1ri5 - Revision history

OCA at 08:23, 14 February 2024

OCA — Wed, 14 Feb 2024 08:23:20 GMT

←Older revision		Revision as of 08:23, 14 February 2024
Line 3:		Line 3:
	<StructureSection load='1ri5' size='340' side='right'caption='[[1ri5]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1ri5' size='340' side='right'caption='[[1ri5]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ri5]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Enccn Enccn~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RI5 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1RI5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ri5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Encephalitozoon_cuniculi Encephalitozoon cuniculi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RI5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RI5 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[1ri1\|1ri1]], [[1ri2\|1ri2]], [[1ri3\|1ri3]], [[1ri4\|1ri4]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">ECU10_0380 ([http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=6035 ENCCN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ri5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ri5 OCA], [https://pdbe.org/1ri5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ri5 RCSB], [https://www.ebi.ac.uk/pdbsum/1ri5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ri5 ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/1ri5 TOPSAN]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1ri5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ri5 OCA], [~~http~~://pdbe.org/1ri5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1ri5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1ri5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1ri5 ProSAT], [~~http~~://www.topsan.org/Proteins/NYSGXRC/1ri5 TOPSAN]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/MCES_ENCCU MCES_ENCCU]] mRNA-capping methyltransferase that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC.<ref>PMID:15760890</ref>	+	[https://www.uniprot.org/uniprot/MCES_ENCCU MCES_ENCCU] mRNA-capping methyltransferase that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC.<ref>PMID:15760890</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 20:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ri5 ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ri5 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	A suite of crystal structures is reported for a cellular mRNA cap (guanine-N7) methyltransferase in complex with AdoMet, AdoHcy, and the cap guanylate. Superposition of ligand complexes suggests an in-line mechanism of methyl transfer, albeit without direct contacts between the enzyme and either the N7 atom of guanine (the attacking nucleophile), the methyl carbon of AdoMet, or the sulfur of AdoMet/AdoHcy (the leaving group). The structures indicate that catalysis of cap N7 methylation is accomplished by optimizing proximity and orientation of the substrates, assisted by a favorable electrostatic environment. The enzyme-ligand structures, together with new mutational data, fully account for the biochemical specificity of the cap guanine-N7 methylation reaction, an essential and defining step of eukaryotic mRNA synthesis.
-
-	Structure and mechanism of mRNA cap (guanine-N7) methyltransferase.,Fabrega C, Hausmann S, Shen V, Shuman S, Lima CD Mol Cell. 2004 Jan 16;13(1):77-89. PMID:14731396<ref>PMID:14731396</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1ri5" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[MRNA capping enzyme\|MRNA capping enzyme]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Enccn~~]]	+	[[Category: Encephalitozoon cuniculi]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Burley~~, S K~~]]	+	[[Category: Burley SK]]
-	[[Category: Fabrega, C]]	+	[[Category: Fabrega C]]
-	[[Category: Hausmann, S]]	+	[[Category: Hausmann S]]
-	[[Category: Lima~~, C D]]~~	+	[[Category: Lima CD]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Shen V]]
-	[[Category: Shen, V]]	+	[[Category: Shuman S]]
-	[[Category: Shuman, S]]	+
-	~~[[Category: Cap]]~~	+
-	~~[[Category: M7g]]~~	+
-	~~[[Category: Messenger rna cap]]~~	+
-	~~[[Category: Methyltransferase]]~~	+
-	~~[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics]]~~	+
-	~~[[Category: PSI, Protein structure initiative]]~~	+
-	~~[[Category: Rna]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 13:26, 16 December 2020

OCA — Wed, 16 Dec 2020 13:26:58 GMT

←Older revision		Revision as of 13:26, 16 December 2020
Line 1:		Line 1:

