[[Category: Three conserved cy]]
	[[Category: Unknown function]]		[[Category: Unknown function]]
	[[Category: Zinc binding]]		[[Category: Zinc binding]]

OCA at 07:01, 24 September 2014

OCA — Wed, 24 Sep 2014 07:01:10 GMT

←Older revision		Revision as of 07:01, 24 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1r9p.~~png~~\|~~left~~\|200px]]	+	==Solution NMR Structure Of The Haemophilus Influenzae Iron-Sulfur Cluster Assembly Protein U (IscU) with Zinc Bound at the Active Site. Northeast Structural Genomics Consortium Target IR24.==
		+	<StructureSection load='1r9p' size='340' side='right' caption='[[1r9p]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1r9p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacterium_influenzae"_lehmann_and_neumann_1896 "bacterium influenzae" lehmann and neumann 1896]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R9P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1R9P FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1q48\|1q48]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HI0377 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=727 "Bacterium influenzae" Lehmann and Neumann 1896])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r9p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r9p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1r9p RCSB], [http://www.ebi.ac.uk/pdbsum/1r9p PDBsum], [http://www.topsan.org/Proteins/NESGC/1r9p TOPSAN]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r9/1r9p_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	IscU is a highly conserved protein that serves as the scaffold for IscS-mediated assembly of iron-sulfur ([Fe-S]) clusters. We report the NMR solution structure of monomeric Haemophilus influenzae IscU with zinc bound at the [Fe-S] cluster assembly site. The compact core of the globular structure has an alpha-beta sandwich architecture with a three-stranded antiparallel beta-sheet and four alpha-helices. A nascent helix is located N-terminal to the core structure. The zinc is ligated by three cysteine residues and one histidine residue that are located in and near conformationally dynamic loops at one end of the IscU structure. Removal of the zinc metal by chelation results in widespread loss of structure in the apo form. The zinc-bound IscU may be a good model for iron-loaded IscU and may demonstrate structural features found in the [Fe-S] cluster bound form. Structural and functional similarities, genomic context in operons containing other homologous genes, and distributions of conserved surface residues support the hypothesis that IscU protein domains are homologous (i.e. derived from a common ancestor) with the SufE/YgdK family of [Fe-S] cluster assembly proteins.

-	~~{{STRUCTURE_1r9p\| PDB=1r9p \| SCENE= }}~~	+	Solution NMR structure of the iron-sulfur cluster assembly protein U (IscU) with zinc bound at the active site.,Ramelot TA, Cort JR, Goldsmith-Fischman S, Kornhaber GJ, Xiao R, Shastry R, Acton TB, Honig B, Montelione GT, Kennedy MA J Mol Biol. 2004 Nov 19;344(2):567-83. PMID:15522305<ref>PMID:15522305</ref>

-	~~===Solution NMR Structure Of The Haemophilus Influenzae Iron-Sulfur Cluster Assembly Protein~~ U ~~(IscU) with Zinc Bound at the Active Site~~. ~~Northeast Structural Genomics Consortium Target IR24~~.~~===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15522305}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1r9p]] is a 1 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R9P OCA].~~	+	</StructureSection>
-		+	[[Category: Bacterium influenzae lehmann and neumann 1896]]
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:015522305<~~/~~ref~~><~~references group="xtra"~~/>	+
-	[[Category: ~~Haemophilus~~ influenzae]]	+
	[[Category: Acton, T B.]]		[[Category: Acton, T B.]]
	[[Category: Cort, J R.]]		[[Category: Cort, J R.]]

