1rei - Revision history

OCA at 08:22, 1 May 2024

OCA — Wed, 01 May 2024 08:22:36 GMT

←Older revision		Revision as of 08:22, 1 May 2024
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	<StructureSection load='1rei' size='340' side='right'caption='[[1rei]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1rei' size='340' side='right'caption='[[1rei]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1rei]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1REI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1REI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1rei]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1REI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1REI FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rei FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rei OCA], [https://pdbe.org/1rei PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rei RCSB], [https://www.ebi.ac.uk/pdbsum/1rei PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rei ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rei FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rei OCA], [https://pdbe.org/1rei PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rei RCSB], [https://www.ebi.ac.uk/pdbsum/1rei PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rei ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/KVD33_HUMAN KVD33_HUMAN] V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).<ref>PMID:17576170</ref> <ref>PMID:20176268</ref> <ref>PMID:22158414</ref> <ref>PMID:24600447</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rei ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rei ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The structure of the variable portions of a K-type Bence-Jones protein REI forming a dimer has been determined by X-ray diffraction to a resolution of 2.0 A. The structure has been refined using a constrained crystallographic refinement procedure. The final R value is 0.24 for 15000 significantly measured reflections; the estimated standard deviation of atomic positions is 0.09 A. A more objective assessment of the error in the atomic positions is possible by comparing the two independently refined monomers. The mean deviation of main-chain atoms of the two chains in internal segments in 0.22 A, of main-chain dihedral angles 6.3 degrees for these segments. The unrefined molecular structure of the VREI dimer has been published (Epp, O., Colman, P., Fehlhammer, H., Bode, W., Schiffer, M., Huber, R., and Palm, W. (1974), Eur. J. Biochem. 45, 513). Now a detailed analysis is presented in terms of hydrogen bonds and conformational angles. Secondary structural elements (antiparallel beta structure, reverse turns) are defined. A more precise atomic arrangement of the amino acid residues forming the contact region and the hapten binding site is given as well as the localization of solvent molecules. Two cis-prolines (Pro-8 and Pro-95) were detected. The intrachain disulfide bridge (Cys-23-Cys-88) occurs statistically in two alternative conformations. The structure suggests reasons for strong conservation of several amino acid residues. The knowledge of the refined molecular structure enables crystal structure analyses of related molecules to be made by Patterson search techniques. The calculated phases based on the refined structure are much improved compared to isomorphous phases. Therefore the effects of hapten binding on the molecular structure can be analyzed by the difference Fourier technique with more reliability. Hapten binding studies have been started.
-
-	The molecular structure of a dimer composed of the variable portions of the Bence-Jones protein REI refined at 2.0-A resolution.,Epp O, Lattman EE, Schiffer M, Huber R, Palm W Biochemistry. 1975 Nov 4;14(22):4943-52. PMID:1182131<ref>PMID:1182131</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1rei" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bode, W]]	+	[[Category: Bode W]]
-	[[Category: Colman, P]]	+	[[Category: Colman P]]
-	[[Category: Epp, O]]	+	[[Category: Epp O]]
-	[[Category: Fehlhammer, H]]	+	[[Category: Fehlhammer H]]
-	[[Category: Huber, R]]	+	[[Category: Huber R]]
-	[[Category: Lattman~~, E E~~]]	+	[[Category: Lattman EE]]
-	[[Category: Palm, W]]	+	[[Category: Palm W]]
-	[[Category: Schiffer, M]]	+	[[Category: Schiffer M]]

OCA at 10:12, 15 September 2021

OCA — Wed, 15 Sep 2021 10:12:18 GMT

←Older revision		Revision as of 10:12, 15 September 2021
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	<StructureSection load='1rei' size='340' side='right'caption='[[1rei]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1rei' size='340' side='right'caption='[[1rei]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1rei]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1REI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1REI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1rei]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1REI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1REI FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1rei FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rei OCA], [~~http~~://pdbe.org/1rei PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1rei RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1rei PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1rei ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rei FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rei OCA], [https://pdbe.org/1rei PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rei RCSB], [https://www.ebi.ac.uk/pdbsum/1rei PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rei ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 11:30, 4 December 2019