	==Structure and mechanism of mRNA cap (guanine N-7) methyltransferase==		==Structure and mechanism of mRNA cap (guanine N-7) methyltransferase==
-	<StructureSection load='1ri5' size='340' side='right' caption='[[1ri5]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='1ri5' size='340' side='right'caption='[[1ri5]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ri5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Enccn Enccn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RI5 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1RI5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ri5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Enccn Enccn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RI5 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1RI5 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ri1\|1ri1]], [[1ri2\|1ri2]], [[1ri3\|1ri3]], [[1ri4\|1ri4]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ri1\|1ri1]], [[1ri2\|1ri2]], [[1ri3\|1ri3]], [[1ri4\|1ri4]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ECU10_0380 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6035 ENCCN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ECU10_0380 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6035 ENCCN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ri5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ri5 OCA], [http://pdbe.org/1ri5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ri5 RCSB], [http://www.ebi.ac.uk/pdbsum/1ri5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ri5 ProSAT], [http://www.topsan.org/Proteins/NYSGXRC/1ri5 TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1ri5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ri5 OCA], [http://pdbe.org/1ri5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ri5 RCSB], [http://www.ebi.ac.uk/pdbsum/1ri5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ri5 ProSAT], [http://www.topsan.org/Proteins/NYSGXRC/1ri5 TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 29:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 1ri5" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1ri5" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[MRNA capping enzyme\|MRNA capping enzyme]]
	== References ==		== References ==
	<references/>		<references/>
Line 34:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Enccn]]		[[Category: Enccn]]
		+	[[Category: Large Structures]]
	[[Category: Burley, S K]]		[[Category: Burley, S K]]
	[[Category: Fabrega, C]]		[[Category: Fabrega, C]]

OCA at 07:59, 28 February 2018

OCA — Wed, 28 Feb 2018 07:59:24 GMT

←Older revision		Revision as of 07:59, 28 February 2018
Line 1:		Line 1:
		+
	==Structure and mechanism of mRNA cap (guanine N-7) methyltransferase==		==Structure and mechanism of mRNA cap (guanine N-7) methyltransferase==
	<StructureSection load='1ri5' size='340' side='right' caption='[[1ri5]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1ri5' size='340' side='right' caption='[[1ri5]], [[Resolution\|resolution]] 2.10Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ri1\|1ri1]], [[1ri2\|1ri2]], [[1ri3\|1ri3]], [[1ri4\|1ri4]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ri1\|1ri1]], [[1ri2\|1ri2]], [[1ri3\|1ri3]], [[1ri4\|1ri4]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ECU10_0380 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6035 ENCCN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ECU10_0380 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6035 ENCCN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ri5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ri5 OCA], [http://pdbe.org/1ri5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ri5 RCSB], [http://www.ebi.ac.uk/pdbsum/1ri5 PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/1ri5 TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ri5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ri5 OCA], [http://pdbe.org/1ri5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ri5 RCSB], [http://www.ebi.ac.uk/pdbsum/1ri5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ri5 ProSAT], [http://www.topsan.org/Proteins/NYSGXRC/1ri5 TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ri/1ri5_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ri/1ri5_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 22:05, 8 February 2016

OCA — Mon, 08 Feb 2016 22:05:51 GMT

←Older revision		Revision as of 22:05, 8 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ri5 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 15:48, 10 September 2015

OCA — Thu, 10 Sep 2015 15:48:38 GMT

←Older revision		Revision as of 15:48, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1ri5' size='340' side='right' caption='[[1ri5]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1ri5' size='340' side='right' caption='[[1ri5]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ri5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Encephalitozoon_cuniculi Encephalitozoon cuniculi~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RI5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RI5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ri5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Enccn Enccn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RI5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RI5 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ri1\|1ri1]], [[1ri2\|1ri2]], [[1ri3\|1ri3]], [[1ri4\|1ri4]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ri1\|1ri1]], [[1ri2\|1ri2]], [[1ri3\|1ri3]], [[1ri4\|1ri4]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ECU10_0380 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6035 ~~Encephalitozoon cuniculi~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ECU10_0380 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6035 ENCCN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ri5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ri5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ri5 RCSB], [http://www.ebi.ac.uk/pdbsum/1ri5 PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/1ri5 TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ri5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ri5 OCA], [http://pdbe.org/1ri5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ri5 RCSB], [http://www.ebi.ac.uk/pdbsum/1ri5 PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/1ri5 TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1ri5" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Encephalitozoon cuniculi~~]]	+	[[Category: Enccn]]
	[[Category: Burley, S K]]		[[Category: Burley, S K]]
	[[Category: Fabrega, C]]		[[Category: Fabrega, C]]