OCA: Protected "1r9p" [edit=sysop:move=sysop]

OCA — Fri, 04 Jan 2013 10:45:40 GMT

Protected "1r9p" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:45, 4 January 2013

OCA at 10:45, 4 January 2013

OCA — Fri, 04 Jan 2013 10:45:37 GMT

←Older revision		Revision as of 10:45, 4 January 2013
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-	{{Seed}}
	[[Image:1r9p.png\|left\|200px]]		[[Image:1r9p.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1r9p", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1r9p\| PDB=1r9p \| SCENE= }}		{{STRUCTURE_1r9p\| PDB=1r9p \| SCENE= }}

	===Solution NMR Structure Of The Haemophilus Influenzae Iron-Sulfur Cluster Assembly Protein U (IscU) with Zinc Bound at the Active Site. Northeast Structural Genomics Consortium Target IR24.===		===Solution NMR Structure Of The Haemophilus Influenzae Iron-Sulfur Cluster Assembly Protein U (IscU) with Zinc Bound at the Active Site. Northeast Structural Genomics Consortium Target IR24.===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15522305}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15522305 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15522305}}		{{ABSTRACT_PUBMED_15522305}}

	==About this Structure==		==About this Structure==
-	~~1R9P~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R9P OCA].	+	[[1r9p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R9P OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15522305~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015522305</ref><references group="xtra"/>
	[[Category: Haemophilus influenzae]]		[[Category: Haemophilus influenzae]]
	[[Category: Acton, T B.]]		[[Category: Acton, T B.]]
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	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Three conserved cy]]		[[Category: Three conserved cy]]
		+	[[Category: Unknown function]]
	[[Category: Zinc binding]]		[[Category: Zinc binding]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 03:38:06 2009''

OCA at 01:38, 18 February 2009

OCA — Wed, 18 Feb 2009 01:38:09 GMT

←Older revision		Revision as of 01:38, 18 February 2009
Line 23:		Line 23:

	==Reference==		==Reference==
-	Solution NMR structure of the iron-sulfur cluster assembly protein U (IscU) with zinc bound at the active site., Ramelot TA, Cort JR, Goldsmith-Fischman S, Kornhaber GJ, Xiao R, Shastry R, Acton TB, Honig B, Montelione GT, Kennedy MA, J Mol Biol. 2004 Nov 19;344(2):567-83. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/15522305 15522305]~~	+	<ref group="xtra">PMID:15522305</ref><references group="xtra"/>
	[[Category: Haemophilus influenzae]]		[[Category: Haemophilus influenzae]]
	[[Category: Acton, T B.]]		[[Category: Acton, T B.]]
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	[[Category: Zinc binding]]		[[Category: Zinc binding]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun Nov 16~~ 18:44:~~25 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 03:38:06 2009''

OCA at 16:44, 16 November 2008

OCA — Sun, 16 Nov 2008 16:44:26 GMT

←Older revision		Revision as of 16:44, 16 November 2008
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	1R9P is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R9P OCA].	+	1R9P is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R9P OCA].

	==Reference==		==Reference==
	Solution NMR structure of the iron-sulfur cluster assembly protein U (IscU) with zinc bound at the active site., Ramelot TA, Cort JR, Goldsmith-Fischman S, Kornhaber GJ, Xiao R, Shastry R, Acton TB, Honig B, Montelione GT, Kennedy MA, J Mol Biol. 2004 Nov 19;344(2):567-83. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15522305 15522305]		Solution NMR structure of the iron-sulfur cluster assembly protein U (IscU) with zinc bound at the active site., Ramelot TA, Cort JR, Goldsmith-Fischman S, Kornhaber GJ, Xiao R, Shastry R, Acton TB, Honig B, Montelione GT, Kennedy MA, J Mol Biol. 2004 Nov 19;344(2):567-83. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15522305 15522305]
	[[Category: Haemophilus influenzae]]		[[Category: Haemophilus influenzae]]
-	[[Category: Single protein]]
	[[Category: Acton, T B.]]		[[Category: Acton, T B.]]
	[[Category: Cort, J R.]]		[[Category: Cort, J R.]]
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	[[Category: Zinc binding]]		[[Category: Zinc binding]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 29 09~~:52:47 2008''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Nov 16 18:44:25 2008''