OCA — Wed, 04 Dec 2019 11:30:37 GMT

←Older revision		Revision as of 11:30, 4 December 2019
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	==THE MOLECULAR STRUCTURE OF A DIMER COMPOSED OF THE VARIABLE PORTIONS OF THE BENCE-JONES PROTEIN REI REFINED AT 2.0 ANGSTROMS RESOLUTION==		==THE MOLECULAR STRUCTURE OF A DIMER COMPOSED OF THE VARIABLE PORTIONS OF THE BENCE-JONES PROTEIN REI REFINED AT 2.0 ANGSTROMS RESOLUTION==
-	<StructureSection load='1rei' size='340' side='right' caption='[[1rei]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='1rei' size='340' side='right'caption='[[1rei]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1rei]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1REI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1REI FirstGlance]. <br>		<table><tr><td colspan='2'>[[1rei]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1REI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1REI FirstGlance]. <br>
Line 10:		Line 10:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/re/1rei_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/re/1rei_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Bode, W]]		[[Category: Bode, W]]
	[[Category: Colman, P]]		[[Category: Colman, P]]

OCA at 06:54, 29 November 2017

OCA — Wed, 29 Nov 2017 06:54:47 GMT

←Older revision		Revision as of 06:54, 29 November 2017
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		+
	==THE MOLECULAR STRUCTURE OF A DIMER COMPOSED OF THE VARIABLE PORTIONS OF THE BENCE-JONES PROTEIN REI REFINED AT 2.0 ANGSTROMS RESOLUTION==		==THE MOLECULAR STRUCTURE OF A DIMER COMPOSED OF THE VARIABLE PORTIONS OF THE BENCE-JONES PROTEIN REI REFINED AT 2.0 ANGSTROMS RESOLUTION==
	<StructureSection load='1rei' size='340' side='right' caption='[[1rei]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1rei' size='340' side='right' caption='[[1rei]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1rei]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1REI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1REI FirstGlance]. <br>		<table><tr><td colspan='2'>[[1rei]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1REI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1REI FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rei FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rei OCA], [http://pdbe.org/1rei PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1rei RCSB], [http://www.ebi.ac.uk/pdbsum/1rei PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rei FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rei OCA], [http://pdbe.org/1rei PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1rei RCSB], [http://www.ebi.ac.uk/pdbsum/1rei PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1rei ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 13:		Line 14:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rei ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 01:39, 12 September 2015

OCA — Sat, 12 Sep 2015 01:39:25 GMT

←Older revision		Revision as of 01:39, 12 September 2015
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	<StructureSection load='1rei' size='340' side='right' caption='[[1rei]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1rei' size='340' side='right' caption='[[1rei]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1rei]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1REI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1REI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1rei]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1REI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1REI FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rei FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rei OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1rei RCSB], [http://www.ebi.ac.uk/pdbsum/1rei PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rei FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rei OCA], [http://pdbe.org/1rei PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1rei RCSB], [http://www.ebi.ac.uk/pdbsum/1rei PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 23:		Line 23:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1rei" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Bode, W]]		[[Category: Bode, W]]
	[[Category: Colman, P]]		[[Category: Colman, P]]

OCA at 07:09, 6 January 2015

OCA — Tue, 06 Jan 2015 07:09:00 GMT

←Older revision		Revision as of 07:09, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1rei]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1REI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1REI FirstGlance]. <br>		<table><tr><td colspan='2'>[[1rei]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1REI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1REI FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rei FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rei OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1rei RCSB], [http://www.ebi.ac.uk/pdbsum/1rei PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rei FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rei OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1rei RCSB], [http://www.ebi.ac.uk/pdbsum/1rei PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Bode, W.]]	+	[[Category: Bode, W]]
-	[[Category: Colman, P.]]	+	[[Category: Colman, P]]
-	[[Category: Epp, O.]]	+	[[Category: Epp, O]]
-	[[Category: Fehlhammer, H.]]	+	[[Category: Fehlhammer, H]]
-	[[Category: Huber, R.]]	+	[[Category: Huber, R]]
-	[[Category: Lattman, E E.]]	+	[[Category: Lattman, E E]]
-	[[Category: Palm, W.]]	+	[[Category: Palm, W]]
-	[[Category: Schiffer, M.]]	+	[[Category: Schiffer, M]]