OCA at 02:26, 25 December 2014

OCA — Thu, 25 Dec 2014 02:26:55 GMT

←Older revision		Revision as of 02:26, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ri5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ri5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ri5 RCSB], [http://www.ebi.ac.uk/pdbsum/1ri5 PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/1ri5 TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ri5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ri5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ri5 RCSB], [http://www.ebi.ac.uk/pdbsum/1ri5 PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/1ri5 TOPSAN]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MCES_ENCCU MCES_ENCCU]] mRNA-capping methyltransferase that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC.<ref>PMID:15760890</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 13:39, 6 November 2014

OCA — Thu, 06 Nov 2014 13:39:36 GMT

←Older revision		Revision as of 13:39, 6 November 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ri5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Encephalitozoon_cuniculi Encephalitozoon cuniculi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RI5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RI5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ri5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Encephalitozoon_cuniculi Encephalitozoon cuniculi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RI5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RI5 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ri1\|1ri1]], [[1ri2\|1ri2]], [[1ri3\|1ri3]], [[1ri4\|1ri4]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ri1\|1ri1]], [[1ri2\|1ri2]], [[1ri3\|1ri3]], [[1ri4\|1ri4]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ECU10_0380 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6035 Encephalitozoon cuniculi])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ECU10_0380 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6035 Encephalitozoon cuniculi])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ri5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ri5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ri5 RCSB], [http://www.ebi.ac.uk/pdbsum/1ri5 PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/1ri5 TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ri5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ri5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ri5 RCSB], [http://www.ebi.ac.uk/pdbsum/1ri5 PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/1ri5 TOPSAN]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Encephalitozoon cuniculi]]		[[Category: Encephalitozoon cuniculi]]
-	[[Category: Burley, S K.]]	+	[[Category: Burley, S K]]
-	[[Category: Fabrega, C.]]	+	[[Category: Fabrega, C]]
-	[[Category: Hausmann, S.]]	+	[[Category: Hausmann, S]]
-	[[Category: Lima, C D.]]	+	[[Category: Lima, C D]]
-	[[Category: ~~NYSGXRC, New York SGX Research Center for~~ Structural ~~Genomics.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Shen, V.]]	+	[[Category: Shen, V]]
-	[[Category: Shuman, S.]]	+	[[Category: Shuman, S]]
	[[Category: Cap]]		[[Category: Cap]]
	[[Category: M7g]]		[[Category: M7g]]
	[[Category: Messenger rna cap]]		[[Category: Messenger rna cap]]
	[[Category: Methyltransferase]]		[[Category: Methyltransferase]]
-	[[Category: New ~~york sgx research center~~ for ~~structural genomic]]~~	+	[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics]]
-	~~[[Category: Nysgxrc~~]]	+	[[Category: PSI, Protein structure initiative]]
-	[[Category: Protein structure initiative]]	+
-	~~[[Category: Psi~~]]	+
	[[Category: Rna]]		[[Category: Rna]]
-	[[Category: Structural genomic]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 17:30, 29 September 2014