OCA at 17:00, 29 September 2014

OCA — Mon, 29 Sep 2014 17:00:09 GMT

←Older revision		Revision as of 17:00, 29 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1rei.~~png\|left~~\|200px]]	+	==THE MOLECULAR STRUCTURE OF A DIMER COMPOSED OF THE VARIABLE PORTIONS OF THE BENCE-JONES PROTEIN REI REFINED AT 2.0 ANGSTROMS RESOLUTION==
		+	<StructureSection load='1rei' size='340' side='right' caption='[[1rei]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1rei]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1REI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1REI FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rei FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rei OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1rei RCSB], [http://www.ebi.ac.uk/pdbsum/1rei PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/re/1rei_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The structure of the variable portions of a K-type Bence-Jones protein REI forming a dimer has been determined by X-ray diffraction to a resolution of 2.0 A. The structure has been refined using a constrained crystallographic refinement procedure. The final R value is 0.24 for 15000 significantly measured reflections; the estimated standard deviation of atomic positions is 0.09 A. A more objective assessment of the error in the atomic positions is possible by comparing the two independently refined monomers. The mean deviation of main-chain atoms of the two chains in internal segments in 0.22 A, of main-chain dihedral angles 6.3 degrees for these segments. The unrefined molecular structure of the VREI dimer has been published (Epp, O., Colman, P., Fehlhammer, H., Bode, W., Schiffer, M., Huber, R., and Palm, W. (1974), Eur. J. Biochem. 45, 513). Now a detailed analysis is presented in terms of hydrogen bonds and conformational angles. Secondary structural elements (antiparallel beta structure, reverse turns) are defined. A more precise atomic arrangement of the amino acid residues forming the contact region and the hapten binding site is given as well as the localization of solvent molecules. Two cis-prolines (Pro-8 and Pro-95) were detected. The intrachain disulfide bridge (Cys-23-Cys-88) occurs statistically in two alternative conformations. The structure suggests reasons for strong conservation of several amino acid residues. The knowledge of the refined molecular structure enables crystal structure analyses of related molecules to be made by Patterson search techniques. The calculated phases based on the refined structure are much improved compared to isomorphous phases. Therefore the effects of hapten binding on the molecular structure can be analyzed by the difference Fourier technique with more reliability. Hapten binding studies have been started.

-	~~{{STRUCTURE_1rei\| PDB=1rei \| SCENE= }}~~	+	The molecular structure of a dimer composed of the variable portions of the Bence-Jones protein REI refined at 2.0-A resolution.,Epp O, Lattman EE, Schiffer M, Huber R, Palm W Biochemistry. 1975 Nov 4;14(22):4943-52. PMID:1182131<ref>PMID:1182131</ref>

-	~~===THE MOLECULAR STRUCTURE OF A DIMER COMPOSED OF THE VARIABLE PORTIONS OF THE BENCE-JONES PROTEIN REI REFINED AT 2.0 ANGSTROMS RESOLUTION===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_1182131}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1rei]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1REI OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:001182131<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bode, W.]]		[[Category: Bode, W.]]

OCA: Protected "1rei" [edit=sysop:move=sysop]

OCA — Fri, 04 Jan 2013 10:28:03 GMT

Protected "1rei" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:28, 4 January 2013

OCA at 10:28, 4 January 2013

OCA — Fri, 04 Jan 2013 10:28:00 GMT

←Older revision		Revision as of 10:28, 4 January 2013
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-	{{Seed}}
	[[Image:1rei.png\|left\|200px]]		[[Image:1rei.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_1rei\| PDB=1rei \| SCENE= }}		{{STRUCTURE_1rei\| PDB=1rei \| SCENE= }}

	===THE MOLECULAR STRUCTURE OF A DIMER COMPOSED OF THE VARIABLE PORTIONS OF THE BENCE-JONES PROTEIN REI REFINED AT 2.0 ANGSTROMS RESOLUTION===		===THE MOLECULAR STRUCTURE OF A DIMER COMPOSED OF THE VARIABLE PORTIONS OF THE BENCE-JONES PROTEIN REI REFINED AT 2.0 ANGSTROMS RESOLUTION===

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	{{ABSTRACT_PUBMED_1182131}}		{{ABSTRACT_PUBMED_1182131}}

	==About this Structure==		==About this Structure==
-	~~1REI~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1REI OCA].	+	[[1rei]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1REI OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~1182131~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:001182131</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bode, W.]]		[[Category: Bode, W.]]
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	[[Category: Palm, W.]]		[[Category: Palm, W.]]
	[[Category: Schiffer, M.]]		[[Category: Schiffer, M.]]
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OCA at 07:19, 18 February 2009

OCA — Wed, 18 Feb 2009 07:19:58 GMT

←Older revision		Revision as of 07:19, 18 February 2009
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	==About this Structure==		==About this Structure==
-	1REI is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1REI OCA].	+	1REI is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1REI OCA].

	==Reference==		==Reference==
-	The molecular structure of a dimer composed of the variable portions of the Bence-Jones protein REI refined at 2.0-A resolution., Epp O, Lattman EE, Schiffer M, Huber R, Palm W, Biochemistry. 1975 Nov 4;14(22):4943-52. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/1182131 1182131]~~	+	<ref group="xtra">PMID:1182131</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Single protein]]
	[[Category: Bode, W.]]		[[Category: Bode, W.]]
	[[Category: Colman, P.]]		[[Category: Colman, P.]]
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	[[Category: Schiffer, M.]]		[[Category: Schiffer, M.]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 29 15~~:34:~~44 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:19:57 2009''