OCA — Mon, 29 Sep 2014 17:30:30 GMT

←Older revision		Revision as of 17:30, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1ri5.~~png~~\|~~left~~\|200px]]	+	==Structure and mechanism of mRNA cap (guanine N-7) methyltransferase==
		+	<StructureSection load='1ri5' size='340' side='right' caption='[[1ri5]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1ri5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Encephalitozoon_cuniculi Encephalitozoon cuniculi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RI5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RI5 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ri1\|1ri1]], [[1ri2\|1ri2]], [[1ri3\|1ri3]], [[1ri4\|1ri4]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ECU10_0380 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6035 Encephalitozoon cuniculi])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ri5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ri5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ri5 RCSB], [http://www.ebi.ac.uk/pdbsum/1ri5 PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/1ri5 TOPSAN]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ri/1ri5_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A suite of crystal structures is reported for a cellular mRNA cap (guanine-N7) methyltransferase in complex with AdoMet, AdoHcy, and the cap guanylate. Superposition of ligand complexes suggests an in-line mechanism of methyl transfer, albeit without direct contacts between the enzyme and either the N7 atom of guanine (the attacking nucleophile), the methyl carbon of AdoMet, or the sulfur of AdoMet/AdoHcy (the leaving group). The structures indicate that catalysis of cap N7 methylation is accomplished by optimizing proximity and orientation of the substrates, assisted by a favorable electrostatic environment. The enzyme-ligand structures, together with new mutational data, fully account for the biochemical specificity of the cap guanine-N7 methylation reaction, an essential and defining step of eukaryotic mRNA synthesis.

-	~~{{STRUCTURE_1ri5\| PDB=1ri5 \| SCENE= }}~~	+	Structure and mechanism of mRNA cap (guanine-N7) methyltransferase.,Fabrega C, Hausmann S, Shen V, Shuman S, Lima CD Mol Cell. 2004 Jan 16;13(1):77-89. PMID:14731396<ref>PMID:14731396</ref>

-	~~===Structure and mechanism~~ of ~~mRNA cap (guanine N-7) methyltransferase===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_14731396}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1ri5]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Encephalitozoon_cuniculi Encephalitozoon cuniculi]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1RI5 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:014731396<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Encephalitozoon cuniculi]]		[[Category: Encephalitozoon cuniculi]]
	[[Category: Burley, S K.]]		[[Category: Burley, S K.]]

OCA: Protected "1ri5" [edit=sysop:move=sysop]

OCA — Fri, 04 Jan 2013 10:33:01 GMT

Protected "1ri5" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:33, 4 January 2013

OCA at 10:32, 4 January 2013

OCA — Fri, 04 Jan 2013 10:32:58 GMT

←Older revision		Revision as of 10:32, 4 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1ri5.png\|left\|200px]]		[[Image:1ri5.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1ri5", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1ri5\| PDB=1ri5 \| SCENE= }}		{{STRUCTURE_1ri5\| PDB=1ri5 \| SCENE= }}

	===Structure and mechanism of mRNA cap (guanine N-7) methyltransferase===		===Structure and mechanism of mRNA cap (guanine N-7) methyltransferase===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_14731396}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 14731396 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_14731396}}		{{ABSTRACT_PUBMED_14731396}}

	==About this Structure==		==About this Structure==
-	~~1RI5~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Encephalitozoon_cuniculi Encephalitozoon cuniculi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RI5 OCA].	+	[[1ri5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Encephalitozoon_cuniculi Encephalitozoon cuniculi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RI5 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~14731396~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:014731396</ref><references group="xtra"/>
	[[Category: Encephalitozoon cuniculi]]		[[Category: Encephalitozoon cuniculi]]
	[[Category: Burley, S K.]]		[[Category: Burley, S K.]]
Line 29:		Line 17:
	[[Category: Hausmann, S.]]		[[Category: Hausmann, S.]]
	[[Category: Lima, C D.]]		[[Category: Lima, C D.]]
-	[[Category: NYSGXRC, New York ~~Structural GenomiX~~ Research ~~Consortium~~.]]	+	[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics.]]
	[[Category: Shen, V.]]		[[Category: Shen, V.]]
	[[Category: Shuman, S.]]		[[Category: Shuman, S.]]
Line 36:		Line 24:
	[[Category: Messenger rna cap]]		[[Category: Messenger rna cap]]
	[[Category: Methyltransferase]]		[[Category: Methyltransferase]]
-	[[Category: New york ~~structural genomix~~ research ~~consortium~~]]	+	[[Category: New york sgx research center for structural genomic]]
	[[Category: Nysgxrc]]		[[Category: Nysgxrc]]
	[[Category: Protein structure initiative]]		[[Category: Protein structure initiative]]
Line 42:		Line 30:
	[[Category: Rna]]		[[Category: Rna]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
-		+	[[Category: Transferase]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 03:52:31 2009''~~	+